ml_id essentiality_rank entry gene_names protein_names sequence_length esm2_essentiality_probability esm2_call hansen_essentiality_score hansen_essentiality_call confidence agreement review_flag mtb_ortholog ortholog_identity mtb_call mtb_essential proteomelm_context_percentile target_priority_score priority_tier rationale model_version computed_at conservative_essentiality_call conservative_essentiality_reason false_negative_guard proteomelm_ess_probability proteomelm_ess_call proteomelm_ess_class ML0001 839 P46388 dnaA ML0001 Chromosomal replication initiator protein DnaA 502 0.14132 non-essential 0.1643 non-essential high NA high_confidence_nonessential NP_214515.1 85.0 0.16656230432060112 51.508 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.167; target-priority score=51.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012863 non-essential Non-essential ML0002 1311 P46387 dnaN ML0002 Beta sliding clamp (Beta clamp) (Sliding clamp) (Beta-clamp processivity factor) (DNA polymerase III beta sliding clamp subunit) (DNA polymerase III subunit beta) 399 0.03259 non-essential 0.11256 non-essential high NA high_confidence_nonessential NP_214516.1 80.8 0.3425172197871008 57.833 Moderate candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.343; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.177692 non-essential Non-essential ML0003 1559 P46391 recF ML0003 DNA replication and repair protein RecF 385 0.05255 non-essential 0.0665 non-essential high NA high_confidence_nonessential NP_214517.1 76.6 0.0068879148403256105 48.67 Exploratory ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.066; ProteomeLM contextual percentile=0.007; target-priority score=48.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.04451 non-essential Non-essential ML0004 1355 Q9CDF4 ML0004 MLB1770.04 UPF0232 protein ML0004 189 0.09148 non-essential 0.10673 non-essential high agree high_confidence_nonessential Rv0004 77.2 NE 0 0.2736380713838447 48.95 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.107; Mtb RBH anchor Rv0004=non-essential (agree); ProteomeLM contextual percentile=0.274; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000585 non-essential Non-essential ML0005 873 Q59533 gyrB ML0005 DNA gyrase subunit B (EC 5.6.2.2) 678 0.13353 non-essential 0.1604 non-essential high NA high_confidence_nonessential NP_214519.2 86.5 0.14840325610519725 62.045 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.148; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.976421 essential Essential ML0006 67 Q57532 gyrA ML0006 DNA gyrase subunit A (EC 5.6.2.2) [Cleaved into: Mle GyrA intein] 1273 0.2107 non-essential 0.34408 non-essential medium NA medium_confidence NP_214520.1 60.6 0.815278647463995 82.265 High-priority ESM-2 calibrated P(essential)=0.211; HANSEN integrated essentiality score=0.344; ProteomeLM contextual percentile=0.815; target-priority score=82.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.815); Target-priority score is high (82.3) rescued_from_possible_false_negative_by_supporting_evidence 0.124064 non-essential Non-essential ML0007 232 O32870 ML0007 MLB1770.07 Uncharacterized protein ML0007 303 0.07317 non-essential 0.23574 non-essential high NA medium_confidence NP_214521.1 53.8 0.849718221665623 68.434 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.850; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.850); Target-priority score is high (68.4) rescued_from_possible_false_negative_by_supporting_evidence 3.1e-05 non-essential Non-essential ML0008 148 Q9CDF1 ML0008 Uncharacterized protein 124 0.07197 non-essential 0.26029 non-essential high NA medium_confidence 0.9906073888541015 71.509 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.260; ProteomeLM contextual percentile=0.991; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.991); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.009488 non-essential Non-essential ML0009 79 Q9CDF0 ML0009 Uncharacterized protein 63 0.14578 non-essential 0.31852 non-essential high NA medium_confidence 0.9918597370068879 72.395 Strong candidate ESM-2 calibrated P(essential)=0.146; HANSEN integrated essentiality score=0.319; ProteomeLM contextual percentile=0.992; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.992); Target-priority score is high (72.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000427 non-essential Non-essential ML0011 614 Q9CDE9 ppiA ML0011 Probable peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Rotamase A) 182 0.01019 non-essential 0.19087 non-essential high NA high_confidence_nonessential NP_214523.1 90.1 0.8384470882905448 80.78 High-priority ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.838; target-priority score=80.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.838); Target-priority score is high (80.8) rescued_from_possible_false_negative_by_supporting_evidence 0.087424 non-essential Non-essential ML0012 1002 Q9CDE8 ML0012 Membrane protein 137 0.02279 non-essential 0.14406 non-essential high NA high_confidence_nonessential NP_214524.1 71.5 0.5616781465247339 61.599 Moderate candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.562; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005665 non-essential Non-essential ML0013 871 Q9CDE7 crgA ML0013 Cell division protein CrgA 93 0.08711 non-essential 0.16056 non-essential high NA high_confidence_nonessential NP_214525.1 89.2 0.38196618659987475 55.367 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.382; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.4e-05 non-essential Non-essential ML0015 1136 Q7AQP6 pabA ML0015 p-aminobenzoate synthase glutamine amidotransferase 232 0.0949 non-essential 0.13075 non-essential high NA high_confidence_nonessential YP_177615.1 79.7 0.18096430807764557 51.925 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.181; target-priority score=51.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.184891 non-essential Non-essential ML0016 733 P54744 pknB ML0016 Serine/threonine-protein kinase PknB (EC 2.7.11.1) 622 0.13642 non-essential 0.17854 non-essential high NA high_confidence_nonessential NP_214528.1 86.1 0.24608641202254228 60.596 Moderate candidate ESM-2 calibrated P(essential)=0.136; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.246; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.801192 essential Essential ML0017 388 P54743 pknA ML0017 Serine/threonine-protein kinase PknA (EC 2.7.11.1) 437 0.07935 non-essential 0.21403 non-essential high NA medium_confidence NP_214529.1 81.0 0.6750156543519098 74.784 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.675; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.8) rescued_from_possible_false_negative_by_supporting_evidence 0.072597 non-essential Non-essential ML0018 1173 Q9CDE6 pbpA ML0018 Peptidoglycan D,D-transpeptidase PbpA (EC 3.4.16.4) (Penicillin-binding protein A) 492 0.09789 non-essential 0.12848 non-essential high NA high_confidence_nonessential NP_214530.1 85.7 0.1258609893550407 61.467 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.126; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.07651 non-essential Non-essential ML0019 1036 Q50186 rodA ML0019 Peptidoglycan glycosyltransferase RodA (EC 2.4.99.28) (Non-canonical transglycosylase RodA) 465 0.09823 non-essential 0.14057 non-essential high NA high_confidence_nonessential NP_214531.1 82.3 0.18910457107075768 63.615 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.189; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.246166 non-essential Uncertain ML0020 754 Q9CDE5 ML0020 Serine/threonine protein phosphatase PstP (EC 3.1.3.16) (Mycobacterial Ser/Thr phosphatase) (PP2C-family Ser/Thr phosphatase) 509 0.09928 non-essential 0.17573 non-essential high NA high_confidence_nonessential NP_214532.1 76.8 0.3944896681277395 62.461 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.394; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.329179 essential Uncertain ML0021 714 Q7AQP5 ML0021 FHA domain-containing protein FhaB (FtsZ-interacting protein A) 155 0.0949 non-essential 0.18021 non-essential high NA high_confidence_nonessential NP_214533.1 91.0 0.4464621164683782 60.585 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.446; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML0022 102 Q9CDE4 ML0022 FHA domain-containing protein 488 0.14503 non-essential 0.2835 non-essential high NA medium_confidence NP_214534.1 62.8 0.8077645585472761 66.124 Strong candidate ESM-2 calibrated P(essential)=0.145; HANSEN integrated essentiality score=0.284; ProteomeLM contextual percentile=0.808; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.808); Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.281928 non-essential Uncertain ML0023 583 Q9CDE3 ML0023 Uncharacterized protein 103 0.00198 non-essential 0.19356 non-essential high NA high_confidence_nonessential 0.9204758922980588 71.076 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.920; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.920); Target-priority score is high (71.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000191 non-essential Non-essential ML0024 90 Q9CDE2 ML0024 Uncharacterized protein 83 0.14132 non-essential 0.29885 non-essential high NA medium_confidence 0.9073262366938009 68.755 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.299; ProteomeLM contextual percentile=0.907; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.907); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0025 619 Q9CDE1 ML0025 Uncharacterized protein 96 0.0 non-essential 0.19053 non-essential high NA high_confidence_nonessential 0.9173450219160927 69.158 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.917; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.917); Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000655 non-essential Non-essential ML0028 1593 Q50191 ML0028 UPF0301 protein ML0028 202 0.04206 non-essential 0.04883 non-essential high agree high_confidence_nonessential Rv0038 88.6 NE 0 0.015654351909830933 44.055 Exploratory ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.049; Mtb RBH anchor Rv0038=non-essential (agree); ProteomeLM contextual percentile=0.016; target-priority score=44.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 5e-05 non-essential Non-essential ML0029 430 Q9CDE0 ML0029 Possible membrane protein 201 0.00888 non-essential 0.20967 non-essential high NA medium_confidence 0.9799624295554165 72.303 Strong candidate ESM-2 calibrated P(essential)=0.009; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.980; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.980); Target-priority score is high (72.3) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML0030 716 O32871 ML0030 MLB1770.18c Uncharacterized protein ML0030 113 0.01648 non-essential 0.18 non-essential high NA high_confidence_nonessential NP_214553.1 63.2 0.7833437695679399 67.953 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.783; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.783); Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 9e-06 non-essential Non-essential ML0031 1256 O33075 ML0031 MLB1770.19c MLCB628.02c Proline-rich 28 kDa antigen homolog 278 0.03424 non-essential 0.11825 non-essential high agree high_confidence_nonessential Rv0040c 63.7 NE 0 0.6606136505948653 63.292 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.118; Mtb RBH anchor Rv0040c=non-essential (agree); ProteomeLM contextual percentile=0.661; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007609 non-essential Non-essential ML0032 1368 Q50192 leuS ML0032 MLB1770.20 MLCB628.03 Leucine--tRNA ligase (EC 6.1.1.4) (Leucyl-tRNA synthetase) (LeuRS) 972 0.05511 non-essential 0.10476 non-essential high NA high_confidence_nonessential NP_214555.1 83.7 0.18409517845961176 60.952 Moderate candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.184; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.188692 non-essential Non-essential ML0041 1343 Q7AQP4 ML0041 Probable secreted protease 446 0.10418 non-essential 0.10882 non-essential high NA high_confidence_nonessential NP_218400.1 79.4 0.020037570444583593 48.317 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.020; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.09119 non-essential Non-essential ML0042 183 Q7AQP3 ML0042 Membrane protein 467 0.13353 non-essential 0.24825 non-essential high NA medium_confidence NP_218399.1 72.1 0.6512210394489668 66.783 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.651; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 0.018326 non-essential Non-essential ML0044 713 Q7AQP2 ML0044 ML0044 protein 113 0.01709 non-essential 0.18023 non-essential high NA high_confidence_nonessential NP_218397.1 55.6 0.775829680651221 70.017 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.776; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.776); Target-priority score is high (70.0) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0047 1158 Q9CDD9 ML0047 Membrane protein 512 0.07973 non-essential 0.12957 non-essential high NA high_confidence_nonessential NP_218394.1 74.2 0.2467125860989355 50.876 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.247; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00014 non-essential Non-essential ML0048 573 Q9CDD8 ML0048 CobQ/CobB/MinD/ParA nucleotide binding domain-containing protein 586 0.04805 non-essential 0.19435 non-essential high NA high_confidence_nonessential NP_218393.1 55.9 0.725735754539762 66.996 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.726; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 0.00717 non-essential Non-essential ML0049 758 Q50206 esxA esaT6 esx L45 ML0049 MLCB628.12c 6 kDa early secretory antigenic target homolog (ESAT-6-like protein) (L-ESAT) 95 0.0 non-essential 0.175 non-essential high NA high_confidence_nonessential 0.823418910457107 70.034 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.823; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.823); Target-priority score is high (70.0) rescued_from_possible_false_negative_by_supporting_evidence 0.028365 non-essential Non-essential ML0050 556 O33084 esxB ML0050 MLCB628.13c ESAT-6-like protein EsxB 100 0.01412 non-essential 0.19628 non-essential high NA high_confidence_nonessential 0.8741390106449592 73.326 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.874; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.874); Target-priority score is high (73.3) rescued_from_possible_false_negative_by_supporting_evidence 0.001644 non-essential Non-essential ML0051 696 Q7AQP1 ML0051 PPE-family protein 302 0.00198 non-essential 0.18263 non-essential high NA high_confidence_nonessential YP_178022.1 46.2 0.8653725735754539 67.942 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.865; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.865); Target-priority score is high (67.9) rescued_from_possible_false_negative_by_supporting_evidence 6.8e-05 non-essential Non-essential ML0052 413 Q9CDD7 ML0052 FtsK domain-containing protein 597 0.05587 non-essential 0.21078 non-essential high NA medium_confidence NP_218388.1 80.0 0.7658108954289292 74.016 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.766; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.766); Target-priority score is high (74.0) rescued_from_possible_false_negative_by_supporting_evidence 0.044568 non-essential Non-essential ML0053 393 Q7AQP0 ML0053 Membrane protein 744 0.06628 non-essential 0.2134 non-essential high NA medium_confidence NP_218387.1 86.1 0.7432686286787727 70.693 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.743; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 0.001673 non-essential Non-essential ML0054 470 Q7AQN9 ML0054 Membrane protein 481 0.10695 non-essential 0.20507 non-essential high NA medium_confidence NP_218386.1 75.6 0.5291170945522855 63.387 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.529; target-priority score=63.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.353835 essential Uncertain ML0055 801 O33089 eccA1 ML0055 MLCB628.18c ESX-1 secretion system protein EccA1 (ESX conserved component A1) (Type VII secretion system protein EccA1) (T7SS protein EccA1) 573 0.06554 non-essential 0.16959 non-essential high NA high_confidence_nonessential NP_218385.1 89.2 0.5097056981840952 63.652 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.510; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002517 non-essential Non-essential ML0056 422 Q9CDD6 ML0056 Uncharacterized protein 169 0.02105 non-essential 0.21018 non-essential high NA medium_confidence 0.9323731997495304 70.515 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.932; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.932); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 0.057695 non-essential Non-essential ML0061 1080 Q9CDD5 gltB ML0061 Ferredoxin-dependent glutamate synthase (EC 1.4.1.13) 1527 0.13165 non-essential 0.13607 non-essential high NA high_confidence_nonessential NP_218376.1 90.2 0.040701314965560426 52.935 Moderate candidate ESM-2 calibrated P(essential)=0.132; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.041; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.132484 non-essential Non-essential ML0062 642 Q9CDD4 gltD ML0062 NADH-dependent glutamate synthase small subunit (EC 1.4.1.13) 488 0.14132 non-essential 0.18798 non-essential high NA high_confidence_nonessential NP_218375.1 87.7 0.27238572323105825 62.895 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.272; target-priority score=62.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.038987 non-essential Non-essential ML0064 648 Q9CDD3 ML0064 Transcriptional regulator 214 0.0332 non-essential 0.18735 non-essential high NA high_confidence_nonessential NP_218372.1 76.4 0.741390106449593 70.831 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.741; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 4.2e-05 non-essential Non-essential ML0065 1177 Q7AQN8 ML0065 FAD-containing monooxygenase EthA (Prodrug activator EtaA) 494 0.10418 non-essential 0.12811 non-essential high NA high_confidence_nonessential NP_218371.1 80.1 0.11897307451471509 53.247 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.119; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000322 non-essential Non-essential ML0066 1252 Q9CDD2 ML0066 Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase (HMG aldolase) (EC 4.1.3.17) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112) (Regulator of ribonuclease activity homolog) (RraA-like protein) 157 0.00543 non-essential 0.11921 non-essential high NA high_confidence_nonessential NP_218370.1 86.6 0.4683782091421415 70.711 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.119; ProteomeLM contextual percentile=0.468; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000104 non-essential Non-essential ML0067 314 Q9CDD1 hns ML0067 Histone-like protein 121 0.04985 non-essential 0.2227 non-essential high NA medium_confidence NP_218369.1 57.5 0.878522229179712 68.939 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.879; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.879); Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.001523 non-essential Non-essential ML0068 1432 Q9CDD0 ML0068 Uncharacterized protein 238 0.09148 non-essential 0.09365 non-essential high agree high_confidence_nonessential Rv3850 74.2 NE 0 0.1596743894802755 45.581 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.094; Mtb RBH anchor Rv3850=non-essential (agree); ProteomeLM contextual percentile=0.160; target-priority score=45.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.005526 non-essential Non-essential ML0069 747 Q9CDC9 ML0069 HTH cro/C1-type domain-containing protein 132 0.01019 non-essential 0.17693 non-essential high NA high_confidence_nonessential NP_218366.1 84.0 0.7839699436443331 71.404 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.784; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.784); Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000211 non-essential Non-essential ML0070 531 Q9CDC8 ML0070 Uncharacterized protein 87 0.01019 non-essential 0.19859 non-essential high NA high_confidence_nonessential 0.9192235441452724 68.738 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.919; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.919); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0071 844 Q9CDC7 ML0071 Peptidase 177 0.06199 non-essential 0.16392 non-essential high agree high_confidence_nonessential Rv3847 96.6 NE 0 0.897307451471509 73.987 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.164; Mtb RBH anchor Rv3847=non-essential (agree); ProteomeLM contextual percentile=0.897; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.897); Target-priority score is high (74.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000416 non-essential Non-essential ML0072 630 P13367 sodA ML0072 Superoxide dismutase [Mn] (EC 1.15.1.1) 207 0.05933 non-essential 0.18913 non-essential high NA high_confidence_nonessential NP_218363.1 80.6 0.617407639323732 75.774 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.617; target-priority score=75.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.8) rescued_from_possible_false_negative_by_supporting_evidence 0.142543 non-essential Non-essential ML0073 737 Q9CDC6 ML0073 Membrane protein 344 0.10418 non-essential 0.178 non-essential high NA high_confidence_nonessential NP_218360.1 62.9 0.41014402003757044 54.042 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.410; target-priority score=54.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.105946 non-essential Non-essential ML0074 290 Q9CDC5 glpQ ML0074 Glycerophosphoryl diester phosphodiesterase (EC 3.1.4.46) 271 0.09638 non-essential 0.22645 non-essential high NA medium_confidence NP_218359.1 87.9 0.6762680025046963 72.605 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.676; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000741 non-essential Non-essential ML0078 1000 Q9CDC4 pheA ML0078 Prephenate dehydratase (PDT) (EC 4.2.1.51) 322 0.03203 non-essential 0.14421 non-essential high NA high_confidence_nonessential NP_218355.1 83.9 0.49279899812147776 70.906 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.493; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.9) rescued_from_possible_false_negative_by_supporting_evidence 0.006637 non-essential Non-essential ML0079 1050 Q9CDC3 ML0079 Phosphoglycerate mutase 231 0.05949 non-essential 0.13913 non-essential high NA high_confidence_nonessential NP_218354.1 71.6 0.3775829680651221 57.067 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.378; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000334 non-essential Non-essential ML0081 1207 Q9CDC2 ML0081 Membrane protein 450 0.02734 non-essential 0.12462 non-essential high agree high_confidence_nonessential Rv3835 74.3 NE 0 0.7514088916718847 66.155 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.125; Mtb RBH anchor Rv3835=non-essential (agree); ProteomeLM contextual percentile=0.751; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.751); Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.011318 non-essential Non-essential ML0082 920 Q9CDC1 serS ML0082 Serine--tRNA ligase (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase) 417 0.04913 non-essential 0.15364 non-essential high NA high_confidence_nonessential NP_218351.1 86.1 0.4577332498434565 75.007 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.458; target-priority score=75.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.0) rescued_from_possible_false_negative_by_supporting_evidence 0.137391 non-essential Non-essential ML0087 947 Q9CDC0 ML0087 Acyltransferase 257 0.03769 non-essential 0.1505 non-essential high NA high_confidence_nonessential NP_218333.1 82.1 0.5234815278647464 64.215 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.523; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012162 non-essential Non-essential ML0089 1146 Q9CDB9 ML0089 Hydrolase 281 0.08446 non-essential 0.13 non-essential high agree high_confidence_nonessential Rv3813c 80.4 NE 0 0.480275516593613 62.589 Moderate candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3813c=non-essential (agree); ProteomeLM contextual percentile=0.480; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005596 non-essential Non-essential ML0091 763 P19361 ML0091 28 kDa antigen 236 0.00674 non-essential 0.17429 non-essential high NA high_confidence_nonessential NP_218327.1 49.3 0.8033813400125235 64.911 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.803; target-priority score=64.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.803) rescued_from_possible_false_negative_by_supporting_evidence 0.002288 non-essential Non-essential ML0092 341 Q9CDB8 glf ML0092 UDP-galactopyranose mutase (EC 5.4.99.9) (UDP-GALP mutase) (Uridine 5-diphosphate galactopyranose mutase) 413 0.10418 non-essential 0.2192 non-essential high NA medium_confidence NP_218326.1 86.8 0.5879774577332498 75.981 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.588; target-priority score=76.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.0) rescued_from_possible_false_negative_by_supporting_evidence 0.00879 non-essential Non-essential ML0093 1372 Q9CDB7 ML0093 Galactofuranosyltransferase GlfT2 (EC 2.4.1.288) (Arabinogalactan galactosyltransferase 2) (Galactofuranosylgalactofuranosylrhamnosyl-N-acetylglucosaminyl-diphospho-decaprenol beta-1,5/1,6-galactofuranosyltransferase) (Polymerizing galactofuranosyltransferase GlfT2) 643 0.05052 non-essential 0.10447 non-essential high NA high_confidence_nonessential NP_218325.1 85.4 0.19849718221665624 62.63 Moderate candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.198; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.114927 non-essential Non-essential ML0094 1035 Q9CDB6 ML0094 Membrane protein 192 0.01019 non-essential 0.1406 non-essential high NA high_confidence_nonessential NP_218324.1 73.8 0.5867251095804634 65.811 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.587; target-priority score=65.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.8) rescued_from_possible_false_negative_by_supporting_evidence 0.001646 non-essential Non-essential ML0095 1508 Q9CDB5 ML0095 Integral membrane protein 302 0.01889 non-essential 0.07906 non-essential high NA high_confidence_nonessential NP_218323.1 83.8 0.22229179711959926 53.082 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.222; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.064306 non-essential Non-essential ML0096 750 Q9CDB4 ML0096 Membrane protein 649 0.06543 non-essential 0.1762 non-essential high NA high_confidence_nonessential NP_218322.1 81.4 0.554164057608015 61.914 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.554; target-priority score=61.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.956709 essential Essential ML0097 575 Q05861 fbpA ML0097 Diacylglycerol acyltransferase/mycolyltransferase Ag85A (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex A) (85A) (Ag85A) (Fibronectin-binding protein A) (Fbps A) 330 0.09459 non-essential 0.19403 non-essential high NA high_confidence_nonessential NP_218321.1 83.0 0.4971822166562304 71.451 Strong candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.497; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000504 non-essential Non-essential ML0098 334 Q05868 mpt51 ML0098 MPT51 antigen 301 0.06528 non-essential 0.22016 non-essential high NA medium_confidence YP_178017.1 77.8 0.7808390732623669 73.006 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.781; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.781); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0099 1422 Q9CDB3 ML0099 Cutinase 336 0.04897 non-essential 0.09608 non-essential high NA high_confidence_nonessential NP_218319.1 73.4 0.18847839699436444 51.674 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.096; ProteomeLM contextual percentile=0.188; target-priority score=51.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008643 non-essential Non-essential ML0100 1047 Q9CDB2 fadD32 ML0100 Acyl-AMP synthetase 635 0.09638 non-essential 0.13935 non-essential high NA high_confidence_nonessential NP_218318.1 93.0 0.20788979336255478 57.659 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.208; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000363 non-essential Non-essential ML0101 577 Q9CDB1 pks13 ML0101 Polyketide synthase 1784 0.09638 non-essential 0.19385 non-essential high NA high_confidence_nonessential NP_218317.1 83.5 0.5165936130244208 61.7 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.517; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000207 non-essential Non-essential ML0102 199 Q9CDB0 accD4 ML0102 Acyl CoA carboxylase [beta] subunit 517 0.1299 non-essential 0.24384 non-essential high NA medium_confidence NP_218316.2 91.1 0.6418284283030683 66.817 Strong candidate ESM-2 calibrated P(essential)=0.130; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.642; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 0.788477 essential Essential ML0104 259 Q9CDA9 embB ML0104 Probable arabinosyltransferase B (EC 2.4.2.-) 1083 0.09187 non-essential 0.23105 non-essential high NA medium_confidence NP_218312.1 79.1 0.7188478396994364 74.367 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.719; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 0.607429 essential Likely essential ML0105 197 Q9CDA8 embA ML0105 Probable arabinosyltransferase A (EC 2.4.2.-) 1111 0.09071 non-essential 0.24444 non-essential high NA medium_confidence NP_218311.1 78.6 0.7952410770194114 76.996 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.795; target-priority score=77.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.795); Target-priority score is high (77.0) rescued_from_possible_false_negative_by_supporting_evidence 0.919174 essential Essential ML0106 571 Q9CDA7 embC ML0106 Probable arabinosyltransferase C (EC 2.4.2.-) 1070 0.0912 non-essential 0.19467 non-essential high NA high_confidence_nonessential NP_218310.1 82.4 0.5278647463994991 67.599 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.528; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (67.6) rescued_from_possible_false_negative_by_supporting_evidence 0.963384 essential Essential ML0107 1506 Q9CDA6 aftA ML0107 Galactan 5-O-arabinofuranosyltransferase (EC 2.4.2.46) (Arabinofuranosyltransferase AftA) 632 0.02054 non-essential 0.07939 non-essential high NA high_confidence_nonessential NP_218309.1 77.5 0.1897307451471509 62.232 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.190; target-priority score=62.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.92882 essential Essential ML0108 984 Q9CDA5 ML0108 Oxidoreductase 254 0.09638 non-essential 0.14634 non-essential high NA high_confidence_nonessential NP_218308.1 89.0 0.2579837194740138 54.612 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.258; target-priority score=54.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003757 non-essential Non-essential ML0109 949 Q9CDA4 ML0109 FAD-linked oxidoreductase 460 0.05949 non-essential 0.15044 non-essential high NA high_confidence_nonessential NP_218307.1 86.6 0.43331246086412023 60.749 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.433; target-priority score=60.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.017473 non-essential Non-essential ML0110 905 Q9CDA3 ML0110 Arabinogalactan biosynthesis recruiting protein ML0110 123 0.01757 non-essential 0.15575 non-essential high NA high_confidence_nonessential NP_218306.1 73.0 0.6311834690043833 69.481 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.631; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.00086 non-essential Non-essential ML0112 1591 Q9CDA2 ML0112 ABC transporter component 276 0.00198 non-essential 0.04976 non-essential high NA high_confidence_nonessential NP_218300.1 84.3 0.1408891671884784 48.53 Exploratory ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.050; ProteomeLM contextual percentile=0.141; target-priority score=48.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006215 non-essential Non-essential ML0113 1319 Q9CDA1 rfbE ML0113 Glycosyl transferase 283 0.02734 non-essential 0.11188 non-essential high NA high_confidence_nonessential YP_178014.1 81.6 0.35003130870381965 62.098 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.350; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003165 non-essential Non-essential ML0114 677 Q9CDA0 ML0114 ABC transporter ATP-binding component 272 0.14132 non-essential 0.18455 non-essential high NA high_confidence_nonessential NP_218298.1 91.4 0.2798998121477771 53.476 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.280; target-priority score=53.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005095 non-essential Non-essential ML0115 26 Q9CD99 bpa ML0115 Bacterial proteasome activator 174 0.27651 non-essential 0.45974 non-essential low disagree review_anchor_disagreement Rv3780 83.4 ES 1 0.19348778960551033 48.979 Exploratory ESM-2 calibrated P(essential)=0.277; HANSEN integrated essentiality score=0.460; Mtb RBH anchor Rv3780=essential (disagree); ProteomeLM contextual percentile=0.193; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.01721 non-essential Non-essential ML0116 1190 Q9CD98 ML0116 Membrane protein 654 0.05259 non-essential 0.12661 non-essential high NA high_confidence_nonessential NP_218296.1 65.5 0.34189104571070755 54.929 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.342; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.116234 non-essential Non-essential ML0117 435 Q9CD97 ML0117 Aminotransferase class V domain-containing protein 398 0.17976 non-essential 0.20926 non-essential high NA medium_confidence NP_218295.1 83.4 0.2498434564809017 53.152 Moderate candidate ESM-2 calibrated P(essential)=0.180; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.250; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004921 non-essential Non-essential ML0118 965 Q9CD96 ML0118 Oxidireductase 336 0.06199 non-essential 0.14813 non-essential high NA high_confidence_nonessential NP_218294.1 76.0 0.40701314965560426 61.181 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.407; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004041 non-essential Non-essential ML0119 937 Q9CD95 lipE ML0119 Probable hydrolase 411 0.07935 non-essential 0.15189 non-essential high NA high_confidence_nonessential NP_218292.1 84.7 0.3575453976205385 58.433 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.358; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2e-05 non-essential Non-essential ML0120 1524 Q9CD94 echA1 ML0120 Enoyl-CoA hydratase 278 0.04985 non-essential 0.07694 non-essential high NA high_confidence_nonessential NP_218291.1 88.3 0.06950532247964934 52.478 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.070; target-priority score=52.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000307 non-essential Non-essential ML0121 473 Q9CD93 ML0121 GXWXG domain-containing protein 89 0.00198 non-essential 0.20481 non-essential high NA medium_confidence 0.986850344395742 70.994 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.987; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.987); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000229 non-essential Non-essential ML0124 74 Q9CD92 ML0124 Coenzyme Q-binding protein COQ10 START domain-containing protein 146 0.20924 non-essential 0.32776 non-essential medium NA medium_confidence 0.7601753287413902 70.644 Strong candidate ESM-2 calibrated P(essential)=0.209; HANSEN integrated essentiality score=0.328; ProteomeLM contextual percentile=0.760; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.760); Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000137 non-essential Non-essential ML0125 778 Q9CD91 ML0125 Glycosyl transferase 438 0.03172 non-essential 0.17217 non-essential high NA high_confidence_nonessential NP_217478.1 77.5 0.6656230432060113 68.558 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.666; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.6) rescued_from_possible_false_negative_by_supporting_evidence 0.007835 non-essential Non-essential ML0126 705 Q9CD90 ML0126 Biotin carboxyl carrier protein 273 0.02734 non-essential 0.18159 non-essential high NA high_confidence_nonessential 0.7420162805259862 68.236 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.742; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0127 401 Q9CD89 ML0127 Rhamnosyl O-methyltransferase (EC 2.1.1.-) 229 0.0533 non-essential 0.21235 non-essential high NA medium_confidence NP_217475.1 76.1 0.7770820288040076 77.344 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.777; target-priority score=77.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.777); Target-priority score is high (77.3) rescued_from_possible_false_negative_by_supporting_evidence 0.733753 essential Essential ML0128 891 Q9CD88 ML0128 Glycosyl transferase 435 0.03172 non-essential 0.15805 non-essential high NA high_confidence_nonessential 0.5904821540388228 65.861 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.590; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.009794 non-essential Non-essential ML0129 1389 Q9CD87 ML0129 Trans-acting enoyl reductase (EC 1.3.1.-) 418 0.06074 non-essential 0.10261 non-essential high NA high_confidence_nonessential NP_217469.1 86.6 0.16405760801502817 54.674 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.164; target-priority score=54.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000446 non-essential Non-essential ML0130 449 Q9CD86 ML0130 Phthiotriol/phenolphthiotriol dimycocerosates methyltransferase (EC 2.1.1.-) 270 0.06214 non-essential 0.20787 non-essential high NA medium_confidence NP_217468.1 83.7 0.720100187852223 73.952 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.720; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.0) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0131 240 Q9CD85 ML0131 Phthiodiolone/phenolphthiodiolone dimycocerosates ketoreductase (EC 1.2.-.-) 382 0.13353 non-essential 0.23457 non-essential high NA medium_confidence NP_217467.1 85.1 0.5648090169067 68.813 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.565; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.00023 non-essential Non-essential ML0132 223 Q9CD84 fadD29 ML0132 Acyl-CoA synthetase 680 0.06543 non-essential 0.23732 non-essential high NA medium_confidence NP_217466.3 80.2 0.8722604884157796 75.993 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.872; target-priority score=76.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.872); Target-priority score is high (76.0) rescued_from_possible_false_negative_by_supporting_evidence 0.002993 non-essential Non-essential ML0133 101 Q9CD83 ML0133 Chorismate pyruvate-lyase (EC 4.1.3.40) (4-HB synthase) (p-hydroxybenzoic acid synthase) 210 0.13377 non-essential 0.28428 non-essential high NA medium_confidence NP_217465.1 62.6 0.8259236067626801 79.071 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.284; ProteomeLM contextual percentile=0.826; target-priority score=79.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.826); Target-priority score is high (79.1) rescued_from_possible_false_negative_by_supporting_evidence 0.00021 non-essential Non-essential ML0134 757 Q9CD82 fadD22 ML0134 Acyl-CoA synthetase 707 0.09638 non-essential 0.17511 non-essential high NA high_confidence_nonessential NP_217464.1 75.9 0.4139010644959299 59.141 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.414; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000481 non-essential Non-essential ML0135 593 Q9CD81 ML0135 Polyketide synthase 2103 0.06543 non-essential 0.19237 non-essential high NA high_confidence_nonessential NP_217462.1 82.0 0.6217908578584846 71.263 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.622; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0136 329 Q9CD80 lppX ML0136 Putative phthiocerol dimycocerosate transporter LppX (Lipoprotein LppX) 233 0.03861 non-essential 0.22107 non-essential high NA medium_confidence NP_217461.1 77.1 0.902316844082655 75.11 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.902; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.902); Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000243 non-essential Non-essential ML0137 239 Q7AQN7 mmpL7 ML0137 Membrane protein 902 0.07497 non-essential 0.23465 non-essential high NA medium_confidence NP_217458.1 61.1 0.8246712586098935 71.951 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.825; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.825); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.006501 non-essential Non-essential ML0138 1171 Q9CD79 fadD28 ML0138 Acyl-CoA synthetase 579 0.09148 non-essential 0.12857 non-essential high NA high_confidence_nonessential NP_217457.1 81.9 0.18159048215403883 52.685 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.182; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000329 non-essential Non-essential ML0139 423 Q9CD78 mas ML0139 Mycocerosic synthase 2116 0.05604 non-essential 0.21005 non-essential high NA medium_confidence NP_217456.1 88.0 0.7633061991233563 73.154 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.763; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.763); Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000169 non-essential Non-essential ML0141 147 Q9CD77 ML0141 Uncharacterized protein 84 0.08711 non-essential 0.26039 non-essential high NA medium_confidence 0.9304946775203506 68.517 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.260; ProteomeLM contextual percentile=0.930; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.930); Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0142 121 Q9CD76 ML0142 Possible membrane protein 82 0.09201 non-essential 0.27301 non-essential high NA medium_confidence 0.9718221665623044 72.071 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.972; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.972); Target-priority score is high (72.1) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0150 1185 Q9CD75 pgi ML0150 Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) 554 0.08711 non-essential 0.12715 non-essential high NA high_confidence_nonessential NP_215461.1 85.9 0.1628052598622417 63.055 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.163; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.119691 non-essential Non-essential ML0151 808 Q9CD74 ML0151 Chorismate mutase domain-containing protein 105 0.09187 non-essential 0.16915 non-essential high NA high_confidence_nonessential NP_215463.1 83.8 0.408891671884784 55.96 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.409; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001078 non-essential Non-essential ML0152 545 Q9CD73 ML0152 Uncharacterized protein 62 0.00543 non-essential 0.1974 non-essential high NA high_confidence_nonessential 0.9311208515967438 69.755 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.931; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.931); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0153 509 Q9CD72 uvrD ML0153 ATP-dependent DNA helicase UvrD1 (EC 5.6.2.4) (DNA 3'-5' helicase UvrD1) 778 0.19217 non-essential 0.20168 non-essential high NA medium_confidence YP_177772.1 81.4 0.13775829680651222 56.733 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.138; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007458 non-essential Non-essential ML0154 1225 Q9CD71 ML0154 M23ase beta-sheet core domain-containing protein 333 0.00543 non-essential 0.12243 non-essential high agree high_confidence_nonessential Rv0950c 71.0 NE 0 0.841577958672511 70.028 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.122; Mtb RBH anchor Rv0950c=non-essential (agree); ProteomeLM contextual percentile=0.842; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.842); Target-priority score is high (70.0) rescued_from_possible_false_negative_by_supporting_evidence 0.00096 non-essential Non-essential ML0155 506 Q9Z5H8 sucC ML0155 MLCB373.03 Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta) 393 0.13529 non-essential 0.20201 non-essential high NA medium_confidence NP_215466.1 86.7 0.36443331246086413 69.064 Strong candidate ESM-2 calibrated P(essential)=0.135; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.364; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 0.547499 essential Likely essential ML0156 489 Q7AQN6 sucD ML0156 Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) 300 0.1873 non-essential 0.20363 non-essential high NA medium_confidence NP_215467.1 86.3 0.15466499686912963 62.488 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.155; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.080213 non-essential Non-essential ML0158 371 Q9CD70 ML0158 34 kDa antigen 314 0.03422 non-essential 0.21631 non-essential high NA medium_confidence NP_215469.1 48.4 0.9104571070757671 69.673 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.910; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.910); Target-priority score is high (69.7) rescued_from_possible_false_negative_by_supporting_evidence 0.018346 non-essential Non-essential ML0159 1519 Q7AQN5 ML0159 Membrane protein 430 0.04985 non-essential 0.07807 non-essential high NA high_confidence_nonessential NP_215470.1 75.9 0.09956167814652474 44.517 Exploratory ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.100; target-priority score=44.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 8.2e-05 non-essential Non-essential ML0160 377 Q7AQN4 purN ML0160 Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART) 215 0.13353 non-essential 0.21543 non-essential high NA medium_confidence NP_215471.1 78.5 0.43894802755165935 73.309 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.439; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.3) rescued_from_possible_false_negative_by_supporting_evidence 0.85795 essential Essential ML0161 1558 Q9Z5H5 purH ML0161 MLCB373.09 Bifunctional purine biosynthesis protein PurH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)] 527 0.03769 non-essential 0.06693 non-essential high NA high_confidence_nonessential NP_215472.1 88.1 0.051972448340638695 57.39 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.067; ProteomeLM contextual percentile=0.052; target-priority score=57.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.531864 essential Likely essential ML0162 133 Q7AQN3 ML0162 Uncharacterized protein 92 0.09148 non-essential 0.26646 non-essential high NA medium_confidence 0.9423919849718222 69.789 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.942; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.942); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0169 1306 Q7AQN2 ML0169 DUF1707 domain-containing protein 200 0.03424 non-essential 0.11293 non-essential high agree high_confidence_nonessential Rv0966c 79.5 NE 0 0.6080150281778335 63.168 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv0966c=non-essential (agree); ProteomeLM contextual percentile=0.608; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00052 non-essential Non-essential ML0173 12 Q9CD69 rpmF ML0173 Large ribosomal subunit protein bL32 (50S ribosomal protein L32) 57 0.38086 non-essential 0.50242 essential medium NA medium_confidence YP_177635.1 84.2 0.9787100814026299 77.924 Strong candidate ESM-2 calibrated P(essential)=0.381; HANSEN integrated essentiality score=0.502; ProteomeLM contextual percentile=0.979; target-priority score=77.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.502); ProteomeLM contextual percentile is high (0.979); Target-priority score is high (77.9) none 9.3e-05 non-essential Non-essential ML0174 964 Q9CD68 mprA ML0174 MLCB373.26 Response regulator MprA (Mycobacterial persistence regulator A) 228 0.06309 non-essential 0.14816 non-essential high NA high_confidence_nonessential NP_215496.2 94.3 0.4107701941139637 58.24 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.411; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000117 non-essential Non-essential ML0175 436 Q9Z5G7 mprB ML0175 MLCB373.27 Signal transduction histidine-protein kinase/phosphatase MprB (EC 2.7.13.3) (EC 3.1.3.-) (Mycobacterial persistence regulator B) 519 0.08711 non-essential 0.20918 non-essential high NA medium_confidence NP_215497.1 81.3 0.6224170319348779 70.845 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.622; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.056454 non-essential Non-essential ML0176 996 Q9CD67 ML0176 Possible secreted serine protease 382 0.05001 non-essential 0.1445 non-essential high NA high_confidence_nonessential NP_215498.1 77.8 0.4452097683155917 59.611 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.445; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.029377 non-essential Non-essential ML0177 238 Q7AQN0 moaB ML0177 Molybdenum cofactor biosynthesis protein 181 0.10418 non-essential 0.23512 non-essential high NA medium_confidence NP_215499.1 88.4 0.6894176581089543 73.322 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.689; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.3) rescued_from_possible_false_negative_by_supporting_evidence 0.005899 non-essential Non-essential ML0178 234 Q9Z5G4 mscL ML0178 MLCB373.30c Large-conductance mechanosensitive channel 154 0.09832 non-essential 0.23563 non-essential high NA medium_confidence NP_215500.1 71.0 0.7401377582968065 66.23 Strong candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.740; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.00026 non-essential Non-essential ML0180 1034 Q9CD66 ML0180 Putative regulatory protein FmdB zinc ribbon domain-containing protein 99 0.04553 non-essential 0.14078 non-essential high agree high_confidence_nonessential Rv0991c 90.6 NE 0 0.8040075140889167 66.13 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.141; Mtb RBH anchor Rv0991c=non-essential (agree); ProteomeLM contextual percentile=0.804; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.804); Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.008146 non-essential Non-essential ML0181 1417 Q7AQM9 ML0181 5-formyltetrahydrofolate cyclo-ligase (EC 6.3.3.2) 197 0.02105 non-essential 0.09875 non-essential high agree high_confidence_nonessential Rv0992c 72.6 NE 0 0.5009392611145899 72.05 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.099; Mtb RBH anchor Rv0992c=non-essential (agree); ProteomeLM contextual percentile=0.501; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.01053 non-essential Non-essential ML0182 1107 Q7AQM8 galU ML0182 UTP--glucose-1-phosphate uridylyltransferase (EC 2.7.7.9) 306 0.10695 non-essential 0.13351 non-essential high NA high_confidence_nonessential NP_215508.1 89.7 0.13024420788979335 55.893 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.130; target-priority score=55.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.095831 non-essential Non-essential ML0183 97 Q7AQM7 moeA ML0183 Molybdopterin molybdenumtransferase (EC 2.10.1.1) 424 0.22459 non-essential 0.29015 non-essential medium NA medium_confidence YP_177776.1 88.5 0.46712586098935505 71.108 Strong candidate ESM-2 calibrated P(essential)=0.225; HANSEN integrated essentiality score=0.290; ProteomeLM contextual percentile=0.467; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.1) rescued_from_possible_false_negative_by_supporting_evidence 0.003031 non-essential Non-essential ML0184 1588 Q9CD65 rimJ ML0184 Possible acetyltransferase 214 0.01019 non-essential 0.05183 non-essential high NA high_confidence_nonessential NP_215510.1 86.0 0.11145898559799625 49.865 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.052; ProteomeLM contextual percentile=0.111; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000623 non-essential Non-essential ML0185 242 Q7AQM6 ML0185 Membrane protein 342 0.15503 non-essential 0.23436 non-essential high NA medium_confidence NP_215511.1 63.3 0.5059486537257357 54.846 Moderate candidate ESM-2 calibrated P(essential)=0.155; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.506; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.062699 non-essential Non-essential ML0187 1110 Q9CD64 ML0187 Acetyltransferase 353 0.04552 non-essential 0.13339 non-essential high NA high_confidence_nonessential NP_215513.1 69.7 0.3994990607388854 59.94 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.399; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000257 non-essential Non-essential ML0188 274 Q9CD63 ML0188 DUF5642 domain-containing protein 87 0.04552 non-essential 0.2294 non-essential high NA medium_confidence 0.9336255479023169 70.346 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.934; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.934); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 7e-06 non-essential Non-essential ML0190 1383 Q9CD62 ML0190 Fe2OG dioxygenase domain-containing protein 205 0.01861 non-essential 0.10305 non-essential high agree high_confidence_nonessential Rv1000c 81.4 NE 0 0.5948653725735754 64.794 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.103; Mtb RBH anchor Rv1000c=non-essential (agree); ProteomeLM contextual percentile=0.595; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7.7e-05 non-essential Non-essential ML0192 1574 Q9CD61 ML0192 Polyprenol-phosphate-mannose--protein mannosyltransferase (EC 2.4.1.-) 510 0.01889 non-essential 0.06052 non-essential high NA high_confidence_nonessential NP_215518.1 79.0 0.10519724483406387 55.806 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.061; ProteomeLM contextual percentile=0.105; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.53175 essential Likely essential ML0193 988 Q9CD60 rsmI ML0193 Ribosomal RNA small subunit methyltransferase I (EC 2.1.1.198) (16S rRNA 2'-O-ribose C1402 methyltransferase) (rRNA (cytidine-2'-O-)-methyltransferase RsmI) 281 0.05368 non-essential 0.14561 non-essential high NA high_confidence_nonessential NP_215519.1 74.0 0.41515341264871636 66.335 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.415; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000421 non-essential Non-essential ML0198 1320 Q7AQM5 cspA ML0198 Probable cold shock protein A 67 0.00702 non-essential 0.11175 non-essential high NA high_confidence_nonessential NP_218165.1 97.0 0.4514715090795241 59.045 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.451; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.0 non-essential Non-essential ML0199 774 Q7AQM4 ML0199 ML0199 protein 200 0.14222 non-essential 0.17316 non-essential high agree high_confidence_nonessential Rv3647c 80.9 NE 0 0.5666875391358798 62.323 Moderate candidate ESM-2 calibrated P(essential)=0.142; HANSEN integrated essentiality score=0.173; Mtb RBH anchor Rv3647c=non-essential (agree); ProteomeLM contextual percentile=0.567; target-priority score=62.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.6e-05 non-essential Non-essential ML0200 549 O69548 topA ML0200 MLCB2548.31c DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme) 947 0.18914 non-essential 0.19683 non-essential high NA high_confidence_nonessential NP_218163.1 84.8 0.12210394489668128 57.079 Moderate candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.122; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.667447 essential Likely essential ML0201 1127 Q7AQM3 ML0201 Membrane protein 530 0.02338 non-essential 0.13162 non-essential high NA high_confidence_nonessential NP_218162.1 85.5 0.49029430181590483 60.071 Moderate candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.132; ProteomeLM contextual percentile=0.490; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006648 non-essential Non-essential ML0202 1444 Q7AQM2 ML0202 DNA polymerase III subunit delta' (EC 2.7.7.7) 405 0.06636 non-essential 0.09235 non-essential high NA high_confidence_nonessential NP_218161.1 84.4 0.07701941139636818 54.996 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.077; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004909 non-essential Non-essential ML0203 636 Q7AQM1 ML0203 Membrane protein 569 0.01233 non-essential 0.18872 non-essential high NA high_confidence_nonessential NP_218152.1 77.0 0.8409517845961177 72.291 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.841; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.841); Target-priority score is high (72.3) rescued_from_possible_false_negative_by_supporting_evidence 0.001392 non-essential Non-essential ML0204 370 Q7AQM0 rmlB2 ML0204 Sugar-nucleotide dehydratase 319 0.09638 non-essential 0.21634 non-essential high NA medium_confidence NP_215015.2 86.1 0.6355666875391359 66.225 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.636; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.003145 non-essential Non-essential ML0205 766 Q7AQL9 ML0205 Membrane protein 356 0.01019 non-essential 0.17406 non-essential high NA high_confidence_nonessential NP_218146.1 66.2 0.7739511584220413 69.087 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.774; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.774); Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 2.1e-05 non-essential Non-essential ML0207 420 Q7AQL8 ML0207 Glycosyltransferase 239 0.13353 non-essential 0.21023 non-essential high NA medium_confidence NP_218148.1 80.2 0.45084533500313084 58.865 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.451; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001764 non-essential Non-essential ML0208 175 Q7AQL7 ML0208 Membrane protein 113 0.15001 non-essential 0.25097 non-essential high NA medium_confidence NP_218149.1 82.0 0.6111458985597996 60.142 Moderate candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.611; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2e-06 non-essential Non-essential ML0210 167 O69540 ppa ML0210 MLCB2548.21 Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase) 162 0.14132 non-essential 0.25309 non-essential high NA medium_confidence NP_218145.1 90.1 0.6180338134001252 75.595 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.618; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.6) rescued_from_possible_false_negative_by_supporting_evidence 8.7e-05 non-essential Non-essential ML0211 27 Q7AQL6 ML0211 Carboxypeptidase 461 0.23313 non-essential 0.45811 non-essential low disagree review_anchor_disagreement Rv3627c 75.1 GD 1 0.3907326236693801 58.324 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.458; Mtb RBH anchor Rv3627c=essential (disagree); ProteomeLM contextual percentile=0.391; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.360493 essential Uncertain ML0213 892 O69538 tilS ML0213 MLCB2548.18c tRNA(Ile)-lysidine synthase (EC 6.3.4.19) (tRNA(Ile)-2-lysyl-cytidine synthase) (tRNA(Ile)-lysidine synthetase) 323 0.02795 non-essential 0.1578 non-essential high NA high_confidence_nonessential NP_218142.1 77.1 0.582968065122104 73.789 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.583; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.8) rescued_from_possible_false_negative_by_supporting_evidence 0.055292 non-essential Non-essential ML0214 694 O69537 hpt hprT ML0214 Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) (HGPRTase) (EC 2.4.2.8) 203 0.13339 non-essential 0.18269 non-essential high NA high_confidence_nonessential NP_218141.1 83.5 0.26925485284909206 65.747 Strong candidate ESM-2 calibrated P(essential)=0.133; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.269; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.103336 non-essential Non-essential ML0217 137 Q9CD59 ML0217 Uncharacterized protein 81 0.08936 non-essential 0.26474 non-essential high NA medium_confidence 0.9411396368190357 70.098 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.265; ProteomeLM contextual percentile=0.941; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.941); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0218 553 Q7AQL5 ML0218 Uncharacterized protein 128 0.01019 non-essential 0.19644 non-essential high NA high_confidence_nonessential 0.9067000626174077 68.714 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.907; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.907); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 7e-06 non-essential Non-essential ML0222 797 Q9CD58 ftsH ML0222 MLCB2548.09c ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) 787 0.07935 non-essential 0.17 non-essential high NA high_confidence_nonessential NP_218127.1 92.7 0.445835942391985 64.643 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.446; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.114268 non-essential Non-essential ML0223 218 O69531 folE ML0223 MLCB2548.08c GTP cyclohydrolase 1 (EC 3.5.4.16) (GTP cyclohydrolase I) (GTP-CH-I) 205 0.09638 non-essential 0.23839 non-essential high NA medium_confidence NP_218126.1 84.6 0.7144646211646838 83.5 High-priority ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.714; target-priority score=83.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (83.5) rescued_from_possible_false_negative_by_supporting_evidence 0.017198 non-essential Non-essential ML0224 699 P0C0X1 folP1 folP ML0224 MLCB2548.07c Dihydropteroate synthase (DHPS) (EC 2.5.1.15) (Dihydropteroate pyrophosphorylase) 284 0.04818 non-essential 0.18235 non-essential high NA high_confidence_nonessential YP_177997.1 77.1 0.6161552911709455 80.062 High-priority ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.616; target-priority score=80.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (80.1) rescued_from_possible_false_negative_by_supporting_evidence 0.037033 non-essential Non-essential ML0225 810 O69529 folB ML0225 MLCB2548.06c Dihydroneopterin aldolase (DHNA) (EC 4.1.2.25) (7,8-dihydroneopterin 2'-epimerase) (7,8-dihydroneopterin aldolase) (7,8-dihydroneopterin epimerase) (EC 5.1.99.8) (7,8-dihydroneopterin hydroxylase) (EC 1.13.11.81) (Dihydroneopterin epimerase) (Dihydroneopterin hydroxylase) 132 0.06738 non-essential 0.169 non-essential high NA high_confidence_nonessential YP_177996.1 74.8 0.4658735128365686 74.501 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.466; target-priority score=74.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.5) rescued_from_possible_false_negative_by_supporting_evidence 0.020053 non-essential Non-essential ML0226 703 O69528 folK ML0226 MLCB2548.05c 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) 191 0.02338 non-essential 0.1817 non-essential high NA high_confidence_nonessential NP_218123.1 65.3 0.7232310582341891 81.034 High-priority ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.723; target-priority score=81.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.0) rescued_from_possible_false_negative_by_supporting_evidence 0.014285 non-essential Non-essential ML0227 1486 Q7AQL4 ML0227 Membrane protein 158 0.01648 non-essential 0.08403 non-essential high agree high_confidence_nonessential Rv3605c 85.4 NE 0 0.45397620538509703 57.496 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv3605c=non-essential (agree); ProteomeLM contextual percentile=0.454; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000181 non-essential Non-essential ML0228 89 Q7AQL3 ML0228 Membrane protein 432 0.14724 non-essential 0.29923 non-essential high NA medium_confidence NP_218121.2 53.4 0.8854101440200376 67.725 Strong candidate ESM-2 calibrated P(essential)=0.147; HANSEN integrated essentiality score=0.299; ProteomeLM contextual percentile=0.885; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.885); Target-priority score is high (67.7) rescued_from_possible_false_negative_by_supporting_evidence 0.169539 non-essential Non-essential ML0229 56 Q7AQL2 ML0229 Oxidoreductase 309 0.00674 non-essential 0.37935 non-essential low disagree review_anchor_disagreement Rv3603c 67.8 ESD 1 0.8841577958672511 73.776 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.379; Mtb RBH anchor Rv3603c=essential (disagree); ProteomeLM contextual percentile=0.884; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 2e-06 non-essential Non-essential ML0230 276 O69524 panC ML0230 MLCB2548.01c Pantothenate synthetase (PS) (EC 6.3.2.1) (Pantoate--beta-alanine ligase) (Pantoate-activating enzyme) 313 0.08519 non-essential 0.22927 non-essential high NA medium_confidence NP_218119.1 79.8 0.715090795241077 82.505 High-priority ESM-2 calibrated P(essential)=0.085; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.715; target-priority score=82.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (82.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000755 non-essential Non-essential ML0231 365 Q9CD57 panD ML0231 Aspartate 1-decarboxylase (EC 4.1.1.11) (Aspartate alpha-decarboxylase) [Cleaved into: Aspartate 1-decarboxylase beta chain; Aspartate 1-decarboxylase alpha chain] 142 0.07471 non-essential 0.21675 non-essential high NA medium_confidence NP_218118.1 82.9 0.6919223544145272 81.709 High-priority ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.692; target-priority score=81.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.7) rescued_from_possible_false_negative_by_supporting_evidence 0.012812 non-essential Non-essential ML0232 426 Q9CD56 coaX ML0232 Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase) 274 0.13088 non-essential 0.20998 non-essential high NA medium_confidence NP_218117.1 90.9 0.42141515341264874 72.522 Strong candidate ESM-2 calibrated P(essential)=0.131; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.421; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 0.149632 non-essential Non-essential ML0233 594 P46861 lysS ML0233 Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS) 507 0.10115 non-essential 0.19213 non-essential high NA high_confidence_nonessential NP_218115.1 85.4 0.45648090169067 71.269 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.456; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 0.473922 essential Likely essential ML0234 554 P24094 lsr2 ML0234 Nucleoid-associated protein Lsr2 (15 kDa antigen) (A15) 112 0.09148 non-essential 0.19634 non-essential high NA high_confidence_nonessential NP_218114.1 88.4 0.5535378835316218 61.757 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.554; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008193 non-essential Non-essential ML0235 1157 P24428 clpC ML0235 Probable ATP-dependent Clp protease ATP-binding subunit 848 0.12139 non-essential 0.1296 non-essential high NA high_confidence_nonessential YP_177995.1 97.0 0.06574827802128992 47.469 Exploratory ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.066; target-priority score=47.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.060643 non-essential Non-essential ML0236 1469 Q7AQL1 pabB ML0236 Para-aminobenzoate synthase component 418 0.01761 non-essential 0.08697 non-essential high NA high_confidence_nonessential NP_215521.1 78.9 0.2686286787726988 55.145 Moderate candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.269; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.027936 non-essential Non-essential ML0238 1531 Q9CD55 metG metS ML0238 Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) 537 0.01648 non-essential 0.07507 non-essential high NA high_confidence_nonessential NP_215523.1 85.7 0.18346900438321853 62.043 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.075; ProteomeLM contextual percentile=0.183; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.951892 essential Essential ML0239 442 Q9CD54 ML0239 Uncharacterized protein 262 0.05422 non-essential 0.20888 non-essential high NA medium_confidence NP_215524.1 82.7 0.7589229805886036 75.133 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.759; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.759); Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.002054 non-essential Non-essential ML0240 292 Q9CD53 ML0240 Resuscitation-promoting factor RpfB 375 0.13353 non-essential 0.2259 non-essential high NA medium_confidence NP_215525.1 82.7 0.530369442705072 63.173 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.530; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003812 non-essential Non-essential ML0241 310 Q9CD52 rsmA ksgA ML0241 Ribosomal RNA small subunit methyltransferase A (EC 2.1.1.182) (16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase) (16S rRNA dimethyladenosine transferase) (16S rRNA dimethylase) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase) 306 0.08969 non-essential 0.22314 non-essential high NA medium_confidence NP_215526.1 85.0 0.6718847839699437 77.908 Strong candidate ESM-2 calibrated P(essential)=0.090; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.672; target-priority score=77.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000111 non-essential Non-essential ML0242 1412 Q9CD51 ispE ML0242 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (CMK) (EC 2.7.1.148) (4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase) 323 0.02518 non-essential 0.09989 non-essential high NA high_confidence_nonessential NP_215527.1 83.2 0.2742642454602379 67.263 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.274; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.3) rescued_from_possible_false_negative_by_supporting_evidence 0.102214 non-essential Non-essential ML0243 908 Q9CD50 ML0243 Acyl-CoA synthetase 544 0.10358 non-essential 0.1556 non-essential high NA high_confidence_nonessential NP_215529.1 82.4 0.2767689417658109 55.51 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.277; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4.2e-05 non-essential Non-essential ML0244 752 Q9CD49 pth ML0244 Peptidyl-tRNA hydrolase (Pth) (EC 3.1.1.29) 199 0.06591 non-essential 0.17582 non-essential high NA high_confidence_nonessential NP_215530.1 77.7 0.5153412648716343 73.605 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.515; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.018662 non-essential Non-essential ML0245 1174 Q9CD48 rplY ctc ML0245 Large ribosomal subunit protein bL25 (50S ribosomal protein L25) (General stress protein CTC) 215 0.06636 non-essential 0.12839 non-essential high NA high_confidence_nonessential NP_215531.1 73.9 0.28741390106449594 55.539 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.287; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.030007 non-essential Non-essential ML0246 585 Q9CD47 lpqT ML0246 Putative lipoprotein LpqT 218 0.02105 non-essential 0.19333 non-essential high NA high_confidence_nonessential NP_215532.1 65.3 0.8290544771446462 71.93 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.829; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.829); Target-priority score is high (71.9) rescued_from_possible_false_negative_by_supporting_evidence 7e-05 non-essential Non-essential ML0247 115 Q9CD46 arsC ML0247 Arsenate reductase 104 0.10085 non-essential 0.27433 non-essential high NA medium_confidence 0.9348778960551033 73.468 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.935; target-priority score=73.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.935); Target-priority score is high (73.5) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0248 828 Q9CD45 prs prsA ML0248 Ribose-phosphate pyrophosphokinase (RPPK) (EC 2.7.6.1) (5-phospho-D-ribosyl alpha-1-diphosphate synthase) (Phosphoribosyl diphosphate synthase) (Phosphoribosyl pyrophosphate synthase) (P-Rib-PP synthase) (PRPP synthase) (PRPPase) 327 0.14132 non-essential 0.16573 non-essential high NA high_confidence_nonessential NP_215533.1 92.0 0.14464621164683783 61.821 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.145; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.615697 essential Likely essential ML0249 1421 Q9CD44 glmU ML0249 Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (N-acetylglucosamine-1-phosphate uridyltransferase); Glucosamine-1-phosphate N-acetyltransferase (EC 2.3.1.157)] 492 0.056 non-essential 0.09612 non-essential high NA high_confidence_nonessential NP_215534.1 83.9 0.12273011897307451 63.162 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.096; ProteomeLM contextual percentile=0.123; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001581 non-essential Non-essential ML0252 759 Q9CD43 mfd ML0252 Transcription-repair-coupling factor (TRCF) (EC 3.6.4.-) 1224 0.07654 non-essential 0.1749 non-essential high NA high_confidence_nonessential NP_215536.1 84.2 0.4884157795867251 64.33 Moderate candidate ESM-2 calibrated P(essential)=0.077; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.488; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.023353 non-essential Non-essential ML0255 1291 Q9CD42 eno ML0255 Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) 429 0.04897 non-essential 0.11436 non-essential high NA high_confidence_nonessential NP_215539.1 89.0 0.2542266750156543 65.88 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.254; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.872273 essential Essential ML0256 1101 Q9CD41 ML0256 Membrane protein 227 0.07447 non-essential 0.13387 non-essential high NA high_confidence_nonessential NP_215540.1 71.2 0.30432060112711334 48.104 Exploratory ESM-2 calibrated P(essential)=0.074; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.304; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.042993 non-essential Non-essential ML0257 57 Q9CD40 ML0257 Septum formation initiator subfamily protein 167 0.0873 non-essential 0.37569 non-essential low disagree review_anchor_disagreement Rv1025 85.1 ES 1 0.44082654978083907 58.46 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.376; Mtb RBH anchor Rv1025=essential (disagree); ProteomeLM contextual percentile=0.441; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.00634 non-essential Non-essential ML0258 1451 Q7AQL0 ML0258 Exopolyphosphatase 2 (EC 3.6.1.11) 317 0.09148 non-essential 0.09137 non-essential high agree high_confidence_nonessential Rv1026 77.3 NE 0 0.09267376330619913 54.417 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.091; Mtb RBH anchor Rv1026=non-essential (agree); ProteomeLM contextual percentile=0.093; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007557 non-essential Non-essential ML0265 243 Q7AQK9 ML0265 Uncharacterized protein 70 0.0582 non-essential 0.23425 non-essential high NA medium_confidence 0.9048215403882279 70.07 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.905; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.905); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000348 non-essential Non-essential ML0269 1349 Q7AQK8 fgd ML0269 F420-dependent glucose-6-phosphate dehydrogenase (FGD) (G6PD) (EC 1.1.98.2) 336 0.07126 non-essential 0.10825 non-essential high NA high_confidence_nonessential NP_214921.1 89.3 0.13650594865372573 58.921 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.108; ProteomeLM contextual percentile=0.137; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00106 non-essential Non-essential ML0270 1222 Q7AQK7 ML0270 Metallo-beta-lactamase domain-containing protein 251 0.02734 non-essential 0.12301 non-essential high NA high_confidence_nonessential NP_214920.1 74.9 0.4276768941765811 57.95 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.428; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3e-06 non-essential Non-essential ML0271 661 Q9CCX5 ML0271 Membrane protein 123 0.00198 non-essential 0.18594 non-essential high NA high_confidence_nonessential NP_214915.1 66.9 0.8710081402629931 72.657 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.871; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.871); Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0275 686 Q9CCX4 metZ ML0275 O-succinylhomoserine sulfhydrylase (OSH sulfhydrylase) (OSHS sulfhydrylase) (EC 2.5.1.-) 406 0.14132 non-essential 0.18358 non-essential high NA high_confidence_nonessential NP_214905.1 87.9 0.24483406386975579 63.454 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.245; target-priority score=63.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010564 non-essential Non-essential ML0276 1509 Q7AQK6 ML0276 Rhodanese domain-containing protein 147 0.02975 non-essential 0.07895 non-essential high agree high_confidence_nonessential Rv0390 79.0 NE 0 0.33876017532874136 54.442 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.079; Mtb RBH anchor Rv0390=non-essential (agree); ProteomeLM contextual percentile=0.339; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000304 non-essential Non-essential ML0279 1441 Q7AQK5 ML0279 Acyl-coenzyme A thioesterase THEM4 (EC 3.1.2.2) (Thioesterase superfamily member 4) 218 0.02734 non-essential 0.09247 non-essential high agree high_confidence_nonessential Rv0356c 73.4 NE 0 0.4308077645585473 65.966 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv0356c=non-essential (agree); ProteomeLM contextual percentile=0.431; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 2.5e-05 non-essential Non-essential ML0280 978 O69595 purA ML0280 MLCB4.23c Adenylosuccinate synthetase (AMPSase) (AdSS) (EC 6.3.4.4) (IMP--aspartate ligase) 432 0.06278 non-essential 0.1468 non-essential high NA high_confidence_nonessential NP_214871.1 87.9 0.37006887914840325 69.846 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.370; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.014015 non-essential Non-essential ML0281 34 Q7AQK4 ML0281 DAGKc domain-containing protein 229 0.18003 non-essential 0.43073 non-essential low disagree review_anchor_disagreement Rv0358 62.9 GD 1 0.43832185347526614 57.758 Moderate candidate ESM-2 calibrated P(essential)=0.180; HANSEN integrated essentiality score=0.431; Mtb RBH anchor Rv0358=essential (disagree); ProteomeLM contextual percentile=0.438; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 4.2e-05 non-essential Non-essential ML0283 598 Q9CCX3 ML0283 Cation-efflux transporter component 268 0.00543 non-essential 0.19188 non-essential high NA high_confidence_nonessential 0.8885410144020037 73.179 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.889; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.889); Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0284 1344 Q7AQK3 ML0284 DUF3151 domain-containing protein 137 0.06981 non-essential 0.1087 non-essential high agree high_confidence_nonessential Rv0360c 85.4 NE 0 0.3863494051346274 56.358 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.109; Mtb RBH anchor Rv0360c=non-essential (agree); ProteomeLM contextual percentile=0.386; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002148 non-essential Non-essential ML0285 631 Q7AQK2 ML0285 Membrane protein 292 0.02734 non-essential 0.18909 non-essential high NA high_confidence_nonessential NP_214875.1 61.6 0.7914840325610519 66.422 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.791; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.791); Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000182 non-essential Non-essential ML0286 1154 O69600 fba ML0286 MLCB4.29c Fructose-bisphosphate aldolase (FBP aldolase) (FBPA) (EC 4.1.2.13) (Fructose-1,6-bisphosphate aldolase) 345 0.12738 non-essential 0.12971 non-essential high NA high_confidence_nonessential NP_214877.1 87.7 0.00939261114589856 57.511 Moderate candidate ESM-2 calibrated P(essential)=0.127; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.009; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.035475 non-essential Non-essential ML0287 791 O69601 ML0287 MLCB4.30 Uncharacterized membrane protein ML0287 222 0.03424 non-essential 0.17124 non-essential high NA high_confidence_nonessential NP_214878.1 66.1 0.656856606136506 65.743 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.657; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000367 non-essential Non-essential ML0291 468 Q7AQK1 ML0291 Uncharacterized protein 130 0.00307 non-essential 0.20562 non-essential high NA medium_confidence 0.9843456480901691 71.762 Strong candidate ESM-2 calibrated P(essential)=0.003; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.984; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.984); Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0292 347 Q9CCX2 ML0292 Uncharacterized protein 79 0.03864 non-essential 0.21851 non-essential high NA medium_confidence 0.9041953663118347 69.317 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.904; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.904); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0293 245 Q9CCX1 ML0293 Uncharacterized protein 69 0.07033 non-essential 0.23414 non-essential high NA medium_confidence 0.8509705698184096 69.225 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.851; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.851); Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML0294 904 Q9ZBL0 thiC ML0294 MLCB1450.28c Phosphomethylpyrimidine synthase (EC 4.1.99.17) (Hydroxymethylpyrimidine phosphate synthase) (HMP-P synthase) (HMP-phosphate synthase) (HMPP synthase) (Thiamine biosynthesis protein ThiC) 547 0.14132 non-essential 0.15577 non-essential high NA high_confidence_nonessential NP_214937.1 90.6 0.08891671884783969 60.854 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.089; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.930793 essential Essential ML0295 609 Q9ZBL1 thiD ML0295 MLCB1450.27c Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase (EC 2.7.1.49) (EC 2.7.4.7) (Hydroxymethylpyrimidine kinase) (HMP kinase) (Hydroxymethylpyrimidine phosphate kinase) (HMP-P kinase) (HMP-phosphate kinase) (HMPP kinase) 279 0.09148 non-essential 0.19132 non-essential high NA high_confidence_nonessential NP_214936.1 77.8 0.4852849092047589 74.928 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.485; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.9) rescued_from_possible_false_negative_by_supporting_evidence 0.05373 non-essential Non-essential ML0297 962 Q9ZBL2 thiG ML0297 MLCB1450.26 Thiazole synthase (EC 2.8.1.10) 261 0.09928 non-essential 0.14836 non-essential high NA high_confidence_nonessential NP_214931.1 87.2 0.2247964934251722 65.428 Strong candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.225; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.4) rescued_from_possible_false_negative_by_supporting_evidence 0.034128 non-essential Non-essential ML0298 134 Q7AQK0 ML0298 Thiamine biosynthesis protein ThiS 74 0.10418 non-essential 0.26616 non-essential high NA medium_confidence NP_214930.1 71.6 0.876017532874139 71.953 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.876; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.876); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000274 non-essential Non-essential ML0299 222 Q7AQJ9 ML0299 glycine oxidase (EC 1.4.3.19) 340 0.11185 non-essential 0.23759 non-essential high NA medium_confidence NP_214929.1 83.1 0.6537257357545397 78.429 Strong candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.654; target-priority score=78.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.4) rescued_from_possible_false_negative_by_supporting_evidence 0.070672 non-essential Non-essential ML0300 976 Q9ZBL5 thiE ML0300 MLCB1450.23c Thiamine-phosphate synthase (TP synthase) (TPS) (EC 2.5.1.3) (Thiamine-phosphate pyrophosphorylase) (TMP pyrophosphorylase) (TMP-PPase) 235 0.02105 non-essential 0.14701 non-essential high NA high_confidence_nonessential NP_214928.1 78.7 0.5422667501565435 76.803 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.542; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.8) rescued_from_possible_false_negative_by_supporting_evidence 0.003957 non-essential Non-essential ML0303 378 Q9CCX0 glnH ML0303 Glutamine-binding protein 326 0.0903 non-essential 0.21521 non-essential high NA medium_confidence NP_214925.1 79.3 0.6556042579837195 66.643 Strong candidate ESM-2 calibrated P(essential)=0.090; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.656; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000271 non-essential Non-essential ML0304 847 P57993 pknG ML0304 MLCB1450.19c Serine/threonine-protein kinase PknG (EC 2.7.11.1) 763 0.11803 non-essential 0.16342 non-essential high NA high_confidence_nonessential NP_214924.1 83.2 0.24232936756418283 60.321 Moderate candidate ESM-2 calibrated P(essential)=0.118; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.242; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.034264 non-essential Non-essential ML0308 621 Q7AQJ8 ML0308 Methyltransferase type 11 domain-containing protein 234 0.03604 non-essential 0.19006 non-essential high NA high_confidence_nonessential 0.7457733249843457 70.331 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.746; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 4e-05 non-essential Non-essential ML0310 712 Q9ZBM2 pssA ML0310 MLCB1450.12 CDP-diacylglycerol--serine O-phosphatidyltransferase (EC 2.7.8.8) (Phosphatidylserine synthase) 300 0.06116 non-essential 0.1805 non-essential high NA high_confidence_nonessential NP_214950.1 77.9 0.5767063243581716 69.515 Strong candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.577; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.011565 non-essential Non-essential ML0311 1270 Q9CCW9 psd ML0311 MLCB1450.11 Phosphatidylserine decarboxylase proenzyme (EC 4.1.1.65) [Cleaved into: Phosphatidylserine decarboxylase alpha chain; Phosphatidylserine decarboxylase beta chain] 243 0.03604 non-essential 0.11726 non-essential high NA high_confidence_nonessential NP_214951.1 73.0 0.3224796493425172 68.664 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.322; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000429 non-essential Non-essential ML0314 1210 Q7AQJ7 ML0314 Esterase 335 0.07273 non-essential 0.12457 non-essential high NA high_confidence_nonessential NP_215592.1 79.7 0.23418910457107076 56.064 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.234; target-priority score=56.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002914 non-essential Non-essential ML0315 1283 Q7AQJ6 ML0315 Oxidoreductase 304 0.03604 non-essential 0.11486 non-essential high NA high_confidence_nonessential NP_214582.1 73.9 0.3406386975579211 57.68 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.341; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000219 non-essential Non-essential ML0316 589 Q9CCW8 ML0316 TetR/AcrR-family transcriptional regulator 200 0.04897 non-essential 0.19304 non-essential high NA high_confidence_nonessential NP_214581.1 68.8 0.7069505322479649 69.326 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.707; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0317 173 P09239 groEL2 groL2 ML0317 MLCB1450.05c Chaperonin GroEL 2 (EC 5.6.1.7) (60 kDa chaperonin 2) (65 kDa antigen) (Chaperonin-60 2) (Cpn60 2) 541 0.1873 non-essential 0.2511 non-essential high NA medium_confidence NP_214954.1 94.8 0.4164057608015028 68.438 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.416; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.4) rescued_from_possible_false_negative_by_supporting_evidence 0.389728 essential Uncertain ML0319 306 Q9ZBM7 lpqE ML0319 MLCB1450.02 Putative lipoprotein LpqE 183 0.04618 non-essential 0.2239 non-essential high NA medium_confidence NP_218101.1 67.3 0.889167188478397 73.443 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.889; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.889); Target-priority score is high (73.4) rescued_from_possible_false_negative_by_supporting_evidence 7.8e-05 non-essential Non-essential ML0320 1428 Q9CCW7 ML0320 Transcription factor 165 0.06716 non-essential 0.09431 non-essential high NA high_confidence_nonessential NP_218100.1 97.5 0.10457107075767064 48.308 Exploratory ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.094; ProteomeLM contextual percentile=0.105; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.031675 non-essential Non-essential ML0321 608 Q9CCW6 ispD ML0321 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (EC 2.7.7.60) (4-diphosphocytidyl-2C-methyl-D-erythritol synthase) (MEP cytidylyltransferase) (MCT) 241 0.06341 non-essential 0.19133 non-essential high NA high_confidence_nonessential NP_218099.1 66.9 0.6092673763306199 76.581 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.609; target-priority score=76.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.6) rescued_from_possible_false_negative_by_supporting_evidence 0.001006 non-essential Non-essential ML0322 924 Q9CCW5 ispF ML0322 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (MECDP-synthase) (MECPP-synthase) (MECPS) (EC 4.6.1.12) 158 0.0 non-essential 0.15336 non-essential high NA high_confidence_nonessential NP_218098.1 79.7 0.6631183469004384 81.256 High-priority ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.663; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.3) rescued_from_possible_false_negative_by_supporting_evidence 0.018343 non-essential Non-essential ML0323 1534 P57990 cysS cysS1 ML0323 Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS) 473 0.01449 non-essential 0.07414 non-essential high NA high_confidence_nonessential YP_177992.1 86.7 0.18785222291797118 61.799 Moderate candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.074; ProteomeLM contextual percentile=0.188; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02097 non-essential Non-essential ML0324 863 Q9CCW4 ML0324 Uncharacterized tRNA/rRNA methyltransferase ML0324 (EC 2.1.1.-) 309 0.11185 non-essential 0.162 non-essential high NA high_confidence_nonessential NP_218096.1 84.4 0.26424546023794615 59.665 Moderate candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.264; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.849588 essential Essential ML0325 4 Q9CCW3 ML0325 Uncharacterized protein 87 0.42684 non-essential 0.53237 essential medium NA medium_confidence 0.960551033187226 72.277 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.532; ProteomeLM contextual percentile=0.961; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.532); ESM-2 transfer probability is moderate (0.427); ProteomeLM contextual percentile is high (0.961); Target-priority score is high (72.3) none 0.000867 non-essential Non-essential ML0333 1397 Q9CCW2 pxpA ML0333 5-oxoprolinase subunit A (5-OPase subunit A) (EC 3.5.2.9) (5-oxoprolinase (ATP-hydrolyzing) subunit A) 252 0.04897 non-essential 0.10183 non-essential high NA high_confidence_nonessential 0.2016280525986224 58.712 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.202; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001274 non-essential Non-essential ML0335 841 Q9CCW1 ML0335 ABC-transporter transmembrane protein 286 0.00198 non-essential 0.16411 non-essential high NA high_confidence_nonessential NP_216576.1 77.3 0.7507827175954915 69.868 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.751; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.751); Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 0.002874 non-essential Non-essential ML0336 1203 Q9CCW0 ML0336 ABC-tranporter ATP-binding protein 275 0.10695 non-essential 0.12515 non-essential high NA high_confidence_nonessential 0.1058234189104571 47.484 Exploratory ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.106; target-priority score=47.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.132203 non-essential Non-essential ML0337 1329 Q9CCV9 ML0337 Periplasmic solute-binding proteins 302 0.00543 non-essential 0.11096 non-essential high agree high_confidence_nonessential Rv2059 64.5 NE 0 0.730745147150908 69.247 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv2059=non-essential (agree); ProteomeLM contextual percentile=0.731; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000172 non-essential Non-essential ML0348 551 Q9CCV8 ML0348 Possible coenzyme F420-dependent oxidoreductase 350 0.06199 non-essential 0.19664 non-essential high NA high_confidence_nonessential NP_218037.1 86.8 0.6681277395115842 69.412 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.668; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 6.4e-05 non-essential Non-essential ML0354 911 Q49865 ilvX ML0354 acetolactate synthase (EC 2.2.1.6) 515 0.06981 non-essential 0.15523 non-essential high NA high_confidence_nonessential NP_218026.1 83.1 0.3913587977457733 68.506 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.391; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.001702 non-essential Non-essential ML0363 620 Q9CCV7 ML0363 ESAT-6-like protein 104 0.0 non-essential 0.19045 non-essential high NA high_confidence_nonessential NP_217961.1 71.2 0.915466499686913 69.642 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.915; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.915); Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0364 159 P38014 rplM ML0364 B229_C3_232 Large ribosomal subunit protein uL13 (50S ribosomal protein L13) 147 0.23313 non-essential 0.25574 non-essential medium NA medium_confidence NP_217960.1 91.8 0.271759549154665 55.393 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.272; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.834613 essential Essential ML0365 672 P40828 rpsI ML0365 B229_C2_191 Small ribosomal subunit protein uS9 (30S ribosomal protein S9) 153 0.1873 non-essential 0.1849 non-essential high NA high_confidence_nonessential NP_217959.1 83.9 0.08641202254226675 48.232 Exploratory ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.086; target-priority score=48.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.020816 non-essential Non-essential ML0366 1274 Q49869 glmM ML0366 Phosphoglucosamine mutase (EC 5.4.2.10) 463 0.09206 non-essential 0.11576 non-essential high NA high_confidence_nonessential NP_217958.1 87.6 0.08954289292423294 57.466 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.116; ProteomeLM contextual percentile=0.090; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.443077 essential Likely essential ML0369 496 Q49877 ML0369 Uncharacterized protein 118 0.00543 non-essential 0.20284 non-essential high NA medium_confidence 0.9574201628052599 71.695 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.957; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.957); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 0.030424 non-essential Non-essential ML0370 1240 Q9CCV6 ML0370 Alpha/beta hydrolase 289 0.0533 non-essential 0.12094 non-essential high agree high_confidence_nonessential Rv3438 80.6 GA 0 0.5710707576706324 63.701 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.121; Mtb RBH anchor Rv3438=non-essential (agree); ProteomeLM contextual percentile=0.571; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4.1e-05 non-essential Non-essential ML0371 1012 P40831 glmS ML0371 B229_C3_238 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16) (D-fructose-6-phosphate amidotransferase) (GFAT) (Glucosamine-6-phosphate synthase) (Hexosephosphate aminotransferase) (L-glutamine--D-fructose-6-phosphate amidotransferase) 625 0.13898 non-essential 0.14296 non-essential high NA high_confidence_nonessential NP_217953.1 89.3 0.041953663118346904 54.848 Moderate candidate ESM-2 calibrated P(essential)=0.139; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.042; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.840147 essential Essential ML0373 764 P37391 nnr ML0373 B229_C2_201 u229g Bifunctional NAD(P)H-hydrate repair enzyme Nnr (Nicotinamide nucleotide repair protein) [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)] 473 0.08711 non-essential 0.17425 non-essential high NA high_confidence_nonessential NP_217950.1 81.4 0.4201628052598622 69.756 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.420; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.005979 non-essential Non-essential ML0375 1045 P38056 alr ML0375 B229_C3_243 Alanine racemase (EC 5.1.1.1) 388 0.03731 non-essential 0.13948 non-essential high NA high_confidence_nonessential NP_217940.1 84.4 0.4314339386349405 74.069 Strong candidate ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.431; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.1) rescued_from_possible_false_negative_by_supporting_evidence 0.008818 non-essential Non-essential ML0376 237 Q9CCV4 ML0376 Membrane protein 333 0.05422 non-essential 0.23525 non-essential high NA medium_confidence 0.9229805886036319 72.1 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.235; ProteomeLM contextual percentile=0.923; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.923); Target-priority score is high (72.1) rescued_from_possible_false_negative_by_supporting_evidence 0.0002 non-essential Non-essential ML0377 1433 Q49864 tsaE ML0377 B229_C2_205 u229f tRNA threonylcarbamoyladenosine biosynthesis protein TsaE (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE) 161 0.01761 non-essential 0.09334 non-essential high NA high_confidence_nonessential NP_217939.1 77.4 0.3018159048215404 56.607 Moderate candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.302; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000673 non-essential Non-essential ML0378 1536 Q49857 ML0378 B229_C1_170 Uncharacterized protein ML0378 359 0.03604 non-essential 0.07336 non-essential high agree high_confidence_nonessential Rv3421c 75.6 NE 0 0.25046963055729493 53.373 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.073; Mtb RBH anchor Rv3421c=non-essential (agree); ProteomeLM contextual percentile=0.250; target-priority score=53.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004386 non-essential Non-essential ML0379 1200 P37969 tsaD gcp ML0379 B1620_C3_226 B229_C3_246 u1620c u229e tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD) (tRNA threonylcarbamoyladenosine biosynthesis protein TsaD) 351 0.06543 non-essential 0.12551 non-essential high NA high_confidence_nonessential NP_217936.1 86.1 0.2536005009392611 62.71 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.254; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.096534 non-essential Non-essential ML0380 717 P24301 groES chpA groS mopB ML0380 B1620_C3_227 B229_C3_247 Co-chaperonin GroES (10 kDa antigen) (10 kDa chaperonin) (Chaperonin-10) (Cpn10) 100 0.10794 non-essential 0.17997 non-essential high NA high_confidence_nonessential NP_217935.1 90.0 0.39887288666249215 55.921 Moderate candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.399; target-priority score=55.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.331247 essential Uncertain ML0381 246 P37578 groEL1 groE1 groL1 ML0381 B1620_C3_228 B229_C3_248 Chaperonin GroEL 1 (EC 5.6.1.7) (60 kDa chaperonin 1) (Chaperonin-60 1) (Cpn60 1) 537 0.14132 non-essential 0.23406 non-essential high NA medium_confidence NP_217934.1 82.9 0.5190983093299938 71.174 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.519; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.084464 non-essential Non-essential ML0382 1415 Q49871 whiB3 whiB ML0382 Transcriptional regulator WhiB 102 0.06116 non-essential 0.09887 non-essential high NA high_confidence_nonessential NP_217933.1 86.3 0.1458985597996243 52.717 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.099; ProteomeLM contextual percentile=0.146; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005637 non-essential Non-essential ML0383 1293 Q9CCV3 ML0383 Uncharacterized protein 281 0.02338 non-essential 0.11426 non-essential high agree high_confidence_nonessential Rv3415c 73.6 NE 0 0.6712586098935505 66.21 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.114; Mtb RBH anchor Rv3415c=non-essential (agree); ProteomeLM contextual percentile=0.671; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 2.4e-05 non-essential Non-essential ML0386 999 Q49742 ML0386 B1620_F3_131 Uncharacterized protein ML0386 137 0.03604 non-essential 0.14425 non-essential high agree high_confidence_nonessential Rv3412 94.1 NE 0 0.8716343143393863 70.927 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.144; Mtb RBH anchor Rv3412=non-essential (agree); ProteomeLM contextual percentile=0.872; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.872); Target-priority score is high (70.9) rescued_from_possible_false_negative_by_supporting_evidence 1.6e-05 non-essential Non-essential ML0387 1182 Q49729 guaB ML0387 B1620_C3_238 Inosine-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPD) (IMPDH) (EC 1.1.1.205) 529 0.08883 non-essential 0.12734 non-essential high NA high_confidence_nonessential NP_217928.1 92.4 0.15716969317470256 62.655 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.157; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.691075 essential Likely essential ML0388 92 Q49721 ML0388 B1620_C2_193 Uncharacterized oxidoreductase ML0388 (EC 1.-.-.-) 375 0.19217 non-essential 0.29473 non-essential high NA medium_confidence NP_217927.1 90.6 0.641202254226675 71.659 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.295; ProteomeLM contextual percentile=0.641; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 0.053033 non-essential Non-essential ML0389 1278 Q9CCV1 choD ML0389 Cholesterol oxidase (EC 1.1.3.6) (EC 5.3.3.1) (Cholesterol isomerase) 569 0.07935 non-essential 0.11542 non-essential high NA high_confidence_nonessential NP_217926.1 88.6 0.14527238572323106 57.663 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.145; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6e-06 non-essential Non-essential ML0392 793 Q49736 ML0392 B1620_F1_30 Uncharacterized glycosyl hydrolase ML0392 (EC 3.2.1.-) 792 0.0338 non-essential 0.17054 non-essential high NA high_confidence_nonessential NP_217918.1 91.4 0.6330619912335629 73.105 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.633; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 0.086833 non-essential Non-essential ML0393 925 Q49741 ML0393 B1620_F3_119 Beta-phosphoglucomutase (Beta-PGM) (EC 5.4.2.6) 261 0.07935 non-essential 0.15331 non-essential high NA high_confidence_nonessential NP_217917.1 74.4 0.345648090169067 65.319 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.346; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.3) rescued_from_possible_false_negative_by_supporting_evidence 2.7e-05 non-essential Non-essential ML0394 465 Q9CCV0 ML0394 Methyltransferase domain-containing protein 170 0.00674 non-essential 0.206 non-essential high NA medium_confidence 0.9599248591108328 75.107 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.960; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.960); Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 3.1e-05 non-essential Non-essential ML0395 657 P46810 guaA ML0395 B1620_C2_205 GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (GMP synthetase) (Glutamine amidotransferase) 529 0.12033 non-essential 0.1864 non-essential high NA high_confidence_nonessential NP_217913.1 86.4 0.3437695679398873 68.209 Strong candidate ESM-2 calibrated P(essential)=0.120; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.344; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 0.053738 non-essential Non-essential ML0396 734 Q57240 ML0396; ML2692 B1620_F3_113 L222-ORF2 Uncharacterized protein ML0396/ML2692 369 0.19217 non-essential 0.17823 non-essential high NA high_confidence_nonessential NP_214560.1 89.1 0.03005635566687539 46.453 Exploratory ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.030; target-priority score=46.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02397 non-essential Non-essential ML0397 591 Q9CCU8 ML0397 Transporter protein 602 0.02338 non-essential 0.19284 non-essential high NA high_confidence_nonessential 0.8140262993112085 72.454 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.814; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.814); Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000541 non-essential Non-essential ML0398 494 Q49738 ML0398 D-ribose-binding protein 345 0.06441 non-essential 0.20299 non-essential high NA medium_confidence 0.6975579211020664 68.326 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.698; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.3) rescued_from_possible_false_negative_by_supporting_evidence 0.006397 non-essential Non-essential ML0405 678 Q49722 ML0405 ESX-1 secretion-associated protein EspA/EspE-like domain-containing protein 394 0.00198 non-essential 0.18441 non-essential high NA high_confidence_nonessential NP_218133.1 61.7 0.8728866624921728 68.957 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.873; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.873); Target-priority score is high (69.0) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML0406 671 Q49723 ML0406 B1620_C2_214 MLCL383.02 EspC protein homolog 106 0.0 non-essential 0.18491 non-essential high NA high_confidence_nonessential 0.8747651847213526 72.409 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.875; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.875); Target-priority score is high (72.4) rescued_from_possible_false_negative_by_supporting_evidence 1.8e-05 non-essential Non-essential ML0407 361 Q49730 ML0407 Secretion protein EspD 216 0.04656 non-essential 0.21686 non-essential high NA medium_confidence NP_218131.1 71.9 0.8584846587351284 69.204 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.858; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.858); Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.00026 non-essential Non-essential ML0410 632 Q49724 ML0410 PE-family protein 100 0.0 non-essential 0.18895 non-essential high NA high_confidence_nonessential 0.8979336255479023 72.606 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.898; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.898); Target-priority score is high (72.6) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0411 697 Q07297 sra ML0411 MLCL383.14 Serine-rich antigen (25L) (45 kDa protein) 408 0.0 non-essential 0.1826 non-essential high NA high_confidence_nonessential 0.8659987476518473 70.767 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.866; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.866); Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000745 non-essential Non-essential ML0414 149 Q49734 otsB ML0414 MLCL383.17c Trehalose-phosphate phosphatase (TPP) (EC 3.1.3.12) (Trehalose-6-phosphate phosphatase) 429 0.14132 non-essential 0.2599 non-essential high NA medium_confidence NP_217889.1 67.1 0.6474639949906074 79.196 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.260; ProteomeLM contextual percentile=0.647; target-priority score=79.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.2) rescued_from_possible_false_negative_by_supporting_evidence 0.009893 non-essential Non-essential ML0418 1014 Q7AQJ5 ML0418 Oxidoreductase 210 0.07935 non-essential 0.14289 non-essential high NA high_confidence_nonessential NP_217885.1 81.4 0.30932999373825926 56.835 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.309; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3e-06 non-essential Non-essential ML0419 795 Q9CCU7 ML0419 Putative tRNA (cytidine(34)-2'-O)-methyltransferase (EC 2.1.1.207) (tRNA (cytidine/uridine-2'-O-)-methyltransferase) 158 0.09148 non-essential 0.1703 non-essential high NA high_confidence_nonessential NP_217883.1 83.8 0.38509705698184094 66.957 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.385; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 0.00524 non-essential Non-essential ML0424 179 Q7AQJ4 bcp ML0424 thioredoxin-dependent peroxiredoxin (EC 1.11.1.24) (Bacterioferritin comigratory protein) (Thioredoxin peroxidase) 161 0.09638 non-essential 0.24965 non-essential high NA medium_confidence NP_217037.1 80.3 0.7871008140262993 81.33 High-priority ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.250; ProteomeLM contextual percentile=0.787; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.787); Target-priority score is high (81.3) rescued_from_possible_false_negative_by_supporting_evidence 2.3e-05 non-essential Non-essential ML0425 682 Q9CCU6 ML0425 Membrane protein 75 0.03847 non-essential 0.18389 non-essential high NA high_confidence_nonessential NP_217036.1 58.7 0.7138384470882906 65.066 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.714; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.1) rescued_from_possible_false_negative_by_supporting_evidence 3.5e-05 non-essential Non-essential ML0426 1189 Q9CCU5 lppS ML0426 Secreted protein 404 0.04818 non-essential 0.12667 non-essential high NA high_confidence_nonessential NP_217034.1 82.4 0.33562930494677523 64.062 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.336; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004096 non-essential Non-essential ML0427 1353 O07708 orn ML0427 MLCL383.34c Oligoribonuclease (EC 3.1.15.-) 215 0.01648 non-essential 0.10685 non-essential high NA high_confidence_nonessential NP_217027.1 83.7 0.36505948653725734 63.862 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.107; ProteomeLM contextual percentile=0.365; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001722 non-essential Non-essential ML0429 1070 Q7AQJ3 ML0429 Oxidoreductase 268 0.06636 non-essential 0.13699 non-essential high NA high_confidence_nonessential NP_217025.1 88.8 0.3343769567939887 56.763 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.334; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003368 non-essential Non-essential ML0430 1321 Q9CCU4 ML0430 Membrane protein 454 0.00429 non-essential 0.11162 non-essential high NA high_confidence_nonessential NP_217024.1 75.7 0.46149029430181593 59.644 Moderate candidate ESM-2 calibrated P(essential)=0.004; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.461; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004276 non-essential Non-essential ML0431 1121 Q9CCU3 ML0431 Membrane protein 259 0.02734 non-essential 0.13241 non-essential high agree high_confidence_nonessential Rv2507 63.3 NE 0 0.8171571696931748 68.582 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv2507=non-essential (agree); ProteomeLM contextual percentile=0.817; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.817); Target-priority score is high (68.6) rescued_from_possible_false_negative_by_supporting_evidence 0.003402 non-essential Non-essential ML0447 546 Q9CCU2 ML0447 Cytochrome P450 158 0.00674 non-essential 0.19703 non-essential high NA high_confidence_nonessential 0.91296180338134 73.142 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.913; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.913); Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000444 non-essential Non-essential ML0448 304 Q7AQJ2 ML0448 Uncharacterized protein 90 0.024 non-essential 0.22402 non-essential high NA medium_confidence 0.9974953036944271 71.453 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.997; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.998); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.044427 non-essential Non-essential ML0450 350 O07145 pdxS ML0450 MLCL581.12c Pyridoxal 5'-phosphate synthase subunit PdxS (PLP synthase subunit PdxS) (EC 4.3.3.6) (Pdx1) 307 0.23815 non-essential 0.21816 non-essential medium NA medium_confidence NP_217122.1 89.7 0.01878522229179712 58.413 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.019; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.205006 non-essential Uncertain ML0451 1194 Q7AQJ1 ML0451 Nudix hydrolase domain-containing protein 349 0.01019 non-essential 0.12621 non-essential high NA high_confidence_nonessential NP_217125.1 77.7 0.5128365685660614 62.15 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.513; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00203 non-essential Non-essential ML0452 1250 O07147 pimA ML0452 MLCL581.14c Phosphatidyl-myo-inositol mannosyltransferase (EC 2.4.1.345) (Alpha-mannosyltransferase) (GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) (PI alpha-mannosyltransferase) 374 0.11185 non-essential 0.11959 non-essential high NA high_confidence_nonessential NP_217126.1 82.3 0.019411396368190358 58.09 Moderate candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.019; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.023008 non-essential Non-essential ML0453 586 Q7AQJ0 ML0453 Phosphatidylinositol mannoside acyltransferase 320 0.05767 non-essential 0.19331 non-essential high NA high_confidence_nonessential NP_217127.1 70.4 0.6700062617407639 68.851 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.670; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.013196 non-essential Non-essential ML0454 887 Q7AQI9 pgsA ML0454 Phosphatidylinositol phosphate synthase (PIP synthase) (EC 2.7.8.-) (CDP-diacylglycerol--D-myo-inositol-3-phosphate 3-phosphatidyltransferase) 239 0.01019 non-essential 0.15836 non-essential high NA high_confidence_nonessential YP_177894.1 79.3 0.6499686912961803 79.83 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.650; target-priority score=79.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.8) rescued_from_possible_false_negative_by_supporting_evidence 0.004054 non-essential Non-essential ML0455 1465 Q9CCU0 ML0455 HIT domain-containing protein 206 0.05949 non-essential 0.08779 non-essential high NA high_confidence_nonessential NP_217129.1 83.2 0.10206637445209768 48.078 Exploratory ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.088; ProteomeLM contextual percentile=0.102; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.031194 non-essential Non-essential ML0456 1197 O07151 thrS ML0456 MLCL581.18c Threonine--tRNA ligase (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS) 702 0.07935 non-essential 0.12596 non-essential high NA high_confidence_nonessential NP_217130.1 84.0 0.19536631183469005 61.723 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.195; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.155317 non-essential Non-essential ML0458 1081 Q9CCT9 ML0458 Oxidoreductase 301 0.02975 non-essential 0.136 non-essential high NA high_confidence_nonessential 0.4796493425172198 62.508 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.480; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6e-06 non-essential Non-essential ML0464 414 Q9CCT8 ML0464 Uncharacterized protein 95 0.01648 non-essential 0.21075 non-essential high NA medium_confidence 0.9567939887288667 70.484 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.957; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.957); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 0.006859 non-essential Non-essential ML0466 646 Q7AQI8 ML0466 Possible secreted protein 301 0.07755 non-essential 0.18751 non-essential high NA high_confidence_nonessential 0.5685660613650595 60.733 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.569; target-priority score=60.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.1e-05 non-essential Non-essential ML0467 830 Q49642 ML0467 B1177_C2_172/B1177_C1_140 MLCL581.27 Uncharacterized membrane protein ML0467 214 0.01017 non-essential 0.16545 non-essential high NA high_confidence_nonessential NP_217153.1 79.9 0.7244834063869756 68.711 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.724; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 9.6e-05 non-essential Non-essential ML0468 1133 Q49657 ML0468 Probable membrane transporter protein 260 0.00543 non-essential 0.13106 non-essential high NA high_confidence_nonessential 0.5597996242955542 63.322 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.560; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002776 non-essential Non-essential ML0470 391 Q7AQI7 ML0470 Uncharacterized protein 96 0.01019 non-essential 0.21343 non-essential high NA medium_confidence 0.9981214777708203 71.608 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.998; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.998); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.00039 non-essential Non-essential ML0472 293 Q9CCT7 ML0472 Uncharacterized protein 80 0.0327 non-essential 0.22567 non-essential high NA medium_confidence 0.9674389480275517 71.405 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.967; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.967); Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000119 non-essential Non-essential ML0473 281 Q9CCT6 ML0473 Uncharacterized protein 90 0.04985 non-essential 0.2281 non-essential high NA medium_confidence 0.9085785848465874 69.514 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.909; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.909); Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.01755 non-essential Non-essential ML0474 375 Q9CCT5 pdxT ML0474 Pyridoxal 5'-phosphate synthase subunit PdxT (EC 4.3.3.6) (Pdx2) (Pyridoxal 5'-phosphate synthase glutaminase subunit) (EC 3.5.1.2) 198 0.10233 non-essential 0.21553 non-essential high NA medium_confidence NP_217120.1 83.3 0.5704445835942392 77.47 Strong candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.570; target-priority score=77.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.5) rescued_from_possible_false_negative_by_supporting_evidence 0.09435 non-essential Non-essential ML0475 360 Q49645 ML0475 B1177_C2_181 u1177b Probable transcriptional regulatory protein ML0475 251 0.13353 non-essential 0.2169 non-essential high NA medium_confidence NP_217119.1 92.4 0.482780212899186 61.362 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.483; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00057 non-essential Non-essential ML0481 837 P40834 ruvC ML0481 B1177_C3_226 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.21.10) (Holliday junction nuclease RuvC) (Holliday junction resolvase RuvC) 188 0.08014 non-essential 0.16444 non-essential high NA high_confidence_nonessential NP_217110.1 81.5 0.40137758296806514 67.386 Strong candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.401; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.4) rescued_from_possible_false_negative_by_supporting_evidence 0.950055 essential Essential ML0482 230 P40832 ruvA ML0482 B1177_C2_188 Holliday junction branch migration complex subunit RuvA 203 0.09148 non-essential 0.23579 non-essential high NA medium_confidence NP_217109.1 76.8 0.7551659361302442 72.106 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.755; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.755); Target-priority score is high (72.1) rescued_from_possible_false_negative_by_supporting_evidence 0.008662 non-essential Non-essential ML0483 1502 P40833 ruvB ML0483 B1177_C3_227 Holliday junction branch migration complex subunit RuvB (EC 3.6.4.-) 349 0.06981 non-essential 0.08128 non-essential high NA high_confidence_nonessential NP_217108.1 94.4 0.0031308703819661866 52.586 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.081; ProteomeLM contextual percentile=0.003; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.062442 non-essential Non-essential ML0484 807 Q9CCT4 fadD9 car ML0484 Carboxylic acid reductase (CAR) (EC 1.2.1.-) (ATP/NADPH-dependent carboxylic acid reductase) 1188 0.10115 non-essential 0.16921 non-essential high NA high_confidence_nonessential NP_217106.1 68.3 0.3400125234815279 65.035 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.340; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (65.0) rescued_from_possible_false_negative_by_supporting_evidence 2.6e-05 non-essential Non-essential ML0485 322 P40829 gabT ML0485 B1177_F2_67 MLCB1259.03c 4-aminobutyrate aminotransferase (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (Glutamate:succinic semialdehyde transaminase) (L-AIBAT) 446 0.14132 non-essential 0.22208 non-essential high NA medium_confidence NP_217105.1 84.2 0.4495929868503444 70.834 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.450; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.003314 non-essential Non-essential ML0486 710 Q49647 yajC ML0486 B1177_C3_235 MLCB1259.04 Sec translocon accessory complex subunit YajC 114 0.01648 non-essential 0.18113 non-essential high NA high_confidence_nonessential NP_217104.1 65.9 0.7877269881026926 68.721 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.788; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.788); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML0487 1403 P38387 secD ML0487 B1177_C1_164 MLCB1259.05 Protein translocase subunit SecD 571 0.09928 non-essential 0.10158 non-essential high NA high_confidence_nonessential NP_217103.1 78.2 0.01628052598622417 42.751 Exploratory ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.016; target-priority score=42.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.102451 non-essential Non-essential ML0488 1526 P38386 secF ML0488 B1177_C3_239 MLCB1259.06 Protein translocase subunit SecF 471 0.0533 non-essential 0.07683 non-essential high NA high_confidence_nonessential NP_217102.1 69.6 0.07764558547276143 44.11 Exploratory ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.078; target-priority score=44.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.474555 essential Likely essential ML0489 916 Q49646 ML0489 B1177_C2_197 MLCB1259.07 Uncharacterized lipoprotein ML0489 555 0.13829 non-essential 0.15394 non-essential high NA high_confidence_nonessential NP_217101.1 79.0 0.12711333750782716 48.923 Exploratory ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.127; target-priority score=48.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.076219 non-essential Non-essential ML0491 719 Q49640 relA ML0491 B1177_C1_168 MLCB1259.09 Probable GTP pyrophosphokinase (EC 2.7.6.5) ((p)ppGpp synthase) (ATP:GTP 3'-pyrophosphotransferase) (ppGpp synthase I) 787 0.19217 non-essential 0.17955 non-essential high NA high_confidence_nonessential NP_217099.1 91.5 0.021289918597370068 52.064 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.021; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.034626 non-essential Non-essential ML0492 605 P46697 ppiB ppi ML0492 B1177_F3_97 MLCB1259.10c Probable peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Rotamase B) 295 0.03079 non-essential 0.19149 non-essential high NA high_confidence_nonessential NP_217098.1 76.9 0.7595491546649968 76.692 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.760; target-priority score=76.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.760); Target-priority score is high (76.7) rescued_from_possible_false_negative_by_supporting_evidence 0.099106 non-essential Non-essential ML0493 1273 Q49649 ML0493 B1177_C3_247 MLCB1259.11 Uncharacterized protein ML0493 (EC 3.-.-.-) 218 0.09359 non-essential 0.1167 non-essential high NA high_confidence_nonessential NP_217097.1 82.4 0.09580463368816532 54.822 Moderate candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.096; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.5e-05 non-essential Non-essential ML0494 940 P46696 hisS ML0494 B1177_C3_248 MLCB1259.12 Histidine--tRNA ligase (EC 6.1.1.21) (Histidyl-tRNA synthetase) (HisRS) 427 0.06636 non-essential 0.15138 non-essential high NA high_confidence_nonessential NP_217096.1 85.9 0.39010644959298685 66.611 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.390; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.006688 non-essential Non-essential ML0501 1448 P36429 aspS ML0501 MLCB1259.19 Aspartate--tRNA(Asp/Asn) ligase (EC 6.1.1.23) (Aspartyl-tRNA synthetase) (AspRS) (Non-discriminating aspartyl-tRNA synthetase) (ND-AspRS) 589 0.05587 non-essential 0.09182 non-essential high NA high_confidence_nonessential NP_217088.1 87.8 0.10895428929242329 59.431 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.109; target-priority score=59.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.040301 non-essential Non-essential ML0508 1570 Q9CCT2 ML0508 Transglutaminase-like domain-containing protein 313 0.02734 non-essential 0.06231 non-essential high agree high_confidence_nonessential Rv2569c 84.9 NE 0 0.21039448966812774 49.723 Exploratory ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.062; Mtb RBH anchor Rv2569c=non-essential (agree); ProteomeLM contextual percentile=0.210; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.009671 non-essential Non-essential ML0510 1061 Q9CCT1 ML0510 AAA+ ATPase domain-containing protein 473 0.14234 non-essential 0.13766 non-essential high agree high_confidence_nonessential Rv2559c 84.2 NE 0 0.2510958046336882 54.293 Moderate candidate ESM-2 calibrated P(essential)=0.142; HANSEN integrated essentiality score=0.138; Mtb RBH anchor Rv2559c=non-essential (agree); ProteomeLM contextual percentile=0.251; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.071696 non-essential Non-essential ML0512 1402 Q9CCT0 alaS ML0512 Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) 908 0.09148 non-essential 0.1016 non-essential high NA high_confidence_nonessential NP_217071.1 84.8 0.017532874139010644 54.523 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.018; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.673304 essential Likely essential ML0513 146 Q9CCS9 ML0513 Putative pre-16S rRNA nuclease (EC 3.1.-.-) 184 0.11111 non-essential 0.261 non-essential high NA medium_confidence NP_217070.1 71.3 0.80463368816531 75.088 Strong candidate ESM-2 calibrated P(essential)=0.111; HANSEN integrated essentiality score=0.261; ProteomeLM contextual percentile=0.805; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.805); Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.002242 non-essential Non-essential ML0514 649 Q9CCS8 mltG ML0514 Endolytic murein transglycosylase (EC 4.2.2.29) (Peptidoglycan lytic transglycosylase) (Peptidoglycan polymerization terminase) 421 0.07502 non-essential 0.18733 non-essential high NA high_confidence_nonessential NP_217069.1 69.8 0.5453976205385097 72.182 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.545; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.2) rescued_from_possible_false_negative_by_supporting_evidence 0.001288 non-essential Non-essential ML0515 1161 Q9CCS7 aroE ML0515 Shikimate 5-dehydrogenase 278 0.03604 non-essential 0.12923 non-essential high NA high_confidence_nonessential NP_217068.1 81.5 0.406386975579211 64.076 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.406; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001568 non-essential Non-essential ML0516 1392 Q9CCS6 aroC aroF ML0516 Chorismate synthase (CS) (EC 4.2.3.5) (5-enolpyruvylshikimate-3-phosphate phospholyase) 407 0.04192 non-essential 0.10218 non-essential high NA high_confidence_nonessential NP_217056.1 88.3 0.21603005635566688 65.513 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.216; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.5) rescued_from_possible_false_negative_by_supporting_evidence 0.13692 non-essential Non-essential ML0517 944 Q9CCS5 aroK ML0517 Shikimate kinase (SK) (EC 2.7.1.71) 199 0.02105 non-essential 0.15072 non-essential high NA high_confidence_nonessential NP_217055.1 79.6 0.567313713212273 75.715 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.567; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000688 non-essential Non-essential ML0518 1238 Q9CCS4 aroB ML0518 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4) 361 0.09148 non-essential 0.12118 non-essential high NA high_confidence_nonessential NP_217054.1 87.3 0.110832811521603 61.967 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.111; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.26562 non-essential Uncertain ML0519 767 Q9CCS3 aroQ aroD ML0519 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type II DHQase) 145 0.01172 non-essential 0.17404 non-essential high NA high_confidence_nonessential NP_217053.1 85.3 0.7263619286161553 82.835 High-priority ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.726; target-priority score=82.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (82.8) rescued_from_possible_false_negative_by_supporting_evidence 0.017631 non-essential Non-essential ML0520 675 Q9CCS2 ML0520 Membrane protein 202 0.02518 non-essential 0.18472 non-essential high NA high_confidence_nonessential NP_217052.1 48.7 0.7714464621164684 67.865 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.771; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.771); Target-priority score is high (67.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000897 non-essential Non-essential ML0521 637 Q9CCS1 pepQ ML0521 Cytoplasmic peptidase 376 0.07497 non-essential 0.18847 non-essential high NA high_confidence_nonessential NP_217051.1 83.0 0.5742016280525987 64.753 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.574; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.05195 non-essential Non-essential ML0522 122 Q9CCS0 efp ML0522 Elongation factor P (EF-P) 187 0.13353 non-essential 0.27297 non-essential high NA medium_confidence NP_217050.1 94.1 0.7720726361928616 75.143 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.772; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.772); Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.032946 non-essential Non-essential ML0523 498 Q9CCR9 nusB ML0523 Transcription antitermination protein NusB (Antitermination factor NusB) 190 0.05857 non-essential 0.20262 non-essential high NA medium_confidence NP_217049.1 75.7 0.7194740137758296 69.249 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.719; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.070283 non-essential Non-essential ML0524 193 Q9CCR8 adi ML0524 Amino acid decarboxylase 950 0.17728 non-essential 0.24587 non-essential high NA medium_confidence YP_177889.1 86.4 0.4546023794614903 60.609 Moderate candidate ESM-2 calibrated P(essential)=0.177; HANSEN integrated essentiality score=0.246; ProteomeLM contextual percentile=0.455; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.287892 non-essential Uncertain ML0525 268 Q9CCR7 ML0525 Uncharacterized protein 58 0.03466 non-essential 0.23013 non-essential high NA medium_confidence 0.9837194740137758 71.725 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.984; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.984); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0527 475 Q9CCR6 ML0527 Uncharacterized protein 84 0.00543 non-essential 0.20447 non-essential high NA medium_confidence 0.9693174702567313 70.903 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.969; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.969); Target-priority score is high (70.9) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML0532 1097 Q9CCR5 pyrB ML0532 Aspartate carbamoyltransferase catalytic subunit (EC 2.1.3.2) (Aspartate transcarbamylase) (ATCase) 321 0.09455 non-essential 0.13436 non-essential high NA high_confidence_nonessential NP_215896.1 89.4 0.17219787100814027 62.683 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.172; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.974347 essential Essential ML0533 1033 Q9CCR4 pyrC ML0533 Dihydroorotase (DHOase) (EC 3.5.2.3) 430 0.08711 non-essential 0.1408 non-essential high NA high_confidence_nonessential NP_215897.1 88.8 0.23544145272385722 65.665 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.235; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.286402 non-essential Uncertain ML0535 297 Q9CCR3 carA ML0535 Carbamoyl phosphate synthase small chain (EC 6.3.5.5) (Carbamoyl phosphate synthetase glutamine chain) 375 0.23815 non-essential 0.22493 non-essential medium NA medium_confidence NP_215899.1 85.7 0.056355666875391355 59.194 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.056; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.636434 essential Likely essential ML0536 337 Q9CCR2 carB ML0536 Carbamoyl phosphate synthase large chain (EC 6.3.4.16) (EC 6.3.5.5) (Carbamoyl phosphate synthetase ammonia chain) 1121 0.23815 non-essential 0.21978 non-essential medium NA medium_confidence YP_177804.1 88.9 0.031934877896055106 57.189 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.032; target-priority score=57.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.569974 essential Likely essential ML0537 1115 Q9CCR1 pyrF ML0537 Orotidine 5'-phosphate decarboxylase (EC 4.1.1.23) (OMP decarboxylase) (OMPDCase) (OMPdecase) 282 0.02338 non-essential 0.13302 non-essential high NA high_confidence_nonessential NP_215901.1 77.3 0.4602379461490294 73.101 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.460; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 0.002734 non-essential Non-essential ML0538 640 Q9CCR0 PE ML0538 PE-family protein 102 0.0 non-essential 0.18818 non-essential high NA high_confidence_nonessential YP_177805.1 72.5 0.8954289292423294 71.909 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.895; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.895); Target-priority score is high (71.9) rescued_from_possible_false_negative_by_supporting_evidence 6.1e-05 non-essential Non-essential ML0539 685 Q9CCQ9 PPE ML0539 PPE-family protein 538 0.01307 non-essential 0.18377 non-essential high NA high_confidence_nonessential YP_177806.1 66.1 0.8184095178459612 68.9 Strong candidate ESM-2 calibrated P(essential)=0.013; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.818; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.818); Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.005962 non-essential Non-essential ML0540 169 Q9CCQ8 mihF ML0540 Integration host factor 105 0.13339 non-essential 0.25251 non-essential high NA medium_confidence NP_215904.1 97.1 0.6768941765810895 66.79 Strong candidate ESM-2 calibrated P(essential)=0.133; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.677; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 3.5e-05 non-essential Non-essential ML0541 654 Q9CCQ7 gmk ML0541 Guanylate kinase (EC 2.7.4.8) (GMP kinase) 210 0.02913 non-essential 0.18678 non-essential high NA high_confidence_nonessential NP_215905.1 77.3 0.7338760175328741 78.597 Strong candidate ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.734; target-priority score=78.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.6) rescued_from_possible_false_negative_by_supporting_evidence 0.112871 non-essential Non-essential ML0542 128 Q9CCQ6 rpoZ ML0542 DNA-directed RNA polymerase subunit omega (RNAP omega subunit) (EC 2.7.7.6) (RNA polymerase omega subunit) (Transcriptase subunit omega) 110 0.15015 non-essential 0.27071 non-essential high NA medium_confidence NP_215906.1 90.9 0.6875391358797746 73.425 Strong candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.271; ProteomeLM contextual percentile=0.688; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.4) rescued_from_possible_false_negative_by_supporting_evidence 0.411525 essential Likely essential ML0543 1025 Q9CCQ5 dfp coaBC ML0543 Coenzyme A biosynthesis bifunctional protein CoaBC (DNA/pantothenate metabolism flavoprotein) (Phosphopantothenoylcysteine synthetase/decarboxylase) (PPCS-PPCDC) [Includes: Phosphopantothenoylcysteine decarboxylase (PPC decarboxylase) (PPC-DC) (EC 4.1.1.36) (CoaC); Phosphopantothenate--cysteine ligase (EC 6.3.2.5) (CoaB) (Phosphopantothenoylcysteine synthetase) (PPC synthetase) (PPC-S)] 419 0.10725 non-essential 0.14177 non-essential high NA high_confidence_nonessential NP_215907.1 87.0 0.15654351909830932 62.994 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.157; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.718798 essential Essential ML0544 1292 Q9CCQ4 metK ML0544 S-adenosylmethionine synthase (AdoMet synthase) (EC 2.5.1.6) (MAT) (Methionine adenosyltransferase) 403 0.08819 non-essential 0.11433 non-essential high NA high_confidence_nonessential NP_215908.1 91.6 0.09016906700062617 60.418 Moderate candidate ESM-2 calibrated P(essential)=0.088; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.090; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.813641 essential Essential ML0548 1489 Q9CCQ3 priA ML0548 Probable replication restart protein PriA (Putative ATP-dependent DNA helicase PriA) 651 0.05422 non-essential 0.08346 non-essential high NA high_confidence_nonessential NP_215918.1 80.7 0.08703819661865998 52.746 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.087; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002271 non-essential Non-essential ML0550 1151 Q9CCQ2 ML0550 MarR-family transcriptional regulator 161 0.07138 non-essential 0.1298 non-essential high NA high_confidence_nonessential NP_215920.1 79.1 0.2773951158422041 53.92 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.277; target-priority score=53.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.0 non-essential Non-essential ML0551 604 Q9CCQ1 ML0551 Methyltransferase 274 0.01648 non-essential 0.19155 non-essential high NA high_confidence_nonessential NP_215921.1 78.0 0.8309329993738259 74.875 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.831; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.831); Target-priority score is high (74.9) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0552 1481 Q9CCQ0 fmt ML0552 Methionyl-tRNA formyltransferase (EC 2.1.2.9) 318 0.02518 non-essential 0.08471 non-essential high NA high_confidence_nonessential NP_215922.1 80.7 0.20100187852222917 61.804 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.201; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.038726 non-essential Non-essential ML0554 1232 Q9CCP9 rpe ML0554 Ribulose-phosphate 3-epimerase (EC 5.1.3.1) 224 0.06652 non-essential 0.1218 non-essential high NA high_confidence_nonessential NP_215924.1 91.0 0.2197871008140263 65.107 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.220; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.1) rescued_from_possible_false_negative_by_supporting_evidence 0.048743 non-essential Non-essential ML0555 1442 Q9CCP8 ribG ML0555 Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase (DRAP deaminase) (EC 3.5.4.26) (Riboflavin-specific deaminase); 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193) (HTP reductase)] 339 0.05949 non-essential 0.09242 non-essential high NA high_confidence_nonessential NP_215925.1 78.5 0.08829054477144646 62.013 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.088; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.156211 non-essential Non-essential ML0556 1495 Q9CCP7 ML0556 Probable triacylglyceride transporter ML0556 (MFS-type drug efflux transporter P55) 509 0.06214 non-essential 0.08247 non-essential high NA high_confidence_nonessential NP_215926.1 82.0 0.06637445209768315 45.427 Exploratory ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.066; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002607 non-essential Non-essential ML0557 1363 Q9CCP6 lprG ML0557 Lipoarabinomannan carrier protein LprG (27 kDa lipoprotein) (Antigen P27) (Lipoprotein LprG) (Triacylglyceride transfer protein LprG) 238 0.02105 non-essential 0.10556 non-essential high NA high_confidence_nonessential NP_215927.1 68.1 0.3544145272385723 57.767 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.354; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000112 non-essential Non-essential ML0558 1212 Q9CCP5 ribC ML0558 Riboflavin synthase (EC 2.5.1.9) 207 0.04818 non-essential 0.12427 non-essential high NA high_confidence_nonessential NP_215928.1 82.4 0.3143393863494051 66.517 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.314; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.5) rescued_from_possible_false_negative_by_supporting_evidence 0.252732 non-essential Uncertain ML0559 1178 Q9CCP4 ribA ribBA ML0559 Riboflavin biosynthesis protein RibBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) (EC 4.1.99.12); GTP cyclohydrolase-2 (EC 3.5.4.25) (GTP cyclohydrolase II)] 435 0.06116 non-essential 0.128 non-essential high NA high_confidence_nonessential NP_215931.1 93.4 0.27614276768941765 66.699 Strong candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.276; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 0.974734 essential Essential ML0560 390 Q9CCP3 ribH ML0560 6,7-dimethyl-8-ribityllumazine synthase (DMRL synthase) (LS) (Lumazine synthase) (EC 2.5.1.78) 160 0.09625 non-essential 0.2135 non-essential high NA medium_confidence NP_215932.2 79.1 0.5842204132748904 78.228 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.584; target-priority score=78.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.2) rescued_from_possible_false_negative_by_supporting_evidence 0.013608 non-essential Non-essential ML0561 1010 Q9CCP2 ML0561 Membrane protein 156 0.0998 non-essential 0.14344 non-essential high NA high_confidence_nonessential NP_215933.1 60.1 0.23731997495303694 50.504 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.237; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML0562 623 Q9CCP1 uvrC ML0562 UvrABC system protein C (Protein UvrC) (Excinuclease ABC subunit C) 647 0.19217 non-essential 0.18976 non-essential high NA high_confidence_nonessential NP_215936.1 87.9 0.09830932999373826 46.303 Exploratory ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.098; target-priority score=46.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.824527 essential Essential ML0563 1580 Q9CCP0 ML0563 Nucleotide-binding protein ML0563 298 0.04552 non-essential 0.05888 non-essential high agree high_confidence_nonessential Rv1421 92.3 NE 0 0.07576706324358172 47.98 Exploratory ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.059; Mtb RBH anchor Rv1421=non-essential (agree); ProteomeLM contextual percentile=0.076; target-priority score=48.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000453 non-essential Non-essential ML0564 1260 Q9CCN9 ML0564 Putative gluconeogenesis factor 359 0.05422 non-essential 0.11809 non-essential high agree high_confidence_nonessential Rv1422 85.7 NE 0 0.5360050093926112 63.921 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.118; Mtb RBH anchor Rv1422=non-essential (agree); ProteomeLM contextual percentile=0.536; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.156941 non-essential Non-essential ML0565 198 Q9CCN8 whiA ML0565 Probable cell division protein WhiA 327 0.28398 non-essential 0.24411 non-essential medium NA medium_confidence NP_215939.1 92.0 0.0012523481527864746 44.772 Exploratory ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.001; target-priority score=44.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.193786 non-essential Non-essential ML0568 472 Q9CCN7 ML0568 Uncharacterized protein 197 0.02173 non-essential 0.2049 non-essential high NA medium_confidence 0.9035691922354414 68.683 Strong candidate ESM-2 calibrated P(essential)=0.022; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.904; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.904); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 5.2e-05 non-essential Non-essential ML0569 1393 Q7AQI6 ML0569 Membrane protein 271 0.01648 non-essential 0.10198 non-essential high agree high_confidence_nonessential Rv1433 68.3 NE 0 0.5629304946775203 71.59 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.102; Mtb RBH anchor Rv1433=non-essential (agree); ProteomeLM contextual percentile=0.563; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.001294 non-essential Non-essential ML0570 490 P46713 gapA gap ML0570 B1496_C3_199 Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (EC 1.2.1.12) (NAD-dependent glyceraldehyde-3-phosphate dehydrogenase) 339 0.09638 non-essential 0.20339 non-essential high NA medium_confidence NP_215952.1 89.4 0.5284909204758923 76.739 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.528; target-priority score=76.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.7) rescued_from_possible_false_negative_by_supporting_evidence 0.248921 non-essential Uncertain ML0571 819 P46712 pgk ML0571 B1496_C2_162 Phosphoglycerate kinase (EC 2.7.2.3) 416 0.13884 non-essential 0.1674 non-essential high NA high_confidence_nonessential NP_215953.1 80.4 0.16343143393863493 62.645 Moderate candidate ESM-2 calibrated P(essential)=0.139; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.163; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.059926 non-essential Non-essential ML0572 979 P46711 tpiA tpi ML0572 B1496_C1_127 Triosephosphate isomerase (TIM) (TPI) (EC 5.3.1.1) (Triose-phosphate isomerase) 261 0.1316 non-essential 0.14669 non-essential high NA high_confidence_nonessential NP_215954.1 84.3 0.08202880400751408 60.199 Moderate candidate ESM-2 calibrated P(essential)=0.132; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.082; target-priority score=60.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.616814 essential Likely essential ML0573 174 Q7AQI5 ML0573 Uncharacterized protein 91 0.07832 non-essential 0.2511 non-essential high NA medium_confidence 0.9110832811521603 70.252 Strong candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.911; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.911); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 5.2e-05 non-essential Non-essential ML0574 309 Q7AQI4 ML0574 Uncharacterized protein 105 0.02386 non-essential 0.22347 non-essential high NA medium_confidence 0.9962429555416406 71.002 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.996; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.996); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 0.00057 non-essential Non-essential ML0575 235 Q9CCN6 ML0575 Uncharacterized protein 72 0.04063 non-essential 0.23561 non-essential high NA medium_confidence 0.9855979962429555 72.72 Strong candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.986; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.986); Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.001394 non-essential Non-essential ML0576 495 Q7AQI3 ML0576 Uncharacterized protein 76 0.01364 non-essential 0.20285 non-essential high NA medium_confidence 0.9236067626800251 70.407 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.924; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.924); Target-priority score is high (70.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000574 non-essential Non-essential ML0577 1008 P38388 secG ML0577 B1496_C3_206 Probable protein-export membrane protein SecG 77 0.07987 non-essential 0.14382 non-essential high NA high_confidence_nonessential NP_215956.2 96.1 0.32623669380087666 52.115 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.326; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.0002 non-essential Non-essential ML0578 1265 P46710 ppc ML0578 B1496_C3_207 Phosphoenolpyruvate carboxylase (PEPC) (PEPCase) (EC 4.1.1.31) 934 0.09928 non-essential 0.11774 non-essential high NA high_confidence_nonessential 0.07451471509079524 55.27 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.075; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012257 non-essential Non-essential ML0579 1328 Q49700 pgl devB ML0579 B1496_F1_31 6-phosphogluconolactonase (6PGL) (EC 3.1.1.31) 247 0.03604 non-essential 0.11101 non-essential high NA high_confidence_nonessential NP_215961.1 73.2 0.29555416405760804 65.317 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.296; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000202 non-essential Non-essential ML0580 233 Q7AQI2 ML0580 Glucose-6-phosphate dehydrogenase assembly protein OpcA 265 0.05322 non-essential 0.2357 non-essential high NA medium_confidence NP_215962.1 70.3 0.9248591108328115 73.938 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.925; target-priority score=73.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.925); Target-priority score is high (73.9) rescued_from_possible_false_negative_by_supporting_evidence 0.053464 non-essential Non-essential ML0582 1204 P55193 tal ML0582 B1496_F2_65/B1496_F1_27 MLCL536.39 Transaldolase (EC 2.2.1.2) 375 0.04041 non-essential 0.12479 non-essential high NA high_confidence_nonessential NP_215964.1 79.1 0.34439574201628054 69.435 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.344; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 0.02255 non-essential Non-essential ML0583 1544 P46708 tkt ML0583 B1496_F1_26 MLCL536.38 Transketolase (TK) (EC 2.2.1.1) 699 0.0533 non-essential 0.07105 non-essential high NA high_confidence_nonessential NP_215965.1 89.3 0.012523481527864746 54.706 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.071; ProteomeLM contextual percentile=0.013; target-priority score=54.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.134449 non-essential Non-essential ML0584 1557 Q9CCN4 ctaB ML0584 Protoheme IX farnesyltransferase (EC 2.5.1.141) (Heme B farnesyltransferase) (Heme O synthase) 308 0.01861 non-essential 0.06791 non-essential high NA high_confidence_nonessential NP_215967.1 85.6 0.14026299311208515 59.084 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.068; ProteomeLM contextual percentile=0.140; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.088781 non-essential Non-essential ML0587 1093 Q7AQI1 ML0587 Membrane protein 311 0.06901 non-essential 0.13479 non-essential high NA high_confidence_nonessential NP_215972.1 84.4 0.30118973074514716 59.524 Moderate candidate ESM-2 calibrated P(essential)=0.069; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.301; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02916 non-essential Non-essential ML0588 231 Q7AQI0 ML0588 PPE-PPW subfamily C-terminal domain-containing protein 80 0.04552 non-essential 0.23577 non-essential high NA medium_confidence 0.971195992485911 70.322 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.971; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.971); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0589 869 Q7AQH9 ML0589 Membrane protein 265 0.00543 non-essential 0.1606 non-essential high NA high_confidence_nonessential NP_215973.1 83.1 0.7175954915466499 68.746 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.718; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 6.4e-05 non-essential Non-essential ML0590 652 Q7AQH8 ML0590 ABC transporter ATP-binding protein 315 0.09598 non-essential 0.18703 non-essential high NA high_confidence_nonessential NP_215974.1 88.0 0.4815278647463995 60.599 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.482; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6.4e-05 non-essential Non-essential ML0591 639 Q7AQH7 ML0591 Membrane protein 593 0.08711 non-essential 0.18824 non-essential high NA high_confidence_nonessential NP_215975.1 74.7 0.5222291797119599 63.036 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.522; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.468224 essential Likely essential ML0592 204 Q7AQH6 ML0592 DNA-binding protein 254 0.10418 non-essential 0.24294 non-essential high NA medium_confidence NP_215976.2 81.3 0.7495303694427051 68.529 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.750; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 8.8e-05 non-essential Non-essential ML0593 6 Q49689 ML0593 B1496_C2_189 MLCL536.28c Iron-sulfur cluster assembly SufBD family protein ML0593 [Cleaved into: Mle pps1 intein] 869 0.28398 non-essential 0.52431 essential low disagree review_anchor_disagreement Rv1461 52.1 ES 1 0.7063243581715717 66.572 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.524; Mtb RBH anchor Rv1461=essential (disagree); ProteomeLM contextual percentile=0.706; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.90927 essential Essential ML0594 51 Q49682 ML0594 B1496_C1_154 MLCL536.27c u1496a Iron-sulfur cluster assembly SufBD family protein ML0594 392 0.18715 non-essential 0.39159 non-essential low disagree review_anchor_disagreement Rv1462 81.3 ES 1 0.06073888541014402 46.447 Exploratory ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.392; Mtb RBH anchor Rv1462=essential (disagree); ProteomeLM contextual percentile=0.061; target-priority score=46.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.910569 essential Essential ML0595 241 Q7AQH5 ML0595 ABC transporter ATP-binding protein 260 0.25358 non-essential 0.23443 non-essential medium NA medium_confidence NP_215979.1 85.8 0.07827175954915466 46.656 Exploratory ESM-2 calibrated P(essential)=0.254; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.078; target-priority score=46.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.448218 essential Likely essential ML0596 216 Q49690 csd2 ML0596 B1496_C2_193 MLCL536.25c Probable cysteine desulfurase 2 (EC 2.8.1.7) 418 0.23313 non-essential 0.23858 non-essential medium NA medium_confidence NP_215980.1 85.4 0.15842204132748905 59.612 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.239; ProteomeLM contextual percentile=0.158; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.140022 non-essential Non-essential ML0597 923 Q7AQH4 ML0597 NIF system FeS cluster assembly NifU N-terminal domain-containing protein 165 0.09166 non-essential 0.15337 non-essential high NA high_confidence_nonessential NP_215981.1 79.4 0.319348778960551 55.17 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.319; target-priority score=55.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.409049 essential Likely essential ML0598 816 Q7AQH3 ML0598 MIP18 family-like domain-containing protein 115 0.07767 non-essential 0.16822 non-essential high NA high_confidence_nonessential Rv1466 82.6 UNCERTAIN 0.4633688165309956 57.713 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.463; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.644138 essential Likely essential ML0603 9 Q7AQH2 ML0603 DNA-directed DNA polymerase (EC 2.7.7.7) 371 0.27619 non-essential 0.51816 essential low disagree review_anchor_disagreement Rv2413c 83.5 ES 1 0.6530995616781465 74.27 Strong candidate ESM-2 calibrated P(essential)=0.276; HANSEN integrated essentiality score=0.518; Mtb RBH anchor Rv2413c=essential (disagree); ProteomeLM contextual percentile=0.653; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.014436 non-essential Non-essential ML0604 557 O33132 rpsT ML0604 MLCL536.06 Small ribosomal subunit protein bS20 (30S ribosomal protein S20) 86 0.03102 non-essential 0.19619 non-essential high NA high_confidence_nonessential NP_216928.1 88.4 0.793988728866625 74.036 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.794; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.794); Target-priority score is high (74.0) rescued_from_possible_false_negative_by_supporting_evidence 6.4e-05 non-essential Non-essential ML0605 1583 Q49755 ML0605 B1937_F1_4 MLCL536.05c u1937b Uncharacterized protein ML0605 561 0.03949 non-essential 0.0559 non-essential high agree high_confidence_nonessential Rv2411c 88.6 GA 0 0.09643080776455855 45.135 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.056; Mtb RBH anchor Rv2411c=non-essential (agree); ProteomeLM contextual percentile=0.096; target-priority score=45.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.04958 non-essential Non-essential ML0606 1247 Q49770 ML0606 DUF403 domain-containing protein 325 0.02795 non-essential 0.11998 non-essential high agree high_confidence_nonessential Rv2410c 90.8 NE 0 0.6988102692548529 66.664 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.120; Mtb RBH anchor Rv2410c=non-essential (agree); ProteomeLM contextual percentile=0.699; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 0.006583 non-essential Non-essential ML0607 1548 Q49757 ML0607 B1937_F2_39 MLCL536.03c Uncharacterized protein ML0607 279 0.07572 non-essential 0.07072 non-essential high agree high_confidence_nonessential Rv2409c 82.1 NE 0 0.03256105197244834 44.056 Exploratory ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv2409c=non-essential (agree); ProteomeLM contextual percentile=0.033; target-priority score=44.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000183 non-essential Non-essential ML0608 1279 Q49744 rnz ML0608 B1937_C1_163 MLCL536.01 Putative ribonuclease Z (RNase Z) (tRNase Z) (EC 3.1.26.11) (tRNA 3 endonuclease) 220 0.00674 non-essential 0.11526 non-essential high NA high_confidence_nonessential NP_216923.1 61.6 ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001866 non-essential Non-essential ML0611 30 P53530 lepA ML0611 B1937_F3_81 Elongation factor 4 (EF-4) (EC 3.6.5.n1) (Ribosomal back-translocase LepA) 646 0.42684 non-essential 0.44919 non-essential medium NA medium_confidence NP_216920.1 88.5 0.47276142767689416 71.778 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.449; ProteomeLM contextual percentile=0.473; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.449); ESM-2 transfer probability is moderate (0.427); Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.008055 non-essential Non-essential ML0614 474 Q49760 ML0614 B1937_F2_47 Uncharacterized protein ML0614 95 0.02414 non-essential 0.20465 non-essential high NA medium_confidence YP_177670.1 66.2 0.8847839699436444 70.82 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.885; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.885); Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.001378 non-essential Non-essential ML0615 731 Q9CCN3 subI ML0615 Sulphate-binding protein 348 0.03424 non-essential 0.17861 non-essential high NA high_confidence_nonessential NP_216916.1 76.5 0.6938008766437069 67.921 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.694; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.9) rescued_from_possible_false_negative_by_supporting_evidence 9e-05 non-essential Non-essential ML0620 482 Q49771 mtb12 ML0620 B1937_F3_91 Low molecular weight antigen MTB12 homolog 167 0.03604 non-essential 0.20394 non-essential high NA medium_confidence NP_216892.1 65.5 0.8265497808390733 70.633 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.827; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.827); Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000196 non-essential Non-essential ML0624 1388 Q9CCN2 hrcA ML0624 B1937_F1_18/B1937_F3_95 Heat-inducible transcription repressor HrcA 343 0.09148 non-essential 0.10264 non-essential high NA high_confidence_nonessential NP_216890.1 89.8 0.048215403882279274 46.177 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.048; target-priority score=46.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2e-06 non-essential Non-essential ML0625 1493 Q49762 dnaJ2 ML0625 B1937_F2_56 Chaperone protein DnaJ 2 378 0.05767 non-essential 0.08301 non-essential high NA high_confidence_nonessential NP_216889.1 88.2 0.07388854101440201 50.935 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.074; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002828 non-essential Non-essential ML0626 689 Q9CCN1 ML0626 Ribosomal RNA small subunit methyltransferase E (EC 2.1.1.193) 257 0.04818 non-essential 0.18324 non-essential high NA high_confidence_nonessential NP_216888.1 77.3 0.6374452097683156 74.589 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.637; target-priority score=74.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.6) rescued_from_possible_false_negative_by_supporting_evidence 0.003531 non-essential Non-essential ML0627 973 Q49751 ML0627 B1937_F1_20 PhoH-like protein 349 0.15557 non-essential 0.14744 non-essential high NA high_confidence_nonessential YP_177874.1 89.2 0.016906700062617408 46.429 Exploratory ESM-2 calibrated P(essential)=0.156; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.017; target-priority score=46.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002784 non-essential Non-essential ML0628 409 Q49752 ybeY ML0628 B1937_F1_21 Endoribonuclease YbeY (EC 3.1.-.-) 178 0.03424 non-essential 0.21138 non-essential high NA medium_confidence NP_216883.1 89.1 0.8503443957420163 80.229 High-priority ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.850; target-priority score=80.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.850); Target-priority score is high (80.2) rescued_from_possible_false_negative_by_supporting_evidence 0.001145 non-essential Non-essential ML0630 431 Q49767 ML0630 Cytidine deaminase 108 0.15503 non-essential 0.20957 non-essential high agree medium_confidence Rv2365c 60.4 NE 0 0.8240450845335003 68.29 Strong candidate ESM-2 calibrated P(essential)=0.155; HANSEN integrated essentiality score=0.210; Mtb RBH anchor Rv2365c=non-essential (agree); ProteomeLM contextual percentile=0.824; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.824); Target-priority score is high (68.3) rescued_from_possible_false_negative_by_supporting_evidence 0.001345 non-essential Non-essential ML0631 1300 Q49768 era ML0631 B1937_F3_102 GTPase Era 300 0.10713 non-essential 0.11355 non-essential high NA high_confidence_nonessential YP_177873.1 81.4 0.031308703819661866 49.33 Exploratory ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.031; target-priority score=49.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.093458 non-essential Non-essential ML0633 163 Q9CCN0 recO ML0633 B1937_F1_25 DNA repair protein RecO (Recombination protein O) 268 0.11487 non-essential 0.25446 non-essential high NA medium_confidence NP_216878.1 86.6 0.7626800250469631 70.414 Strong candidate ESM-2 calibrated P(essential)=0.115; HANSEN integrated essentiality score=0.254; ProteomeLM contextual percentile=0.763; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.763); Target-priority score is high (70.4) rescued_from_possible_false_negative_by_supporting_evidence 0.004733 non-essential Non-essential ML0634 972 P38119 uppS ML0634 B1937_F2_65 Decaprenyl diphosphate synthase (DecaPP) (EC 2.5.1.86) (EC 2.5.1.87) (Decaprenyl pyrophosphate synthase) (Long-chain isoprenyl diphosphate synthase) (Trans,polycis-decaprenyl diphosphate synthase) 296 0.09481 non-essential 0.14749 non-essential high NA high_confidence_nonessential NP_216877.1 88.2 0.2485911083281152 62.556 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.249; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002305 non-essential Non-essential ML0637 954 P53528 uvrD2 ML0637 B1937_F1_27 ATP-dependent DNA helicase UvrD2 (EC 5.6.2.4) (DNA 3'-5' helicase UvrD2) 714 0.0667 non-essential 0.14939 non-essential high NA high_confidence_nonessential NP_217714.1 82.9 0.37883531621790856 65.933 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.379; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.005258 non-essential Non-essential ML0638 524 Q49769 ML0638 B1937_F3_110 Uncharacterized protein ML0638 100 0.00198 non-essential 0.19926 non-essential high NA high_confidence_nonessential 0.9530369442705072 71.401 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.953; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.953); Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0639 1024 Q49765 whiB7 whiB ML0639 Transcriptional regulator WhiB 89 0.00543 non-essential 0.14193 non-essential high NA high_confidence_nonessential YP_177940.1 68.1 0.6098935504070131 68.018 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.610; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 8.6e-05 non-essential Non-essential ML0640 129 Q9CCM8 ML0640 ABC1 atypical kinase-like domain-containing protein 473 0.14132 non-essential 0.27026 non-essential high NA medium_confidence NP_217713.1 83.0 0.7370068879148404 69.476 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.270; ProteomeLM contextual percentile=0.737; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 9.8e-05 non-essential Non-essential ML0642 1590 Q49746 ML0642 Hydrolase 479 0.02734 non-essential 0.05007 non-essential high agree high_confidence_nonessential Rv3195 78.5 NE 0 0.10832811521603006 45.663 Exploratory ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.050; Mtb RBH anchor Rv3195=non-essential (agree); ProteomeLM contextual percentile=0.108; target-priority score=45.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000124 non-essential Non-essential ML0643 1254 Q9CCM7 ML0643 endopeptidase La (EC 3.4.21.53) 340 0.09059 non-essential 0.11889 non-essential high agree high_confidence_nonessential Rv3194c 80.6 NE 0 0.3206011271133375 64.95 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.119; Mtb RBH anchor Rv3194c=non-essential (agree); ProteomeLM contextual percentile=0.321; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.040722 non-essential Non-essential ML0644 881 Q9CCM6 ML0644 MLCB1779.46 UPF0182 protein ML0644 983 0.15503 non-essential 0.1589 non-essential high NA high_confidence_nonessential NP_217709.1 85.6 0.08766437069505323 46.15 Exploratory ESM-2 calibrated P(essential)=0.155; HANSEN integrated essentiality score=0.159; ProteomeLM contextual percentile=0.088; target-priority score=46.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009737 non-essential Non-essential ML0656 362 Q7AQH1 ML0656 Uncharacterized protein 93 0.01595 non-essential 0.21683 non-essential high NA medium_confidence 0.9924859110832811 71.336 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.992; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.992); Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML0659 311 Q7AQH0 ML0659 Uncharacterized protein 108 0.0309 non-essential 0.2231 non-essential high NA medium_confidence 0.9649342517219787 69.917 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.965; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.965); Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0660 970 Q7AQG9 fadE23 ML0660 Acyl-CoA dehydrogenase 400 0.1045 non-essential 0.14791 non-essential high NA high_confidence_nonessential NP_217656.1 89.5 0.22730118973074515 55.508 Moderate candidate ESM-2 calibrated P(essential)=0.105; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.227; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004696 non-essential Non-essential ML0661 1015 Q7AQG8 fadE24 ML0661 Acyl-CoA dehydrogenase 465 0.13829 non-essential 0.14283 non-essential high NA high_confidence_nonessential NP_217655.1 83.6 0.06762680025046963 46.927 Exploratory ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.068; target-priority score=46.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.9e-05 non-essential Non-essential ML0662 1007 Q7AQG7 ML0662 Histidinol-phosphatase (EC 3.1.3.15) 255 0.08446 non-essential 0.1439 non-essential high NA high_confidence_nonessential NP_217653.1 81.8 0.2636192861615529 66.421 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.264; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.01477 non-essential Non-essential ML0663 1087 Q7AQG6 ML0663 Uncharacterized protein 104 0.05295 non-essential 0.13544 non-essential high agree high_confidence_nonessential Rv3136A 69.3 NE 0 0.7075767063243582 65.817 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.135; Mtb RBH anchor Rv3136A=non-essential (agree); ProteomeLM contextual percentile=0.708; target-priority score=65.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000448 non-essential Non-essential ML0664 647 Q9CCM5 ML0664 Uncharacterized protein 87 0.00543 non-essential 0.18745 non-essential high NA high_confidence_nonessential 0.8753913587977458 68.795 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.875; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.875); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.004817 non-essential Non-essential ML0666 836 O32886 fprA ML0666 MLCB1779.25 NADPH-ferredoxin reductase FprA (NFR) (EC 1.18.1.2) 456 0.11301 non-essential 0.16463 non-essential high NA high_confidence_nonessential NP_217622.1 81.0 0.2617407639323732 63.988 Moderate candidate ESM-2 calibrated P(essential)=0.113; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.262; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001971 non-essential Non-essential ML0667 1304 O32885 prfB ML0667 MLCB1779.24c Peptide chain release factor 2 (RF-2) 374 0.02734 non-essential 0.11305 non-essential high NA high_confidence_nonessential NP_217621.1 90.1 0.371947401377583 56.993 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.372; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.691737 essential Likely essential ML0669 374 Q7AQG5 ftsE ML0669 Cell division ATP-binding protein FtsE 229 0.17698 non-essential 0.21576 non-essential high NA medium_confidence NP_217618.1 91.7 0.29117094552285533 56.429 Moderate candidate ESM-2 calibrated P(essential)=0.177; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.291; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001197 non-essential Non-essential ML0670 103 O32882 ftsX ML0670 MLCB1779.20c Cell division protein FtsX 297 0.19217 non-essential 0.28098 non-essential high NA medium_confidence NP_217617.1 81.1 0.5792110206637445 65.231 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.281; ProteomeLM contextual percentile=0.579; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.040399 non-essential Non-essential ML0671 670 O32881 smpB ML0671 MLCB1779.19c SsrA-binding protein (Small protein B) 160 0.07314 non-essential 0.18491 non-essential high NA high_confidence_nonessential NP_217616.1 85.5 0.5610519724483406 64.959 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.561; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.277168 non-essential Uncertain ML0674 974 O32879 folD ML0674 Bifunctional protein FolD [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] 282 0.14132 non-essential 0.14739 non-essential high NA high_confidence_nonessential NP_217873.1 86.8 0.041327489041953665 60.275 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.041; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.07564 non-essential Non-essential ML0675 800 Q7AQG3 ML0675 Integral membrane protein 91 0.04401 non-essential 0.1698 non-essential high NA high_confidence_nonessential NP_217872.1 78.9 0.6142767689417659 62.098 Moderate candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.614; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.2e-05 non-essential Non-essential ML0676 1168 Q9CCM4 ML0676 DUF732 domain-containing protein 158 0.00543 non-essential 0.12873 non-essential high agree high_confidence_nonessential Rv3354 56.0 GA 0 0.8960551033187226 71.742 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv3354=non-essential (agree); ProteomeLM contextual percentile=0.896; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.896); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0678 515 Q7AQG2 ML0678 Transposase IS116/IS110/IS902 C-terminal domain-containing protein 175 0.0 non-essential 0.20121 non-essential high NA medium_confidence 0.9643080776455855 74.552 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.964; target-priority score=74.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.964); Target-priority score is high (74.6) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0679 516 Q9CCM3 ML0679 Uncharacterized protein 75 0.00674 non-essential 0.20109 non-essential high NA medium_confidence 0.947401377582968 69.539 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.947; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.947); Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0682 1516 O32874 metXA metA ML0682 MLCB1779.11 Homoserine O-acetyltransferase (HAT) (EC 2.3.1.31) (Homoserine transacetylase) (HTA) 382 0.01648 non-essential 0.07823 non-essential high NA high_confidence_nonessential NP_217858.1 85.0 0.1959924859110833 64.113 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.196; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02384 non-essential Non-essential ML0685 221 Q7AQG1 ML0685 Hydrolase 303 0.08446 non-essential 0.23804 non-essential high NA medium_confidence 0.7983719474013776 72.877 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.798; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.798); Target-priority score is high (72.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000114 non-essential Non-essential ML0686 1049 Q49901 trpS ML0686 L308_C1_147 Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) 343 0.03769 non-essential 0.1392 non-essential high NA high_confidence_nonessential NP_217853.1 83.8 0.4376956793988729 70.795 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.438; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.393628 essential Uncertain ML0687 1475 Q7AQG0 ML0687 Membrane protein 313 0.00543 non-essential 0.0858 non-essential high NA high_confidence_nonessential NP_217852.1 68.5 0.32185347526612396 53.708 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.086; ProteomeLM contextual percentile=0.322; target-priority score=53.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000356 non-essential Non-essential ML0691 356 Q9CCM2 ML0691 D-alanyl-D-alanine carboxypeptidase 411 0.14132 non-essential 0.21733 non-essential high NA medium_confidence NP_217847.1 76.4 0.44207889793362554 63.892 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.442; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.072577 non-essential Non-essential ML0696 1233 Q7AQF9 sdhB ML0696 succinate dehydrogenase (EC 1.3.5.1) 264 0.08231 non-essential 0.12165 non-essential high NA high_confidence_nonessential NP_217836.1 89.8 0.17470256731371323 55.499 Moderate candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.175; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000568 non-essential Non-essential ML0697 66 Q9CCM1 sdhA ML0697 Succinate dehydrogenase flavoprotein subunit (EC 1.3.5.1) 584 0.23815 non-essential 0.34636 non-essential medium NA medium_confidence NP_217835.1 92.7 0.704445835942392 81.686 High-priority ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.346; ProteomeLM contextual percentile=0.704; target-priority score=81.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.7) rescued_from_possible_false_negative_by_supporting_evidence 0.003578 non-essential Non-essential ML0698 691 Q7AQF8 sdhD ML0698 Succinate dehydrogenase hydrophobic membrane anchor protei 163 0.0949 non-essential 0.18319 non-essential high NA high_confidence_nonessential NP_217834.1 85.2 0.46775203506574825 59.3 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.468; target-priority score=59.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00018 non-essential Non-essential ML0699 618 Q9CCM0 sdhC ML0699 Succinate dehydrogenase cytochrome B-556 subunit 153 0.02862 non-essential 0.1906 non-essential high NA high_confidence_nonessential NP_217833.1 88.4 0.7820914214151534 70.628 Strong candidate ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.782; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.782); Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 5e-05 non-essential Non-essential ML0700 540 Q9CCL9 add ML0700 L308_C2_206 Adenosine deaminase (EC 3.5.4.4) (Adenosine aminohydrolase) 362 0.10418 non-essential 0.19773 non-essential high NA high_confidence_nonessential NP_217830.1 88.2 0.4771446462116468 70.708 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.477; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 0.001275 non-essential Non-essential ML0703 1312 Q9CCL8 ML0703 Primosomal protein 423 0.06981 non-essential 0.11254 non-essential high agree high_confidence_nonessential Rv3311 78.5 NE 0 0.4264245460237946 56.028 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv3311=non-essential (agree); ProteomeLM contextual percentile=0.426; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00024 non-essential Non-essential ML0706 1147 Q9CCL7 pmmB ML0706 Phospho-sugar mutase 538 0.03424 non-essential 0.12998 non-essential high NA high_confidence_nonessential NP_217825.1 74.7 0.4283030682529743 60.928 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.428; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008951 non-essential Non-essential ML0707 1288 P46862 punA deoD ML0707 L308_F2_56 Purine nucleoside phosphorylase (PNP) (Pu-NPase) (EC 2.4.2.1) (Inosine phosphorylase) (Inosine-guanosine phosphorylase) 268 0.03079 non-essential 0.11454 non-essential high NA high_confidence_nonessential NP_217824.1 82.1 0.3312460864120225 68.423 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.331; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.4) rescued_from_possible_false_negative_by_supporting_evidence 0.00138 non-essential Non-essential ML0711 898 Q9CCL6 ML0711 Gamma-glutamylcyclotransferase 159 0.06543 non-essential 0.15632 non-essential high agree high_confidence_nonessential Rv3304 92.5 NE 0 0.7933625547902317 75.446 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.156; Mtb RBH anchor Rv3304=non-essential (agree); ProteomeLM contextual percentile=0.793; target-priority score=75.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.793); Target-priority score is high (75.4) rescued_from_possible_false_negative_by_supporting_evidence 4.9e-05 non-essential Non-essential ML0713 1305 P53435 glpD ML0713 L308_C1_179 Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3) 585 0.09638 non-essential 0.11304 non-essential high NA high_confidence_nonessential NP_217819.1 90.9 0.058860363180964305 55.71 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.059; target-priority score=55.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.780602 essential Essential ML0715 530 Q9CCL5 lpqC ML0715 Secreted hydrolase 304 0.01942 non-essential 0.19877 non-essential high NA high_confidence_nonessential NP_217815.1 72.0 0.8572323105823418 75.786 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.857; target-priority score=75.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.857); Target-priority score is high (75.8) rescued_from_possible_false_negative_by_supporting_evidence 0.003438 non-essential Non-essential ML0717 455 Q9CCL4 ML0717 TetR-family transcriptional regulator 223 0.09148 non-essential 0.20715 non-essential high NA medium_confidence NP_217812.1 85.5 0.6055103318722604 65.703 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.606; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 3.9e-05 non-essential Non-essential ML0726 526 P46392 bccA ML0726 B1308_C1_129 Biotin-dependent acyl-coenzyme A carboxylase alpha3 subunit [Includes: Biotin carboxylase (BC) (EC 6.3.4.14); Biotin carboxyl carrier protein (BCCP)] 598 0.13353 non-essential 0.19903 non-essential high NA high_confidence_nonessential NP_217802.1 86.0 0.3487789605510332 71.174 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.349; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.514753 essential Likely essential ML0728 327 P46700 sseA ML0728 B1308_C1_127 Putative thiosulfate sulfurtransferase SseA (EC 2.8.1.1) 296 0.13453 non-essential 0.22166 non-essential high NA medium_confidence NP_217800.1 83.8 0.47902316844082654 70.593 Strong candidate ESM-2 calibrated P(essential)=0.135; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.479; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.014464 non-essential Non-essential ML0729 1350 Q49670 ML0729 B1308_C2_167 u1308r Nucleoside triphosphate pyrophosphatase (EC 3.6.1.9) (Nucleotide pyrophosphatase) (Nucleotide PPase) 213 0.01709 non-essential 0.10814 non-essential high agree high_confidence_nonessential Rv3282 65.7 NE 0 0.6030056355666875 75.181 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.108; Mtb RBH anchor Rv3282=non-essential (agree); ProteomeLM contextual percentile=0.603; target-priority score=75.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.2) rescued_from_possible_false_negative_by_supporting_evidence 0.004678 non-essential Non-essential ML0730 62 Q7AQF7 ML0730 ML0730 protein 84 0.24476 non-essential 0.35954 non-essential medium NA medium_confidence NP_217798.1 80.3 0.7964934251721979 66.44 Strong candidate ESM-2 calibrated P(essential)=0.245; HANSEN integrated essentiality score=0.360; ProteomeLM contextual percentile=0.796; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.796); Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.093021 non-essential Non-essential ML0731 991 P53002 accD5 pccB ML0731 B1308_C1_125 Biotin-dependent acetyl-/propionyl-coenzyme A carboxylase beta5 subunit (Acetyl-CoA carboxylase) (ACC) (EC 2.1.3.15) (Propionyl-CoA carboxylase) (PCC) (EC 2.1.3.-) 549 0.14132 non-essential 0.14507 non-essential high NA high_confidence_nonessential NP_217797.1 88.7 0.035691922354414526 57.547 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.036; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.868869 essential Essential ML0732 792 Q9CCL3 birA ML0732 biotin--[biotin carboxyl-carrier protein] ligase (EC 6.3.4.15) 274 0.06636 non-essential 0.17076 non-essential high NA high_confidence_nonessential NP_217796.1 71.2 0.5046963055729493 66.407 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.505; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.009623 non-essential Non-essential ML0733 856 Q9CCL2 ML0733 Membrane protein 172 0.01412 non-essential 0.16255 non-essential high NA high_confidence_nonessential NP_217795.1 83.1 0.6963055729492799 66.332 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.696; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000259 non-essential Non-essential ML0734 599 Q7AQF6 ML0734 Membrane protein 228 0.02682 non-essential 0.19185 non-essential high NA high_confidence_nonessential NP_217794.1 84.2 0.7989981214777708 70.187 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.799; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.799); Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000802 non-essential Non-essential ML0735 1091 P46701 purK ML0735 B1308_F1_32 N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase) 439 0.06636 non-essential 0.13508 non-essential high NA high_confidence_nonessential NP_217793.1 77.6 0.29304946775203505 66.998 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.293; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 0.416189 essential Likely essential ML0736 785 P46702 purE ML0736 B1308_F3_98 N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase) (EC 5.4.99.18) (5-(carboxyamino)imidazole ribonucleotide mutase) 171 0.10537 non-essential 0.17163 non-essential high NA high_confidence_nonessential NP_217792.1 81.5 0.32498434564809014 68.381 Strong candidate ESM-2 calibrated P(essential)=0.105; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.325; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.4) rescued_from_possible_false_negative_by_supporting_evidence 0.00596 non-essential Non-essential ML0737 1420 P46703 fadE25 acd ML0737 B1308_F1_34 Probable acyl-CoA dehydrogenase fadE25 (EC 1.3.99.-) 389 0.05422 non-essential 0.09657 non-essential high NA high_confidence_nonessential NP_217791.1 92.0 0.15153412648716344 57.032 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.097; ProteomeLM contextual percentile=0.152; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000234 non-essential Non-essential ML0747 1299 Q9CCL1 ctpC ML0747 Manganese-exporting P-type ATPase (EC 7.2.2.22) 725 0.07935 non-essential 0.11356 non-essential high NA high_confidence_nonessential NP_217787.1 85.3 0.1358797745773325 57.146 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.136; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.0001 non-essential Non-essential ML0748 1165 Q9CCL0 ML0748 Uncharacterized protein 92 0.03654 non-essential 0.12903 non-essential high agree high_confidence_nonessential Rv3269 73.6 NE 0 0.7489041953663118 64.42 Moderate candidate ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv3269=non-essential (agree); ProteomeLM contextual percentile=0.749; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1e-06 non-essential Non-essential ML0750 1485 Q9CCK9 ML0750 LytR family transcriptional regulator 489 0.03949 non-essential 0.08423 non-essential high agree high_confidence_nonessential Rv3267 79.7 NE 0 0.3337507827175955 54.334 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv3267=non-essential (agree); ProteomeLM contextual percentile=0.334; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.01448 non-essential Non-essential ML0751 518 Q9CCK8 rmlD ML0751 dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) 311 0.03424 non-essential 0.20066 non-essential high NA medium_confidence NP_217783.1 74.0 0.7883531621790858 79.858 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.788; target-priority score=79.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.788); Target-priority score is high (79.9) rescued_from_possible_false_negative_by_supporting_evidence 0.066422 non-essential Non-essential ML0752 1268 Q9CCK7 wbbL ML0752 N-acetylglucosaminyl-diphospho-decaprenol L-rhamnosyltransferase (EC 2.4.1.289) (Rhamnosyltransferase WbbL) (dTDP-Rha:alpha-D-GlcNAc-pyrophosphate polyprenol, alpha-3-L-rhamnosyltransferase) 308 0.06199 non-essential 0.11739 non-essential high NA high_confidence_nonessential YP_177952.3 84.7 0.23356293049467752 58.677 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.234; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012176 non-essential Non-essential ML0753 860 Q9CCK6 rmlA2 ML0753 Sugar-phosphate nucleotidyl transferase 358 0.12506 non-essential 0.1621 non-essential high NA high_confidence_nonessential YP_177951.1 78.0 0.221665623043206 53.739 Moderate candidate ESM-2 calibrated P(essential)=0.125; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.222; target-priority score=53.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.511317 essential Likely essential ML0755 595 Q9CCK5 ML0755 NUDIX hydrolase 86 0.00198 non-essential 0.19212 non-essential high NA high_confidence_nonessential 0.9060738885410144 73.094 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.906; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.906); Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 0.002196 non-essential Non-essential ML0756 1276 Q9CCK4 ML0756 site-specific DNA-methyltransferase (adenine-specific) (EC 2.1.1.72) 555 0.04041 non-essential 0.11553 non-essential high NA high_confidence_nonessential NP_217780.1 81.9 0.31308703819661865 61.558 Moderate candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.116; ProteomeLM contextual percentile=0.313; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.013241 non-essential Non-essential ML0757 298 Q9CCK3 ML0757 Uncharacterized protein 230 0.05422 non-essential 0.22492 non-essential high NA medium_confidence 0.8591108328115216 73.163 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.859; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.859); Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 1.4e-05 non-essential Non-essential ML0758 779 Q9CCK2 fbiB ML0758 Bifunctional F420 biosynthesis protein FbiB [Includes: Coenzyme F420:L-glutamate ligase (EC 6.3.2.31) (EC 6.3.2.34) (Coenzyme F420-0:L-glutamate ligase) (Coenzyme F420-1:gamma-L-glutamate ligase); Dehydro-coenzyme F420-0 reductase (EC 1.3.8.17)] 457 0.07497 non-essential 0.17212 non-essential high NA high_confidence_nonessential NP_217779.1 82.2 0.45272385723231057 73.352 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.453; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.4) rescued_from_possible_false_negative_by_supporting_evidence 0.002447 non-essential Non-essential ML0759 762 Q9CCK1 fbiA ML0759 Phosphoenolpyruvate transferase (EC 2.7.8.28) (EPPG:FO PEP transferase) 333 0.05767 non-essential 0.17458 non-essential high NA high_confidence_nonessential NP_217778.1 79.3 0.5391358797745773 75.88 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.539; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.9) rescued_from_possible_false_negative_by_supporting_evidence 0.185568 non-essential Non-essential ML0760 884 Q9CCK0 whiB2 whiB ML0760 Transcriptional regulator WhiB 89 0.00543 non-essential 0.15872 non-essential high NA high_confidence_nonessential NP_217777.1 86.5 0.6956793988728867 72.433 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.159; ProteomeLM contextual percentile=0.696; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000819 non-essential Non-essential ML0761 1324 Q9CCJ9 ML0761 Exonuclease 167 0.1288 non-essential 0.11136 non-essential high agree high_confidence_nonessential Rv3259 89.2 NE 0 0.11646837820914215 44.861 Exploratory ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv3259=non-essential (agree); ProteomeLM contextual percentile=0.116; target-priority score=44.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000157 non-essential Non-essential ML0762 1568 Q9CCJ8 ML0762 DUF3499 domain-containing protein 165 0.01648 non-essential 0.06277 non-essential high agree high_confidence_nonessential Rv3258c 76.2 NE 0 0.284909204758923 48.79 Exploratory ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.063; Mtb RBH anchor Rv3258c=non-essential (agree); ProteomeLM contextual percentile=0.285; target-priority score=48.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.002003 non-essential Non-essential ML0763 1537 Q9CCJ7 pmmA ML0763 Phosphomannomutase 468 0.03604 non-essential 0.07261 non-essential high NA high_confidence_nonessential NP_217774.1 83.1 0.11458985597996243 50.031 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.073; ProteomeLM contextual percentile=0.115; target-priority score=50.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.241957 non-essential Uncertain ML0764 1453 Q9CCJ6 ML0764 TobH protein 365 0.07935 non-essential 0.09127 non-essential high agree high_confidence_nonessential Rv3256c 75.6 NE 0 0.18534752661239826 50.252 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.091; Mtb RBH anchor Rv3256c=non-essential (agree); ProteomeLM contextual percentile=0.185; target-priority score=50.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6.4e-05 non-essential Non-essential ML0765 1550 Q9CCJ5 manA ML0765 mannose-6-phosphate isomerase (EC 5.3.1.8) 410 0.03949 non-essential 0.06985 non-essential high NA high_confidence_nonessential NP_217772.1 82.7 0.06449592986850344 56.171 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.070; ProteomeLM contextual percentile=0.064; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.232016 non-essential Uncertain ML0771 667 Q9CCJ4 ahcY sahH ML0771 Adenosylhomocysteinase (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) 492 0.19217 non-essential 0.18526 non-essential high NA high_confidence_nonessential NP_217765.1 91.4 0.033813400125234816 59.228 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.034; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.227018 non-essential Uncertain ML0772 948 Q9CCJ3 tmk ML0772 Thymidylate kinase (EC 2.7.4.9) (dTMP kinase) 210 0.01019 non-essential 0.15048 non-essential high NA high_confidence_nonessential NP_217764.1 77.8 0.6230432060112712 73.237 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.623; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000355 non-essential Non-essential ML0773 318 Q9CCJ2 mtrA ML0773 DNA-binding response regulator MtrA 225 0.12863 non-essential 0.22232 non-essential high NA medium_confidence NP_217763.1 99.1 0.5341264871634315 62.377 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.534; target-priority score=62.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.053886 non-essential Non-essential ML0774 913 Q9CCJ1 mtrB ML0774 Sensor histidine kinase MtrB (EC 2.7.13.3) 562 0.10418 non-essential 0.15455 non-essential high NA high_confidence_nonessential NP_217762.1 91.4 0.2604884157795867 58.013 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.260; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.035293 non-essential Non-essential ML0775 170 Q9CCJ0 lpqB ML0775 Lipoprotein LpqB 589 0.13829 non-essential 0.25179 non-essential high NA medium_confidence NP_217761.1 87.9 0.6505948653725736 66.648 Strong candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.252; ProteomeLM contextual percentile=0.651; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.893729 essential Essential ML0776 1073 Q9CCI9 ML0776 ML0776 protein 85 0.00543 non-essential 0.13697 non-essential high agree high_confidence_nonessential Rv3242c 78.1 GA 0 0.9743268628678773 72.564 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.137; Mtb RBH anchor Rv3242c=non-essential (agree); ProteomeLM contextual percentile=0.974; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.974); Target-priority score is high (72.6) rescued_from_possible_false_negative_by_supporting_evidence 4.7e-05 non-essential Non-essential ML0777 529 Q9CCI8 ML0777 Uncharacterized protein 64 0.00543 non-essential 0.19879 non-essential high NA high_confidence_nonessential 0.9373825923606762 70.394 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.937; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.937); Target-priority score is high (70.4) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML0778 960 Q9CCI7 hpf ML0778 Ribosome hibernation promoting factor (HPF) 229 0.05604 non-essential 0.14846 non-essential high agree high_confidence_nonessential Rv3241c 89.3 GA 0 0.7908578584846587 71.493 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.148; Mtb RBH anchor Rv3241c=non-essential (agree); ProteomeLM contextual percentile=0.791; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.791); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.004002 non-essential Non-essential ML0779 156 P57996 secA1 ML0779 Protein translocase subunit SecA 1 (EC 7.4.2.8) 940 0.23815 non-essential 0.25648 non-essential medium NA medium_confidence YP_177950.1 86.9 0.2398246712586099 59.91 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.240; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.062207 non-essential Non-essential ML0781 1150 Q9CCI6 ML0781 RCK C-terminal domain-containing protein 160 0.05767 non-essential 0.12983 non-essential high agree high_confidence_nonessential Rv3237c 80.6 NE 0 0.6293049467752035 64.592 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3237c=non-essential (agree); ProteomeLM contextual percentile=0.629; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 9e-06 non-essential Non-essential ML0782 1196 Q9CCI5 ML0782 Transmembrane transport protein 385 0.02795 non-essential 0.12602 non-essential high NA high_confidence_nonessential YP_177949.1 81.8 0.4395742016280526 58.988 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.440; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 5.2e-05 non-essential Non-essential ML0791 1522 Q9CCI4 ML0791 Ribosome small subunit-dependent GTPase A 327 0.05255 non-essential 0.07716 non-essential high agree high_confidence_nonessential Rv3228 84.3 NE 0 0.20037570444583594 51.184 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.077; Mtb RBH anchor Rv3228=non-essential (agree); ProteomeLM contextual percentile=0.200; target-priority score=51.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.014109 non-essential Non-essential ML0792 1566 Q9CCI3 aroA ML0792 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS) 430 0.03924 non-essential 0.06316 non-essential high NA high_confidence_nonessential NP_217744.1 79.0 0.021916092673763307 57.654 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.063; ProteomeLM contextual percentile=0.022; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.303296 non-essential Uncertain ML0793 1284 Q9CCI2 ML0793 Abasic site processing protein (EC 3.4.-.-) 252 0.02448 non-essential 0.11483 non-essential high agree high_confidence_nonessential Rv3226c 70.9 NE 0 0.6449592986850344 71.295 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv3226c=non-essential (agree); ProteomeLM contextual percentile=0.645; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00355 non-essential Non-essential ML0796 130 Q7AQF5 ML0796 Uncharacterized protein 58 0.08711 non-essential 0.27013 non-essential high NA medium_confidence 0.976205385097057 72.451 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.270; ProteomeLM contextual percentile=0.976; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.976); Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 1.8e-05 non-essential Non-essential ML0798 1066 Q9CCI1 ML0798 Uncharacterized protein 592 0.08883 non-essential 0.13746 non-essential high agree high_confidence_nonessential Rv2787 76.5 NE 0 0.5316217908578584 62.002 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.137; Mtb RBH anchor Rv2787=non-essential (agree); ProteomeLM contextual percentile=0.532; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.043433 non-essential Non-essential ML0799 480 Q9CCI0 ML0799 YbaK/aminoacyl-tRNA synthetase-associated domain-containing protein 135 0.00543 non-essential 0.20402 non-essential high NA medium_confidence 0.9486537257357546 77.027 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.949; target-priority score=77.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.949); Target-priority score is high (77.0) rescued_from_possible_false_negative_by_supporting_evidence 0.001026 non-essential Non-essential ML0802 116 Q9CCH9 ML0802 Biotinylated protein TB7.3 homolog 71 0.13353 non-essential 0.27416 non-essential high NA medium_confidence Rv3221c 93.2 UNCERTAIN 0.7958672510958046 69.422 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.796; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.796); Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000309 non-essential Non-essential ML0803 957 Q9CCH8 ML0803 histidine kinase (EC 2.7.13.3) 500 0.0905 non-essential 0.14914 non-essential high NA high_confidence_nonessential NP_217736.1 81.8 0.28616155291170947 59.813 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.286; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001448 non-essential Non-essential ML0804 1264 Q9CCH7 whiB1 whiB ML0804 Transcriptional regulator WhiB 84 0.07333 non-essential 0.11793 non-essential high NA high_confidence_nonessential NP_217735.1 95.2 0.19411396368190356 55.472 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.194; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000805 non-essential Non-essential ML0806 285 Q9CCH6 ML0806 Membrane protein 173 0.08115 non-essential 0.22736 non-essential high NA medium_confidence NP_217733.1 77.1 0.7664370695053225 67.537 Strong candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.766; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.766); Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML0808 497 Q9CCH5 entC ML0808 isochorismate synthase (EC 5.4.4.2) (Isochorismate mutase) 577 0.00543 non-essential 0.20275 non-essential high NA medium_confidence NP_217731.1 74.0 0.9267376330619912 81.949 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.927; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.927); Target-priority score is high (81.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000223 non-essential Non-essential ML0810 5 Q9CCH4 ML0810 Membrane protein 407 0.28398 non-essential 0.52752 essential low disagree review_anchor_disagreement Rv3212 79.9 GD 1 0.7301189730745147 68.238 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.528; Mtb RBH anchor Rv3212=essential (disagree); ProteomeLM contextual percentile=0.730; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.167951 non-essential Non-essential ML0811 353 Q9CCH3 rhlE ML0811 RNA helicase (EC 3.6.4.13) 544 0.13829 non-essential 0.21778 non-essential high NA medium_confidence NP_217727.1 79.6 0.4596117720726362 63.569 Moderate candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.460; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.043292 non-essential Non-essential ML0813 1201 Q9CCH2 ML0813 Membrane protein 195 0.01019 non-essential 0.12547 non-essential high agree high_confidence_nonessential Rv3209 57.3 NE 0 0.8403256105197244 70.641 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.125; Mtb RBH anchor Rv3209=non-essential (agree); ProteomeLM contextual percentile=0.840; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.840); Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000246 non-essential Non-essential ML0814 1149 Q9CCH1 ML0814 ATP-binding protein 82 0.03604 non-essential 0.12984 non-essential high agree high_confidence_nonessential Rv3208A 82.3 NE 0 0.7501565435190983 66.407 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3208A=non-essential (agree); ProteomeLM contextual percentile=0.750; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.750); Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0815 938 Q9CCH0 ML0815 TetR-family transcriptional regulator 228 0.02975 non-essential 0.15155 non-essential high NA high_confidence_nonessential NP_217724.1 82.4 0.5660613650594866 64.221 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.566; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.9e-05 non-essential Non-essential ML0816 1549 Q9CCG9 ML0816 Peptidase metallopeptidase domain-containing protein 341 0.03949 non-essential 0.07032 non-essential high agree high_confidence_nonessential Rv3207c 80.6 NE 0 0.21790857858484658 49.671 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.070; Mtb RBH anchor Rv3207c=non-essential (agree); ProteomeLM contextual percentile=0.218; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.079843 non-essential Non-essential ML0817 1261 Q9CCG8 moeZ ML0817 Probable adenylyltransferase/sulfurtransferase MoeZ 395 0.09148 non-essential 0.11806 non-essential high NA high_confidence_nonessential YP_177942.1 86.4 0.12836568566061365 49.771 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.128; target-priority score=49.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.402543 essential Likely essential ML0818 1269 Q9CCG7 ML0818 Aminoglycoside phosphotransferase domain-containing protein 297 0.03424 non-essential 0.11734 non-essential high agree high_confidence_nonessential Rv3205c 87.3 NE 0 0.6361928616155291 66.364 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.117; Mtb RBH anchor Rv3205c=non-essential (agree); ProteomeLM contextual percentile=0.636; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.004998 non-essential Non-essential ML0824 896 Q9CCG6 furB ML0824 Zinc uptake regulation protein 131 0.00888 non-essential 0.15706 non-essential high NA high_confidence_nonessential NP_216875.1 84.6 0.6731371321227301 71.397 Strong candidate ESM-2 calibrated P(essential)=0.009; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.673; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 2e-05 non-essential Non-essential ML0825 718 Q9CCG5 ML0825 ArsR-family transcriptional regulator 140 0.03604 non-essential 0.17969 non-essential high NA high_confidence_nonessential NP_216874.1 72.9 0.6931747025673137 67.488 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.693; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000628 non-essential Non-essential ML0826 1484 Q9CCG4 glyS glyQS ML0826 Glycine--tRNA ligase (EC 6.1.1.14) (Glycyl-tRNA synthetase) (GlyRS) 463 0.03172 non-essential 0.08461 non-essential high NA high_confidence_nonessential NP_216873.1 90.2 0.17094552285535378 61.618 Moderate candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.171; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.017457 non-essential Non-essential ML0831 1599 Q9CCG3 ML0831 Deoxyguanosinetriphosphate triphosphohydrolase-like protein 429 0.01019 non-essential 0.03306 non-essential high NA high_confidence_nonessential NP_216860.1 84.4 0.011897307451471509 46.168 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.033; ProteomeLM contextual percentile=0.012; target-priority score=46.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.014522 non-essential Non-essential ML0833 1082 Q9CCG2 dnaG ML0833 DNA primase (EC 2.7.7.101) 642 0.13829 non-essential 0.13597 non-essential high NA high_confidence_nonessential NP_216859.1 80.1 0.002504696305572949 55.365 Moderate candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.003; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009735 non-essential Non-essential ML0834 1223 Q9CCG1 ML0834 Uncharacterized protein 100 0.01648 non-essential 0.12276 non-essential high agree high_confidence_nonessential Rv2342 76.9 NE 0 0.8027551659361303 65.198 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.123; Mtb RBH anchor Rv2342=non-essential (agree); ProteomeLM contextual percentile=0.803; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.803); Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 1.4e-05 non-essential Non-essential ML0837 464 Q9CCG0 ML0837 Class II aldolase/adducin N-terminal domain-containing protein 127 0.03157 non-essential 0.2062 non-essential high NA medium_confidence 0.8578584846587352 71.471 Strong candidate ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.858; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.858); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 5e-06 non-essential Non-essential ML0838 1027 Q7AQF4 cysE ML0838 Serine acetyltransferase (EC 2.3.1.30) 227 0.04552 non-essential 0.14145 non-essential high NA high_confidence_nonessential NP_216851.1 76.4 0.4232936756418284 67.964 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.423; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.336781 essential Uncertain ML0839 411 O32978 cysK ML0839 MLCB22.47 O-acetylserine sulfhydrylase (OAS sulfhydrylase) (OASS) (EC 2.5.1.47) (Cysteine synthase A) (CSase A) (O-acetylserine (thiol)-lyase A) (OAS-TL A) (O-acetylserine-specific cysteine synthase) (Sulfide-dependent cysteine synthase) 310 0.09373 non-essential 0.2112 non-essential high NA medium_confidence YP_177868.1 85.8 0.5835942391984972 77.756 Strong candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.584; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000233 non-essential Non-essential ML0840 324 Q7AQF3 ML0840 Thioester domain-containing protein 434 0.03949 non-essential 0.22195 non-essential high NA medium_confidence 0.9079524107701941 73.595 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.908; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.908); Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.008537 non-essential Non-essential ML0841 510 P46841 enc mmpI ML0841 MLCB22.45c Type 2A encapsulin shell protein (35 kDa antigen) (Major membrane protein I) (MMPI) 307 0.08245 non-essential 0.20168 non-essential high NA medium_confidence 0.6149029430181591 65.681 Strong candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.615; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.023781 non-essential Non-essential ML0842 270 O32975 cyd csd1 ML0842 MLCB22.44c Probable cysteine desulfurase 1 (EC 2.8.1.7) 611 0.09638 non-essential 0.22984 non-essential high NA medium_confidence 0.680651221039449 77.903 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.681; target-priority score=77.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.9) rescued_from_possible_false_negative_by_supporting_evidence 0.004343 non-essential Non-essential ML0844 832 Q7AQF2 narK ML0844 Nitrite extrusion protein 517 0.00198 non-essential 0.16515 non-essential high NA high_confidence_nonessential NP_216845.1 69.1 0.7570444583594239 69.813 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.757; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.757); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 1.7e-05 non-essential Non-essential ML0845 676 Q7AQF1 ML0845 Acyl-CoA oxidase C-terminal domain-containing protein 193 0.00543 non-essential 0.1847 non-essential high NA high_confidence_nonessential 0.8541014402003757 70.544 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.854; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.854); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 0.043143 non-essential Non-essential ML0848 650 Q9CCF9 ML0848 ABC transporter 724 0.0723 non-essential 0.18725 non-essential high NA high_confidence_nonessential NP_216842.1 77.3 0.5854727614276769 62.649 Moderate candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.585; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002224 non-essential Non-essential ML0849 1551 Q7AQF0 ML0849 Cobalt transport protein 283 0.03604 non-essential 0.0697 non-essential high agree high_confidence_nonessential Rv2325c 77.9 NE 0 0.23105823418910457 49.938 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.070; Mtb RBH anchor Rv2325c=non-essential (agree); ProteomeLM contextual percentile=0.231; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000496 non-essential Non-essential ML0852 1193 Q7AQE9 ribF ML0852 Riboflavin biosynthesis protein [Includes: Riboflavin kinase (EC 2.7.1.26) (Flavokinase); FMN adenylyltransferase (EC 2.7.7.2) (FAD pyrophosphorylase) (FAD synthase)] 331 0.06543 non-essential 0.12643 non-essential high NA high_confidence_nonessential NP_217302.1 87.5 0.2548528490920476 64.136 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.255; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.076342 non-essential Non-essential ML0853 206 O32967 rpsO ML0853 MLCB22.28c Small ribosomal subunit protein uS15 (30S ribosomal protein S15) 89 0.09599 non-essential 0.24223 non-essential high NA medium_confidence NP_217301.1 93.3 0.7695679398872887 73.078 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.770; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.770); Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 8.5e-05 non-essential Non-essential ML0854 1074 Q9CCF8 pnp ML0854 Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase) 773 0.14132 non-essential 0.13674 non-essential high NA high_confidence_nonessential NP_217299.1 90.6 0.001878522229179712 52.379 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.002; target-priority score=52.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.834625 essential Essential ML0855 109 O32965 ML0855 MLCB22.26c Uncharacterized zinc protease ML0855 (EC 3.4.24.-) 445 0.20518 non-essential 0.27599 non-essential medium NA medium_confidence NP_217298.1 84.1 0.48090169067000627 68.384 Strong candidate ESM-2 calibrated P(essential)=0.205; HANSEN integrated essentiality score=0.276; ProteomeLM contextual percentile=0.481; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.4) rescued_from_possible_false_negative_by_supporting_evidence 0.004142 non-essential Non-essential ML0857 253 Q7AQE8 ML0857 Membrane protein 250 0.19217 non-essential 0.23259 non-essential high NA medium_confidence NP_216735.1 80.8 0.3306199123356293 52.99 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.331; target-priority score=53.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.96589 essential Essential ML0858 607 O32962 lipA ML0858 MLCB22.20 Lipoyl synthase (EC 2.8.1.8) (Lip-syn) (LS) (Lipoate synthase) (Lipoic acid synthase) (Sulfur insertion protein LipA) 314 0.09148 non-essential 0.19141 non-essential high NA high_confidence_nonessential NP_216734.1 86.8 0.48904195366311837 73.84 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.489; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.8) rescued_from_possible_false_negative_by_supporting_evidence 0.041257 non-essential Non-essential ML0859 688 O32961 lipB ML0859 MLCB22.19 Octanoyltransferase (EC 2.3.1.181) (Lipoate-protein ligase B) (Lipoyl/octanoyl transferase) (Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase) 235 0.03424 non-essential 0.18338 non-essential high NA high_confidence_nonessential NP_216733.1 78.4 0.6844082654978084 80.641 High-priority ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.684; target-priority score=80.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (80.6) rescued_from_possible_false_negative_by_supporting_evidence 0.187841 non-essential Non-essential ML0860 1462 O32960 ML0860 MLCB22.18 Epimerase family protein ML0860 307 0.01019 non-essential 0.0885 non-essential high NA high_confidence_nonessential NP_216732.1 84.2 0.3137132122730119 54.449 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.089; ProteomeLM contextual percentile=0.314; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000359 non-essential Non-essential ML0861 440 Q7AQE7 ML0861 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (EC 2.3.1.-) 530 0.1084 non-essential 0.20902 non-essential high NA medium_confidence NP_216731.1 77.8 0.5322479649342517 67.96 Strong candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.532; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.00211 non-essential Non-essential ML0862 1021 Q7AQE6 ephD ML0862 Oxidoreductase 596 0.07471 non-essential 0.14222 non-essential high NA high_confidence_nonessential NP_216730.1 80.4 0.3256105197244834 57.187 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.326; target-priority score=57.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000602 non-essential Non-essential ML0863 301 Q7AQE5 ML0863 Uncharacterized protein 104 0.03466 non-essential 0.2245 non-essential high NA medium_confidence 0.9542892924232936 70.467 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.954; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.954); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 1.8e-05 non-essential Non-essential ML0864 154 O32956 pepA ML0864 MLCB22.14 Probable cytosol aminopeptidase (EC 3.4.11.1) (Leucine aminopeptidase) (LAP) (EC 3.4.11.10) (Leucyl aminopeptidase) 524 0.19029 non-essential 0.2574 non-essential high NA medium_confidence NP_216729.1 83.0 0.4370695053224796 69.345 Strong candidate ESM-2 calibrated P(essential)=0.190; HANSEN integrated essentiality score=0.257; ProteomeLM contextual percentile=0.437; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 0.157722 non-essential Non-essential ML0865 369 O32955 gcvT ML0865 MLCB22.13c Aminomethyltransferase (EC 2.1.2.10) (Glycine cleavage system T protein) 367 0.18523 non-essential 0.21635 non-essential high NA medium_confidence NP_216727.1 84.5 0.2429555416405761 61.139 Moderate candidate ESM-2 calibrated P(essential)=0.185; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.243; target-priority score=61.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.430787 essential Likely essential ML0866 1434 O32954 ilvE ML0866 MLCB22.12c Probable branched-chain-amino-acid aminotransferase (BCAT) (EC 2.6.1.42) 368 0.01079 non-essential 0.09318 non-essential high NA high_confidence_nonessential NP_216726.1 87.2 0.30619912335629307 65.418 Strong candidate ESM-2 calibrated P(essential)=0.011; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.306; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.4) rescued_from_possible_false_negative_by_supporting_evidence 0.002586 non-essential Non-essential ML0868 1209 O32953 cobT ML0868 MLCB22.08 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (NN:DBI PRT) (EC 2.4.2.21) (N(1)-alpha-phosphoribosyltransferase) 351 0.01648 non-essential 0.12458 non-essential high NA high_confidence_nonessential NP_216723.1 83.8 0.443331246086412 72.724 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.443; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.040662 non-essential Non-essential ML0869 427 Q9CCF6 ML0869 MLCB22.07 Uncharacterized protein ML0869 229 0.08883 non-essential 0.20992 non-essential high NA medium_confidence NP_216722.2 67.5 0.6343143393863494 65.588 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.634; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.6) rescued_from_possible_false_negative_by_supporting_evidence 1.1e-05 non-essential Non-essential ML0871 1487 Q9CCF5 ML0871 Core domain-containing protein 118 0.09148 non-essential 0.08373 non-essential high agree high_confidence_nonessential Rv2204c 92.4 NE 0 0.06512210394489668 44.659 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv2204c=non-essential (agree); ProteomeLM contextual percentile=0.065; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.00056 non-essential Non-essential ML0872 1246 Q9CCF4 ML0872 Membrane protein 171 0.07374 non-essential 0.1201 non-essential high NA high_confidence_nonessential NP_216719.1 72.4 0.2229179711959925 49.377 Exploratory ESM-2 calibrated P(essential)=0.074; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.223; target-priority score=49.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4.5e-05 non-essential Non-essential ML0873 971 Q9CCF3 ML0873 Carbohydrate kinase 324 0.1283 non-essential 0.14789 non-essential high NA high_confidence_nonessential NP_216718.1 83.6 0.13212273011897308 50.724 Moderate candidate ESM-2 calibrated P(essential)=0.128; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.132; target-priority score=50.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002231 non-essential Non-essential ML0874 486 Q9CCF2 asnB ML0874 asparagine synthase (glutamine-hydrolyzing) (EC 6.3.5.4) 677 0.07471 non-essential 0.20365 non-essential high NA medium_confidence NP_216717.1 83.3 0.6242955541640576 78.487 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.624; target-priority score=78.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.5) rescued_from_possible_false_negative_by_supporting_evidence 0.583333 essential Likely essential ML0875 933 Q9CCF1 ctaC ML0875 Probable cytochrome c oxidase subunit 2 (EC 7.1.1.9) (Cytochrome aa3 subunit 2) (Cytochrome c oxidase polypeptide II) 353 0.07168 non-essential 0.15237 non-essential high NA high_confidence_nonessential NP_216716.1 82.6 0.37319974953036944 66.032 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.373; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 0.094009 non-essential Non-essential ML0876 1459 Q9CCF0 ctaF ML0876 Probable cytochrome c oxidase polypeptide 4 (EC 7.1.1.9) (Cytochrome aa3 subunit 4) (Cytochrome c oxidase polypeptide IV) 139 0.01172 non-essential 0.08939 non-essential high NA high_confidence_nonessential NP_216715.1 91.4 0.2986850344395742 58.947 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.089; ProteomeLM contextual percentile=0.299; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001264 non-essential Non-essential ML0877 958 Q9CCE9 mmpS3 ML0877 Probable transport accessory protein MmpS3 293 0.01648 non-essential 0.14905 non-essential high NA high_confidence_nonessential NP_216714.1 66.7 0.6205385097056982 61.414 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.621; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.019471 non-essential Non-essential ML0878 225 Q9CCE8 ML0878 Transmembrane protein 212 0.09201 non-essential 0.23701 non-essential high NA medium_confidence NP_216713.1 62.6 0.7789605510331872 65.646 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.779; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.779); Target-priority score is high (65.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000156 non-essential Non-essential ML0879 1262 P15878 qcrB mla12A ML0879 Cytochrome bc1 complex cytochrome b subunit (EC 7.1.1.8) (Cytochrome bc1 reductase complex subunit QcrB) (Ubiquinol--cytochrome c reductase cytochrome b subunit) 551 0.0582 non-essential 0.11805 non-essential high NA high_confidence_nonessential NP_216712.1 92.5 0.24733876017532874 61.211 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.247; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.986771 essential Essential ML0880 1169 Q9CCE7 qcrA ML0880 Cytochrome bc1 complex Rieske iron-sulfur subunit (Cytochrome bc1 reductase complex subunit QcrA) (Rieske iron-sulfur protein) 394 0.10418 non-essential 0.12868 non-essential high NA high_confidence_nonessential NP_216711.1 80.9 0.13838447088290545 47.801 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.138; target-priority score=47.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000406 non-essential Non-essential ML0881 381 O69583 qcrC ML0881 MLCB268.36 Cytochrome bc1 complex cytochrome c subunit (EC 7.1.1.8) (Cytochrome bc1 reductase complex subunit QcrC) (Ubiquinol--cytochrome c reductase cytochrome c subunit) 289 0.07947 non-essential 0.21498 non-essential high NA medium_confidence NP_216710.1 82.3 0.6775203506574827 75.63 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.678; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.6) rescued_from_possible_false_negative_by_supporting_evidence 0.063652 non-essential Non-essential ML0882 1424 O69582 ctaE ML0882 Probable cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome aa3 subunit 3) (Cytochrome c oxidase polypeptide III) 202 0.05755 non-essential 0.09502 non-essential high NA high_confidence_nonessential NP_216709.1 90.6 0.1327489041953663 55.137 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.095; ProteomeLM contextual percentile=0.133; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.21731 non-essential Uncertain ML0883 1208 O69581 trpD ML0883 MLCB268.34c Anthranilate phosphoribosyltransferase (EC 2.4.2.18) 366 0.06759 non-essential 0.1246 non-essential high NA high_confidence_nonessential NP_216708.1 80.7 0.2316844082654978 64.985 Moderate candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.232; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00384 non-essential Non-essential ML0885 1206 Q7AQE3 ML0885 Secreted protein 374 0.04818 non-essential 0.1247 non-essential high NA high_confidence_nonessential NP_216706.1 66.2 0.3506574827802129 55.02 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.351; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.01206 non-essential Non-essential ML0886 38 Q7AQE2 ML0886 GDP-mannose-dependent alpha-(1-6)-phosphatidylinositol monomannoside mannosyltransferase (EC 2.4.1.346) (Alpha-D-mannose-alpha-(1-6)-phosphatidylmyo-inositol-mannosyltransferase) (Alpha-mannosyltransferase) (Guanosine diphosphomannose-phosphatidyl-inositol alpha-mannosyltransferase) (Phosphatidylinositol alpha-mannosyltransferase) 384 0.38036 non-essential 0.42102 non-essential medium NA medium_confidence NP_216704.2 81.5 0.514715090795241 73.678 Strong candidate ESM-2 calibrated P(essential)=0.380; HANSEN integrated essentiality score=0.421; ProteomeLM contextual percentile=0.515; target-priority score=73.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.421); Target-priority score is high (73.7) rescued_from_possible_false_negative_by_supporting_evidence 0.036951 non-essential Non-essential ML0887 1425 Q9CCE6 ML0887 Acyl-CoA synthetase 600 0.06543 non-essential 0.09459 non-essential high NA high_confidence_nonessential NP_216703.1 80.5 0.11020663744520977 49.624 Exploratory ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.095; ProteomeLM contextual percentile=0.110; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000225 non-essential Non-essential ML0888 19 Q7AQE1 ML0888 Polyketide cyclase / dehydrase and lipid transport 135 0.18744 non-essential 0.47786 non-essential low disagree review_anchor_disagreement Rv2186c 80.0 ES 1 0.8015028177833438 70.483 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.478; Mtb RBH anchor Rv2186c=essential (disagree); ProteomeLM contextual percentile=0.802; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.227327 non-essential Uncertain ML0889 929 Q7AQE0 ML0889 Coenzyme Q-binding protein COQ10 START domain-containing protein 144 0.09677 non-essential 0.15288 non-essential high agree high_confidence_nonessential Rv2185c 85.4 NE 0 0.6186599874765185 65.898 Strong candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.153; Mtb RBH anchor Rv2185c=non-essential (agree); ProteomeLM contextual percentile=0.619; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 5e-06 non-essential Non-essential ML0890 1409 Q7AQD9 ML0890 Possible membrane transport ATPase 415 0.04897 non-essential 0.10016 non-essential high agree high_confidence_nonessential Rv2184c 79.4 NE 0 0.4176581089542893 58.015 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.100; Mtb RBH anchor Rv2184c=non-essential (agree); ProteomeLM contextual percentile=0.418; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 8.6e-05 non-essential Non-essential ML0891 1380 Q7AQD8 ML0891 Uncharacterized protein 130 0.00674 non-essential 0.10328 non-essential high agree high_confidence_nonessential Rv2183c 62.6 NE 0 0.6812773951158422 62.208 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.103; Mtb RBH anchor Rv2183c=non-essential (agree); ProteomeLM contextual percentile=0.681; target-priority score=62.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.3e-05 non-essential Non-essential ML0892 1298 Q7AQD7 ML0892 Possible acyltransferase 244 0.10418 non-essential 0.11369 non-essential high NA high_confidence_nonessential NP_216698.1 79.8 0.05385097056981841 46.556 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.054; target-priority score=46.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.016306 non-essential Non-essential ML0893 975 Q7AQD6 ML0893 Probable conserved integral membrane protein 428 0.00543 non-essential 0.14704 non-essential high NA high_confidence_nonessential NP_216697.1 80.1 0.6405760801502818 67.807 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.641; target-priority score=67.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.8) rescued_from_possible_false_negative_by_supporting_evidence 0.00855 non-essential Non-essential ML0895 922 Q7AQD5 ML0895 3'-5' exoribonuclease (EC 3.1.13.-) 171 0.0 non-essential 0.15352 non-essential high NA high_confidence_nonessential NP_216695.1 83.1 0.6831559173450219 74.771 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.683; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.8) rescued_from_possible_false_negative_by_supporting_evidence 6.4e-05 non-essential Non-essential ML0896 874 Q7AQD4 aroG ML0896 Phospho-2-dehydro-3-deoxyheptonate aldolase (EC 2.5.1.54) 462 0.09187 non-essential 0.16039 non-essential high NA high_confidence_nonessential NP_216694.1 89.7 0.32122730118973075 68.24 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.321; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 0.013092 non-essential Non-essential ML0897 279 Q7AQD3 ML0897 non-specific serine/threonine protein kinase (EC 2.7.11.1) 400 0.10115 non-essential 0.2282 non-essential high NA medium_confidence NP_216692.1 75.3 0.6649968691296181 72.511 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.665; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 0.007275 non-essential Non-essential ML0898 1005 Q7AQD2 ML0898 DNA-binding protein 134 0.09625 non-essential 0.14403 non-essential high NA high_confidence_nonessential NP_216691.1 81.3 0.24921728240450847 53.19 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.249; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000753 non-essential Non-essential ML0899 1219 Q7AQD1 ML0899 Alpha-(1->6)-mannopyranosyltransferase A 505 0.04234 non-essential 0.12322 non-essential high NA high_confidence_nonessential NP_216690.1 78.9 0.3594239198497182 58.188 Moderate candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.359; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.202989 non-essential Uncertain ML0901 1 Q7AQD0 ML0901 Methylenetetrahydrofolate reductase 304 0.38444 non-essential 0.56198 essential low disagree review_anchor_disagreement Rv2172c 81.3 ES 1 0.5003130870381967 62.571 Moderate candidate ESM-2 calibrated P(essential)=0.384; HANSEN integrated essentiality score=0.562; Mtb RBH anchor Rv2172c=essential (disagree); ProteomeLM contextual percentile=0.500; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.000226 non-essential Non-essential ML0902 683 Q7AQC9 ML0902 Probable lipoprotein 239 0.07065 non-essential 0.18388 non-essential high NA high_confidence_nonessential NP_216687.1 76.4 0.5785848465873513 60.835 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.579; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000765 non-essential Non-essential ML0903 821 Q7AQC8 ML0903 N-acetyltransferase domain-containing protein 210 0.02105 non-essential 0.16671 non-essential high NA high_confidence_nonessential NP_216686.1 77.1 0.6800250469630558 69.375 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.680; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 0.012219 non-essential Non-essential ML0904 700 Q7AQC7 ML0904 Probable membrane protein 134 0.10418 non-essential 0.18228 non-essential high NA high_confidence_nonessential NP_216685.1 86.6 0.43581715716969316 53.865 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.436; target-priority score=53.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000703 non-essential Non-essential ML0905 803 O69561 mraZ ML0905 MLCB268.11c Transcriptional regulator MraZ 143 0.00674 non-essential 0.1695 non-essential high NA high_confidence_nonessential NP_216682.1 92.3 0.7564182842830307 71.293 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.756; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.756); Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000183 non-essential Non-essential ML0906 726 O69560 rsmH mraW ML0906 MLCB268.10c Ribosomal RNA small subunit methyltransferase H (EC 2.1.1.199) (16S rRNA m(4)C1402 methyltransferase) (rRNA (cytosine-N(4)-)-methyltransferase RsmH) 372 0.02734 non-essential 0.17926 non-essential high NA high_confidence_nonessential NP_216681.4 73.7 0.6994364433312461 78.066 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.699; target-priority score=78.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.1) rescued_from_possible_false_negative_by_supporting_evidence 0.006236 non-essential Non-essential ML0907 18 Q7AQC6 ML0907 Conserved membrane protein 377 0.28095 non-essential 0.47823 non-essential low disagree review_anchor_disagreement Rv2164c 59.8 GD 1 0.3519098309329994 48.929 Exploratory ESM-2 calibrated P(essential)=0.281; HANSEN integrated essentiality score=0.478; Mtb RBH anchor Rv2164c=essential (disagree); ProteomeLM contextual percentile=0.352; target-priority score=48.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.754901 essential Essential ML0908 1001 Q7AQC5 pbpB ML0908 Penicillin-binding protein 2 675 0.14132 non-essential 0.1442 non-essential high NA high_confidence_nonessential NP_216679.1 80.4 0.06261740763932373 46.651 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.063; target-priority score=46.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.025645 non-essential Non-essential ML0909 852 O69557 murE ML0909 MLCB268.07c UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase (EC 6.3.2.13) (Meso-A2pm-adding enzyme) (Meso-diaminopimelate-adding enzyme) (UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase) (UDP-MurNAc-tripeptide synthetase) (UDP-N-acetylmuramyl-tripeptide synthetase) 530 0.04867 non-essential 0.16294 non-essential high NA high_confidence_nonessential NP_216674.1 74.4 0.506574827802129 77.723 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.507; target-priority score=77.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.7) rescued_from_possible_false_negative_by_supporting_evidence 0.04017 non-essential Non-essential ML0910 1340 O69556 murF ML0910 MLCB268.06c UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase (EC 6.3.2.10) (D-alanyl-D-alanine-adding enzyme) (UDP-MurNAc-pentapeptide synthetase) 517 0.06543 non-essential 0.10922 non-essential high NA high_confidence_nonessential NP_216673.1 75.3 0.14777708202880402 66.111 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.148; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.685549 essential Likely essential ML0911 1048 O69555 mraY murX ML0911 MLCB268.05c Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase) 359 0.08276 non-essential 0.13935 non-essential high NA high_confidence_nonessential NP_216672.1 91.1 0.2417031934877896 67.418 Strong candidate ESM-2 calibrated P(essential)=0.083; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.242; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.4) rescued_from_possible_false_negative_by_supporting_evidence 0.062683 non-essential Non-essential ML0912 1287 P57995 murD ML0912 MLCB268.04c UDP-N-acetylmuramoylalanine--D-glutamate ligase (EC 6.3.2.9) (D-glutamic acid-adding enzyme) (UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase) 490 0.06981 non-essential 0.11455 non-essential high NA high_confidence_nonessential NP_216671.3 75.9 0.16030056355666875 65.689 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.160; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.022983 non-essential Non-essential ML0913 200 Q7AQC4 ftsW ML0913 Probable peptidoglycan glycosyltransferase FtsW (EC 2.4.99.28) (Cell division protein FtsW) (Cell wall polymerase) (Peptidoglycan polymerase) 534 0.09677 non-essential 0.2436 non-essential high NA medium_confidence NP_216670.1 78.1 0.7445209768315592 83.098 High-priority ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.745; target-priority score=83.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (83.1) rescued_from_possible_false_negative_by_supporting_evidence 0.744511 essential Essential ML0914 143 O69552 murG ML0914 MLCB268.02c UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase) 407 0.18914 non-essential 0.26188 non-essential high NA medium_confidence NP_216669.1 76.6 0.4477144646211647 76.475 Strong candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.448; target-priority score=76.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.5) rescued_from_possible_false_negative_by_supporting_evidence 0.474893 essential Likely essential ML0915 1282 P57994 murC ML0915 UDP-N-acetylmuramate--L-alanine ligase (EC 6.3.2.8) (UDP-N-acetylmuramoyl-L-alanine synthetase) 495 0.04656 non-essential 0.11487 non-essential high NA high_confidence_nonessential NP_216668.1 79.3 0.25860989355040703 69.187 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.259; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.003542 non-essential Non-essential ML0916 203 Q9CCE5 ftsQ ML0916 Cell division protein FtsQ 341 0.06716 non-essential 0.24297 non-essential high NA medium_confidence NP_216667.1 70.0 0.8966812773951158 76.295 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.897; target-priority score=76.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.897); Target-priority score is high (76.3) rescued_from_possible_false_negative_by_supporting_evidence 0.003912 non-essential Non-essential ML0917 359 Q9CCE4 ftsZ ML0917 Cell division protein FtsZ 379 0.23815 non-essential 0.21711 non-essential medium NA medium_confidence NP_216666.1 96.6 0.040075140889167186 49.09 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.040; target-priority score=49.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.894989 essential Essential ML0918 387 Q9CCE3 ML0918 Purine nucleoside phosphorylase ML0918 (EC 2.4.2.1) (Adenosine deaminase ML0918) (EC 3.5.4.4) (S-methyl-5'-thioadenosine phosphorylase ML0918) (EC 2.4.2.28) 249 0.01761 non-essential 0.2141 non-essential high NA medium_confidence NP_216665.1 60.2 0.9292423293675642 84.786 High-priority ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.929; target-priority score=84.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.929); Target-priority score is high (84.8) rescued_from_possible_false_negative_by_supporting_evidence 0.153503 non-essential Non-essential ML0919 1230 Q9CCE2 ML0919 Pyridoxal phosphate homeostasis protein (PLP homeostasis protein) 257 0.04818 non-essential 0.12207 non-essential high agree high_confidence_nonessential Rv2148c 73.6 NE 0 0.6048841577958672 65.347 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.122; Mtb RBH anchor Rv2148c=non-essential (agree); ProteomeLM contextual percentile=0.605; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.3) rescued_from_possible_false_negative_by_supporting_evidence 0.003783 non-essential Non-essential ML0920 1517 Q9CCE1 sepF ML0920 Cell division protein SepF 210 0.05247 non-essential 0.07818 non-essential high NA high_confidence_nonessential NP_216663.1 83.5 0.08453350031308704 45.768 Exploratory ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.085; target-priority score=45.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.019573 non-essential Non-essential ML0921 885 Q9CCE0 ML0921 Possible membrane protein 96 0.01233 non-essential 0.1585 non-essential high NA high_confidence_nonessential NP_216662.1 89.6 0.6793988728866625 66.779 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.159; ProteomeLM contextual percentile=0.679; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 8.2e-05 non-essential Non-essential ML0922 80 P46815 wag31 ag84 ML0922 Cell wall synthesis protein Wag31 (Antigen 84) 266 0.19217 non-essential 0.31839 non-essential high NA medium_confidence NP_216661.1 86.5 0.7858484658735129 69.794 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.318; ProteomeLM contextual percentile=0.786; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.786); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.45245 essential Likely essential ML0923 325 Q9CCD9 ML0923 Possible membrane protein 130 0.04805 non-essential 0.22189 non-essential high NA medium_confidence NP_216660.1 50.4 0.8816530995616781 69.063 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.882; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.882); Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000105 non-essential Non-essential ML0925 660 Q9CCD8 glnA ML0925 Glutamine synthetase (EC 6.3.1.2) 478 0.06628 non-essential 0.18598 non-essential high NA high_confidence_nonessential NP_216736.1 92.1 0.5729492798998121 73.767 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.573; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.8) rescued_from_possible_false_negative_by_supporting_evidence 0.012039 non-essential Non-essential ML0926 161 Q9CCD7 ML0926 Uncharacterized protein 122 0.08711 non-essential 0.25486 non-essential high NA medium_confidence 0.8872886662492173 72.158 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.255; ProteomeLM contextual percentile=0.887; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.887); Target-priority score is high (72.2) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0927 342 Q9CCD6 ML0927 Uncharacterized protein 102 0.024 non-essential 0.21908 non-essential high NA medium_confidence 0.9699436443331246 70.935 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.970; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.970); Target-priority score is high (70.9) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML0928 171 Q9CCD5 ML0928 Uncharacterized protein 94 0.05949 non-essential 0.25128 non-essential high NA medium_confidence 0.9956167814652473 71.249 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.996; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.996); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0938 397 Q9CCD4 ML0938 Uncharacterized protein 98 0.01709 non-essential 0.21306 non-essential high NA medium_confidence 0.9580463368816531 73.719 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.958; target-priority score=73.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.958); Target-priority score is high (73.7) rescued_from_possible_false_negative_by_supporting_evidence 5.7e-05 non-essential Non-essential ML0939 164 Q9CCD3 ML0939 Uncharacterized protein 80 0.06236 non-essential 0.25421 non-essential high NA medium_confidence 1.0 71.14 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.254; ProteomeLM contextual percentile=1.000; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (1.000); Target-priority score is high (71.1) rescued_from_possible_false_negative_by_supporting_evidence 7.1e-05 non-essential Non-essential ML0946 564 Q7AQC3 ML0946 Uncharacterized protein 107 0.0 non-essential 0.19551 non-essential high NA high_confidence_nonessential 0.9436443331246086 70.189 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.944; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.944); Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 1.4e-05 non-essential Non-essential ML0947 127 Q9CCD2 ML0947 Uncharacterized protein 85 0.09638 non-essential 0.27072 non-essential high NA medium_confidence 0.9448966812773951 69.815 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.271; ProteomeLM contextual percentile=0.945; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.945); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 6.3e-05 non-essential Non-essential ML0949 536 Q9CCD1 ML0949 HTH tetR-type domain-containing protein 137 0.00198 non-essential 0.19792 non-essential high NA high_confidence_nonessential 0.9398872886662493 73.199 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.940; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.940); Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000209 non-essential Non-essential ML0950 478 Q9CCD0 ML0950 Uncharacterized protein 66 0.00301 non-essential 0.20435 non-essential high NA medium_confidence 0.9774577332498434 71.684 Strong candidate ESM-2 calibrated P(essential)=0.003; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.977; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.977); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 2e-05 non-essential Non-essential ML0953 303 Q9CCC9 ML0953 Uncharacterized protein 79 0.04176 non-essential 0.22411 non-essential high NA medium_confidence 0.9179711959924859 70.958 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.918; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.918); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML0955 357 Q7AQC2 ppdK ML0955 Pyruvate, phosphate dikinase 601 0.07935 non-essential 0.21726 non-essential high NA medium_confidence NP_215643.1 71.8 0.7094552285535379 69.522 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.709; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.055764 non-essential Non-essential ML0956 776 Q9CCC8 ML0956 Integral membrane protein 169 0.00198 non-essential 0.17273 non-essential high NA high_confidence_nonessential 0.7946149029430182 72.208 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.795; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.795); Target-priority score is high (72.2) rescued_from_possible_false_negative_by_supporting_evidence 2.1e-05 non-essential Non-essential ML0957 181 Q9CCC7 ML0957 Uncharacterized protein 124 0.07625 non-essential 0.2487 non-essential high NA medium_confidence 0.9098309329993738 69.12 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.249; ProteomeLM contextual percentile=0.910; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.910); Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 5e-06 non-essential Non-essential ML0958 406 Q9CCC6 ML0958 Membrane protein 143 0.01019 non-essential 0.21161 non-essential high NA medium_confidence 0.9862241703193487 71.999 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.986; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.986); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000947 non-essential Non-essential ML0959 582 Q9CCC5 ML0959 Uncharacterized protein 117 0.00198 non-essential 0.1936 non-essential high NA high_confidence_nonessential 0.9273638071383845 68.8 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.927; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.927); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000982 non-essential Non-essential ML0961 438 O05564 metE ML0961 MLCB33.14 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (EC 2.1.1.14) (Cobalamin-independent methionine synthase) (Methionine synthase, vitamin-B12 independent isozyme) 760 0.14132 non-essential 0.20912 non-essential high NA medium_confidence NP_215649.1 85.0 0.3769567939887289 69.616 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.377; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 0.00536 non-essential Non-essential ML0963 323 Q9CCC4 ML0963 Uncharacterized protein 154 0.02095 non-essential 0.222 non-essential high NA medium_confidence 0.9993738259236068 71.519 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.999; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.999); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000264 non-essential Non-essential ML0964 448 Q9CCC3 ML0964 Uncharacterized protein 85 0.01019 non-essential 0.20796 non-essential high NA medium_confidence 0.9686912961803381 70.665 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.969; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.969); Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 9.5e-05 non-essential Non-essential ML0977 88 O05560 ftsK ML0977 MLCB33.09c DNA translocase FtsK 840 0.19217 non-essential 0.29924 non-essential high NA medium_confidence NP_217264.1 80.4 0.6756418284283031 68.976 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.299; ProteomeLM contextual percentile=0.676; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (69.0) rescued_from_possible_false_negative_by_supporting_evidence 0.534121 essential Likely essential ML0978 1404 Q7AQC1 ML0978 Acetyltransferase 180 0.09928 non-essential 0.10144 non-essential high NA high_confidence_nonessential NP_217263.1 86.2 0.007514088916718848 45.461 Exploratory ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.101; ProteomeLM contextual percentile=0.008; target-priority score=45.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.845457 essential Essential ML0979 335 Q7AQC0 ML0979 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) 193 0.0503 non-essential 0.22009 non-essential high NA medium_confidence NP_217262.1 76.6 0.8252974326862867 81.108 High-priority ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.825; target-priority score=81.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.825); Target-priority score is high (81.1) rescued_from_possible_false_negative_by_supporting_evidence 0.006999 non-essential Non-essential ML0984 558 Q9CCC2 ML0984 Limonene-1,2-epoxide hydrolase domain-containing protein 164 0.0 non-essential 0.19617 non-essential high NA high_confidence_nonessential NP_217256.1 50.7 0.9298685034439574 76.189 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.930; target-priority score=76.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.930); Target-priority score is high (76.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000327 non-essential Non-essential ML0985 903 Q7AQB9 ML0985 Possible glycosyltransferase 392 0.06636 non-essential 0.156 non-essential high NA high_confidence_nonessential NP_217255.1 80.9 0.4345648090169067 60.723 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.435; target-priority score=60.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001507 non-essential Non-essential ML0986 720 Q9CCC1 ML0986 Signal transduction histidine kinase 67 0.09148 non-essential 0.17951 non-essential high agree high_confidence_nonessential Rv2738c 83.6 NE 0 0.8772698810269255 73.778 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.180; Mtb RBH anchor Rv2738c=non-essential (agree); ProteomeLM contextual percentile=0.877; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.877); Target-priority score is high (73.8) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML0987 50 P35901 recA ML0987 Protein RecA (Recombinase A) [Cleaved into: Mle RecA intein] 711 0.26047 non-essential 0.39497 non-essential medium NA medium_confidence NP_217253.1 45.8 0.9016906700062617 77.034 Strong candidate ESM-2 calibrated P(essential)=0.260; HANSEN integrated essentiality score=0.395; ProteomeLM contextual percentile=0.902; target-priority score=77.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.902); Target-priority score is high (77.0) rescued_from_possible_false_negative_by_supporting_evidence 0.980012 essential Essential ML0988 152 P37859 recX ML0988 u2235b Regulatory protein RecX 171 0.13407 non-essential 0.25878 non-essential high NA medium_confidence NP_217252.1 77.0 0.7050720100187852 68.696 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.705; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 2.1e-05 non-essential Non-essential ML0989 1327 Q49842 miaB ML0989 B2235_C2_195 tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase (EC 2.8.4.3) ((Dimethylallyl)adenosine tRNA methylthiotransferase MiaB) (tRNA-i(6)A37 methylthiotransferase) 517 0.05255 non-essential 0.11101 non-essential high NA high_confidence_nonessential NP_217249.1 80.9 0.23231058234189106 61.059 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.232; target-priority score=61.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.715304 essential Essential ML0990 645 Q7AQB8 ML0990 Possible conserved membrane protein 209 0.06543 non-essential 0.18755 non-essential high NA high_confidence_nonessential NP_217248.1 73.3 0.6192861615529117 62.461 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.619; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002515 non-essential Non-essential ML0994 1477 Q7AQB7 ML0994 Uncharacterized protein 232 0.01648 non-essential 0.08558 non-essential high agree high_confidence_nonessential Rv2728c 69.0 NE 0 0.46086412022542267 59.217 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.086; Mtb RBH anchor Rv2728c=non-essential (agree); ProteomeLM contextual percentile=0.461; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.5e-05 non-essential Non-essential ML0995 1042 P46811 miaA ML0995 B2235_C3_232 tRNA dimethylallyltransferase (EC 2.5.1.75) (Dimethylallyl diphosphate:tRNA dimethylallyltransferase) (DMAPP:tRNA dimethylallyltransferase) (DMATase) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (IPTase) 311 0.06199 non-essential 0.14 non-essential high NA high_confidence_nonessential NP_217243.1 82.2 0.34627426424546026 65.576 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.346; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.6) rescued_from_possible_false_negative_by_supporting_evidence 0.00929 non-essential Non-essential ML0996 1077 P46814 dapF ML0996 B2235_C3_233 Diaminopimelate epimerase (DAP epimerase) (EC 5.1.1.7) (PLP-independent amino acid racemase) 296 0.04552 non-essential 0.13661 non-essential high NA high_confidence_nonessential NP_217242.1 76.0 0.38697557921102066 70.62 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.387; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.049613 non-essential Non-essential ML0997 946 Q9CCC0 hflX ML0997 GTPase HflX (GTP-binding protein HflX) 488 0.13353 non-essential 0.1506 non-essential high NA high_confidence_nonessential NP_217241.1 84.5 0.12335629304946776 50.965 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.123; target-priority score=51.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010504 non-essential Non-essential ML1001 219 Q9CCB9 ML1001 Uncharacterized protein 91 0.04243 non-essential 0.23812 non-essential high NA medium_confidence 0.9968691296180339 71.101 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.997; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.997); Target-priority score is high (71.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000725 non-essential Non-essential ML1002 1545 Q7AQB6 ML1002 Possible conserved membrane protein 687 0.06278 non-essential 0.071 non-essential high agree high_confidence_nonessential Rv2721c 61.9 NE 0 0.11396368190356919 43.869 Exploratory ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv2721c=non-essential (agree); ProteomeLM contextual percentile=0.114; target-priority score=43.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.003439 non-essential Non-essential ML1003 1051 Q49848 lexA ML1003 B2235_F2_55 LexA repressor (EC 3.4.21.88) 235 0.09615 non-essential 0.13889 non-essential high NA high_confidence_nonessential NP_217236.2 84.5 0.19787100814026298 60.517 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.198; target-priority score=60.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.774457 essential Essential ML1004 392 Q7AQB5 ML1004 Possible conserved membrane protein 164 0.04818 non-essential 0.21341 non-essential high NA medium_confidence NP_217235.1 57.0 0.8334376956793988 68.294 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.833; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.833); Target-priority score is high (68.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000793 non-essential Non-essential ML1005 615 Q49844 nrdR ML1005 B2235_C2_209 u2235a Transcriptional repressor NrdR 154 0.09327 non-essential 0.19069 non-essential high NA high_confidence_nonessential NP_217234.1 92.7 0.5053224796493425 64.076 Moderate candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.505; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003624 non-essential Non-essential ML1006 1116 Q9CCB8 ML1006 Peroxynitrite isomerase (EC 5.99.-.-) (Ferric nitrobindin) (Nb(III)) 161 0.03949 non-essential 0.133 non-essential high agree high_confidence_nonessential Rv2717c 74.2 NE 0 0.6869129618033814 81.236 High-priority ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv2717c=non-essential (agree); ProteomeLM contextual percentile=0.687; target-priority score=81.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000416 non-essential Non-essential ML1009 1530 Q7AQB4 ML1009 Proteasome protein 326 0.07935 non-essential 0.07573 non-essential high agree high_confidence_nonessential Rv2714 90.2 NE 0 0.057608015028177834 44.732 Exploratory ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.076; Mtb RBH anchor Rv2714=non-essential (agree); ProteomeLM contextual percentile=0.058; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 1.1e-05 non-essential Non-essential ML1010 434 Q9CCB7 ML1010 Uncharacterized protein 80 0.02224 non-essential 0.20936 non-essential high NA medium_confidence 0.9254852849092048 69.367 Strong candidate ESM-2 calibrated P(essential)=0.022; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.925; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.925); Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 0.00014 non-essential Non-essential ML1011 425 Q9CCB6 ML1011 Uncharacterized protein 140 0.00674 non-essential 0.20999 non-essential high NA medium_confidence 0.9943644333124608 71.378 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.994; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.994); Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 0.00019 non-essential Non-essential ML1013 794 Q9CCB5 ideR ML1013 Iron-dependent repressor IdeR 230 0.18412 non-essential 0.17036 non-essential high NA high_confidence_nonessential NP_217227.1 90.0 0.022542266750156543 45.818 Exploratory ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.023; target-priority score=45.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.485735 essential Likely essential ML1014 140 Q59531 ML1014 RNA polymerase sigma factor 319 0.10418 non-essential 0.26279 non-essential high NA medium_confidence NP_217226.1 96.2 0.8534752661239825 72.883 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.263; ProteomeLM contextual percentile=0.853; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.853); Target-priority score is high (72.9) rescued_from_possible_false_negative_by_supporting_evidence 0.04121 non-essential Non-essential ML1015 864 Q9CCB4 ML1015 Possible conserved membrane protein 139 0.00543 non-essential 0.16187 non-essential high NA high_confidence_nonessential NP_217225.1 75.2 0.73888541014402 64.058 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.739; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001557 non-essential Non-essential ML1016 789 Q7AQB3 ML1016 DUF3039 domain-containing protein 107 0.08936 non-essential 0.1714 non-essential high agree high_confidence_nonessential Rv2708c 88.6 GA 0 0.8365685660613651 68.255 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.171; Mtb RBH anchor Rv2708c=non-essential (agree); ProteomeLM contextual percentile=0.837; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.837); Target-priority score is high (68.3) rescued_from_possible_false_negative_by_supporting_evidence 0.303213 non-essential Uncertain ML1017 1447 Q7AQB2 ML1017 Possible conserved integral membrane protein 330 0.01233 non-essential 0.09206 non-essential high agree high_confidence_nonessential Rv2707 75.4 GA 0 0.54351909830933 60.619 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv2707=non-essential (agree); ProteomeLM contextual percentile=0.544; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005855 non-essential Non-essential ML1018 522 Q9CCB3 ML1018 Uncharacterized protein 71 0.00198 non-essential 0.19994 non-essential high NA high_confidence_nonessential 0.9618033813400125 69.787 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.200; ProteomeLM contextual percentile=0.962; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.962); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 8.2e-05 non-essential Non-essential ML1022 98 Q7AQB1 rpoT sigA ML1022 RNA polymerase sigma factor SigA 574 0.21287 non-essential 0.28998 non-essential medium NA medium_confidence NP_217219.1 74.4 0.5497808390732624 60.943 Moderate candidate ESM-2 calibrated P(essential)=0.213; HANSEN integrated essentiality score=0.290; ProteomeLM contextual percentile=0.550; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.97038 essential Essential ML1023 488 Q49988 ppgK ML1023 u1764fg Polyphosphate glucokinase (EC 2.7.1.63) (ATP-dependent glucokinase) (EC 2.7.1.2) (Polyphosphate--glucose phosphotransferase) 324 0.0245 non-essential 0.20364 non-essential high NA medium_confidence NP_217218.1 83.7 0.8447088290544772 81.858 High-priority ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.845; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.845); Target-priority score is high (81.9) rescued_from_possible_false_negative_by_supporting_evidence 0.006167 non-essential Non-essential ML1024 525 P46813 suhB ssyA ML1024 Inositol-1-monophosphatase (I-1-Pase) (IMPase) (Inositol-1-phosphatase) (EC 3.1.3.25) 291 0.0822 non-essential 0.19919 non-essential high NA high_confidence_nonessential NP_217217.1 76.4 0.5773324984345648 73.847 Strong candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.577; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.8) rescued_from_possible_false_negative_by_supporting_evidence 0.001349 non-essential Non-essential ML1025 1266 Q7AQB0 ML1025 Possible secreted protein 216 0.06849 non-essential 0.1175 non-essential high agree high_confidence_nonessential Rv2700 82.9 NE 0 0.4733876017532874 58.135 Moderate candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.117; Mtb RBH anchor Rv2700=non-essential (agree); ProteomeLM contextual percentile=0.473; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.107855 non-essential Non-essential ML1026 22 Q7AQA9 ML1026 dUTPase 100 0.23311 non-essential 0.47017 non-essential low disagree review_anchor_disagreement Rv2699c 96.0 ES 1 0.5228553537883531 56.04 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.470; Mtb RBH anchor Rv2699c=essential (disagree); ProteomeLM contextual percentile=0.523; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.001174 non-essential Non-essential ML1027 1118 Q7AQA8 ML1027 Possible membrane protein 157 0.04821 non-essential 0.13286 non-essential high NA high_confidence_nonessential NP_217214.1 79.5 0.39574201628052597 55.963 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.396; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008189 non-essential Non-essential ML1028 1099 Q49992 dut ML1028 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase) 154 0.01648 non-essential 0.13392 non-essential high NA high_confidence_nonessential NP_217213.1 90.9 0.4965560425798372 73.296 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.497; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.3) rescued_from_possible_false_negative_by_supporting_evidence 0.003337 non-essential Non-essential ML1029 959 Q7AQA7 ML1029 DUF3710 domain-containing protein 273 0.08883 non-essential 0.14863 non-essential high agree high_confidence_nonessential Rv2696c 67.9 NE 0 0.638697557921102 62.914 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.149; Mtb RBH anchor Rv2696c=non-essential (agree); ProteomeLM contextual percentile=0.639; target-priority score=62.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.173718 non-essential Non-essential ML1030 1449 Q7AQA6 ML1030 AB hydrolase-1 domain-containing protein 232 0.03424 non-essential 0.0917 non-essential high agree high_confidence_nonessential Rv2695 77.0 NE 0 0.41577958672510956 59.15 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv2695=non-essential (agree); ProteomeLM contextual percentile=0.416; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 5e-06 non-essential Non-essential ML1036 1199 P46838 ag45 ML1036 46 kDa membrane protein 429 0.08711 non-essential 0.12561 non-essential high NA high_confidence_nonessential NP_217200.1 74.3 0.19035691922354414 50.607 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.190; target-priority score=50.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4.3e-05 non-essential Non-essential ML1037 761 Q7AQA5 ML1037 CBS domain-containing protein 184 0.09148 non-essential 0.17471 non-essential high agree high_confidence_nonessential Rv2683 73.8 NE 0 0.8459611772072636 70.449 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.175; Mtb RBH anchor Rv2683=non-essential (agree); ProteomeLM contextual percentile=0.846; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.846); Target-priority score is high (70.4) rescued_from_possible_false_negative_by_supporting_evidence 1.2e-05 non-essential Non-essential ML1038 1290 Q50000 dxs tktB ML1038 1-deoxy-D-xylulose-5-phosphate synthase (EC 2.2.1.7) (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS) 643 0.05604 non-essential 0.11436 non-essential high NA high_confidence_nonessential YP_177898.1 87.2 0.22604884157795868 64.429 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.226; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.035416 non-essential Non-essential ML1040 1587 Q7AQA4 ML1040 HRDC domain-containing protein 429 0.03172 non-essential 0.0525 non-essential high agree high_confidence_nonessential Rv2681 72.4 NE 0 0.09768315591734503 47.406 Exploratory ESM-2 calibrated P(essential)=0.032; HANSEN integrated essentiality score=0.053; Mtb RBH anchor Rv2681=non-essential (agree); ProteomeLM contextual percentile=0.098; target-priority score=47.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.017398 non-essential Non-essential ML1041 1592 Q7AQA3 ML1041 DUF3000 domain-containing protein 196 0.02734 non-essential 0.04902 non-essential high agree high_confidence_nonessential Rv2680 83.9 NE 0 0.10018785222291797 45.193 Exploratory ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.049; Mtb RBH anchor Rv2680=non-essential (agree); ProteomeLM contextual percentile=0.100; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 7.2e-05 non-essential Non-essential ML1043 444 P46809 hemE ML1043 Uroporphyrinogen decarboxylase (UPD) (URO-D) (EC 4.1.1.37) 357 0.06199 non-essential 0.2084 non-essential high NA medium_confidence NP_217194.1 83.8 0.7006887914840325 81.867 High-priority ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.701; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.9) rescued_from_possible_false_negative_by_supporting_evidence 0.053735 non-essential Non-essential ML1044 889 Q50008 cgoX hemY ML1044 Coproporphyrinogen III oxidase (EC 1.3.3.15) 451 0.04818 non-essential 0.15826 non-essential high NA high_confidence_nonessential YP_177675.1 75.4 0.49092047589229804 74.443 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.491; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 0.010668 non-essential Non-essential ML1045 47 Q9CCB2 chdC ML1045 Coproheme decarboxylase (EC 1.3.98.5) (Coproheme III oxidative decarboxylase) (Hydrogen peroxide-dependent heme synthase) 231 0.12918 non-essential 0.40467 non-essential low disagree review_anchor_disagreement Rv2676c 87.4 ES 1 0.4126487163431434 71.797 Strong candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.405; Mtb RBH anchor Rv2676c=essential (disagree); ProteomeLM contextual percentile=0.413; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.011957 non-essential Non-essential ML1051 1330 Q7AQA2 xclC ML1051 Acyl-CoA synthase 476 0.07017 non-essential 0.1109 non-essential high NA high_confidence_nonessential NP_215709.1 81.5 0.17783343769567939 51.877 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.178; target-priority score=51.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000462 non-essential Non-essential ML1052 1055 Q9CCB1 ML1052 Transcriptional regulator 421 0.13997 non-essential 0.13862 non-essential high agree high_confidence_nonessential Rv1194c 70.1 NE 0 0.28428303068252975 52.41 Moderate candidate ESM-2 calibrated P(essential)=0.140; HANSEN integrated essentiality score=0.139; Mtb RBH anchor Rv1194c=non-essential (agree); ProteomeLM contextual percentile=0.284; target-priority score=52.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.1e-05 non-essential Non-essential ML1053 684 Q7AQ88 ML1053 ML1183 PE domain-containing protein 99 0.0 non-essential 0.18387 non-essential high NA high_confidence_nonessential YP_177975.1 47.3 0.8703819661865999 71.819 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.870; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.870); Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000345 non-essential Non-essential ML1055 1100 Q49945 ML1055 u1756c; ML1181 MLCB1701.07c Putative ESAT-6-like protein Y 100 0.0 non-essential 0.13389 non-essential high NA high_confidence_nonessential NP_215713.1 58.3 0.6061365059486538 61.692 Moderate candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.606; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000165 non-essential Non-essential ML1056 813 Q49946 ML1056 u1756d; ML1180 MLCB1701.06c Putative ESAT-6-like protein X 95 0.0 non-essential 0.16843 non-essential high NA high_confidence_nonessential NP_215553.1 64.8 0.788979336255479 68.603 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.789; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.789); Target-priority score is high (68.6) rescued_from_possible_false_negative_by_supporting_evidence 0.002689 non-essential Non-essential ML1057 178 Q7AQA0 ML1057 Uncharacterized protein 117 0.07218 non-essential 0.2497 non-essential high NA medium_confidence 0.9361302442078898 68.505 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.250; ProteomeLM contextual percentile=0.936; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.936); Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000242 non-essential Non-essential ML1058 859 Q7AQ99 dapD ML1058 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117) (Tetrahydrodipicolinate N-succinyltransferase) (THDP succinyltransferase) (THP succinyltransferase) (Tetrahydropicolinate succinylase) 317 0.10418 non-essential 0.16229 non-essential high NA high_confidence_nonessential NP_215717.1 85.2 0.2805259862241703 66.677 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.281; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 0.258337 non-essential Uncertain ML1059 1334 Q9CCB0 dapE ML1059 Succinyl-diaminopimelate desuccinylase (EC 3.5.1.18) 354 0.06981 non-essential 0.1106 non-essential high NA high_confidence_nonessential YP_177796.1 87.0 0.15341264871634314 60.147 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.153; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.036246 non-essential Non-essential ML1061 1249 Q7AQ98 ML1061 Cytokinin riboside 5'-monophosphate phosphoribohydrolase (EC 3.2.2.n1) 187 0.06981 non-essential 0.11967 non-essential high agree high_confidence_nonessential Rv1205 72.4 NE 0 0.4445835942391985 66.643 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.120; Mtb RBH anchor Rv1205=non-essential (agree); ProteomeLM contextual percentile=0.445; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000209 non-essential Non-essential ML1063 867 P0C0X2 folP2 ML1063 Inactive dihydropteroate synthase 2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) 291 0.0733 non-essential 0.16079 non-essential high NA high_confidence_nonessential NP_215723.1 86.8 0.43018159048215404 60.964 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.430; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.042479 non-essential Non-essential ML1064 1572 Q9CCA9 ML1064 Glucosyl-3-phosphoglycerate synthase (EC 2.4.1.266) 326 0.03604 non-essential 0.06195 non-essential high NA high_confidence_nonessential NP_215724.1 79.8 0.044458359423919847 52.563 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.062; ProteomeLM contextual percentile=0.044; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.020071 non-essential Non-essential ML1065 749 Q7AQ97 ML1065 Cell division protein DivIVA 114 0.09638 non-essential 0.17654 non-essential high agree high_confidence_nonessential Rv1209 79.5 NE 0 0.8484658735128365 67.723 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.177; Mtb RBH anchor Rv1209=non-essential (agree); ProteomeLM contextual percentile=0.848; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.848); Target-priority score is high (67.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000488 non-essential Non-essential ML1066 895 Q7AQ96 tagA ML1066 DNA-3-methyladenine glycosidase I 192 0.01172 non-essential 0.15708 non-essential high NA high_confidence_nonessential NP_215726.1 80.7 0.6637445209768316 70.198 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.664; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 2.9e-05 non-essential Non-essential ML1067 890 Q7AQ95 ML1067 DUF3117 domain-containing protein 75 0.04218 non-essential 0.15816 non-essential high agree high_confidence_nonessential Rv1211 90.7 NE 0 0.963055729492799 73.085 Strong candidate ESM-2 calibrated P(essential)=0.042; HANSEN integrated essentiality score=0.158; Mtb RBH anchor Rv1211=non-essential (agree); ProteomeLM contextual percentile=0.963; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.963); Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000234 non-essential Non-essential ML1069 481 Q9CCA8 glgC ML1069 Glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) (ADP-glucose pyrophosphorylase) (ADPGlc PPase) (ADP-glucose synthase) 404 0.14132 non-essential 0.20397 non-essential high NA medium_confidence NP_215729.1 90.8 0.34815278647463993 69.103 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.348; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 0.001175 non-essential Non-essential ML1070 588 Q7AQ94 ML1070 TetR-family transcriptional regulator 217 0.0733 non-essential 0.19324 non-essential high NA high_confidence_nonessential 0.6073888541014402 65.624 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.607; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.6) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML1075 338 Q9CCA7 ML1075 Putative O-methyltransferase ML1075 (EC 2.1.1.-) 224 0.09638 non-essential 0.21972 non-essential high NA medium_confidence NP_215736.1 85.5 0.6336881653099562 73.636 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.634; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.085809 non-essential Non-essential ML1076 456 Q9CCA6 sigE ML1076 ECF subfamily sigma subunit 263 0.06638 non-essential 0.20694 non-essential high NA medium_confidence NP_215737.1 83.1 0.7157169693174703 66.982 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.716; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 0.008882 non-essential Non-essential ML1077 760 Q9CCA5 ML1077 RNA polymerase subunit sigma-70 139 0.03079 non-essential 0.17482 non-essential high NA high_confidence_nonessential NP_215738.1 67.8 0.6981840951784596 64.224 Moderate candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.698; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.03341 non-essential Non-essential ML1078 376 Q7AQ93 htrA ML1078 Possinble serine protease 533 0.05587 non-essential 0.21546 non-essential high NA medium_confidence NP_215739.2 81.8 0.802128991859737 71.04 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.802; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.802); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 0.372075 essential Uncertain ML1079 1064 Q9CCA4 tatB ML1079 Sec-independent protein translocase protein TatB 120 0.01544 non-essential 0.1376 non-essential high NA high_confidence_nonessential NP_215740.1 74.8 0.5641828428303068 59.298 Moderate candidate ESM-2 calibrated P(essential)=0.015; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.564; target-priority score=59.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000221 non-essential Non-essential ML1080 1195 P53382 mrp ML1080 Iron-sulfur cluster carrier protein 383 0.12585 non-essential 0.12608 non-essential high NA high_confidence_nonessential NP_215745.1 82.1 0.026299311208515967 46.881 Exploratory ESM-2 calibrated P(essential)=0.126; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.026; target-priority score=46.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.333624 essential Uncertain ML1086 265 Q9CCA3 ML1086 Probable solute-binding transport lipoprotein 468 0.06981 non-essential 0.23019 non-essential high NA medium_confidence NP_215751.1 77.8 0.8190356919223544 73.0 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.819; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.819); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000824 non-essential Non-essential ML1087 1518 Q9CCA2 ML1087 Probable ABC-transport protein, inner membrane component 304 0.03731 non-essential 0.07812 non-essential high NA high_confidence_nonessential NP_215752.1 81.8 0.14715090795241076 47.992 Exploratory ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.147; target-priority score=48.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001006 non-essential Non-essential ML1088 834 Q9CCA1 ML1088 Trehalose transport system permease protein SugB 287 0.03466 non-essential 0.16495 non-essential high NA high_confidence_nonessential NP_215753.1 89.7 0.6211646837820914 64.638 Moderate candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.621; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001884 non-essential Non-essential ML1089 229 Q7AQ92 ML1089 Trehalose import ATP-binding protein SugC (Nucleotide-binding domain of SugABC transporter) (SugABC transporter ATPase SugC) 392 0.19217 non-essential 0.23579 non-essential high NA medium_confidence NP_215754.1 79.9 0.33500313087038197 57.89 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.335; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4.5e-05 non-essential Non-essential ML1090 1377 Q9CCA0 corA ML1090 Magnesium transport protein CorA 369 0.02518 non-essential 0.10393 non-essential high NA high_confidence_nonessential NP_215755.1 79.4 0.32811521603005633 57.032 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.328; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000286 non-essential Non-essential ML1091 829 P50917 mdh ML1091 Malate dehydrogenase (EC 1.1.1.37) 329 0.14132 non-essential 0.16568 non-essential high NA high_confidence_nonessential NP_215756.1 89.4 0.14902943018159048 60.226 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.149; target-priority score=60.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.040769 non-essential Non-essential ML1093 662 Q9CC99 ML1093 Lipoprotein 285 0.0949 non-essential 0.18575 non-essential high NA high_confidence_nonessential NP_215760.1 73.5 0.47839699436443334 60.799 Moderate candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.478; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000696 non-essential Non-essential ML1094 967 Q9CC98 ML1094 Short chain alcohol dehydrogenase 277 0.07126 non-essential 0.14804 non-essential high NA high_confidence_nonessential NP_215761.1 78.7 0.3713212273011897 58.674 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.371; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.4e-05 non-essential Non-essential ML1095 1267 Q9CC97 kgd ML1095 Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)] 1238 0.10115 non-essential 0.11749 non-essential high NA high_confidence_nonessential NP_215764.2 90.5 0.059486537257357544 56.974 Moderate candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.059; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.100193 non-essential Non-essential ML1096 715 Q9CC96 ML1096 Membrane protein 224 0.03604 non-essential 0.1802 non-essential high NA high_confidence_nonessential NP_215765.1 66.8 0.7031934877896056 65.099 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.703; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.1) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML1098 1507 Q9CC95 ML1098 AAA+ ATPase domain-containing protein 1152 0.03424 non-essential 0.07936 non-essential high agree high_confidence_nonessential Rv1251c 75.5 NE 0 0.3168440826549781 54.265 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.079; Mtb RBH anchor Rv1251c=non-essential (agree); ProteomeLM contextual percentile=0.317; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003672 non-essential Non-essential ML1099 1117 Q9CC94 lprE ML1099 Putative lipoprotein LprE 202 0.00543 non-essential 0.13295 non-essential high NA high_confidence_nonessential NP_215768.1 64.0 0.5754539762053851 61.775 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.575; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000204 non-essential Non-essential ML1101 897 Q9CC93 ML1101 Possible acyltransferase 379 0.03924 non-essential 0.1566 non-essential high NA high_confidence_nonessential NP_215770.1 79.4 0.5504070131496556 64.86 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.550; target-priority score=64.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.122424 non-essential Non-essential ML1103 1381 Q9CC92 ML1103 Possible oxidoreductase subunit 453 0.09526 non-essential 0.10307 non-essential high NA high_confidence_nonessential NP_215773.1 85.8 0.030682529743268627 47.096 Exploratory ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.031; target-priority score=47.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005183 non-essential Non-essential ML1105 629 Q9CC91 udgB ML1105 Type-5 uracil-DNA glycosylase (EC 3.2.2.-) 229 0.06371 non-essential 0.18931 non-essential high NA high_confidence_nonessential NP_215775.1 85.5 0.606762680025047 72.927 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.607; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000116 non-essential Non-essential ML1106 194 Q9CC90 ML1106 Uncharacterized protein 113 0.05502 non-essential 0.24572 non-essential high NA medium_confidence 0.9705698184095178 75.61 Strong candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.246; ProteomeLM contextual percentile=0.971; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.971); Target-priority score is high (75.6) rescued_from_possible_false_negative_by_supporting_evidence 2.4e-05 non-essential Non-essential ML1113 567 Q9CC89 ML1113 Fatty acid ABC transporter ATP-binding/permease protein 629 0.09638 non-essential 0.19488 non-essential high NA high_confidence_nonessential NP_215788.1 75.3 0.5253600500939261 60.787 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.525; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6e-06 non-essential Non-essential ML1114 501 Q9CC88 ML1114 Probable ABC transporter protein, ATP-binding component 584 0.09677 non-essential 0.20259 non-essential high NA medium_confidence NP_215789.1 77.8 0.5635566687539136 62.61 Moderate candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.564; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3e-05 non-essential Non-essential ML1115 695 Q9CC87 lprB ML1115 Putative lipoprotein LprB 188 0.00198 non-essential 0.18266 non-essential high NA high_confidence_nonessential NP_215790.1 78.7 0.8515967438948028 72.69 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.852; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.852); Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 5.6e-05 non-essential Non-essential ML1116 961 Q9CC86 ML1116 Lipoprotein 187 0.03424 non-essential 0.14846 non-essential high NA high_confidence_nonessential NP_215791.1 82.7 0.5403882279273639 59.767 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.540; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001363 non-essential Non-essential ML1117 1578 Q9CC85 ML1117 Uncharacterized protein ML1117 (EC 3.1.3.-) 161 0.00502 non-essential 0.05926 non-essential high agree high_confidence_nonessential Rv1276c 65.4 NE 0 0.26988102692548527 58.524 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.059; Mtb RBH anchor Rv1276c=non-essential (agree); ProteomeLM contextual percentile=0.270; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 5e-06 non-essential Non-essential ML1119 1362 Q9CC84 ML1119 Nuclease SbcCD subunit D 383 0.09148 non-essential 0.10562 non-essential high agree high_confidence_nonessential Rv1277 82.0 NE 0 0.24358171571696932 52.746 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.106; Mtb RBH anchor Rv1277=non-essential (agree); ProteomeLM contextual percentile=0.244; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7.6e-05 non-essential Non-essential ML1120 1504 Q9CC83 ML1120 Endonuclease GajA/Old nuclease/RecF-like AAA domain-containing protein 873 0.03424 non-essential 0.08009 non-essential high agree high_confidence_nonessential Rv1278 68.0 NE 0 0.33312460864120225 52.464 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.080; Mtb RBH anchor Rv1278=non-essential (agree); ProteomeLM contextual percentile=0.333; target-priority score=52.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 8.5e-05 non-essential Non-essential ML1121 1416 Q9CC82 ML1121 Probable extracellular solute-binding dependent transport lipoprotein 557 0.03769 non-essential 0.09875 non-essential high NA high_confidence_nonessential NP_215796.1 80.3 0.2517219787100814 53.125 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.099; ProteomeLM contextual percentile=0.252; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000301 non-essential Non-essential ML1122 429 Q9CC81 ML1122 Oligopeptide transport ATP-binding protein OppD (EC 7.4.2.6) 609 0.14132 non-essential 0.2097 non-essential high NA medium_confidence NP_215797.1 84.3 0.3938634940513463 65.022 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.394; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.0) rescued_from_possible_false_negative_by_supporting_evidence 6e-06 non-essential Non-essential ML1123 1576 Q9CC80 ML1123 Oligopeptide transport system permease protein OppC 299 0.00543 non-essential 0.05973 non-essential high NA high_confidence_nonessential NP_215798.1 82.6 0.1797119599248591 49.89 Exploratory ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.060; ProteomeLM contextual percentile=0.180; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.2e-05 non-essential Non-essential ML1124 798 Q9CC79 ML1124 Probable binding-protein dependent transport protein 325 0.01889 non-essential 0.16999 non-essential high NA high_confidence_nonessential NP_215799.1 83.4 0.7113337507827175 68.66 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.711; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML1127 1317 P45840 argS ML1127 Arginine--tRNA ligase (EC 6.1.1.19) (Arginyl-tRNA synthetase) (ArgRS) 550 0.06371 non-essential 0.11208 non-essential high NA high_confidence_nonessential NP_215808.1 85.1 0.19098309329993737 59.837 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.191; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.082985 non-essential Non-essential ML1128 956 Q50140 lysA ML1128 Diaminopimelate decarboxylase (DAP decarboxylase) (DAPDC) (EC 4.1.1.20) 472 0.03424 non-essential 0.14916 non-essential high NA high_confidence_nonessential NP_215809.1 86.8 0.5015654351909831 74.382 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.502; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 0.307947 non-essential Uncertain ML1129 1095 P46806 hom ML1129 Homoserine dehydrogenase (HDH) (HSD) (EC 1.1.1.3) 441 0.12098 non-essential 0.1345 non-essential high NA high_confidence_nonessential NP_215810.1 89.1 0.06011271133375078 59.823 Moderate candidate ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.060; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.625626 essential Likely essential ML1130 139 P45837 thrC ML1130 Threonine synthase (TS) (EC 4.2.3.1) 360 0.13353 non-essential 0.26297 non-essential high NA medium_confidence NP_215811.1 93.9 0.6950532247964935 81.326 High-priority ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.263; ProteomeLM contextual percentile=0.695; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.3) rescued_from_possible_false_negative_by_supporting_evidence 0.090861 non-essential Non-essential ML1131 1563 P45836 thrB ML1131 Homoserine kinase (HK) (HSK) (EC 2.7.1.39) 315 0.03424 non-essential 0.06467 non-essential high NA high_confidence_nonessential NP_215812.1 82.0 0.050093926111458985 58.901 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.065; ProteomeLM contextual percentile=0.050; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.066367 non-essential Non-essential ML1132 687 P45835 rho ML1132 Transcription termination factor Rho (EC 3.6.4.-) (ATP-dependent helicase Rho) 610 0.19217 non-essential 0.18342 non-essential high NA high_confidence_nonessential NP_215813.1 80.5 0.047589229805886035 50.865 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.048; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.843692 essential Essential ML1133 185 P45834 rpmE ML1133 Large ribosomal subunit protein bL31 (50S ribosomal protein L31) 84 0.08115 non-essential 0.24756 non-essential high NA medium_confidence NP_215814.1 89.6 0.8603631809643081 76.006 Strong candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.860; target-priority score=76.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.860); Target-priority score is high (76.0) rescued_from_possible_false_negative_by_supporting_evidence 0.002039 non-essential Non-essential ML1134 939 P45833 prfA ML1134 Peptide chain release factor 1 (RF-1) 361 0.03424 non-essential 0.15151 non-essential high NA high_confidence_nonessential NP_215815.1 89.4 0.5485284909204758 63.1 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.549; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.387064 essential Uncertain ML1135 610 P45832 prmC hemK ML1135 Release factor glutamine methyltransferase (RF MTase) (EC 2.1.1.297) (M.MleHemKP) (N5-glutamine methyltransferase PrmC) (Protein-(glutamine-N5) MTase PrmC) (Protein-glutamine N-methyltransferase PrmC) 288 0.04552 non-essential 0.19111 non-essential high NA high_confidence_nonessential NP_215816.1 74.5 0.6856606136505948 78.085 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.686; target-priority score=78.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.1) rescued_from_possible_false_negative_by_supporting_evidence 0.203834 non-essential Uncertain ML1136 1251 P45831 ML1136 Putative threonylcarbamoyl-AMP synthase (TC-AMP synthase) (EC 2.7.7.87) (L-threonylcarbamoyladenylate synthase) (tRNA threonylcarbamoyladenosine biosynthesis protein ML1136) 220 0.04552 non-essential 0.1195 non-essential high NA high_confidence_nonessential NP_215817.1 83.3 0.30807764558547274 63.24 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.308; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.102503 non-essential Non-essential ML1137 487 P45830 wecA rfe ML1137 Decaprenyl-phosphate N-acetylglucosaminephosphotransferase (EC 2.7.8.35) (Decaprenyl-phosphate GlcNAc-1-phosphate transferase) (Decaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase) (UDP-GlcNAc:decaprenyl-phosphate GlcNAc-1-phosphate transferase) (UDP-N-acetylglucosamine--decaprenyl-phosphate N-acetylglucosaminephosphotransferase) 398 0.0949 non-essential 0.20364 non-essential high NA medium_confidence NP_215818.1 89.4 0.5460237946149029 73.589 Strong candidate ESM-2 calibrated P(essential)=0.095; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.546; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.055607 non-essential Non-essential ML1138 1280 P53431 ML1138 u471d Uncharacterized protein ML1138 153 0.06766 non-essential 0.11491 non-essential high agree high_confidence_nonessential Rv1303 69.7 NE 0 0.45209768315591736 58.205 Moderate candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv1303=non-essential (agree); ProteomeLM contextual percentile=0.452; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001145 non-essential Non-essential ML1139 1029 P45829 atpB ML1139 ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6) 251 0.00198 non-essential 0.14123 non-essential high NA high_confidence_nonessential NP_215820.1 84.0 0.6249217282404509 66.889 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.625; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.9) rescued_from_possible_false_negative_by_supporting_evidence 0.007331 non-essential Non-essential ML1140 520 P45828 atpE ML1140 ATP synthase subunit c (ATP synthase F(0) sector subunit c) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein) 81 0.05628 non-essential 0.20012 non-essential high NA medium_confidence NP_215821.1 92.6 0.7119599248591109 70.381 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.200; ProteomeLM contextual percentile=0.712; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.4) rescued_from_possible_false_negative_by_supporting_evidence 0.002636 non-essential Non-essential ML1141 138 P45827 atpF ML1141 ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b) 170 0.11857 non-essential 0.2637 non-essential high NA medium_confidence NP_215822.1 79.5 0.8002504696305573 70.334 Strong candidate ESM-2 calibrated P(essential)=0.119; HANSEN integrated essentiality score=0.264; ProteomeLM contextual percentile=0.800; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.800); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 8.1e-05 non-essential Non-essential ML1142 503 P53006 atpFH atpF atpH ML1142 ATP synthase subunit b-delta [Includes: ATP synthase subunit b (ATP synthase F(0) sector subunit b 2) (ATPase subunit I 2) (F-type ATPase subunit b 2) (F-ATPase subunit b 2); ATP synthase subunit delta (ATP synthase F(1) sector subunit delta) (F-type ATPase subunit delta) (F-ATPase subunit delta)] 446 0.14132 non-essential 0.20235 non-essential high NA medium_confidence NP_215823.1 71.7 0.3725735754539762 57.571 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.373; target-priority score=57.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7.7e-05 non-essential Non-essential ML1143 280 P45825 atpA ML1143 ATP synthase subunit alpha (EC 7.1.2.2) (ATP synthase F1 sector subunit alpha) (F-ATPase subunit alpha) 558 0.23815 non-essential 0.2281 non-essential medium NA medium_confidence NP_215824.1 90.3 0.08140262993112085 57.009 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.081; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.735771 essential Essential ML1144 77 P45824 atpG ML1144 ATP synthase gamma chain (ATP synthase F1 sector gamma subunit) (F-ATPase gamma subunit) 298 0.38101 non-essential 0.32274 non-essential medium NA medium_confidence NP_215825.1 83.9 0.013149655604257984 46.644 Exploratory ESM-2 calibrated P(essential)=0.381; HANSEN integrated essentiality score=0.323; ProteomeLM contextual percentile=0.013; target-priority score=46.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.847813 essential Essential ML1145 70 P45823 atpD ML1145 ATP synthase subunit beta (EC 7.1.2.2) (ATP synthase F1 sector subunit beta) (F-ATPase subunit beta) 485 0.37988 non-essential 0.33887 non-essential medium NA medium_confidence NP_215826.1 94.1 0.08265497808390733 57.038 Moderate candidate ESM-2 calibrated P(essential)=0.380; HANSEN integrated essentiality score=0.339; ProteomeLM contextual percentile=0.083; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.901306 essential Essential ML1146 866 P45822 atpC ML1146 ATP synthase epsilon chain (ATP synthase F1 sector epsilon subunit) (F-ATPase epsilon subunit) 121 0.06652 non-essential 0.16108 non-essential high NA high_confidence_nonessential NP_215827.1 87.6 0.4571070757670632 62.965 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.457; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005967 non-essential Non-essential ML1147 851 P53432 ML1147 u471b Uncharacterized protein ML1147 147 0.08377 non-essential 0.16295 non-essential high agree high_confidence_nonessential Rv1312 88.4 NE 0 0.7752035065748278 70.338 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.163; Mtb RBH anchor Rv1312=non-essential (agree); ProteomeLM contextual percentile=0.775; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.775); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 0.001025 non-essential Non-essential ML1148 512 Q7AQ91 ML1148 Doubtful CDS 51 0.00674 non-essential 0.20143 non-essential high NA medium_confidence 0.9430181590482154 71.713 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.943; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.943); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 2.1e-05 non-essential Non-essential ML1149 1431 P53523 ML1149 u471a Corrinoid adenosyltransferase (EC 2.5.1.17) (Cob(II)alamin adenosyltransferase) (Cob(II)yrinic acid a,c-diamide adenosyltransferase) (Cobinamide/cobalamin adenosyltransferase) 191 0.02105 non-essential 0.09391 non-essential high NA high_confidence_nonessential NP_215830.1 81.2 0.2598622417031935 66.619 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.094; ProteomeLM contextual percentile=0.260; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.030128 non-essential Non-essential ML1150 989 P45821 murA murZ ML1150 UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) (Enoylpyruvate transferase) (UDP-N-acetylglucosamine enolpyruvyl transferase) (EPT) 418 0.13685 non-essential 0.14513 non-essential high NA high_confidence_nonessential NP_215831.1 96.2 0.042579837194740136 62.294 Moderate candidate ESM-2 calibrated P(essential)=0.137; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.043; target-priority score=62.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.995759 essential Essential ML1151 876 P52982 ogt ML1151 Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase) 165 0.05192 non-essential 0.16013 non-essential high NA high_confidence_nonessential NP_215832.1 78.2 0.49530369442705074 70.861 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.495; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000219 non-essential Non-essential ML1155 1075 P53524 nucS ML1155 B1549_C3_223 Endonuclease NucS (EC 3.1.-.-) 220 0.07126 non-essential 0.1367 non-essential high NA high_confidence_nonessential NP_215837.1 87.7 0.30494677520350655 58.551 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.305; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00084 non-essential Non-essential ML1157 1113 Q7AQ90 ML1157 VOC domain-containing protein 155 0.03604 non-essential 0.13323 non-essential high agree high_confidence_nonessential Rv1322A 75.3 NE 0 0.7620538509705698 70.806 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv1322A=non-essential (agree); ProteomeLM contextual percentile=0.762; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.762); Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000242 non-essential Non-essential ML1158 812 P46707 fadA4 ML1158 B1549_C1_166 Probable acetyl-CoA acetyltransferase (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) 393 0.09148 non-essential 0.1687 non-essential high NA high_confidence_nonessential NP_215839.1 86.9 0.3744520976831559 67.365 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.374; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.4) rescued_from_possible_false_negative_by_supporting_evidence 0.077062 non-essential Non-essential ML1159 1408 Q9CC76 ML1159 Thioredoxin domain-containing protein 301 0.02734 non-essential 0.1002 non-essential high NA high_confidence_nonessential NP_215840.1 67.8 0.3068252974326863 53.421 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.307; target-priority score=53.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003189 non-essential Non-essential ML1165 528 P53423 clpS ML1165 B1549_C2_207 ATP-dependent Clp protease adapter protein ClpS 108 0.07502 non-essential 0.19879 non-essential high NA high_confidence_nonessential NP_215847.1 84.2 0.6324358171571697 65.524 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.632; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.5) rescued_from_possible_false_negative_by_supporting_evidence 0.019916 non-essential Non-essential ML1166 471 P53424 aosR ML1166 B1549_C3_236 Putative oxidative stress regulator AosR 217 0.03604 non-essential 0.20503 non-essential high NA medium_confidence NP_215848.1 75.1 0.8303068252974327 71.539 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.830; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.830); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000101 non-essential Non-essential ML1167 732 P53425 ML1167 B1549_C2_208 Uncharacterized aminopeptidase ML1167 (EC 3.4.11.-) 362 0.07935 non-essential 0.17858 non-essential high NA high_confidence_nonessential NP_215849.1 76.1 0.49217282404508456 66.045 Strong candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.492; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 0.01575 non-essential Non-essential ML1171 835 P53426 ML1171 B1549_C3_240 Uncharacterized protein ML1171 251 0.00432 non-essential 0.1647 non-essential high NA high_confidence_nonessential NP_215853.1 73.9 0.7470256731371321 68.674 Strong candidate ESM-2 calibrated P(essential)=0.004; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.747; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 2.5e-05 non-essential Non-essential ML1172 823 P46705 murI ML1172 B1549_C2_210 Glutamate racemase (EC 5.1.1.3) 272 0.09625 non-essential 0.16636 non-essential high NA high_confidence_nonessential NP_215854.1 88.9 0.3287413901064496 70.804 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.329; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.212151 non-essential Uncertain ML1173 1122 P50474 ML1173 B1549_C2_211 Uncharacterized protein ML1173 284 0.01761 non-essential 0.13211 non-essential high agree high_confidence_nonessential Rv1339 87.3 NE 0 0.8434564809016907 74.399 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv1339=non-essential (agree); ProteomeLM contextual percentile=0.843; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.843); Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 0.004224 non-essential Non-essential ML1174 1144 P37939 rph rnpH rphA ML1174 B1549_C1_182 Ribonuclease PH (RNase PH) (EC 2.7.7.56) (tRNA nucleotidyltransferase) 259 0.08245 non-essential 0.13006 non-essential high NA high_confidence_nonessential NP_215856.1 89.2 0.20726361928616155 61.039 Moderate candidate ESM-2 calibrated P(essential)=0.082; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.207; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00729 non-essential Non-essential ML1175 934 P52063 ML1175 B1549_C2_213 MLCB1701.01 dITP/XTP pyrophosphatase (EC 3.6.1.66) (Non-canonical purine NTP pyrophosphatase) (Non-standard purine NTP pyrophosphatase) (Nucleoside-triphosphate diphosphatase) (Nucleoside-triphosphate pyrophosphatase) (NTPase) 208 0.02734 non-essential 0.1523 non-essential high NA high_confidence_nonessential NP_215857.1 82.9 0.5566687539135879 72.679 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.557; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.404545 essential Likely essential ML1176 16 P54133 ML1176 B1549_F2_59 MLCB1701.02c Uncharacterized protein ML1176 119 0.19663 non-essential 0.48435 non-essential low disagree review_anchor_disagreement Rv1342c 68.3 GD 1 0.8102692548528491 70.698 Strong candidate ESM-2 calibrated P(essential)=0.197; HANSEN integrated essentiality score=0.484; Mtb RBH anchor Rv1342c=essential (disagree); ProteomeLM contextual percentile=0.810; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 6.6e-05 non-essential Non-essential ML1177 1141 P54134 lprD ML1177 B1549_F3_106 MLCB1701.03c Putative lipoprotein LprD 126 0.01172 non-essential 0.13041 non-essential high NA high_confidence_nonessential NP_215859.1 79.2 0.5378835316217908 59.668 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.538; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000187 non-essential Non-essential ML1180 17 proteomelm_only NA proteomelm_only 0.8922980588603632 ProteomeLM-only row imported from proteomelm_ess_predictions; integrated HANSEN essentiality score not available. proteomelm_ess_sync_20260626 2026-06-23T05:39:18Z Uncertain ProteomeLM-only row; integrated HANSEN evidence not available. none 0.002689 non-essential Non-essential ML1181 17 proteomelm_only NA proteomelm_only 0.8929242329367564 ProteomeLM-only row imported from proteomelm_ess_predictions; integrated HANSEN essentiality score not available. proteomelm_ess_sync_20260626 2026-06-23T05:39:18Z Uncertain ProteomeLM-only row; integrated HANSEN evidence not available. none 0.000165 non-essential Non-essential ML1182 669 Q7AQ89 ML1182 PPE-family protein 421 0.0 non-essential 0.18508 non-essential high NA high_confidence_nonessential YP_177801.1 39.9 0.8804007514088916 70.825 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.880; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.880); Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000272 non-essential Non-essential ML1183 17 proteomelm_only NA proteomelm_only 0.8941765810895429 ProteomeLM-only row imported from proteomelm_ess_predictions; integrated HANSEN essentiality score not available. proteomelm_ess_sync_20260626 2026-06-23T05:39:18Z Uncertain ProteomeLM-only row; integrated HANSEN evidence not available. none 0.000345 non-essential Non-essential ML1186 445 Q9CC71 ML1186 Uncharacterized protein 100 0.01005 non-essential 0.20823 non-essential high NA medium_confidence 0.9724483406386976 70.138 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.972; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.972); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML1188 410 Q9CC70 ML1188 HTH gntR-type domain-containing protein 86 0.01544 non-essential 0.21126 non-essential high NA medium_confidence 0.9536631183469004 74.182 Strong candidate ESM-2 calibrated P(essential)=0.015; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.954; target-priority score=74.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.954); Target-priority score is high (74.2) rescued_from_possible_false_negative_by_supporting_evidence 1.3e-05 non-essential Non-essential ML1189 258 Q7AQ87 ML1189 Uncharacterized protein 127 0.03486 non-essential 0.23127 non-essential high NA medium_confidence 0.9780839073262367 75.61 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.978; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.978); Target-priority score is high (75.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000461 non-essential Non-essential ML1190 1413 Q7AQ86 ML1190 Rv2525c-like glycoside hydrolase-like domain-containing protein 239 0.04041 non-essential 0.09925 non-essential high agree high_confidence_nonessential Rv2525c 82.2 NE 0 ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.099; Mtb RBH anchor Rv2525c=non-essential (agree); ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.001276 non-essential Non-essential ML1191 437 Q7AQ85 fas ML1191 Fatty acid synthase 3076 0.12712 non-essential 0.20915 non-essential high NA medium_confidence NP_217040.1 85.2 ESM-2 calibrated P(essential)=0.127; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.05128 non-essential Non-essential ML1192 1535 Q9X7E3 acpS ML1192 MLCB458.07 Holo-[acyl-carrier-protein] synthase (Holo-ACP synthase) (EC 2.7.8.7) (4'-phosphopantetheinyl transferase AcpS) 130 0.02105 non-essential 0.07411 non-essential high NA high_confidence_nonessential NP_217039.1 87.5 0.1659361302442079 58.957 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.074; ProteomeLM contextual percentile=0.166; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003935 non-essential Non-essential ML1193 1423 Q7AQ84 ML1193 Peptidase M20 dimerisation domain-containing protein 442 0.03424 non-essential 0.09554 non-essential high agree high_confidence_nonessential Rv2522c 86.4 NE 0 ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.096; Mtb RBH anchor Rv2522c=non-essential (agree); ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.002286 non-essential Non-essential ML1195 918 Q9X7E5 ileS ML1195 MLCB458.10 Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) 1059 0.05604 non-essential 0.15371 non-essential high NA high_confidence_nonessential NP_216052.1 84.4 ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.035801 non-essential Non-essential ML1198 986 Q9X7E6 ansA ML1198 MLCB458.13c L-asparaginase (L-ASNase) (EC 3.5.1.1) (L-asparagine amidohydrolase) 310 0.04964 non-essential 0.14615 non-essential high NA high_confidence_nonessential NP_216054.1 72.1 0.4289292423293676 69.031 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.429; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000326 non-essential Non-essential ML1199 135 Q9X7E7 lspA ML1199 MLCB458.14 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) 201 0.10418 non-essential 0.26585 non-essential high NA medium_confidence NP_216055.1 82.2 0.8346900438321854 85.386 High-priority ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.835; target-priority score=85.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.835); Target-priority score is high (85.4) rescued_from_possible_false_negative_by_supporting_evidence 0.41713 essential Likely essential ML1200 1450 Q7AQ83 ML1200 Pseudouridine synthase (EC 5.4.99.-) 308 0.07126 non-essential 0.09152 non-essential high NA high_confidence_nonessential NP_216056.1 89.3 0.049467752035065746 55.062 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.049; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.525619 essential Likely essential ML1207 784 Q9X7F0 dnaE ML1207 MLCB458.21 DNA polymerase III subunit alpha (EC 2.7.7.7) 1177 0.08883 non-essential 0.17168 non-essential high NA high_confidence_nonessential NP_216063.1 91.2 0.4076393237319975 66.176 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.408; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.017704 non-essential Non-essential ML1209 441 Q9X7F1 ilvA ML1209 L-threonine dehydratase biosynthetic IlvA (EC 4.3.1.19) (Threonine deaminase) 427 0.14132 non-essential 0.20895 non-essential high NA medium_confidence NP_216075.1 87.4 0.37507827175954916 69.921 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.375; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 0.070626 non-essential Non-essential ML1210 389 Q9CC69 ML1210 Uncharacterized protein 61 0.01709 non-essential 0.21377 non-essential high NA medium_confidence 0.9668127739511584 72.177 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.967; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.967); Target-priority score is high (72.2) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML1213 1114 Q9CC68 ML1213 Conserved membrane protein 733 0.04011 non-essential 0.13305 non-essential high agree high_confidence_nonessential Rv1565c 76.5 NE 0 0.7357545397620538 70.821 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv1565c=non-essential (agree); ProteomeLM contextual percentile=0.736; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.054917 non-essential Non-essential ML1214 883 Q9CC67 ML1214 Secreted p60-family protein 212 0.09148 non-essential 0.15873 non-essential high agree high_confidence_nonessential Rv1566c 75.4 GA 0 0.7038196618659988 66.908 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.159; Mtb RBH anchor Rv1566c=non-essential (agree); ProteomeLM contextual percentile=0.704; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.9) rescued_from_possible_false_negative_by_supporting_evidence 0.015414 non-essential Non-essential ML1216 1059 P45488 bioA ML1216 B1170_C2_195 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase (EC 2.6.1.62) (7,8-diamino-pelargonic acid aminotransferase) (DAPA AT) (DAPA aminotransferase) (7,8-diaminononanoate synthase) (DANS) (Diaminopelargonic acid synthase) 436 0.06981 non-essential 0.13803 non-essential high NA high_confidence_nonessential NP_216084.1 85.1 0.2905447714464621 68.372 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.291; target-priority score=68.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.4) rescued_from_possible_false_negative_by_supporting_evidence 0.01661 non-essential Non-essential ML1217 1370 P45487 ML1217 B1170_C2_196 8-amino-7-oxononanoate synthase (AONS) (EC 2.3.1.47) (7-keto-8-amino-pelargonic acid synthase) (7-KAP synthase) (KAPA synthase) (8-amino-7-ketopelargonate synthase) (Alpha-oxoamine synthase) 385 0.04816 non-essential 0.10465 non-essential high NA high_confidence_nonessential YP_177822.1 80.1 0.2028804007514089 65.18 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.203; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.02001 non-essential Non-essential ML1218 935 P45486 bioD ML1218 B1170_C1_159 ATP-dependent dethiobiotin synthetase BioD (EC 6.3.3.3) (DTB synthetase) (DTBS) (Dethiobiotin synthase) 226 0.02518 non-essential 0.15212 non-essential high NA high_confidence_nonessential NP_216086.1 74.7 0.5510331872260489 77.609 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.551; target-priority score=77.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.6) rescued_from_possible_false_negative_by_supporting_evidence 0.009988 non-essential Non-essential ML1220 1414 P46715 bioB ML1220 B1170_C3_228 Biotin synthase (EC 2.8.1.6) 345 0.06307 non-essential 0.09913 non-essential high NA high_confidence_nonessential NP_216105.1 87.1 0.11271133375078271 61.545 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.099; ProteomeLM contextual percentile=0.113; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002321 non-essential Non-essential ML1221 969 Q49616 bsaP ML1221 B1170_C1_162 Biotin synthase auxiliary protein 80 0.08711 non-essential 0.14792 non-essential high agree high_confidence_nonessential Rv1590 67.1 NE 0 0.6274264245460238 65.834 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.148; Mtb RBH anchor Rv1590=non-essential (agree); ProteomeLM contextual percentile=0.627; target-priority score=65.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.8) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML1222 1092 Q49626 ML1222 B1170_C3_229 Uncharacterized protein ML1222 198 0.00543 non-essential 0.13499 non-essential high NA high_confidence_nonessential NP_216107.1 66.3 0.5817157169693175 63.725 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.582; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000897 non-essential Non-essential ML1224 1527 Q9CC66 ML1224 Nudix hydrolase domain-containing protein 239 0.03949 non-essential 0.07677 non-essential high agree high_confidence_nonessential Rv1593c 85.7 NE 0 0.2654978083907326 53.048 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.077; Mtb RBH anchor Rv1593c=non-essential (agree); ProteomeLM contextual percentile=0.265; target-priority score=53.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.029446 non-essential Non-essential ML1225 227 Q49622 nadA ML1225 B1170_C2_201 Quinolinate synthase (EC 2.5.1.72) 352 0.14132 non-essential 0.23652 non-essential high NA medium_confidence NP_216110.1 84.7 0.5172197871008141 76.736 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.517; target-priority score=76.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.7) rescued_from_possible_false_negative_by_supporting_evidence 0.151424 non-essential Non-essential ML1226 1004 Q49617 nadB ML1226 B1170_C1_167 L-aspartate oxidase (LASPO) (EC 1.4.3.16) (Quinolinate synthase B) 526 0.07497 non-essential 0.14405 non-essential high NA high_confidence_nonessential NP_216111.1 76.7 0.2999373825923607 69.161 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.300; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.146347 non-essential Non-essential ML1227 1313 P46714 nadC ML1227 B1170_C1_168 Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC 2.4.2.19) (Quinolinate phosphoribosyltransferase [decarboxylating]) (QAPRTase) 284 0.06981 non-essential 0.11246 non-essential high NA high_confidence_nonessential NP_216112.1 79.2 0.15216030056355667 64.276 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.152; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.389655 essential Uncertain ML1229 663 Q49624 pks3 ML1229 Mycocerosic acid synthase (Polyketide synthase) 2118 0.03604 non-essential 0.18566 non-essential high NA high_confidence_nonessential NP_216043.1 64.8 0.7163431433938635 71.537 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.716; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000183 non-essential Non-essential ML1230 1457 Q49618 papA3 ML1230 Condensation domain-containing protein 471 0.03604 non-essential 0.0911 non-essential high NA high_confidence_nonessential NP_215698.1 75.6 0.21728240450845335 52.106 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.217; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3.2e-05 non-essential Non-essential ML1231 1575 Q49619 mmpL10 tp1 ML1231 B1170_C1_181 Probable transport protein MmpL10 1008 0.02862 non-essential 0.06001 non-essential high NA high_confidence_nonessential NP_215699.1 68.4 0.08515967438948027 46.411 Exploratory ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.060; ProteomeLM contextual percentile=0.085; target-priority score=46.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002195 non-essential Non-essential ML1232 1038 Q9CC62 ML1232 PE-PPE domain-containing protein 358 0.04386 non-essential 0.14038 non-essential high agree high_confidence_nonessential Rv1184c 62.7 NE 0 0.7902316844082655 70.072 Strong candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.140; Mtb RBH anchor Rv1184c=non-essential (agree); ProteomeLM contextual percentile=0.790; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.790); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000563 non-essential Non-essential ML1233 736 Q49630 ML1233 Conserved membrane protein 230 0.01321 non-essential 0.17813 non-essential high NA high_confidence_nonessential NP_218338.1 45.0 0.7852222917971196 68.684 Strong candidate ESM-2 calibrated P(essential)=0.013; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.785; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.785); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 1.9e-05 non-essential Non-essential ML1234 1213 P54200 fadD21 masC ML1234 Putative fatty-acid--CoA ligase fadD21 (EC 6.2.1.-) (Acyl-CoA synthetase) 579 0.09148 non-essential 0.12426 non-essential high NA high_confidence_nonessential NP_215701.1 72.4 0.14965560425798372 54.923 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.150; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3.6e-05 non-essential Non-essential ML1241 1307 P53526 echA12 ML1241 B1170_C2_224 MLCB1610.01 Probable enoyl-CoA hydratase echA12 (EC 4.2.1.17) 294 0.01019 non-essential 0.11291 non-essential high NA high_confidence_nonessential NP_215988.1 72.0 0.42517219787100813 65.359 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.425; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.4) rescued_from_possible_false_negative_by_supporting_evidence 1.9e-05 non-essential Non-essential ML1243 263 Q9CC60 ML1243 Uncharacterized protein 153 0.03898 non-essential 0.23048 non-essential high NA medium_confidence 0.965560425798372 71.847 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.966; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.966); Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.011212 non-essential Non-essential ML1244 968 Q7AQ82 ML1244 Diacylglycerol O-acyltransferase (EC 2.3.1.20) 491 0.06981 non-essential 0.14794 non-essential high NA high_confidence_nonessential NP_217000.1 75.2 0.3537883531621791 66.697 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.354; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML1245 616 Q7AQ81 ML1245 Possible transferase 579 0.09928 non-essential 0.19062 non-essential high NA high_confidence_nonessential NP_216999.1 83.3 0.4865372573575454 60.944 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.487; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.021593 non-essential Non-essential ML1246 1031 Q9X7B0 plsB ML1246 MLCB1610.07 Glycerol-3-phosphate acyltransferase (GPAT) (EC 2.3.1.15) 775 0.1277 non-essential 0.14091 non-essential high NA high_confidence_nonessential NP_216998.1 80.8 0.07514088916718847 57.053 Moderate candidate ESM-2 calibrated P(essential)=0.128; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.075; target-priority score=57.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML1248 460 Q7AQ80 ettA ML1248 Energy-dependent translational throttle protein EttA (EC 3.6.1.-) (Translational regulatory factor EttA) 556 0.20559 non-essential 0.20659 non-essential medium NA medium_confidence NP_216993.1 92.3 0.09893550407013149 58.823 Moderate candidate ESM-2 calibrated P(essential)=0.206; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.099; target-priority score=58.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.207641 non-essential Uncertain ML1249 802 Q7AQ79 ML1249 Uncharacterized protein 1622 0.10045 non-essential 0.16951 non-essential high NA high_confidence_nonessential NP_216992.1 81.2 0.36944270507201 56.714 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.369; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002263 non-essential Non-essential ML1253 1083 Q9CC59 glbO ML1253 Group 2 truncated hemoglobin GlbO (Hemoglobin-like protein HbO) (Truncated hemoglobin) (TrHbO) 128 0.06185 non-essential 0.13565 non-essential high NA high_confidence_nonessential NP_216986.1 88.1 0.3375078271759549 60.06 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.338; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3.2e-05 non-essential Non-essential ML1254 1514 Q7AQ78 ML1254 HNH nuclease domain-containing protein 215 0.01906 non-essential 0.07833 non-essential high agree high_confidence_nonessential Rv2469c 77.7 NE 0 0.3976205385097057 54.266 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.078; Mtb RBH anchor Rv2469c=non-essential (agree); ProteomeLM contextual percentile=0.398; target-priority score=54.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 9.6e-05 non-essential Non-essential ML1255 1159 Q9CC58 ML1255 DUF5130 domain-containing protein 163 0.08883 non-essential 0.12948 non-essential high agree high_confidence_nonessential Rv2468c 81.2 NE 0 0.47401377582968063 57.551 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv2468c=non-essential (agree); ProteomeLM contextual percentile=0.474; target-priority score=57.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001796 non-essential Non-essential ML1257 1318 Q9CC57 hisD ML1257 MLCB1610.20 Histidinol dehydrogenase (HDH) (EC 1.1.1.23) 449 0.03769 non-essential 0.11199 non-essential high NA high_confidence_nonessential NP_216115.1 84.8 0.2855353788353162 68.11 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.286; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.334373 essential Uncertain ML1258 651 Q9X7B8 hisC ML1258 MLCB1610.21 Histidinol-phosphate aminotransferase (EC 2.6.1.9) (Imidazole acetol-phosphate transaminase) 377 0.19217 non-essential 0.18712 non-essential high NA high_confidence_nonessential YP_177823.1 83.6 0.053224796493425174 56.356 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.053; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.675785 essential Likely essential ML1259 783 Q9X7B9 hisB ML1259 MLCB1610.22 Imidazoleglycerol-phosphate dehydratase (IGPD) (EC 4.2.1.19) 210 0.02543 non-essential 0.17198 non-essential high NA high_confidence_nonessential NP_216117.1 85.2 0.6662492172824045 77.772 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.666; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.8) rescued_from_possible_false_negative_by_supporting_evidence 0.934089 essential Essential ML1260 1418 Q9X7C0 hisH ML1260 MLCB1610.23 Imidazole glycerol phosphate synthase subunit HisH (EC 4.3.2.10) (IGP synthase glutaminase subunit) (EC 3.5.1.2) (IGP synthase subunit HisH) (ImGP synthase subunit HisH) (IGPS subunit HisH) 206 0.04552 non-essential 0.0972 non-essential high NA high_confidence_nonessential NP_216118.1 79.1 0.1759549154664997 63.563 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.097; ProteomeLM contextual percentile=0.176; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.027922 non-essential Non-essential ML1261 345 Q9CC56 priA hisA ML1261 MLCB1610.24 Phosphoribosyl isomerase A (1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase) (EC 5.3.1.16) (N-(5'-phosphoribosyl)anthranilate isomerase) (PRAI) (EC 5.3.1.24) (Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase) 244 0.10162 non-essential 0.21888 non-essential high NA medium_confidence NP_216119.1 84.8 0.5923606762680025 77.834 Strong candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.592; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.8) rescued_from_possible_false_negative_by_supporting_evidence 0.142706 non-essential Non-essential ML1263 114 Q9X7C2 hisF ML1263 MLCB1610.26 Imidazole glycerol phosphate synthase subunit HisF (EC 4.3.2.10) (IGP synthase cyclase subunit) (IGP synthase subunit HisF) (ImGP synthase subunit HisF) (IGPS subunit HisF) 261 0.18867 non-essential 0.27499 non-essential high NA medium_confidence NP_216121.1 88.8 0.5309956167814652 75.113 Strong candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.275; ProteomeLM contextual percentile=0.531; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.296101 non-essential Uncertain ML1264 1181 Q9X7C3 hisI ML1264 MLCB1610.27 Phosphoribosyl-AMP cyclohydrolase (PRA-CH) (EC 3.5.4.19) 115 0.0299 non-essential 0.12748 non-essential high NA high_confidence_nonessential NP_216638.2 84.3 0.40513462742642453 70.57 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.405; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.134546 non-essential Non-essential ML1267 1316 Q7AQ77 ML1267 Antiporter 364 0.00543 non-essential 0.11213 non-essential high NA high_confidence_nonessential NP_216123.1 73.9 0.45835942391984974 59.956 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.112; ProteomeLM contextual percentile=0.458; target-priority score=60.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.1e-05 non-essential Non-essential ML1269 915 Q9X7C5 trpE ML1269 MLCB1610.31 Anthranilate synthase component 1 (AS) (ASI) (EC 4.1.3.27) 529 0.08883 non-essential 0.15442 non-essential high NA high_confidence_nonessential NP_216125.1 88.2 0.3030682529743269 67.216 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.303; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.2) rescued_from_possible_false_negative_by_supporting_evidence 0.413231 essential Likely essential ML1270 443 Q9CC55 ML1270 Possible conserved membrane protein 265 0.03424 non-essential 0.20862 non-essential high NA medium_confidence NP_216126.1 64.1 0.862867877269881 70.459 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.863; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.863); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 4.4e-05 non-essential Non-essential ML1271 811 Q9X7C7 trpC ML1271 MLCB1610.33 Indole-3-glycerol phosphate synthase (IGPS) (EC 4.1.1.48) 272 0.0499 non-essential 0.16878 non-essential high NA high_confidence_nonessential NP_216127.1 90.8 0.5466499686912962 73.864 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.547; target-priority score=73.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.9) rescued_from_possible_false_negative_by_supporting_evidence 0.472571 essential Likely essential ML1272 211 Q9CC54 trpB ML1272 Tryptophan synthase beta chain (EC 4.2.1.20) 417 0.09441 non-essential 0.24106 non-essential high NA medium_confidence NP_216128.1 86.7 0.7463994990607389 81.069 High-priority ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.241; ProteomeLM contextual percentile=0.746; target-priority score=81.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.1) rescued_from_possible_false_negative_by_supporting_evidence 0.226059 non-essential Uncertain ML1273 770 Q9CC53 trpA ML1273 Tryptophan synthase alpha chain (EC 4.2.1.20) 270 0.05255 non-essential 0.17361 non-essential high NA high_confidence_nonessential NP_216129.1 86.0 0.5554164057608015 76.401 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.555; target-priority score=76.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.4) rescued_from_possible_false_negative_by_supporting_evidence 0.001502 non-essential Non-essential ML1274 993 Q9CC52 lgt ML1274 Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase (EC 2.5.1.145) 330 0.03079 non-essential 0.14498 non-essential high NA high_confidence_nonessential NP_216130.1 78.7 0.4978083907326237 72.664 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.498; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.067532 non-essential Non-essential ML1275 535 Q9CC51 ML1275 Uncharacterized protein 78 0.00198 non-essential 0.19806 non-essential high NA high_confidence_nonessential 0.9480275516593613 70.705 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.948; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.948); Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 0.110051 non-essential Non-essential ML1276 1396 Q9CC50 ML1276 Conserved membrane protein 146 0.01709 non-essential 0.10187 non-essential high agree high_confidence_nonessential Rv1616 66.7 NE 0 0.6011271133375078 63.018 Moderate candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.102; Mtb RBH anchor Rv1616=non-essential (agree); ProteomeLM contextual percentile=0.601; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.054997 non-essential Non-essential ML1277 613 Q9CC49 pykA ML1277 Pyruvate kinase (EC 2.7.1.40) 472 0.19217 non-essential 0.19092 non-essential high NA high_confidence_nonessential NP_216133.1 90.9 0.07263619286161553 57.353 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.073; target-priority score=57.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.273776 non-essential Uncertain ML1278 977 Q9CC48 tesB ML1278 Acyl CoA thioesterase II 297 0.01172 non-essential 0.14681 non-essential high NA high_confidence_nonessential NP_216134.1 85.1 0.6117720726361928 67.345 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.612; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.3) rescued_from_possible_false_negative_by_supporting_evidence 3.6e-05 non-essential Non-essential ML1286 277 Q9CC47 ML1286 Transcriptional regulatory protein PdtaR 205 0.12863 non-essential 0.229 non-essential high NA medium_confidence NP_216142.1 90.7 0.569818409517846 63.598 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.570; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000345 non-essential Non-essential ML1288 1354 Q9CC46 ML1288 Possible peptidase 467 0.06307 non-essential 0.10677 non-essential high agree high_confidence_nonessential Rv2141c 84.3 NE 0 0.3919849718221666 59.465 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.107; Mtb RBH anchor Rv2141c=non-essential (agree); ProteomeLM contextual percentile=0.392; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.4e-05 non-essential Non-essential ML1289 1496 Q9CC45 ML1289 Uncharacterized protein 176 0.00198 non-essential 0.08178 non-essential high agree high_confidence_nonessential Rv2140c 86.3 NE 0 0.5028177833437696 60.621 Moderate candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.082; Mtb RBH anchor Rv2140c=non-essential (agree); ProteomeLM contextual percentile=0.503; target-priority score=60.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.0 non-essential Non-essential ML1292 172 Q7AQ76 ML1292 Uncharacterized protein 80 0.06963 non-essential 0.25114 non-essential high NA medium_confidence 0.9511584220413275 70.267 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.951; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.951); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML1293 1386 P46727 pyrD ML1293 B2126_F3_143 Dihydroorotate dehydrogenase (quinone) (EC 1.3.5.2) (DHOdehase) (DHOD) (DHODase) (Dihydroorotate oxidase) 356 0.06042 non-essential 0.10267 non-essential high NA high_confidence_nonessential NP_216655.1 80.9 0.14402003757044457 62.113 Moderate candidate ESM-2 calibrated P(essential)=0.060; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.144; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.132006 non-essential Non-essential ML1294 214 Q9CC44 ML1294 Dihydroorotate dehydrogenase 84 0.09625 non-essential 0.2395 non-essential high NA medium_confidence 0.765184721352536 68.688 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.239; ProteomeLM contextual percentile=0.765; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.765); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 0.001391 non-essential Non-essential ML1296 1175 Q9CC43 ML1296 Uncharacterized protein 111 0.02041 non-essential 0.12814 non-essential high agree high_confidence_nonessential Rv2137c 75.5 NE 0 0.817783343769568 68.234 Strong candidate ESM-2 calibrated P(essential)=0.020; HANSEN integrated essentiality score=0.128; Mtb RBH anchor Rv2137c=non-essential (agree); ProteomeLM contextual percentile=0.818; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.818); Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 0.004693 non-essential Non-essential ML1297 824 Q9CC42 uppP bacA upk ML1297 B2126_C2_190/B2126_C3_227 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase) 282 0.02105 non-essential 0.16635 non-essential high NA high_confidence_nonessential NP_216652.1 82.6 0.6587351283656857 75.881 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.659; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000271 non-essential Non-essential ML1298 1379 Q9CC41 ML1298 Phosphoglycerate mutase 250 0.06195 non-essential 0.10347 non-essential high agree high_confidence_nonessential Rv2135c 75.2 NE 0 0.3794614902943018 56.706 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.103; Mtb RBH anchor Rv2135c=non-essential (agree); ProteomeLM contextual percentile=0.379; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001674 non-essential Non-essential ML1299 1376 Q7AQ75 ML1299 DUF3090 domain-containing protein 196 0.03861 non-essential 0.10394 non-essential high agree high_confidence_nonessential Rv2134c 91.1 NE 0 0.5103318722604884 59.468 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.104; Mtb RBH anchor Rv2134c=non-essential (agree); ProteomeLM contextual percentile=0.510; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.9e-05 non-essential Non-essential ML1300 1539 Q9CC40 ML1300 Phosphatidylinositol kinase 262 0.02105 non-essential 0.07202 non-essential high agree high_confidence_nonessential Rv2133c 79.8 NE 0 0.3174702567313713 55.291 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.072; Mtb RBH anchor Rv2133c=non-essential (agree); ProteomeLM contextual percentile=0.317; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000776 non-essential Non-essential ML1301 385 P46726 cysQ ML1301 B2126_C3_229 3'-phosphoadenosine 5'-phosphate phosphatase (PAP phosphatase) (EC 3.1.3.7) (3'(2'),5'-bisphosphate nucleotidase) (3'(2'),5-bisphosphonucleoside 3'(2')-phosphohydrolase) (D-fructose-1,6-bisphosphate 1-phosphohydrolase) (DPNPase) (Fructose-1,6-bisphosphatase) (FBPase) (EC 3.1.3.11) (Inositol-1-monophosphatase) (I-1-Pase) (IMPase) (EC 3.1.3.25) (Inositol-1-phosphatase) 271 0.12677 non-essential 0.2143 non-essential high NA medium_confidence NP_216647.1 78.5 0.46399499060738886 73.083 Strong candidate ESM-2 calibrated P(essential)=0.127; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.464; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 0.043891 non-essential Non-essential ML1302 1528 Q49784 mshC cysS2 ML1302 B2126_C2_193 L-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase (L-Cys:GlcN-Ins ligase) (EC 6.3.1.13) (Mycothiol ligase) (MSH ligase) 412 0.00674 non-essential 0.07637 non-essential high NA high_confidence_nonessential NP_216646.1 84.2 0.23043206011271133 63.873 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.076; ProteomeLM contextual percentile=0.230; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.106364 non-essential Non-essential ML1304 1577 Q7AQ74 ansP1 ML1304 Probable L-asparagine permease 498 0.01172 non-essential 0.05972 non-essential high NA high_confidence_nonessential YP_177863.1 83.3 0.15403882279273637 48.781 Exploratory ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.060; ProteomeLM contextual percentile=0.154; target-priority score=48.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002185 non-essential Non-essential ML1305 1567 Q7AQ73 ansP2 ML1305 Probable L-asparagine permease 505 0.01172 non-essential 0.06294 non-essential high NA high_confidence_nonessential 0.17157169693174704 49.268 Exploratory ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.063; ProteomeLM contextual percentile=0.172; target-priority score=49.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003526 non-essential Non-essential ML1306 1067 Q9CC38 ML1306 Carboxylate--amine ligase 274 0.08658 non-essential 0.13725 non-essential high agree high_confidence_nonessential Rv2125 84.7 NE 0 0.5410144020037571 62.397 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.137; Mtb RBH anchor Rv2125=non-essential (agree); ProteomeLM contextual percentile=0.541; target-priority score=62.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000461 non-essential Non-essential ML1307 131 Q49775 metH ML1307 B2126_C1_157 MLCB2533.04 Methionine synthase (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Methionine synthase, vitamin-B12 dependent) (MS) 1206 0.28398 non-essential 0.27009 non-essential medium NA medium_confidence NP_216640.1 88.1 0.10958046336881654 59.906 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.270; ProteomeLM contextual percentile=0.110; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.013127 non-essential Non-essential ML1309 617 Q49786 hisE ML1309 B2126_C2_204 MLCB2533.06 Phosphoribosyl-ATP pyrophosphatase (PRA-PH) (EC 3.6.1.31) 93 0.02795 non-essential 0.19062 non-essential high NA high_confidence_nonessential YP_177860.1 87.1 0.7576706324358171 80.021 High-priority ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.758; target-priority score=80.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.758); Target-priority score is high (80.0) rescued_from_possible_false_negative_by_supporting_evidence 0.003018 non-essential Non-essential ML1310 723 Q49776 hisG ML1310 B2126_C1_162 MLCB2533.07 ATP phosphoribosyltransferase (ATP-PRT) (ATP-PRTase) (EC 2.4.2.17) 287 0.14132 non-essential 0.17937 non-essential high NA high_confidence_nonessential NP_216637.1 87.8 0.22354414527238572 62.272 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.224; target-priority score=62.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.092106 non-essential Non-essential ML1312 1466 Q7AQ72 ML1312 PD-(D/E)XK endonuclease-like domain-containing protein 294 0.04476 non-essential 0.08766 non-essential high agree high_confidence_nonessential Rv2119 79.9 NE 0 0.3318722604884158 55.233 Moderate candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.088; Mtb RBH anchor Rv2119=non-essential (agree); ProteomeLM contextual percentile=0.332; target-priority score=55.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000273 non-essential Non-essential ML1313 1561 Q7AQ71 ML1313 tRNA (adenine(58)-N(1))-methyltransferase TrmI (EC 2.1.1.220) 281 0.04818 non-essential 0.06552 non-essential high NA high_confidence_nonessential NP_216634.1 84.3 0.006261740763932373 53.755 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.066; ProteomeLM contextual percentile=0.006; target-priority score=53.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.103306 non-essential Non-essential ML1314 1471 Q7AQ70 ML1314 DUF503 domain-containing protein 97 0.02465 non-essential 0.08668 non-essential high agree high_confidence_nonessential Rv2117 85.6 NE 0 0.43268628678772697 57.248 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.087; Mtb RBH anchor Rv2117=non-essential (agree); ProteomeLM contextual percentile=0.433; target-priority score=57.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.015694 non-essential Non-essential ML1315 809 Q49803 lppK ML1315 B2126_F3_115 MLCB2533.11c Putative lipoprotein LppK 194 0.01019 non-essential 0.16914 non-essential high NA high_confidence_nonessential NP_216632.1 51.7 0.7482780212899186 67.965 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.748; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000335 non-essential Non-essential ML1316 539 P46509 mpa ML1316 a2126a B2126_C1_167 MLCB2533.12 Proteasome-associated ATPase (AAA ATPase forming ring-shaped complexes) (ARC) (Mycobacterial proteasome ATPase) 609 0.19405 non-essential 0.19774 non-essential high NA high_confidence_nonessential NP_216631.1 92.9 0.11709455228553538 52.947 Moderate candidate ESM-2 calibrated P(essential)=0.194; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.117; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00343 non-essential Non-essential ML1320 1501 Q7AQ69 ML1320 Proteasome accessory factor PafA2 514 0.02734 non-essential 0.08156 non-essential high NA high_confidence_nonessential NP_216628.1 95.4 0.1828428303068253 58.291 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.183; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00133 non-essential Non-essential ML1321 76 Q9ZBE0 pup ML1321 MLCB2533.18 Prokaryotic ubiquitin-like protein Pup (Bacterial ubiquitin-like modifier) 63 0.15606 non-essential 0.32279 non-essential high NA medium_confidence NP_216627.1 84.4 0.954915466499687 77.448 Strong candidate ESM-2 calibrated P(essential)=0.156; HANSEN integrated essentiality score=0.323; ProteomeLM contextual percentile=0.955; target-priority score=77.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.955); Target-priority score is high (77.4) rescued_from_possible_false_negative_by_supporting_evidence 0.001098 non-essential Non-essential ML1322 1176 Q49780 prcB ML1322 Proteasome subunit beta (EC 3.4.25.1) (20S proteasome beta subunit) (Proteasome core protein PrcB) 291 0.07987 non-essential 0.12813 non-essential high NA high_confidence_nonessential NP_216626.1 80.8 0.19912335629304947 63.955 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.128; ProteomeLM contextual percentile=0.199; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.01445 non-essential Non-essential ML1323 296 Q9S375 prcA ML1323 B2126_C3_260 Proteasome subunit alpha (20S proteasome alpha subunit) (Proteasome core protein PrcA) 265 0.10418 non-essential 0.22496 non-essential high NA medium_confidence NP_216625.1 91.8 0.6399499060738886 69.828 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.640; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.305161 non-essential Uncertain ML1328 504 P54077 pafA ML1328 B2126_C2_219 MLCB2533.24 Pup--protein ligase (EC 6.3.1.19) (Proteasome accessory factor A) (Pup-conjugating enzyme) 452 0.03786 non-essential 0.20234 non-essential high NA medium_confidence NP_216613.1 95.1 0.7670632435817157 84.816 High-priority ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.767; target-priority score=84.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.767); Target-priority score is high (84.8) rescued_from_possible_false_negative_by_supporting_evidence 1e-05 non-essential Non-essential ML1329 822 P54076 pafB ML1329 B2126_C3_266 MLCB2533.25 Protein PafB 331 0.05933 non-essential 0.16661 non-essential high NA high_confidence_nonessential NP_216612.1 80.2 0.5347526612398247 58.841 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.535; target-priority score=58.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003848 non-essential Non-essential ML1330 1352 P54075 pafC ML1330 B2126_C2_220 MLCB2533.26 Protein PafC 324 0.06253 non-essential 0.10738 non-essential high NA high_confidence_nonessential NP_216611.1 74.2 0.20601127113337508 47.17 Exploratory ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.107; ProteomeLM contextual percentile=0.206; target-priority score=47.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010347 non-essential Non-essential ML1331 570 P54079 tatA ML1331 B2126_C1_182 MLCB2533.27 u2126b Sec-independent protein translocase protein TatA 88 0.00674 non-essential 0.19481 non-essential high NA high_confidence_nonessential NP_216610.1 69.3 0.9054477144646211 71.249 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.905; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.905); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.002209 non-essential Non-essential ML1332 1571 P54078 tatC mttB ML1332 B2126_C1_183 MLCB2533.28 u2126a Sec-independent protein translocase protein TatC 310 0.01019 non-essential 0.06205 non-essential high NA high_confidence_nonessential NP_216609.1 84.5 0.17532874139010646 48.6 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.062; ProteomeLM contextual percentile=0.175; target-priority score=48.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.277679 non-essential Uncertain ML1333 1541 Q9ZBD8 helY ML1333 MLCB2533.29 Probable helicase HelY (EC 3.6.4.-) 920 0.05547 non-essential 0.07183 non-essential high NA high_confidence_nonessential NP_216608.1 81.5 0.020663744520976832 50.094 Moderate candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.072; ProteomeLM contextual percentile=0.021; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00817 non-essential Non-essential ML1334 626 Q7AQ65 ML1334 Possible conserved membrane protein 272 0.02518 non-essential 0.18957 non-essential high NA high_confidence_nonessential NP_216607.1 58.8 0.8058860363180964 65.869 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.806; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.806); Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.003826 non-essential Non-essential ML1338 1216 Q7AQ64 ML1338 Possible conserved integral membrane protein 440 0.01889 non-essential 0.12399 non-essential high NA high_confidence_nonessential NP_217189.1 82.3 0.46211646837820913 61.404 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.462; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004415 non-essential Non-essential ML1339 1257 Q7AQ63 ML1339 Secreted protease 525 0.06981 non-essential 0.11824 non-essential high NA high_confidence_nonessential NP_217188.1 73.3 0.21916092673763307 53.065 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.219; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001083 non-essential Non-essential ML1340 1235 Q7AQ62 ML1340 Possible reductase 268 0.06116 non-essential 0.12162 non-essential high NA high_confidence_nonessential NP_217187.1 72.9 0.2623669380087664 58.63 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.262; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000199 non-essential Non-essential ML1344 402 Q9CC35 ML1344 Doubtful CDS 86 0.02368 non-essential 0.21208 non-essential high NA medium_confidence 0.9279899812147777 71.691 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.928; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.928); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 5.1e-05 non-essential Non-essential ML1346 1188 Q9CC34 ML1346 Possible long-chain acyl-CoA synthase 1002 0.10115 non-essential 0.12681 non-essential high NA high_confidence_nonessential NP_216199.1 85.9 0.13901064495929868 48.568 Exploratory ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.139; target-priority score=48.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004733 non-essential Non-essential ML1347 10 Q9CC33 ML1347 UPF0434 protein ML1347 77 0.23623 non-essential 0.51516 essential low disagree review_anchor_disagreement Rv1684 70.1 GD 1 0.8766437069505323 71.508 Strong candidate ESM-2 calibrated P(essential)=0.236; HANSEN integrated essentiality score=0.515; Mtb RBH anchor Rv1684=essential (disagree); ProteomeLM contextual percentile=0.877; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.024274 non-essential Non-essential ML1351 855 O05678 ML1351 MLC1351.17c Putative 3-methyladenine DNA glycosylase (EC 3.2.2.-) 214 0.02518 non-essential 0.16256 non-essential high NA high_confidence_nonessential NP_216204.1 78.3 0.6318096430807765 71.036 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.632; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 0.035797 non-essential Non-essential ML1352 1552 Q49900 tyrS ML1352 MLC1351.16c Tyrosine--tRNA ligase (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) 426 0.03424 non-essential 0.06919 non-essential high NA high_confidence_nonessential NP_216205.1 83.8 0.07952410770194114 57.931 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.069; ProteomeLM contextual percentile=0.080; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.040274 non-essential Non-essential ML1357 144 Q9CC31 ML1357 Uncharacterized protein 61 0.12534 non-essential 0.26179 non-essential high NA medium_confidence Rv1693 73.8 UNCERTAIN 0.7683155917345021 66.829 Strong candidate ESM-2 calibrated P(essential)=0.125; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.768; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.768); Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 3.9e-05 non-essential Non-essential ML1358 997 Q7AQ61 tlyA ML1358 Cytotoxin/hemolysin 269 0.04983 non-essential 0.14433 non-essential high NA high_confidence_nonessential NP_216210.1 78.7 0.44145272385723233 60.824 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.441; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.052298 non-essential Non-essential ML1359 917 Q49897 nadK ML1359 MLC1351.13c NAD kinase (EC 2.7.1.23) (ATP-dependent NAD kinase) 311 0.09875 non-essential 0.1539 non-essential high NA high_confidence_nonessential NP_216211.1 87.9 0.2661239824671259 63.272 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.266; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.484922 essential Likely essential ML1360 1525 Q49896 recN ML1360 MLC1351.12c DNA repair protein RecN (Recombination protein N) 587 0.06307 non-essential 0.07684 non-essential high NA high_confidence_nonessential NP_216212.1 76.4 0.025046963055729492 46.779 Exploratory ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.025; target-priority score=46.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.080132 non-essential Non-essential ML1361 25 Q9CC30 ML1361 Conserved membrane protein 393 0.28398 non-essential 0.46024 non-essential low disagree review_anchor_disagreement Rv1697 90.6 ES 1 0.15028177833437695 49.637 Exploratory ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.460; Mtb RBH anchor Rv1697=essential (disagree); ProteomeLM contextual percentile=0.150; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.092947 non-essential Non-essential ML1362 1337 Q49894 mctB ML1362 MLC1351.10c u0247f Copper transporter MctB 317 0.10418 non-essential 0.10993 non-essential high NA high_confidence_nonessential NP_216214.1 73.8 0.03757044458359424 44.578 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.110; ProteomeLM contextual percentile=0.038; target-priority score=44.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.018118 non-essential Non-essential ML1363 1253 P53529 pyrG ML1363 MLC1351.09c CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase) 590 0.10418 non-essential 0.11902 non-essential high NA high_confidence_nonessential NP_216215.1 89.3 0.050720100187852224 58.271 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.119; ProteomeLM contextual percentile=0.051; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.998605 essential Essential ML1365 1022 Q49890 xerD ML1365 MLC1351.07c u0247d Tyrosine recombinase XerD 316 0.14132 non-essential 0.14207 non-essential high NA high_confidence_nonessential NP_216217.1 85.4 0.046963055729492796 47.715 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.047; target-priority score=47.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.129541 non-essential Non-essential ML1367 1482 Q9CC29 ML1367 Possible regulatory protein 287 0.02734 non-essential 0.08469 non-essential high NA high_confidence_nonessential NP_216224.1 89.5 0.22417031934877896 50.515 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.224; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.288954 non-essential Uncertain ML1368 596 Q7AQ60 ML1368 Segregation and condensation protein A 268 0.06652 non-essential 0.1919 non-essential high NA high_confidence_nonessential NP_216225.1 78.9 0.6380713838447089 63.094 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.638; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.069941 non-essential Non-essential ML1369 729 Q7AQ59 ML1369 Segregation and condensation protein B 231 0.14132 non-essential 0.17882 non-essential high NA high_confidence_nonessential NP_216226.1 78.4 0.25234815278647466 51.392 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.252; target-priority score=51.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.032707 non-essential Non-essential ML1370 106 O05668 ML1370 MLCB1351.03c u0247g Uncharacterized RNA pseudouridine synthase ML1370 (EC 5.4.99.-) (RNA pseudouridylate synthase) (RNA-uridine isomerase) 256 0.23801 non-essential 0.27748 non-essential medium NA medium_confidence NP_216227.1 80.5 0.3475266123982467 65.513 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.277; ProteomeLM contextual percentile=0.348; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.5) rescued_from_possible_false_negative_by_supporting_evidence 0.059932 non-essential Non-essential ML1371 788 Q49885 cmk ML1371 MLCB1351.02c Cytidylate kinase (CK) (EC 2.7.4.25) (Cytidine monophosphate kinase) (CMP kinase) 223 0.13829 non-essential 0.17144 non-essential high NA high_confidence_nonessential NP_216228.1 74.8 0.19661865998747652 60.302 Moderate candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.197; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.039125 non-essential Non-essential ML1372 1032 Q49884 der engA ML1372 MLCB1351.01 u0247e GTPase Der (GTP-binding protein EngA) 461 0.1084 non-essential 0.14087 non-essential high NA high_confidence_nonessential NP_216229.1 88.8 0.17845961177207265 51.958 Moderate candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.178; target-priority score=52.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000703 non-essential Non-essential ML1380 1553 Q7AQ58 ML1380 Uncharacterized protein 187 0.03949 non-essential 0.0687 non-essential high agree high_confidence_nonessential Rv1780 82.4 GA 0 0.20350657482780213 49.306 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.069; Mtb RBH anchor Rv1780=non-essential (agree); ProteomeLM contextual percentile=0.204; target-priority score=49.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000102 non-essential Non-essential ML1381 1458 P46835 polA ML1381 DNA polymerase I (POL I) (EC 2.7.7.7) 911 0.06652 non-essential 0.09046 non-essential high NA high_confidence_nonessential NP_216145.1 85.2 0.06825297432686286 53.945 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.090; ProteomeLM contextual percentile=0.068; target-priority score=53.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.832086 essential Essential ML1382 625 P46836 rpsA ML1382 Small ribosomal subunit protein bS1 (30S ribosomal protein S1) 481 0.19217 non-essential 0.18967 non-essential high NA high_confidence_nonessential NP_216146.1 93.8 0.09204758922980588 48.26 Exploratory ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.092; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.199154 non-essential Non-essential ML1383 1037 Q50178 coaE ML1383 o410 Dephospho-CoA kinase (EC 2.7.1.24) (Dephosphocoenzyme A kinase) 410 0.09148 non-essential 0.14039 non-essential high NA high_confidence_nonessential NP_216147.1 77.5 0.21415153412648716 65.246 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.214; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.003545 non-essential Non-essential ML1384 86 Q9CC28 ML1384 Uncharacterized protein 112 0.13675 non-essential 0.30621 non-essential high NA medium_confidence 0.9680651221039449 69.938 Strong candidate ESM-2 calibrated P(essential)=0.137; HANSEN integrated essentiality score=0.306; ProteomeLM contextual percentile=0.968; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.968); Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML1387 433 P57991 uvrB ML1387 UvrABC system protein B (Protein UvrB) (Excinuclease ABC subunit B) 698 0.23815 non-essential 0.20942 non-essential medium NA medium_confidence NP_216149.3 94.8 0.003757044458359424 46.041 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.004; target-priority score=46.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.036422 non-essential Non-essential ML1389 1227 Q9CC27 ML1389 Conserved membrane protein 527 0.02688 non-essential 0.12238 non-essential high NA high_confidence_nonessential NP_216151.1 71.4 0.4207889793362555 59.747 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.421; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000128 non-essential Non-essential ML1390 1483 Q9CC26 ML1390 UspA domain-containing protein 147 0.05093 non-essential 0.08467 non-essential high NA high_confidence_nonessential NP_216152.1 89.0 0.1308703819661866 45.393 Exploratory ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.131; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.615193 essential Likely essential ML1391 1499 Q9CC25 ML1391 Metallo-beta-lactamase domain-containing protein 232 0.06116 non-essential 0.0817 non-essential high agree high_confidence_nonessential Rv1637c 86.0 NE 0 0.1997495303694427 50.061 Moderate candidate ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.082; Mtb RBH anchor Rv1637c=non-essential (agree); ProteomeLM contextual percentile=0.200; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002056 non-essential Non-essential ML1392 99 Q9CC24 uvrA ML1392 UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) 969 0.19217 non-essential 0.28677 non-essential high NA medium_confidence NP_216154.1 90.5 0.6086412022542267 66.82 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.287; ProteomeLM contextual percentile=0.609; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 0.005679 non-essential Non-essential ML1393 476 Q9CC23 lysX ML1393 Lysylphosphatidylglycerol biosynthesis bifunctional protein LysX [Includes: Lysine--tRNA ligase (EC 6.1.1.6) (Lysyl-tRNA synthetase) (LysRS); Phosphatidylglycerol lysyltransferase (EC 2.3.2.3) (Lysylphosphatidylglycerol synthetase) (LPG synthetase)] 1133 0.02734 non-essential 0.20444 non-essential high NA medium_confidence NP_216156.1 81.6 0.8340638697557922 82.639 High-priority ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.834; target-priority score=82.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.834); Target-priority score is high (82.6) rescued_from_possible_false_negative_by_supporting_evidence 0.056726 non-essential Non-essential ML1394 226 Q9CC22 infC ML1394 Translation initiation factor IF-3 202 0.13353 non-essential 0.23681 non-essential high NA medium_confidence NP_216157.1 90.1 0.5898559799624296 64.768 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.590; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.885819 essential Essential ML1395 8 Q9CC21 rpmI ML1395 Large ribosomal subunit protein bL35 (50S ribosomal protein L35) 64 0.42684 non-essential 0.52183 essential medium NA medium_confidence NP_216158.1 90.6 0.8904195366311835 75.041 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.522; ProteomeLM contextual percentile=0.890; target-priority score=75.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.522); ESM-2 transfer probability is moderate (0.427); ProteomeLM contextual percentile is high (0.890); Target-priority score is high (75.0) none 0.000824 non-essential Non-essential ML1396 41 Q9CC20 rplT ML1396 Large ribosomal subunit protein bL20 (50S ribosomal protein L20) 129 0.42684 non-essential 0.4169 non-essential medium NA medium_confidence NP_216159.1 90.7 0.32686286787726987 56.794 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.417; ProteomeLM contextual percentile=0.327; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.417); ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.644566 essential Likely essential ML1397 1394 Q9CC19 tsnR ML1397 rRNA methyltransferase 259 0.02538 non-essential 0.10195 non-essential high NA high_confidence_nonessential NP_216160.1 73.2 0.31559173450219163 56.999 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.316; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004098 non-essential Non-essential ML1399 1452 Q9CC18 ML1399 Guanylate cyclase domain-containing protein 324 0.06716 non-essential 0.09137 non-essential high NA high_confidence_nonessential NP_216163.1 74.4 0.09705698184095178 44.975 Exploratory ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.097; target-priority score=45.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.002721 non-essential Non-essential ML1401 1275 Q9CC17 pheS ML1401 Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS) 341 0.05242 non-essential 0.11556 non-essential high NA high_confidence_nonessential NP_216165.3 85.0 0.25297432686286786 63.324 Moderate candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.116; ProteomeLM contextual percentile=0.253; target-priority score=63.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.764846 essential Essential ML1402 1063 Q9CC16 pheT ML1402 Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS) 835 0.12977 non-essential 0.13761 non-essential high NA high_confidence_nonessential NP_216166.1 78.9 0.05134627426424546 55.328 Moderate candidate ESM-2 calibrated P(essential)=0.130; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.051; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.372737 essential Uncertain ML1406 1375 Q9CC15 argC ML1406 N-acetyl-gamma-glutamyl-phosphate reductase (AGPR) (EC 1.2.1.38) (N-acetyl-glutamate semialdehyde dehydrogenase) (NAGSA dehydrogenase) 347 0.06439 non-essential 0.10397 non-essential high NA high_confidence_nonessential NP_216168.1 81.1 0.13149655604257984 62.78 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.131; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.7839 essential Essential ML1407 1234 Q9CC14 argJ ML1407 Arginine biosynthesis bifunctional protein ArgJ [Cleaved into: Arginine biosynthesis bifunctional protein ArgJ alpha chain; Arginine biosynthesis bifunctional protein ArgJ beta chain] [Includes: Glutamate N-acetyltransferase (EC 2.3.1.35) (Ornithine acetyltransferase) (OATase) (Ornithine transacetylase); Amino-acid acetyltransferase (EC 2.3.1.1) (N-acetylglutamate synthase) (AGSase)] 407 0.03769 non-essential 0.12165 non-essential high NA high_confidence_nonessential NP_216169.1 82.4 0.3393863494051346 69.118 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.339; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 0.469688 essential Likely essential ML1408 439 Q9CC13 argB ML1408 Acetylglutamate kinase (EC 2.7.2.8) (N-acetyl-L-glutamate 5-phosphotransferase) (NAG kinase) (NAGK) 297 0.18715 non-essential 0.20908 non-essential high NA medium_confidence NP_216170.1 87.5 0.184721352536005 63.397 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.209; ProteomeLM contextual percentile=0.185; target-priority score=63.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003313 non-essential Non-essential ML1409 261 Q9CC12 argD ML1409 Acetylornithine aminotransferase (ACOAT) (EC 2.6.1.11) 404 0.10418 non-essential 0.23065 non-essential high NA medium_confidence NP_216171.1 82.9 0.6437069505322479 79.926 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.644; target-priority score=79.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.9) rescued_from_possible_false_negative_by_supporting_evidence 0.029151 non-essential Non-essential ML1410 966 Q9CC11 argF ML1410 Ornithine carbamoyltransferase (OTCase) (EC 2.1.3.3) 306 0.09148 non-essential 0.14812 non-essential high NA high_confidence_nonessential NP_216172.1 84.0 0.2573575453976205 66.019 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.257; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 0.632879 essential Likely essential ML1411 674 P57992 argR ML1411 Arginine repressor 167 0.14132 non-essential 0.18483 non-essential high NA high_confidence_nonessential NP_216173.1 81.6 0.27301189730745146 56.386 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.273; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00422 non-essential Non-essential ML1412 1221 Q9CC10 argG ML1412 Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase) 399 0.10418 non-essential 0.12301 non-essential high NA high_confidence_nonessential NP_216174.1 91.0 0.07013149655604257 59.659 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.070; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.33742 essential Uncertain ML1413 1594 Q9CC09 argH ML1413 Argininosuccinate lyase (ASAL) (EC 4.3.2.1) (Arginosuccinase) 470 0.01364 non-essential 0.04649 non-essential high NA high_confidence_nonessential NP_216175.1 88.1 0.045084533500313086 56.371 Moderate candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.046; ProteomeLM contextual percentile=0.045; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.462238 essential Likely essential ML1417 467 Q9CC08 cdh ML1417 Probable CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) (CDP-diacylglycerol phosphatidylhydrolase) (CDP-diglyceride hydrolase) 268 0.02975 non-essential 0.20578 non-essential high NA medium_confidence NP_216805.1 66.4 0.8278021289918598 83.702 High-priority ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.828; target-priority score=83.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.828); Target-priority score is high (83.7) rescued_from_possible_false_negative_by_supporting_evidence 8e-05 non-essential Non-essential ML1418 1366 Q9CC07 ML1418 Thioredoxin domain-containing protein 182 0.02734 non-essential 0.10487 non-essential high agree high_confidence_nonessential Rv1732c 86.3 NE 0 0.5560425798371947 65.723 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv1732c=non-essential (agree); ProteomeLM contextual percentile=0.556; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.002894 non-essential Non-essential ML1419 706 Q7AQ57 ML1419 Possible regulatory protein 563 0.02518 non-essential 0.18149 non-essential high NA high_confidence_nonessential 0.7476518472135254 69.501 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.748; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000653 non-essential Non-essential ML1420 611 Q7AQ56 ML1420 Uncharacterized protein 117 0.00198 non-essential 0.19103 non-essential high NA high_confidence_nonessential 0.9123356293049468 68.773 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.912; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.912); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.141056 non-essential Non-essential ML1423 941 Q7AQ55 ML1423 PNPLA domain-containing protein 329 0.03424 non-essential 0.15104 non-essential high NA high_confidence_nonessential NP_216553.1 80.5 0.5372573575453976 66.001 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.537; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 2.8e-05 non-essential Non-essential ML1424 286 Q7AQ54 ML1424 Trehalose import ATP-binding protein SugC (Nucleotide-binding domain of SugABC transporter) (SugABC transporter ATPase SugC) 356 0.13353 non-essential 0.22733 non-essential high NA medium_confidence NP_216554.1 79.7 0.532874139010645 65.187 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.533; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000182 non-essential Non-essential ML1425 332 Q7AQ53 ML1425 Probable ABC-transport protein, inner membrane component 283 0.06199 non-essential 0.22063 non-essential high NA medium_confidence NP_216555.1 79.2 0.8052598622417032 70.772 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.805; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.805); Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 2e-06 non-essential Non-essential ML1426 771 Q7AQ52 ML1426 Probable ABC-transport protein, inner membrane component 319 0.05112 non-essential 0.1733 non-essential high NA high_confidence_nonessential NP_216556.1 81.6 0.5967438948027551 63.958 Moderate candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.597; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002446 non-essential Non-essential ML1427 862 Q7AQ51 ML1427 Possible ABC-transport lipoprotein 445 0.07317 non-essential 0.16205 non-essential high NA high_confidence_nonessential NP_216557.1 77.4 0.44708829054477145 57.934 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.447; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7.2e-05 non-essential Non-essential ML1430 584 Q9CC06 ML1430 Possible membrane protein 108 0.00198 non-essential 0.19346 non-essential high NA high_confidence_nonessential 0.9167188478396995 72.14 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.917; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.917); Target-priority score is high (72.1) rescued_from_possible_false_negative_by_supporting_evidence 1.7e-05 non-essential Non-essential ML1439 1398 Q9CC05 rbpA ML1439 RNA polymerase-binding protein RbpA 111 0.08554 non-essential 0.10177 non-essential high NA high_confidence_nonessential NP_216566.1 97.3 0.07075767063243582 46.037 Exploratory ESM-2 calibrated P(essential)=0.086; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.071; target-priority score=46.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000248 non-essential Non-essential ML1440 408 Q7AQ50 ML1440 Bifunctional apolipoprotein N-acyltransferase/polyprenol monophosphomannose synthase (EC 2.3.1.269) (EC 2.4.1.83) 277 0.09148 non-essential 0.21144 non-essential high NA medium_confidence 0.604257983719474 74.712 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.604; target-priority score=74.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.7) rescued_from_possible_false_negative_by_supporting_evidence 0.261334 non-essential Uncertain ML1441 1089 Q7AQ49 lnt ML1441 Apolipoprotein N-acyltransferase (ALP N-acyltransferase) (EC 2.3.1.269) 644 0.06278 non-essential 0.13532 non-essential high NA high_confidence_nonessential NP_216567.1 73.8 0.3187226048841578 64.343 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.319; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.956751 essential Essential ML1444 1546 Q9CC04 ML1444 Possible dienelactone hydrolase 232 0.02105 non-essential 0.07077 non-essential high agree high_confidence_nonessential Rv2054 76.1 GA 0 0.29931120851596743 56.414 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv2054=non-essential (agree); ProteomeLM contextual percentile=0.299; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.5e-05 non-essential Non-essential ML1445 201 Q9CC03 ML1445 Uncharacterized protein 74 0.06257 non-essential 0.2432 non-essential high NA medium_confidence 0.9386349405134627 69.662 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.939; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.939); Target-priority score is high (69.7) rescued_from_possible_false_negative_by_supporting_evidence 0.00522 non-essential Non-essential ML1446 1172 Q9CC02 ML1446 Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein 128 0.04386 non-essential 0.12852 non-essential high agree high_confidence_nonessential Rv2061c 71.0 NE 0 0.6737633061991234 69.645 Strong candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv2061c=non-essential (agree); ProteomeLM contextual percentile=0.674; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML1448 1072 Q9CC01 ML1448 RNA polymerase sigma factor 184 0.02975 non-essential 0.13698 non-essential high NA high_confidence_nonessential NP_216585.1 81.7 0.48716343143393864 61.907 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.487; target-priority score=61.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7.3e-05 non-essential Non-essential ML1452 1003 Q9CC00 ML1452 Possible phosphoglycerate mutase 224 0.07589 non-essential 0.14405 non-essential high NA high_confidence_nonessential NP_216935.1 80.4 0.32748904195366313 58.376 Moderate candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.327; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.074786 non-essential Non-essential ML1453 1315 Q9CBZ9 rsfS ML1453 Ribosomal silencing factor RsfS 129 0.02734 non-essential 0.1122 non-essential high agree high_confidence_nonessential Rv2420c 87.0 NE 0 0.6167814652473388 68.238 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.112; Mtb RBH anchor Rv2420c=non-essential (agree); ProteomeLM contextual percentile=0.617; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 3.9e-05 non-essential Non-essential ML1454 315 Q9CBZ8 nadD ML1454 Probable nicotinate-nucleotide adenylyltransferase (EC 2.7.7.18) (Deamido-NAD(+) diphosphorylase) (Deamido-NAD(+) pyrophosphorylase) (Nicotinate mononucleotide adenylyltransferase) (NaMN adenylyltransferase) 214 0.23687 non-essential 0.22264 non-essential medium NA medium_confidence NP_216937.1 80.2 0.055103318722604884 57.02 Moderate candidate ESM-2 calibrated P(essential)=0.237; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.055; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.975471 essential Essential ML1458 1295 Q9CBZ7 proA ML1458 Gamma-glutamyl phosphate reductase (GPR) (EC 1.2.1.41) (Glutamate-5-semialdehyde dehydrogenase) (Glutamyl-gamma-semialdehyde dehydrogenase) (GSA dehydrogenase) 409 0.05949 non-essential 0.11415 non-essential high NA high_confidence_nonessential NP_216943.1 81.9 0.2128991859737007 63.109 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.213; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.209967 non-essential Uncertain ML1463 1228 Q9CBZ6 nadE ML1463 Glutamine-dependent NAD(+) synthetase (EC 6.3.5.1) (NAD(+) synthase [glutamine-hydrolyzing]) 680 0.1 non-essential 0.12229 non-essential high NA high_confidence_nonessential NP_216954.2 84.5 0.07889793362554791 61.758 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.079; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.909939 essential Essential ML1464 1281 Q9CBZ5 proB ML1464 Glutamate 5-kinase (EC 2.7.2.11) (Gamma-glutamyl kinase) (GK) 367 0.09178 non-essential 0.11488 non-essential high NA high_confidence_nonessential NP_216955.1 84.4 0.08077645585472762 59.112 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.115; ProteomeLM contextual percentile=0.081; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.164562 non-essential Non-essential ML1465 1472 Q9CBZ4 obg ML1465 GTPase Obg (EC 3.6.5.-) (GTP-binding protein Obg) 479 0.07214 non-essential 0.08656 non-essential high NA high_confidence_nonessential NP_216956.1 84.3 0.026925485284909206 51.418 Moderate candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.027; target-priority score=51.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.128573 non-essential Non-essential ML1466 123 Q9CBZ3 rpmA ML1466 Large ribosomal subunit protein bL27 (50S ribosomal protein L27) 88 0.13353 non-essential 0.27236 non-essential high NA medium_confidence NP_216957.1 93.8 0.7777082028804008 72.001 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.272; ProteomeLM contextual percentile=0.778; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.778); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.556557 essential Likely essential ML1467 64 Q9CBZ2 rplU ML1467 Large ribosomal subunit protein bL21 (50S ribosomal protein L21) 103 0.28398 non-essential 0.35305 non-essential medium NA medium_confidence NP_216958.1 91.2 0.5798371947401377 65.937 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.353; ProteomeLM contextual percentile=0.580; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.047955 non-essential Non-essential ML1468 73 Q9CBZ1 ML1468 Ribonuclease E (EC 3.1.26.12) 924 0.38101 non-essential 0.32861 non-essential medium NA medium_confidence NP_216960.1 76.5 0.043206011271133375 48.153 Exploratory ESM-2 calibrated P(essential)=0.381; HANSEN integrated essentiality score=0.329; ProteomeLM contextual percentile=0.043; target-priority score=48.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.103634 non-essential Non-essential ML1469 722 Q9CBZ0 ndk ML1469 Nucleoside diphosphate kinase (NDK) (NDP kinase) (EC 2.7.4.6) (Nucleoside-2-P kinase) 136 0.06257 non-essential 0.17941 non-essential high NA high_confidence_nonessential NP_216961.1 88.1 0.5522855353788353 73.435 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.552; target-priority score=73.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.4) rescued_from_possible_false_negative_by_supporting_evidence 0.44767 essential Likely essential ML1470 272 Q9CBY9 ML1470 Conserved membrane protein 123 0.07625 non-essential 0.22951 non-essential high NA medium_confidence NP_216962.1 66.7 0.7971195992485911 69.064 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.797; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.797); Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 0.263115 non-essential Uncertain ML1471 1079 Q9CBY8 folC ML1471 Dihydrofolate synthase/folylpolyglutamate synthase (EC 6.3.2.12) (EC 6.3.2.17) (Tetrahydrofolylpolyglutamate synthase) 485 0.10418 non-essential 0.13624 non-essential high NA high_confidence_nonessential NP_216963.1 78.7 0.14339386349405134 61.204 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.143; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.946802 essential Essential ML1472 1187 Q9CBY7 valS ML1472 Valine--tRNA ligase (EC 6.1.1.9) (Valyl-tRNA synthetase) (ValRS) 886 0.03424 non-essential 0.12693 non-essential high NA high_confidence_nonessential NP_216964.1 85.4 0.3888541014402004 68.229 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.389; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 0.074644 non-essential Non-essential ML1477 417 Q9CBY6 clpX ML1477 ATP-dependent Clp protease ATP-binding subunit ClpX 426 0.23815 non-essential 0.21049 non-essential medium NA medium_confidence NP_216973.1 96.0 0.004383218534752661 47.984 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.004; target-priority score=48.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.826492 essential Essential ML1478 1473 Q9CBY5 ML1478 S-methylmethionine:homocysteine methyltransferase 293 0.00674 non-essential 0.08638 non-essential high NA high_confidence_nonessential NP_216974.1 79.4 0.3036944270507201 58.981 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.086; ProteomeLM contextual percentile=0.304; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000583 non-essential Non-essential ML1479 363 Q9CBY4 clpP2 ML1479 ATP-dependent Clp protease proteolytic subunit 2 (EC 3.4.21.92) (Endopeptidase Clp 2) 214 0.09625 non-essential 0.2168 non-essential high NA medium_confidence NP_216976.1 97.2 0.6136505948653725 74.806 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.614; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.8) rescued_from_possible_false_negative_by_supporting_evidence 0.170183 non-essential Non-essential ML1480 806 Q9CBY3 clpP1 clpP ML1480 ATP-dependent Clp protease proteolytic subunit 1 (EC 3.4.21.92) (Endopeptidase Clp 1) 200 0.09306 non-essential 0.16932 non-essential high NA high_confidence_nonessential YP_177883.1 95.0 0.37570444583594237 65.722 Strong candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.376; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.001835 non-essential Non-essential ML1481 880 Q9CBY2 tig ML1481 Trigger factor (TF) (EC 5.2.1.8) (PPIase) 469 0.05422 non-essential 0.15957 non-essential high NA high_confidence_nonessential NP_216978.1 71.4 0.48465873512836566 69.775 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.485; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.002277 non-essential Non-essential ML1484 907 Q9CBY1 rpiB ML1484 Ribose-5-phosphate isomerase B (EC 5.3.1.6) (Phosphoriboisomerase B) 162 0.01019 non-essential 0.15571 non-essential high NA high_confidence_nonessential YP_177884.1 89.5 0.6349405134627426 79.639 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.635; target-priority score=79.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.6) rescued_from_possible_false_negative_by_supporting_evidence 0.42634 essential Likely essential ML1485 952 Q9CBY0 ML1485 Uncharacterized protein 207 0.07065 non-essential 0.14966 non-essential high agree high_confidence_nonessential Rv2466c 80.6 NE 0 0.7326236693800877 68.015 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.150; Mtb RBH anchor Rv2466c=non-essential (agree); ProteomeLM contextual percentile=0.733; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.45786 essential Likely essential ML1486 1454 Q9CBX9 ML1486 Aminopeptidase N (EC 3.4.11.2) (Alanine aminopeptidase) (Lysyl aminopeptidase) 862 0.01648 non-essential 0.09127 non-essential high NA high_confidence_nonessential YP_177885.1 83.4 0.28240450845335 60.814 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.282; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006701 non-essential Non-essential ML1488 909 Q9CBX8 ML1488 Aminotransferase (EC 2.6.1.-) 367 0.14338 non-essential 0.15553 non-essential high NA high_confidence_nonessential NP_215694.1 83.4 0.10144020037570445 52.909 Moderate candidate ESM-2 calibrated P(essential)=0.143; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.101; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.119717 non-essential Non-essential ML1489 1205 Q9CBX7 fdxA ML1489 Ferredoxin 108 0.09152 non-essential 0.12477 non-essential high NA high_confidence_nonessential NP_215693.1 91.5 0.16468378209142143 50.766 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.165; target-priority score=50.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.293974 non-essential Uncertain ML1492 799 Q9CBX6 fbiC ML1492 FO synthase [Includes: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase (EC 4.3.1.32); 5-amino-6-(D-ribitylamino)uracil--L-tyrosine 4-hydroxyphenyl transferase (EC 2.5.1.147)] 863 0.09638 non-essential 0.16988 non-essential high NA high_confidence_nonessential NP_215689.1 88.5 0.35316217908578584 69.333 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.353; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 0.009867 non-essential Non-essential ML1494 1120 Q9CBX5 ML1494 Conserved membrane protein 117 0.01412 non-essential 0.13256 non-essential high agree high_confidence_nonessential Rv1171 62.5 NE 0 0.8835316217908579 71.471 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv1171=non-essential (agree); ProteomeLM contextual percentile=0.884; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.884); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 1e-05 non-essential Non-essential ML1495 155 Q9CBX4 mshB ML1495 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase (GlcNAc-Ins deacetylase) (EC 3.5.1.103) (N-acetyl-1-D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase) 308 0.19217 non-essential 0.25736 non-essential high NA medium_confidence NP_215686.1 73.7 0.4295554164057608 68.889 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.257; ProteomeLM contextual percentile=0.430; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.331991 essential Uncertain ML1497 1162 Q9CBX3 ML1497 Possible secreted protein 617 0.09148 non-essential 0.1292 non-essential high NA high_confidence_nonessential NP_215682.1 80.3 0.19223544145272387 50.325 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.192; target-priority score=50.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.078719 non-essential Non-essential ML1498 96 Q9CBX2 bipA ML1498 Large ribosomal subunit assembly factor BipA (EC 3.6.5.-) (GTP-binding protein BipA) 628 0.2488 non-essential 0.29051 non-essential medium NA medium_confidence NP_215681.1 84.9 0.36693800876643706 68.146 Strong candidate ESM-2 calibrated P(essential)=0.249; HANSEN integrated essentiality score=0.291; ProteomeLM contextual percentile=0.367; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.001221 non-essential Non-essential ML1503 321 Q9CBX1 ML1503.1 ML1503A Putative pterin-4-alpha-carbinolamine dehydratase (PHS) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase) (Pterin carbinolamine dehydratase) (PCD) 94 0.07502 non-essential 0.22222 non-essential high NA medium_confidence YP_177641.1 71.0 0.7382592360676268 76.391 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.738; target-priority score=76.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.4) rescued_from_possible_false_negative_by_supporting_evidence 1.4e-05 non-essential Non-essential ML1504 985 Q9CBX0 ML1504 Probable conserved membrane protein 430 0.00543 non-essential 0.14628 non-essential high NA high_confidence_nonessential NP_215675.1 77.1 0.6368190356919223 67.566 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.637; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.6) rescued_from_possible_false_negative_by_supporting_evidence 0.278888 non-essential Uncertain ML1505 1464 Q9CBW9 ML1505 Conserved hypothetical Proline rich protein 182 0.01588 non-essential 0.08796 non-essential high agree high_confidence_nonessential Rv1158c 70.9 NE 0 0.509079524107702 55.054 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.088; Mtb RBH anchor Rv1158c=non-essential (agree); ProteomeLM contextual percentile=0.509; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00011 non-essential Non-essential ML1506 1490 Q9CBW8 ML1506 Secreted protein 348 0.00674 non-essential 0.08343 non-essential high agree high_confidence_nonessential Rv1157c 64.8 NE 0 0.5109580463368817 56.568 Moderate candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.083; Mtb RBH anchor Rv1157c=non-essential (agree); ProteomeLM contextual percentile=0.511; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009971 non-essential Non-essential ML1508 215 Q9CBW7 ML1508 Pyridoxamine 5'-phosphate oxidase N-terminal domain-containing protein 163 0.09148 non-essential 0.23893 non-essential high NA medium_confidence NP_215671.1 87.8 0.7726988102692548 72.422 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.239; ProteomeLM contextual percentile=0.773; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.773); Target-priority score is high (72.4) rescued_from_possible_false_negative_by_supporting_evidence 0.018108 non-essential Non-essential ML1511 955 Q9CBW6 cobB ML1511 NAD-dependent protein deacylase (EC 2.3.1.286) (Regulatory protein SIR2 homolog) 237 0.02734 non-essential 0.14937 non-essential high NA high_confidence_nonessential NP_215667.1 85.2 0.5366311834690044 73.639 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.537; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.0565 non-essential Non-essential ML1512 765 Q9CBW5 rnj ML1512 Ribonuclease J (RNase J) (EC 3.1.-.-) 558 0.14132 non-essential 0.17412 non-essential high NA high_confidence_nonessential NP_217268.1 89.2 0.20538509705698185 57.947 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.205; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007046 non-essential Non-essential ML1513 1085 Q9CBW4 dapA ML1513 4-hydroxy-tetrahydrodipicolinate synthase (HTPA synthase) (EC 4.3.3.7) 300 0.05162 non-essential 0.13555 non-essential high NA high_confidence_nonessential NP_217269.1 87.0 0.35504070131496557 69.857 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.355; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 0.235561 non-essential Uncertain ML1514 1119 Q9CBW3 thyX ML1514 Flavin-dependent thymidylate synthase (FDTS) (EC 2.1.1.148) (FAD-dependent thymidylate synthase) (Thymidylate synthase ThyX) (TS) (TSase) 254 0.0518 non-essential 0.13276 non-essential high NA high_confidence_nonessential NP_217270.1 81.9 0.33625547902316844 70.395 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.336; target-priority score=70.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.4) rescued_from_possible_false_negative_by_supporting_evidence 0.7416 essential Essential ML1517 83 Q9CBW2 ML1517 Uncharacterized protein 93 0.15015 non-essential 0.3122 non-essential high NA medium_confidence 0.9342517219787101 72.517 Strong candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.312; ProteomeLM contextual percentile=0.934; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.934); Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 9.4e-05 non-essential Non-essential ML1518 1242 Q9CBW1 folA ML1518 Dihydrofolate reductase (EC 1.5.1.3) 165 0.04818 non-essential 0.12076 non-essential high NA high_confidence_nonessential NP_217279.1 70.6 0.2836568566061365 69.914 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.284; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 0.001407 non-essential Non-essential ML1519 1046 Q9CBW0 thyA ML1519 Thymidylate synthase (TS) (TSase) (EC 2.1.1.45) 266 0.03466 non-essential 0.13939 non-essential high NA high_confidence_nonessential NP_217280.1 85.5 0.44395742016280526 73.763 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.444; target-priority score=73.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.8) rescued_from_possible_false_negative_by_supporting_evidence 0.345576 essential Uncertain ML1523 458 Q9CBV9 ML1523 Transmembrane protein 96 0.01861 non-essential 0.20668 non-essential high NA medium_confidence 0.9242329367564183 70.082 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.924; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.924); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.001795 non-essential Non-essential ML1525 1179 Q9CBV8 ML1525 Flavodoxin 151 0.09148 non-essential 0.12765 non-essential high agree high_confidence_nonessential Rv2771c 53.4 NE 0 0.43519098309329995 58.478 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.128; Mtb RBH anchor Rv2771c=non-essential (agree); ProteomeLM contextual percentile=0.435; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 8e-06 non-essential Non-essential ML1526 849 Q9CBV7 ML1526 Conserved membrane protein 160 0.01172 non-essential 0.16313 non-essential high NA high_confidence_nonessential NP_217288.1 76.6 0.7107075767063243 66.349 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.711; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00502 non-essential Non-essential ML1532 538 Q9CBV6 ald ML1532 Alanine dehydrogenase (EC 1.4.1.1) 371 0.10418 non-essential 0.19783 non-essential high NA high_confidence_nonessential NP_217296.1 85.4 0.4664996869129618 74.539 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.466; target-priority score=74.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.5) rescued_from_possible_false_negative_by_supporting_evidence 0.067102 non-essential Non-essential ML1536 709 Q9CBV5 ML1536 AAA+ ATPase domain-containing protein 610 0.08411 non-essential 0.18121 non-essential high NA high_confidence_nonessential NP_216314.1 89.8 0.4996869129618034 61.32 Moderate candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.500; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.036646 non-essential Non-essential ML1537 461 Q9CBV4 ML1537 Possible secreted protein 401 0.12556 non-essential 0.20651 non-essential high NA medium_confidence NP_216313.1 67.7 0.4646211646837821 59.167 Moderate candidate ESM-2 calibrated P(essential)=0.126; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.465; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.025851 non-essential Non-essential ML1538 1272 Q9CBV3 ML1538 Possible protease 567 0.09724 non-essential 0.11681 non-essential high NA high_confidence_nonessential NP_216312.1 69.9 0.09517845961177207 49.568 Exploratory ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.095; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.792179 essential Essential ML1539 725 Q9CBV2 ML1539 Probable membrane protein 503 0.04677 non-essential 0.17932 non-essential high NA high_confidence_nonessential NP_216311.1 69.2 0.6487163431433939 65.117 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.649; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.1) rescued_from_possible_false_negative_by_supporting_evidence 0.023908 non-essential Non-essential ML1540 43 Q7AQ48 ML1540 ESX secretion-associated protein EspG 300 0.18438 non-essential 0.40726 non-essential low disagree review_anchor_disagreement Rv1794 88.0 GD 1 0.2097683155917345 51.301 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.407; Mtb RBH anchor Rv1794=essential (disagree); ProteomeLM contextual percentile=0.210; target-priority score=51.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.114328 non-essential Non-essential ML1543 113 Q7AQ47 ML1543 Possible SpoIIIE-family membrane protein 1345 0.13986 non-essential 0.27516 non-essential high NA medium_confidence YP_007410461.1 87.3 0.7689417658108955 70.691 Strong candidate ESM-2 calibrated P(essential)=0.140; HANSEN integrated essentiality score=0.275; ProteomeLM contextual percentile=0.769; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.769); Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 0.631424 essential Likely essential ML1544 638 Q7AQ46 ML1544 Conserved membrane protein 506 0.13353 non-essential 0.18828 non-essential high NA high_confidence_nonessential NP_216298.1 82.8 0.32999373825923606 56.061 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.330; target-priority score=56.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.903248 essential Essential ML1546 432 Q9Z5I4 truB ML1546 MLCB596.24 tRNA pseudouridine synthase B (EC 5.4.99.25) (tRNA pseudouridine(55) synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) 320 0.06042 non-essential 0.20952 non-essential high NA medium_confidence NP_217309.1 74.1 0.7238572323105823 78.672 Strong candidate ESM-2 calibrated P(essential)=0.060; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.724; target-priority score=78.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.7) rescued_from_possible_false_negative_by_supporting_evidence 0.168166 non-essential Non-essential ML1547 1084 Q7AQ45 ML1547 4'-phosphopantetheinyl transferase 227 0.02975 non-essential 0.13563 non-essential high NA high_confidence_nonessential NP_217310.1 79.7 0.47088290544771444 64.761 Moderate candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.471; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012935 non-essential Non-essential ML1548 1410 Q7AQ44 ML1548 Calcineurin-like phosphoesterase domain-containing protein 321 0.03604 non-essential 0.10007 non-essential high agree high_confidence_nonessential Rv2795c 88.2 NE 0 0.47213525360050096 62.476 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.100; Mtb RBH anchor Rv2795c=non-essential (agree); ProteomeLM contextual percentile=0.472; target-priority score=62.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000245 non-essential Non-essential ML1553 1357 Q9Z5I7 proS ML1553 MLCB596.17c Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS) 480 0.03424 non-essential 0.1058 non-essential high NA high_confidence_nonessential 0.27927363807138383 63.23 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.279; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001443 non-essential Non-essential ML1555 205 Q9Z5I8 rbfA ML1555 MLCB596.15 Ribosome-binding factor A 164 0.23801 non-essential 0.24259 non-essential medium NA medium_confidence NP_217354.1 80.8 0.1859737006887915 50.665 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.186; target-priority score=50.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.030954 non-essential Non-essential ML1556 42 Q9Z5I9 infB ML1556 MLCB596.14 Translation initiation factor IF-2 924 0.42684 non-essential 0.41339 non-essential medium NA medium_confidence NP_217355.1 80.9 0.31246086412022545 54.664 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.413; ProteomeLM contextual percentile=0.312; target-priority score=54.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review HANSEN integrated score is moderate (0.413); ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.991558 essential Essential ML1557 901 Q7AQ43 ML1557 YlxR domain-containing protein 106 0.08883 non-essential 0.15603 non-essential high agree high_confidence_nonessential Rv2840c 82.3 GA 0 0.7013149655604258 65.202 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.156; Mtb RBH anchor Rv2840c=non-essential (agree); ProteomeLM contextual percentile=0.701; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.002426 non-essential Non-essential ML1558 1106 Q9Z5J1 nusA ML1558 MLCB596.12 Transcription termination/antitermination protein NusA 347 0.14132 non-essential 0.13351 non-essential high NA high_confidence_nonessential NP_217357.1 91.9 0.005635566687539136 44.655 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.006; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.070922 non-essential Non-essential ML1559 1217 Q9Z5J2 rimP ML1559 MLCB596.11 Putative ribosome maturation factor RimP 150 0.01761 non-essential 0.12373 non-essential high NA high_confidence_nonessential NP_217358.1 52.5 ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3.1e-05 non-essential Non-essential ML1560 1314 Q7AQ42 ML1560 Uncharacterized protein 178 0.01019 non-essential 0.11226 non-essential high agree high_confidence_nonessential Rv2843 68.5 NE 0 0.7313713212273012 66.027 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.112; Mtb RBH anchor Rv2843=non-essential (agree); ProteomeLM contextual percentile=0.731; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 0.003829 non-essential Non-essential ML1561 1573 Q7AQ41 ML1561 DUF4439 domain-containing protein 165 0.01019 non-essential 0.06109 non-essential high agree high_confidence_nonessential Rv2844 71.5 NE 0 0.2886662492172824 52.223 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.061; Mtb RBH anchor Rv2844=non-essential (agree); ProteomeLM contextual percentile=0.289; target-priority score=52.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.01619 non-essential Non-essential ML1562 745 Q7AQ40 ML1562 Transmembrane efflux protein 534 0.01861 non-essential 0.17734 non-essential high NA high_confidence_nonessential NP_217362.1 86.5 0.7526612398246713 69.736 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.753; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.753); Target-priority score is high (69.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000786 non-essential Non-essential ML1572 513 Q9CBV0 ML1572 PglZ domain-containing protein 132 0.00198 non-essential 0.20138 non-essential high NA medium_confidence 0.9586725109580463 73.729 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.959; target-priority score=73.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.959); Target-priority score is high (73.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000262 non-essential Non-essential ML1573 1332 Q9CBU9 ML1573 Possible amidotransferase 249 0.02518 non-essential 0.11085 non-essential high NA high_confidence_nonessential NP_217375.1 71.5 0.3638071383844709 58.732 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.364; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009793 non-essential Non-essential ML1575 343 Q9CBU8 ML1575 Uncharacterized protein 97 0.02041 non-essential 0.21895 non-essential high NA medium_confidence 0.9824671258609894 72.008 Strong candidate ESM-2 calibrated P(essential)=0.020; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.982; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.982); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.002292 non-essential Non-essential ML1576 914 Q9CBU7 mapB map ML1576 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) 285 0.14132 non-essential 0.15452 non-essential high NA high_confidence_nonessential YP_177911.1 89.8 0.09142141515341265 57.5 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.091; target-priority score=57.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.157886 non-essential Non-essential ML1577 380 Q9CBU6 ML1577 Probable penicillin binding protein 608 0.12863 non-essential 0.21504 non-essential high NA medium_confidence NP_217380.1 81.5 0.48966812773951157 62.933 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.490; target-priority score=62.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.181834 non-essential Non-essential ML1581 459 Q9CBU5 ispG gcpE ML1581 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (EC 1.17.7.3) (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase) 392 0.14132 non-essential 0.20667 non-essential high NA medium_confidence NP_217384.1 87.2 0.36192861615529115 69.825 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.362; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.180244 non-essential Non-essential ML1582 1598 Q9CBU4 rip1 ML1582 Zinc metalloprotease Rip1 (EC 3.4.24.-) (S2P endopeptidase) (Site-2 protease Rip1) (S2P protease Rip1) (Site-2-type intramembrane protease) 404 0.00543 non-essential 0.0344 non-essential high NA high_confidence_nonessential NP_217385.1 82.2 0.02567313713212273 51.61 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.034; ProteomeLM contextual percentile=0.026; target-priority score=51.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004687 non-essential Non-essential ML1583 1019 Q9CBU3 dxr ML1583 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXP reductoisomerase) (EC 1.1.1.267) (1-deoxyxylulose-5-phosphate reductoisomerase) (2-C-methyl-D-erythritol 4-phosphate synthase) 406 0.02638 non-essential 0.1425 non-essential high NA high_confidence_nonessential NP_217386.2 83.1 0.4940513462742642 75.859 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.494; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.9) rescued_from_possible_false_negative_by_supporting_evidence 0.953004 essential Essential ML1584 508 Q9CBU2 ML1584 Uncharacterized protein ML1584 84 0.04792 non-essential 0.20185 non-essential high NA medium_confidence NP_217392.1 73.9 0.7708202880400752 66.859 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.771; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.771); Target-priority score is high (66.9) rescued_from_possible_false_negative_by_supporting_evidence 9e-06 non-essential Non-essential ML1589 845 Q9CBU1 cdsA ML1589 Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-diacylglycerol synthase) (CDP-DAG synthase) (CDP-DG synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase) 312 0.0332 non-essential 0.16383 non-essential high NA high_confidence_nonessential NP_217397.1 70.5 0.5911083281152161 74.889 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.591; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.9) rescued_from_possible_false_negative_by_supporting_evidence 6.8e-05 non-essential Non-essential ML1590 1289 O33046 frr ML1590 MLCB250.76 Ribosome-recycling factor (RRF) (Ribosome-releasing factor) 185 0.1035 non-essential 0.11436 non-essential high NA high_confidence_nonessential NP_217398.1 90.8 0.054477144646211645 48.741 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.054; target-priority score=48.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000611 non-essential Non-essential ML1591 865 O33045 pyrH ML1591 MLCB250.75 Uridylate kinase (UK) (EC 2.7.4.22) (Uridine monophosphate kinase) (UMP kinase) (UMPK) 255 0.10115 non-essential 0.16167 non-essential high NA high_confidence_nonessential NP_217399.1 95.3 0.29242329367564185 66.123 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.292; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.292939 non-essential Uncertain ML1596 1467 O33040 amiC ML1596 MLCB250.65 Putative amidase AmiC (EC 3.5.1.4) 468 0.02795 non-essential 0.08719 non-essential high NA high_confidence_nonessential NP_217404.1 76.9 0.20413274890419536 61.368 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.204; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1.1e-05 non-essential Non-essential ML1597 336 O33039 tsf ML1597 MLCB250.64 Elongation factor Ts (EF-Ts) 276 0.13353 non-essential 0.22006 non-essential high NA medium_confidence NP_217405.1 83.7 0.49906073888541014 62.132 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.499; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.230797 non-essential Uncertain ML1598 827 O33038 rpsB ML1598 MLCB250.63 Small ribosomal subunit protein uS2 (30S ribosomal protein S2) 277 0.14132 non-essential 0.16584 non-essential high NA high_confidence_nonessential NP_217406.1 94.9 0.17407639323731997 52.032 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.174; target-priority score=52.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.906565 essential Essential ML1600 664 Q9CBU0 xerC ML1600 MLCB250.62 Tyrosine recombinase XerC 297 0.07281 non-essential 0.18558 non-essential high NA high_confidence_nonessential NP_217410.1 85.1 0.5623043206011271 66.379 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.562; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.017902 non-essential Non-essential ML1601 191 Q7AQ39 ML1601 Carbamoyltransferase domain-containing protein 121 0.04985 non-essential 0.24658 non-essential high NA medium_confidence 0.9937382592360676 77.526 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.994; target-priority score=77.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.994); Target-priority score is high (77.5) rescued_from_possible_false_negative_by_supporting_evidence 0.009954 non-essential Non-essential ML1602 555 Q9CBT9 ML1602 Uncharacterized protein 106 0.00198 non-essential 0.19629 non-essential high NA high_confidence_nonessential 0.936756418284283 70.998 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.937; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.937); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 3.4e-05 non-essential Non-essential ML1603 289 Q9CBT8 ML1603 Uncharacterized protein 86 0.04563 non-essential 0.22679 non-essential high NA medium_confidence 0.9211020663744521 69.213 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.921; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.921); Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.009797 non-essential Non-essential ML1604 317 Q9CBT7 ML1604 Uncharacterized protein 129 0.02734 non-essential 0.22251 non-essential high NA medium_confidence 0.9730745147150908 71.51 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.973; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.973); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.020518 non-essential Non-essential ML1605 469 Q9CBT6 ML1605 Uncharacterized protein 66 0.01233 non-essential 0.20525 non-essential high NA medium_confidence 0.9455228553537883 69.789 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.205; ProteomeLM contextual percentile=0.946; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.946); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000624 non-essential Non-essential ML1607 1090 O33024 ML1607 MLCB250.49 UPF0102 protein ML1607 96 0.00543 non-essential 0.13531 non-essential high agree high_confidence_nonessential Rv2898c 58.3 NE 0 0.9561678146524734 72.881 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.135; Mtb RBH anchor Rv2898c=non-essential (agree); ProteomeLM contextual percentile=0.956; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.956); Target-priority score is high (72.9) rescued_from_possible_false_negative_by_supporting_evidence 0.030134 non-essential Non-essential ML1610 563 Q7AQ38 ML1610 Protein often found in Actinomycetes clustered with signal peptidase and/or RNaseHII 101 0.13799 non-essential 0.19571 non-essential high agree high_confidence_nonessential Rv2901c 99.0 NE 0 0.7814652473387602 69.551 Strong candidate ESM-2 calibrated P(essential)=0.138; HANSEN integrated essentiality score=0.196; Mtb RBH anchor Rv2901c=non-essential (agree); ProteomeLM contextual percentile=0.781; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.781); Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 0.002723 non-essential Non-essential ML1611 249 O33022 rnhB ML1611 MLCB250.40 Ribonuclease HII (RNase HII) (EC 3.1.26.4) 240 0.06124 non-essential 0.23344 non-essential high NA medium_confidence NP_217418.1 76.7 0.8453350031308704 83.926 High-priority ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.845; target-priority score=83.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.845); Target-priority score is high (83.9) rescued_from_possible_false_negative_by_supporting_evidence 0.007265 non-essential Non-essential ML1612 1505 O33021 lepB ML1612 MLCB250.39 Probable signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) 289 0.03424 non-essential 0.07996 non-essential high NA high_confidence_nonessential NP_217419.1 69.8 0.14151534126487164 58.389 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.080; ProteomeLM contextual percentile=0.142; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.016972 non-essential Non-essential ML1613 81 O33020 rplS ML1613 MLCB250.38 Large ribosomal subunit protein bL19 (50S ribosomal protein L19) 113 0.28398 non-essential 0.3159 non-essential medium NA medium_confidence NP_217420.1 93.8 0.38384470882905447 58.287 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.316; ProteomeLM contextual percentile=0.384; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004195 non-essential Non-essential ML1615 641 O33017 trmD ML1615 MLCB250.35 tRNA (guanine-N(1)-)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) 238 0.04041 non-essential 0.18815 non-essential high NA high_confidence_nonessential NP_217422.1 87.7 0.6925485284909205 77.795 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.693; target-priority score=77.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.8) rescued_from_possible_false_negative_by_supporting_evidence 0.641062 essential Likely essential ML1616 550 O33016 rimM ML1616 MLCB250.34 Ribosome maturation factor RimM 179 0.1035 non-essential 0.19669 non-essential high NA high_confidence_nonessential NP_217423.1 73.1 0.49843456480901693 62.441 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.498; target-priority score=62.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.244998 non-essential Uncertain ML1617 14 O33015 khpA ML1617 MLCB250.30 RNA-binding protein KhpA (KH-domain protein A) 80 0.23801 non-essential 0.49311 non-essential low disagree review_anchor_disagreement Rv2908c 93.8 GD 1 0.6706324358171571 66.496 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.493; Mtb RBH anchor Rv2908c=essential (disagree); ProteomeLM contextual percentile=0.671; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.001368 non-essential Non-essential ML1618 118 O33014 rpsP ML1618 MLCB250.32 Small ribosomal subunit protein bS16 (30S ribosomal protein S16) 160 0.14132 non-essential 0.27362 non-essential high NA medium_confidence NP_217425.1 90.9 0.7532874139010645 70.671 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.753; target-priority score=70.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.753); Target-priority score is high (70.7) rescued_from_possible_false_negative_by_supporting_evidence 0.015379 non-essential Non-essential ML1622 500 O33013 ffh ML1622 MLCB250.20 Signal recognition particle protein (EC 3.6.5.4) (Fifty-four homolog) 521 0.12534 non-essential 0.20259 non-essential high NA medium_confidence NP_217432.1 84.7 0.41891045710707575 67.215 Strong candidate ESM-2 calibrated P(essential)=0.125; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.419; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.2) rescued_from_possible_false_negative_by_supporting_evidence 0.01859 non-essential Non-essential ML1623 753 O33012 htpG ML1623 MLCB250.19c Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G) 656 0.09373 non-essential 0.1758 non-essential high NA high_confidence_nonessential NP_216815.1 80.8 0.43206011271133377 58.473 Moderate candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.432; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 9.5e-05 non-essential Non-essential ML1624 1597 O33011 ML1624 MLCB250.18c Uncharacterized protein ML1624 596 0.01019 non-essential 0.03453 non-essential high agree high_confidence_nonessential Rv2917 79.9 NE 0 0.052598622417031934 46.303 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.035; Mtb RBH anchor Rv2917=non-essential (agree); ProteomeLM contextual percentile=0.053; target-priority score=46.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.008184 non-essential Non-essential ML1628 1512 O33010 ftsY ML1628 MLCB250.02 Signal recognition particle receptor FtsY (SRP receptor) (EC 3.6.5.4) 430 0.056 non-essential 0.07864 non-essential high NA high_confidence_nonessential NP_217437.1 81.2 0.043832185347526614 55.019 Moderate candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.044; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.043147 non-essential Non-essential ML1629 843 Q9CBT5 smc ML1629 MLCB250.01 Chromosome partition protein Smc 1203 0.152 non-essential 0.16399 non-essential high NA high_confidence_nonessential NP_217438.2 78.3 0.12147777082028804 49.563 Exploratory ESM-2 calibrated P(essential)=0.152; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.121; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002015 non-essential Non-essential ML1630 1043 Q9CBT4 glnE ML1630 Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme (ATP:glutamine synthetase adenylyltransferase) (ATase) [Includes: Glutamine synthetase adenylyl-L-tyrosine phosphorylase (EC 2.7.7.89) (Adenylyl removase) (AR) (AT-N); Glutamine synthetase adenylyl transferase (EC 2.7.7.42) (Adenylyl transferase) (AT) (AT-C)] 1004 0.10418 non-essential 0.13991 non-essential high NA high_confidence_nonessential NP_216737.1 82.1 0.17908578584846588 56.409 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.179; target-priority score=56.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.016367 non-essential Non-essential ML1631 1579 Q9CBT3 glnA2 ML1631 Glutamine synthetase (EC 6.3.1.2) (Glutamate--ammonia ligase) (Glutamine synthetase I alpha) 448 0.02734 non-essential 0.0589 non-essential high NA high_confidence_nonessential NP_216738.1 93.3 0.05823418910457107 55.345 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.059; ProteomeLM contextual percentile=0.058; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 5.9e-05 non-essential Non-essential ML1632 1479 Q9CBT2 ML1632 Possible hydrolase 511 0.03424 non-essential 0.08539 non-essential high NA high_confidence_nonessential NP_216739.1 71.9 0.19160926737633063 52.223 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.192; target-priority score=52.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000636 non-essential Non-essential ML1633 1060 Q9CBT1 ML1633 Possible secreted hydrolase 535 0.03604 non-essential 0.1379 non-essential high NA high_confidence_nonessential NP_216740.1 84.8 0.4652473387601753 61.388 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.465; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML1635 1309 Q9CBT0 panB ML1635 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11) (Ketopantoate hydroxymethyltransferase) (KPHMT) 286 0.06686 non-essential 0.11269 non-essential high NA high_confidence_nonessential NP_216741.1 82.5 0.16718847839699436 64.232 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.167; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.390584 essential Uncertain ML1637 262 Q7AQ37 ML1637 RNase H type-1 domain-containing protein 371 0.09201 non-essential 0.23061 non-essential high NA medium_confidence NP_216744.1 77.1 0.7251095804633688 71.157 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.725; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.065346 non-essential Non-essential ML1638 882 Q9CBS9 ML1638 MLCB1243.37 Uncharacterized protein ML1638 232 0.05767 non-essential 0.15878 non-essential high agree high_confidence_nonessential Rv2229c 60.4 NE 0 0.8822792736380713 71.901 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.159; Mtb RBH anchor Rv2229c=non-essential (agree); ProteomeLM contextual percentile=0.882; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.882); Target-priority score is high (71.9) rescued_from_possible_false_negative_by_supporting_evidence 4e-06 non-essential Non-essential ML1639 1384 O69481 ML1639 MLCB1243.36 GTP cyclohydrolase 1 type 2 homolog 385 0.03424 non-essential 0.10292 non-essential high NA high_confidence_nonessential NP_216746.1 79.5 0.27864746399499063 57.686 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.279; target-priority score=57.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.011116 non-essential Non-essential ML1644 1584 Q7AQ36 ML1644 SURF1-like protein 270 0.01828 non-essential 0.05534 non-essential high NA high_confidence_nonessential NP_216751.1 74.2 0.10331872260488416 47.04 Exploratory ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.055; ProteomeLM contextual percentile=0.103; target-priority score=47.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.217287 non-essential Uncertain ML1649 1132 Q7AQ35 ML1649 DUF3052 domain-containing protein 140 0.04041 non-essential 0.13114 non-essential high agree high_confidence_nonessential Rv2239c 85.7 NE 0 0.7288666249217283 68.002 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv2239c=non-essential (agree); ProteomeLM contextual percentile=0.729; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 1.7e-05 non-essential Non-essential ML1651 1369 Q9CBS8 aceE ML1651 Pyruvate dehydrogenase E1 component (EC 1.2.4.1) 936 0.09809 non-essential 0.10466 non-essential high NA high_confidence_nonessential NP_216757.3 89.4 0.008766437069505322 53.326 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.009; target-priority score=53.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009151 non-essential Non-essential ML1652 46 Q7AQ34 ML1652 PucR family transcriptional regulator 414 0.16776 non-essential 0.40598 non-essential low disagree review_anchor_disagreement Rv2242 88.4 ES 1 0.28991859737006886 52.657 Moderate candidate ESM-2 calibrated P(essential)=0.168; HANSEN integrated essentiality score=0.406; Mtb RBH anchor Rv2242=essential (disagree); ProteomeLM contextual percentile=0.290; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.000923 non-essential Non-essential ML1653 457 Q7AQ33 fabD ML1653 Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39) 304 0.09148 non-essential 0.20687 non-essential high NA medium_confidence NP_216759.1 82.2 0.5716969317470256 76.649 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.572; target-priority score=76.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.6) rescued_from_possible_false_negative_by_supporting_evidence 0.203857 non-essential Uncertain ML1654 244 O69475 acpM ML1654 MLCB1243.21c Meromycolate extension acyl carrier protein (ACP) 115 0.09683 non-essential 0.23416 non-essential high NA medium_confidence NP_216760.1 96.8 0.7332498434564809 67.969 Strong candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.234; ProteomeLM contextual percentile=0.733; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.001935 non-essential Non-essential ML1655 724 Q9CBS7 kasA ML1655 MLCB1243.20c 3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC 2.3.1.293) (Beta-ketoacyl-ACP synthase 1) (KAS 1) 416 0.06981 non-essential 0.17933 non-essential high NA high_confidence_nonessential NP_216761.1 92.8 0.5078271759549154 77.104 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.508; target-priority score=77.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.1) rescued_from_possible_false_negative_by_supporting_evidence 0.237485 non-essential Uncertain ML1656 565 O69473 kasB ML1656 MLCB1243.19c 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC 2.3.1.294) (Beta-ketoacyl-ACP synthase 2) (KAS 2) 420 0.06981 non-essential 0.19517 non-essential high NA high_confidence_nonessential NP_216762.1 91.6 0.5929868503443957 79.816 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.593; target-priority score=79.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.8) rescued_from_possible_false_negative_by_supporting_evidence 0.029338 non-essential Non-essential ML1657 899 Q7AQ32 ML1657 Acetyl/propionyl CoA carboxylase [beta] subunit 473 0.14132 non-essential 0.15624 non-essential high NA high_confidence_nonessential NP_216763.1 92.8 0.12648716343143393 49.022 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.126; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.025237 non-essential Non-essential ML1658 1123 O69470 mutM fpg ML1658 MLCB1243.16 Formamidopyrimidine-DNA glycosylase (Fapy-DNA glycosylase) (EC 3.2.2.23) (DNA-(apurinic or apyrimidinic site) lyase MutM) (AP lyase MutM) (EC 4.2.99.18) 282 0.09638 non-essential 0.13189 non-essential high NA high_confidence_nonessential NP_217440.1 80.6 0.15904821540388228 59.353 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.132; ProteomeLM contextual percentile=0.159; target-priority score=59.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004933 non-essential Non-essential ML1659 1440 O69469 rnc ML1659 MLCB1243.15 Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) 238 0.06543 non-essential 0.09255 non-essential high NA high_confidence_nonessential NP_217441.1 85.8 0.08015028177833437 55.771 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.080; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.834857 essential Essential ML1660 1129 O69468 ML1660 MLCB1243.14 Uncharacterized protein ML1660 217 0.02734 non-essential 0.1314 non-essential high agree high_confidence_nonessential Rv2926c 67.2 NE 0 0.8065122103944896 68.694 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv2926c=non-essential (agree); ProteomeLM contextual percentile=0.807; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.807); Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000315 non-essential Non-essential ML1661 33 Q9CBS6 ML1661 MLCB1243.13 Uncharacterized protein ML1661 245 0.23815 non-essential 0.43238 non-essential low disagree review_anchor_disagreement Rv2927c 86.5 ES 1 0.16530995616781466 45.914 Exploratory ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.432; Mtb RBH anchor Rv2927c=essential (disagree); ProteomeLM contextual percentile=0.165; target-priority score=45.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.260578 non-essential Uncertain ML1663 68 O69466 coaD kdtB ML1663 MLCB1243.10 Phosphopantetheine adenylyltransferase (EC 2.7.7.3) (Dephospho-CoA pyrophosphorylase) (Pantetheine-phosphate adenylyltransferase) (PPAT) 160 0.23815 non-essential 0.34172 non-essential medium NA medium_confidence NP_217481.1 84.1 0.678146524733876 81.365 High-priority ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.342; ProteomeLM contextual percentile=0.678; target-priority score=81.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.4) rescued_from_possible_false_negative_by_supporting_evidence 0.001337 non-essential Non-essential ML1664 655 Q9CBS5 ML1664 Methyltransferase 157 0.01553 non-essential 0.18675 non-essential high NA high_confidence_nonessential NP_217482.1 72.3 0.8083907326236693 74.423 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.808; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.808); Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 0.007165 non-essential Non-essential ML1666 400 Q7AQ31 ML1666 Conserved integral membrane protein 214 0.0998 non-essential 0.21268 non-essential high NA medium_confidence NP_217484.1 72.0 0.6005009392611146 65.497 Strong candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.601; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.5) rescued_from_possible_false_negative_by_supporting_evidence 0.02298 non-essential Non-essential ML1667 36 Q9CBS4 ML1667 Possible conserved membrane protein 264 0.12049 non-essential 0.42726 non-essential low disagree review_anchor_disagreement Rv2969c 66.0 ES 1 0.7182216656230432 66.287 Strong candidate ESM-2 calibrated P(essential)=0.120; HANSEN integrated essentiality score=0.427; Mtb RBH anchor Rv2969c=essential (disagree); ProteomeLM contextual percentile=0.718; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.152925 non-essential Non-essential ML1669 868 O69462 ML1669 MLCB1243.03c Aldo-keto reductase ML1669 (EC 1.1.1.-) 282 0.05162 non-essential 0.16074 non-essential high NA high_confidence_nonessential NP_217487.1 82.4 0.5021916092673764 70.207 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.502; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 0.007991 non-essential Non-essential ML1671 453 O69460 recG ML1671 MLCB1243.01 ATP-dependent DNA helicase RecG (EC 5.6.2.4) (DNA branch migration protein RecG) (Probable DNA 3'-5' helicase RecG) 743 0.16853 non-essential 0.20737 non-essential high NA medium_confidence NP_217489.1 79.4 0.2648716343143394 61.774 Moderate candidate ESM-2 calibrated P(essential)=0.169; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.265; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00696 non-essential Non-essential ML1674 93 P68998 rpmB ML1674 Large ribosomal subunit protein bL28 (50S ribosomal protein L28) 64 0.23313 non-essential 0.29184 non-essential medium NA medium_confidence YP_009030042.1 90.6 ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.292; ProteomeLM contextual percentile=0.500 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001251 non-essential Non-essential ML1675 1405 Q9CBS3 ung ML1675 Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) 227 0.00198 non-essential 0.10134 non-essential high NA high_confidence_nonessential NP_217492.1 88.5 0.3882279273638071 67.595 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.101; ProteomeLM contextual percentile=0.388; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.6) rescued_from_possible_false_negative_by_supporting_evidence 0.003276 non-essential Non-essential ML1676 1427 Q9CBS2 thiL ML1676 Thiamine-monophosphate kinase (TMP kinase) (Thiamine-phosphate kinase) (EC 2.7.4.16) 325 0.02644 non-essential 0.09432 non-essential high NA high_confidence_nonessential NP_217493.1 80.9 0.23919849718221667 66.061 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.094; ProteomeLM contextual percentile=0.239; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.008553 non-essential Non-essential ML1677 1041 Q9CBS1 ML1677 Possible secreted protein 191 0.06981 non-essential 0.14001 non-essential high agree high_confidence_nonessential Rv2980 67.3 NE 0 0.6581089542892924 64.625 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.140; Mtb RBH anchor Rv2980=non-essential (agree); ProteomeLM contextual percentile=0.658; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.038562 non-essential Non-essential ML1678 1406 Q9CBS0 ddl ddlA ML1678 D-alanine--D-alanine ligase (EC 6.3.2.4) (D-Ala-D-Ala ligase) (D-alanylalanine synthetase) 384 0.04041 non-essential 0.10111 non-essential high NA high_confidence_nonessential NP_217497.1 81.7 0.21352536005009393 66.567 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.101; ProteomeLM contextual percentile=0.214; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.052523 non-essential Non-essential ML1679 574 Q9CBR9 gpsA ML1679 MLCB637.38 Glycerol-3-phosphate dehydrogenase [NAD(P)+] (EC 1.1.1.94) (NAD(P)(+)-dependent glycerol-3-phosphate dehydrogenase) (NAD(P)H-dependent dihydroxyacetone-phosphate reductase) 349 0.06981 non-essential 0.19413 non-essential high NA high_confidence_nonessential NP_217498.1 77.9 0.5892298058860364 79.023 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.589; target-priority score=79.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.0) rescued_from_possible_false_negative_by_supporting_evidence 0.01324 non-essential Non-essential ML1680 1103 O33128 fbiD ML1680 MLCB637.37c Phosphoenolpyruvate guanylyltransferase (PEP guanylyltransferase) (EC 2.7.7.105) 216 0.00543 non-essential 0.13364 non-essential high NA high_confidence_nonessential NP_217499.1 79.1 0.5353788353162179 76.779 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.535; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000411 non-essential Non-essential ML1681 963 O33127 ppk ML1681 MLCB637.36c Polyphosphate kinase (EC 2.7.4.1) (ATP-polyphosphate phosphotransferase) (Polyphosphoric acid kinase) 739 0.10418 non-essential 0.14827 non-essential high NA high_confidence_nonessential NP_217500.1 87.9 0.21540388227927365 60.794 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.148; ProteomeLM contextual percentile=0.215; target-priority score=60.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.042955 non-essential Non-essential ML1682 902 Q9CBR8 ML1682 Nudix hydrolase domain-containing protein 311 0.09638 non-essential 0.15602 non-essential high NA high_confidence_nonessential NP_217501.1 71.8 0.30995616781465246 56.302 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.310; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6.3e-05 non-essential Non-essential ML1683 65 O33125 hupB hlp lbp21 ML1683 MLCB637.34 DNA-binding protein HupB (HupB) (EC 1.16.3.1) (21 kDa laminin-2-binding protein) (ML-LBP21) (DNA-binding protein HU homolog) (Histone-like protein) (Hlp) 200 0.2301 non-essential 0.35066 non-essential medium NA medium_confidence NP_217502.1 96.5 0.7827175954915466 76.235 Strong candidate ESM-2 calibrated P(essential)=0.230; HANSEN integrated essentiality score=0.351; ProteomeLM contextual percentile=0.783; target-priority score=76.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.783); Target-priority score is high (76.2) rescued_from_possible_false_negative_by_supporting_evidence 0.564023 essential Likely essential ML1684 1245 O33124 leuD ML1684 MLCB637.33 3-isopropylmalate dehydratase small subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) 198 0.02105 non-essential 0.12038 non-essential high NA high_confidence_nonessential NP_217503.1 87.8 0.4095178459611772 68.686 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.410; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 0.462698 essential Likely essential ML1685 893 O33123 leuC ML1685 MLCB637.32 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33) (Alpha-IPM isomerase) (IPMI) (Isopropylmalate isomerase) 476 0.04673 non-essential 0.15748 non-essential high NA high_confidence_nonessential NP_217504.1 88.7 0.493425172197871 74.297 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.157; ProteomeLM contextual percentile=0.493; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.3) rescued_from_possible_false_negative_by_supporting_evidence 0.259092 non-essential Uncertain ML1688 485 O33120 gltX gltS ML1688 MLCB637.29 Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase) (GluRS) 502 0.09148 non-essential 0.20366 non-essential high NA medium_confidence YP_177915.1 82.0 0.5572949279899813 75.132 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.557; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.091246 non-essential Non-essential ML1689 730 Q7AQ28 ML1689 Possible hydrolase 242 0.06371 non-essential 0.17863 non-essential high NA high_confidence_nonessential NP_217509.3 85.9 0.5654351909830932 65.62 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.565; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.6) rescued_from_possible_false_negative_by_supporting_evidence 0.001127 non-essential Non-essential ML1691 1138 O33117 leuB ML1691 MLCB637.26 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase) (IMDH) 336 0.05936 non-essential 0.13056 non-essential high NA high_confidence_nonessential NP_217511.1 83.9 0.2943018159048215 68.46 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.294; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.178633 non-essential Non-essential ML1692 421 O33116 serA ML1692 MLCB637.25 D-3-phosphoglycerate dehydrogenase (PGDH) (EC 1.1.1.95) (2-oxoglutarate reductase) (EC 1.1.1.399) 528 0.14132 non-essential 0.21019 non-essential high NA medium_confidence YP_177916.1 89.8 0.3807138384470883 70.485 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.381; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 0.003923 non-essential Non-essential ML1694 1017 O33114 ilvC ML1694 MLCB637.22 Ketol-acid reductoisomerase (NADP(+)) (KARI) (EC 1.1.1.86) (Acetohydroxy-acid isomeroreductase) (AHIR) (Alpha-keto-beta-hydroxylacyl reductoisomerase) (Ketol-acid reductoisomerase type 1) (Ketol-acid reductoisomerase type I) 333 0.14132 non-essential 0.14257 non-essential high NA high_confidence_nonessential NP_217517.3 86.5 0.018159048215403883 58.512 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.018; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.296153 non-essential Uncertain ML1695 125 O33113 ilvH ilvN ML1695 MLCB637.21 Acetolactate synthase small subunit (EC 2.2.1.6) (Acetohydroxy-acid synthase small subunit) (AHAS) (ALS) 169 0.18715 non-essential 0.27156 non-essential high NA medium_confidence NP_217518.1 83.5 0.5247338760175329 72.76 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.272; ProteomeLM contextual percentile=0.525; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.8) rescued_from_possible_false_negative_by_supporting_evidence 0.001918 non-essential Non-essential ML1696 746 O33112 ilvB ML1696 MLCB637.20 Acetolactate synthase (EC 2.2.1.6) (ALS) (Acetohydroxy-acid synthase) 625 0.13353 non-essential 0.17709 non-essential high NA high_confidence_nonessential YP_177917.1 86.2 0.23794614902943018 64.974 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.238; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.930828 essential Essential ML1698 1435 Q7AQ27 ML1698 Conserved membrane protein 277 0.01172 non-essential 0.09316 non-essential high agree high_confidence_nonessential Rv3005c 68.7 NE 0 0.5604257983719474 60.173 Moderate candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.093; Mtb RBH anchor Rv3005c=non-essential (agree); ProteomeLM contextual percentile=0.560; target-priority score=60.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004018 non-essential Non-essential ML1699 519 Q7AQ26 ML1699 Lipoprotein 372 0.13353 non-essential 0.20051 non-essential high NA medium_confidence NP_217522.1 86.2 0.40200375704445834 56.046 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.402; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.487208 essential Likely essential ML1700 1062 O33107 gatB ML1700 MLCB637.15 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B (Asp/Glu-ADT subunit B) (EC 6.3.5.-) 509 0.14132 non-essential 0.13766 non-essential high NA high_confidence_nonessential NP_217525.1 88.4 0.008140262993112084 52.089 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.008; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.380361 essential Uncertain ML1701 358 O33106 pfkA ML1701 MLCB637.14 ATP-dependent 6-phosphofructokinase (ATP-PFK) (Phosphofructokinase) (EC 2.7.1.11) (Phosphohexokinase) 343 0.14132 non-essential 0.21723 non-essential high NA medium_confidence NP_217526.1 90.4 0.41828428303068255 71.787 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.418; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.206151 non-essential Uncertain ML1702 870 O33105 gatA ML1702 MLCB637.13 Glutamyl-tRNA(Gln) amidotransferase subunit A (Glu-ADT subunit A) (EC 6.3.5.7) 497 0.13353 non-essential 0.16059 non-essential high NA high_confidence_nonessential NP_217527.2 89.0 0.15529117094552286 60.076 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.155; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.832443 essential Essential ML1703 145 O33104 gatC ML1703 MLCB637.12 Glutamyl-tRNA(Gln) amidotransferase subunit C (Glu-ADT subunit C) (EC 6.3.5.-) 99 0.12863 non-essential 0.26173 non-essential high NA medium_confidence NP_217528.1 75.8 0.728240450845335 75.195 Strong candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.728; target-priority score=75.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.2) rescued_from_possible_false_negative_by_supporting_evidence 0.043032 non-essential Non-essential ML1704 1011 Q9CBR7 ML1704 ACT domain-containing protein 232 0.09148 non-essential 0.14303 non-essential high agree high_confidence_nonessential Rv3013 84.3 GA 0 0.5735754539762054 61.566 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.143; Mtb RBH anchor Rv3013=non-essential (agree); ProteomeLM contextual percentile=0.574; target-priority score=61.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001191 non-essential Non-essential ML1705 541 O33102 ligA lig ML1705 MLCB637.10 DNA ligase (EC 6.5.1.2) (Polydeoxyribonucleotide synthase [NAD(+)]) 694 0.19217 non-essential 0.19766 non-essential high NA high_confidence_nonessential NP_217530.1 84.9 0.10707576706324358 59.132 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.107; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.965298 essential Essential ML1706 1296 Q9CBR6 ML1706 Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein 337 0.0933 non-essential 0.11398 non-essential high agree high_confidence_nonessential Rv3015c 78.3 NE 0 0.2974326862867877 56.513 Moderate candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.114; Mtb RBH anchor Rv3015c=non-essential (agree); ProteomeLM contextual percentile=0.297; target-priority score=56.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004313 non-essential Non-essential ML1707 1258 O33099 mnmA trmU ML1707 MLCB637.07 tRNA-specific 2-thiouridylase MnmA (EC 2.8.1.13) 358 0.06981 non-essential 0.11817 non-essential high NA high_confidence_nonessential NP_217540.1 85.4 0.19724483406386975 60.375 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.197; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.064796 non-essential Non-essential ML1708 446 Q9CBR5 ML1708 cysteine desulfurase (EC 2.8.1.7) 410 0.11765 non-essential 0.20812 non-essential high NA medium_confidence NP_217541.1 84.9 0.48403256105197245 68.125 Strong candidate ESM-2 calibrated P(essential)=0.118; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.484; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.071331 non-essential Non-essential ML1711 100 O33096 etfA fixB ML1711 MLCB637.04 Electron transfer flavoprotein subunit alpha (Alpha-ETF) (Electron transfer flavoprotein large subunit) (ETFLS) 318 0.19217 non-essential 0.28572 non-essential high NA medium_confidence NP_217544.1 84.9 0.5973700688791485 68.54 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.286; ProteomeLM contextual percentile=0.597; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.091245 non-essential Non-essential ML1712 196 O33095 etfB fixA ML1712 MLCB637.03 Electron transfer flavoprotein subunit beta (Beta-ETF) (Electron transfer flavoprotein small subunit) (ETFSS) 266 0.19217 non-essential 0.24445 non-essential high NA medium_confidence NP_217545.1 95.1 0.38447088290544773 58.401 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.244; ProteomeLM contextual percentile=0.384; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.512466 essential Likely essential ML1713 1237 Q7AQ25 ML1713 Methyltransferase type 11 domain-containing protein 280 0.04552 non-essential 0.12128 non-essential high NA high_confidence_nonessential NP_217546.1 77.8 0.33813400125234816 56.569 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.338; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.176603 non-essential Non-essential ML1714 815 Q9CBR4 ML1714 1,4-alpha-glucan branching enzyme (EC 2.4.1.18) (1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase) (Alpha-(1->4)-glucan branching enzyme) (Branching enzyme) 522 0.06199 non-essential 0.16833 non-essential high NA high_confidence_nonessential NP_217547.1 86.3 0.49592986850344395 71.348 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.496; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 0.230478 non-essential Uncertain ML1715 879 Q9CBR3 ML1715 Transferase 438 0.07471 non-essential 0.15966 non-essential high NA high_confidence_nonessential NP_217548.1 87.9 0.419536631183469 60.139 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.420; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.444519 essential Likely essential ML1717 176 Q9CBR2 ML1717 Doubtful CDS 97 0.06981 non-essential 0.25054 non-essential high NA medium_confidence 0.9505322479649343 69.001 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.251; ProteomeLM contextual percentile=0.951; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.951); Target-priority score is high (69.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000459 non-essential Non-essential ML1719 142 Q9CBR1 ML1719 Transferase 245 0.13353 non-essential 0.26244 non-essential high NA medium_confidence NP_217550.1 90.6 0.7269881026925485 69.405 Strong candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.262; ProteomeLM contextual percentile=0.727; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 0.804236 essential Essential ML1720 21 Q9CBR0 ML1720 Pyrrolo-quinoline quinone repeat domain-containing protein 364 0.15769 non-essential 0.47063 non-essential low disagree review_anchor_disagreement Rv3035 76.0 GD 1 0.8897933625547902 74.089 Strong candidate ESM-2 calibrated P(essential)=0.158; HANSEN integrated essentiality score=0.471; Mtb RBH anchor Rv3035=essential (disagree); ProteomeLM contextual percentile=0.890; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.181785 non-essential Non-essential ML1723 32 Q9CBQ9 ML1723 Methyltransferase type 11 domain-containing protein 327 0.18438 non-essential 0.43323 non-essential low disagree review_anchor_disagreement Rv3038c 80.7 ES 1 0.42391984971822166 60.413 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.433; Mtb RBH anchor Rv3038c=essential (disagree); ProteomeLM contextual percentile=0.424; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.168839 non-essential Non-essential ML1724 271 Q9CBQ8 ML1724 Enoyl-CoA hydratase/isomerase 252 0.14132 non-essential 0.22956 non-essential high NA medium_confidence NP_217555.1 85.6 0.5140889167188478 63.876 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.514; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010087 non-essential Non-essential ML1726 562 Q9CBQ7 ML1726 ABC transporter protein, ATP-binding component 305 0.06636 non-essential 0.19573 non-essential high NA high_confidence_nonessential NP_217557.1 83.4 0.65184721352536 66.312 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.652; target-priority score=66.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.3) rescued_from_possible_false_negative_by_supporting_evidence 0.002117 non-essential Non-essential ML1727 817 Q9CBQ6 ML1727 phosphoserine phosphatase (EC 3.1.3.3) (O-phosphoserine phosphohydrolase) 411 0.09625 non-essential 0.16776 non-essential high NA high_confidence_nonessential NP_217558.1 86.3 0.3431433938634941 68.699 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.343; target-priority score=68.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.7) rescued_from_possible_false_negative_by_supporting_evidence 0.027924 non-essential Non-essential ML1728 1155 Q9CBQ5 ctaD ML1728 Probable cytochrome c oxidase subunit 1 (EC 7.1.1.9) (Cytochrome aa3 subunit 1) (Cytochrome c oxidase polypeptide I) 574 0.03029 non-essential 0.12971 non-essential high NA high_confidence_nonessential NP_217559.1 95.6 0.41202254226675017 72.074 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.412; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.1) rescued_from_possible_false_negative_by_supporting_evidence 0.859871 essential Essential ML1729 587 Q9CBQ4 fecB ML1729 FeIII-dicitrate transporter lipoprotein 364 0.05001 non-essential 0.19327 non-essential high NA high_confidence_nonessential NP_217560.1 75.6 0.7056981840951785 68.595 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.706; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.6) rescued_from_possible_false_negative_by_supporting_evidence 0.009474 non-essential Non-essential ML1730 853 Q9CBQ3 adhA ML1730 NADP-dependent alcohol dehydrogenase C (EC 1.1.1.2) 362 0.04985 non-essential 0.16286 non-essential high NA high_confidence_nonessential NP_217561.1 85.8 0.5216030056355667 70.611 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.522; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.002438 non-essential Non-essential ML1731 1543 Q9CBQ2 nrdF ML1731 Ribonucleoside-diphosphate reductase subunit beta (EC 1.17.4.1) (Ribonucleotide reductase small subunit) 325 0.05767 non-essential 0.07168 non-essential high NA high_confidence_nonessential YP_177921.1 93.5 0.0006261740763932373 53.186 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.072; ProteomeLM contextual percentile=0.001; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.152272 non-essential Non-essential ML1733 313 Q9CBQ1 ML1733 TetR-family transcriptional regulator 275 0.05827 non-essential 0.22299 non-essential high NA medium_confidence NP_217566.1 86.6 0.8328115216030056 71.917 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.833; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.833); Target-priority score is high (71.9) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML1734 1401 Q9CBQ0 nrdE ML1734 Ribonucleoside-diphosphate reductase subunit alpha (EC 1.17.4.1) (Ribonucleotide reductase R1 subunit) 721 0.08894 non-essential 0.10162 non-essential high NA high_confidence_nonessential NP_217567.1 93.2 0.028177833437695678 54.916 Moderate candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.028; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.958766 essential Essential ML1735 87 Q9CBP9 nrdI ML1735 Protein NrdI 138 0.18427 non-essential 0.30264 non-essential high NA medium_confidence NP_217568.1 82.7 0.7294927989981215 69.803 Strong candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.303; ProteomeLM contextual percentile=0.729; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.076775 non-essential Non-essential ML1736 407 Q9CBP8 nrdH ML1736 Glutaredoxin-like protein NrdH 80 0.09928 non-essential 0.2115 non-essential high NA medium_confidence NP_217569.1 91.1 0.5992485911083281 64.387 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.599; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.022175 non-essential Non-essential ML1740 945 Q9CBP7 ML1740 Possible short chain reductase 312 0.07126 non-essential 0.1507 non-essential high NA high_confidence_nonessential NP_217573.1 81.8 0.3876017532874139 58.453 Moderate candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.388; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00012 non-essential Non-essential ML1750 1053 Q9CBP6 ML1750 Uncharacterized protein 623 0.05798 non-essential 0.13877 non-essential high agree high_confidence_nonessential Rv1354c 63.3 NE 0 0.7088290544771446 66.2 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.139; Mtb RBH anchor Rv1354c=non-essential (agree); ProteomeLM contextual percentile=0.709; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000868 non-essential Non-essential ML1751 1338 Q9CBP5 ML1751 THIF-type NAD/FAD binding fold domain-containing protein 721 0.03424 non-essential 0.10978 non-essential high NA high_confidence_nonessential NP_215871.1 57.5 0.3199749530369443 57.356 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.110; ProteomeLM contextual percentile=0.320; target-priority score=57.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000269 non-essential Non-essential ML1752 1125 Q9CBP4 ML1752 EAL domain-containing protein 302 0.03424 non-essential 0.1318 non-essential high agree high_confidence_nonessential Rv1357c 73.9 NE 0 0.7639323731997495 69.721 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv1357c=non-essential (agree); ProteomeLM contextual percentile=0.764; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.764); Target-priority score is high (69.7) rescued_from_possible_false_negative_by_supporting_evidence 4.9e-05 non-essential Non-essential ML1753 534 Q9CBP3 ML1753 Possible transcriptional regulator 1106 0.04897 non-essential 0.19825 non-essential high NA high_confidence_nonessential NP_215874.1 58.1 0.7376330619912336 69.311 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.738; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00017 non-essential Non-essential ML1755 990 Q9CBP2 sdaA ML1755 L-serine dehydratase (EC 4.3.1.17) 458 0.0515 non-essential 0.14508 non-essential high NA high_confidence_nonessential NP_214583.1 69.0 0.4145272385723231 68.884 Strong candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.415; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.43751 essential Likely essential ML1756 850 Q9CBP1 mmr ML1756 Multidrug resistance protein mmr 107 0.00543 non-essential 0.16303 non-essential high NA high_confidence_nonessential YP_177922.1 78.5 0.7351283656856606 67.652 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.735; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.7) rescued_from_possible_false_negative_by_supporting_evidence 0.003465 non-essential Non-essential ML1761 693 Q9CBP0 ML1761 Uncharacterized protein 114 0.02389 non-essential 0.18278 non-essential high NA high_confidence_nonessential 0.7733249843456481 65.351 Strong candidate ESM-2 calibrated P(essential)=0.024; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.773; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.773); Target-priority score is high (65.4) rescued_from_possible_false_negative_by_supporting_evidence 3e-05 non-essential Non-essential ML1763 403 Q9CBN9 ML1763 Uncharacterized protein 71 0.01019 non-essential 0.212 non-essential high NA medium_confidence 0.9899812147777082 71.519 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.990; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.990); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000685 non-essential Non-essential ML1768 953 Q9CBN8 uspA ML1768 Sugar transport integral membrane protein 328 0.02581 non-essential 0.14941 non-essential high NA high_confidence_nonessential NP_216832.1 83.5 0.5760801502817783 62.69 Moderate candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.149; ProteomeLM contextual percentile=0.576; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 8e-06 non-essential Non-essential ML1769 743 Q9CBN7 uspE ML1769 Sugar transport integral membrane protein 274 0.03255 non-essential 0.17761 non-essential high NA high_confidence_nonessential YP_177866.1 85.0 0.6969317470256732 67.477 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.697; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000244 non-essential Non-essential ML1770 1374 Q9CBN6 uspC ML1770 Sugar transport periplasmic binding protein 446 0.03424 non-essential 0.10411 non-essential high NA high_confidence_nonessential NP_216834.1 73.5 0.2949279899812148 54.541 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.295; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010081 non-essential Non-essential ML1781 1497 Q9CBN5 ML1781 DUF3145 domain-containing protein 170 0.0587 non-essential 0.08172 non-essential high agree high_confidence_nonessential Rv2256c 93.5 NE 0 0.21665623043206012 49.679 Exploratory ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.082; Mtb RBH anchor Rv2256c=non-essential (agree); ProteomeLM contextual percentile=0.217; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.004435 non-essential Non-essential ML1782 1542 Q9CBN4 ML1782 Beta-lactamase-related domain-containing protein 273 0.04563 non-essential 0.07169 non-essential high agree high_confidence_nonessential Rv2257c 76.4 NE 0 0.1928616155291171 50.06 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.072; Mtb RBH anchor Rv2257c=non-essential (agree); ProteomeLM contextual percentile=0.193; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003662 non-essential Non-essential ML1783 477 Q9CBN3 ML1783 Transcriptional regulator 322 0.01364 non-essential 0.20444 non-essential high NA medium_confidence NP_216774.1 65.2 0.9198497182216656 74.852 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.920; target-priority score=74.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.920); Target-priority score is high (74.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000638 non-essential Non-essential ML1784 738 Q9CBN2 adhE2 ML1784 Alcohol dehydrogenase (Zn dependent) 361 0.06371 non-essential 0.17799 non-essential high NA high_confidence_nonessential NP_216775.1 88.9 0.5591734502191609 66.476 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.559; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000505 non-essential Non-essential ML1788 537 Q7AQ24 ML1788 Uncharacterized protein 154 0.00543 non-essential 0.19791 non-essential high NA high_confidence_nonessential 0.9355040701314965 69.277 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.936; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.935); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 5.7e-05 non-essential Non-essential ML1791 1164 Q9CBN1 ML1791 RNA-binding protein 147 0.03861 non-essential 0.12905 non-essential high agree high_confidence_nonessential Rv1976c 65.3 NE 0 0.7207263619286162 67.61 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv1976c=non-essential (agree); ProteomeLM contextual percentile=0.721; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.6) rescued_from_possible_false_negative_by_supporting_evidence 4.4e-05 non-essential Non-essential ML1793 542 Q9CBN0 ML1793 Uncharacterized protein 101 0.00198 non-essential 0.19766 non-essential high NA high_confidence_nonessential 0.9461490294301816 70.546 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.946; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.946); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000603 non-essential Non-essential ML1794 1028 Q9CBM9 ML1794 Putative cystathionine beta-lyase (CBL) (EC 4.4.1.13) (Beta-cystathionase) (Cysteine lyase) (Cysteine-S-conjugate beta-lyase) 402 0.02795 non-essential 0.14139 non-essential high NA high_confidence_nonessential NP_216810.1 76.2 0.4915466499686913 72.046 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.492; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.001371 non-essential Non-essential ML1795 572 P12809 hsp18 ML1795 18 kDa antigen (HSP 16.7) 148 0.01889 non-essential 0.19456 non-essential high NA high_confidence_nonessential 0.8490920475892298 70.974 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.849; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.849); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000535 non-essential Non-essential ML1796 177 P13733 ML1796 Uncharacterized protein ML1796 137 0.06601 non-essential 0.24994 non-essential high NA medium_confidence 0.9555416405760802 72.017 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.250; ProteomeLM contextual percentile=0.956; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.956); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML1798 1039 Q9CBM8 ML1798 Kinase 327 0.08819 non-essential 0.14024 non-essential high NA high_confidence_nonessential NP_216012.1 83.0 0.26111458985597996 54.109 Moderate candidate ESM-2 calibrated P(essential)=0.088; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.261; target-priority score=54.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00103 non-essential Non-essential ML1799 656 Q9CBM7 mutB ML1799 Probable methylmalonyl-CoA mutase large subunit (EC 5.4.99.2) 758 0.10418 non-essential 0.18659 non-essential high NA high_confidence_nonessential NP_216009.1 88.9 0.42705072010018785 65.466 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.427; target-priority score=65.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.5) rescued_from_possible_false_negative_by_supporting_evidence 0.010439 non-essential Non-essential ML1800 1184 Q9CBM6 mutA ML1800 Methylmalonyl-CoA mutase small subunit (EC 5.4.99.2) 636 0.04818 non-essential 0.12721 non-essential high NA high_confidence_nonessential NP_216008.1 75.2 0.33249843456480904 66.225 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.332; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.001422 non-essential Non-essential ML1802 1277 Q9CBM5 ML1802 Band 7 domain-containing protein 374 0.09564 non-essential 0.11548 non-essential high agree high_confidence_nonessential Rv1488 89.8 NE 0 0.31621790857858484 52.948 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv1488=non-essential (agree); ProteomeLM contextual percentile=0.316; target-priority score=52.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.020001 non-essential Non-essential ML1803 1367 Q9CBM4 ML1803 NfeD-like C-terminal domain-containing protein 143 0.01861 non-essential 0.10485 non-essential high agree high_confidence_nonessential Rv1487 74.8 NE 0 0.6123982467125861 64.885 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv1487=non-essential (agree); ProteomeLM contextual percentile=0.612; target-priority score=64.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001273 non-essential Non-essential ML1804 1371 Q9CBM3 ML1804 Uncharacterized protein ML1804 298 0.03604 non-essential 0.10452 non-essential high agree high_confidence_nonessential Rv1486c 76.7 NE 0 0.5272385723231058 60.347 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv1486c=non-essential (agree); ProteomeLM contextual percentile=0.527; target-priority score=60.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.075055 non-essential Non-essential ML1805 1137 Q9CBM2 cpfC hemH hemZ ML1805 Coproporphyrin III ferrochelatase (EC 4.99.1.9) 336 0.04897 non-essential 0.1307 non-essential high NA high_confidence_nonessential NP_216001.1 76.8 0.34126487163431435 68.972 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.341; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.0) rescued_from_possible_false_negative_by_supporting_evidence 0.031145 non-essential Non-essential ML1806 1325 Q9CBM1 inhA ML1806 Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9) 269 0.07542 non-essential 0.11131 non-essential high NA high_confidence_nonessential NP_216000.1 90.3 0.12022542266750157 64.1 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.120; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000681 non-essential Non-essential ML1807 507 Q9CBM0 fabG1 ML1807 3-oxoacyl-[ACP] reductase (Aka MabA) 253 0.07126 non-essential 0.20196 non-essential high NA medium_confidence NP_215999.1 69.7 0.6562304320601127 69.627 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.656; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 0.09867 non-essential Non-essential ML1808 1056 Q9CBL9 ML1808 UPF0353 protein ML1808 335 0.14132 non-essential 0.13855 non-essential high NA high_confidence_nonessential NP_215997.1 91.0 0.03506574827802129 44.713 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.035; target-priority score=44.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.02222 non-essential Non-essential ML1809 29 Q9CBL8 ML1809 DUF58 domain-containing protein 320 0.25107 non-essential 0.45638 non-essential low disagree review_anchor_disagreement Rv1480 87.5 ES 1 0.2968065122103945 52.126 Moderate candidate ESM-2 calibrated P(essential)=0.251; HANSEN integrated essentiality score=0.456; Mtb RBH anchor Rv1480=essential (disagree); ProteomeLM contextual percentile=0.297; target-priority score=52.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.069592 non-essential Non-essential ML1810 514 Q9CBL7 moxR ML1810 MoxR homolog 377 0.12139 non-essential 0.20136 non-essential high NA medium_confidence YP_177816.1 90.2 0.4533500313087038 59.215 Moderate candidate ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.453; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.99507 essential Essential ML1811 299 Q9CBL6 ML1811 Exported p60 protein homologue 241 0.06311 non-essential 0.22476 non-essential high NA medium_confidence NP_215994.1 77.1 0.8227927363807138 71.313 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.823; target-priority score=71.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.823); Target-priority score is high (71.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00115 non-essential Non-essential ML1812 590 Q9CBL5 ML1812 Exported p60 protein homologue 479 0.12863 non-essential 0.19299 non-essential high NA high_confidence_nonessential NP_215993.1 77.3 0.3800876643706951 56.095 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.193; ProteomeLM contextual percentile=0.380; target-priority score=56.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.017685 non-essential Non-essential ML1813 627 Q9CBL4 ML1813 Uncharacterized protein 190 0.09928 non-essential 0.18954 non-essential high NA high_confidence_nonessential NP_215992.1 78.7 0.48778960551033185 58.363 Moderate candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.488; target-priority score=58.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.514988 essential Likely essential ML1814 742 Q9CBL3 acn ML1814 Aconitate hydratase A (EC 4.2.1.3) (EC 4.2.1.99) ((2R,3S)-2-methylisocitrate dehydratase) ((2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydratase) (Iron-responsive protein-like) (Probable 2-methyl-cis-aconitate hydratase) (RNA-binding protein) 944 0.10115 non-essential 0.17763 non-essential high NA high_confidence_nonessential NP_215991.1 87.1 0.38321853475266127 67.169 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.383; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (67.2) rescued_from_possible_false_negative_by_supporting_evidence 0.986575 essential Essential ML1816 349 Q9CBL2 ML1816 ABC transporter ATP-binding protein, possibly in EF-3 subfamily 545 0.09148 non-essential 0.21827 non-essential high NA medium_confidence NP_215989.1 88.1 0.6687539135879774 66.459 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.669; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000115 non-essential Non-essential ML1818 224 Q9CBL1 trxB ML1818 Thioredoxin 130 0.05422 non-essential 0.23714 non-essential high NA medium_confidence YP_177815.1 65.4 0.9217282404508453 76.298 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.237; ProteomeLM contextual percentile=0.922; target-priority score=76.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.922); Target-priority score is high (76.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000359 non-essential Non-essential ML1821 305 Q9CBL0 ML1821 Uncharacterized protein 117 0.02561 non-essential 0.22391 non-essential high NA medium_confidence 0.9849718221665623 72.985 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.985; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.985); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 1.7e-05 non-essential Non-essential ML1828 679 Q7AQ23 PPE ML1828 PPE-family protein 572 0.00198 non-essential 0.1842 non-essential high NA high_confidence_nonessential YP_177704.1 58.6 0.867877269881027 70.236 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.868; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.868); Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 0.001715 non-essential Non-essential ML1829 308 Q9CBK9 ML1829 Uncharacterized protein 125 0.03079 non-essential 0.22379 non-essential high NA medium_confidence 0.9611772072636193 72.753 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.961; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.961); Target-priority score is high (72.8) rescued_from_possible_false_negative_by_supporting_evidence 2.1e-05 non-essential Non-essential ML1831 1390 Q7AQ22 mapA map ML1831 Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) 266 0.03769 non-essential 0.10252 non-essential high NA high_confidence_nonessential YP_177748.1 83.4 0.24546023794614902 62.782 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.245; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001534 non-essential Non-essential ML1832 217 O33007 adk ML1832 MLCB2492.28 Adenylate kinase (AK) (EC 2.7.4.3) (ATP-AMP transphosphorylase) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) 181 0.174 non-essential 0.23839 non-essential high NA medium_confidence NP_215247.1 84.0 0.3963681903569192 70.572 Strong candidate ESM-2 calibrated P(essential)=0.174; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.396; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.330347 essential Uncertain ML1833 781 O33006 secY ML1833 MLCB2492.27 Protein translocase subunit SecY 438 0.10152 non-essential 0.17202 non-essential high NA high_confidence_nonessential NP_215246.1 91.8 0.38134001252348154 55.997 Moderate candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.381; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.488482 essential Likely essential ML1835 307 Q7AQ21 ML1835 N-acetyltransferase domain-containing protein 227 0.04985 non-essential 0.22384 non-essential high NA medium_confidence NP_215244.1 80.3 0.8622417031934878 76.761 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.862; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.862); Target-priority score is high (76.8) rescued_from_possible_false_negative_by_supporting_evidence 0.002004 non-essential Non-essential ML1839 1395 Q7AQ20 sppA ML1839 Protease IV, signal peptide peptidase 602 0.06199 non-essential 0.10192 non-essential high NA high_confidence_nonessential NP_215238.1 80.4 0.16092673763306198 52.423 Moderate candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.161; target-priority score=52.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004306 non-essential Non-essential ML1840 186 O33002 rplO ML1840 MLCB2492.23 Large ribosomal subunit protein uL15 (50S ribosomal protein L15) 146 0.15591 non-essential 0.24755 non-essential high NA medium_confidence NP_215237.1 82.2 0.5529117094552286 63.888 Moderate candidate ESM-2 calibrated P(essential)=0.156; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.553; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.197513 non-essential Non-essential ML1841 45 O33001 rpmD ML1841 MLCB2492.22 Large ribosomal subunit protein uL30 (50S ribosomal protein L30) 71 0.28398 non-essential 0.40662 non-essential medium NA medium_confidence NP_215236.1 89.2 0.8666249217282405 75.565 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.407; ProteomeLM contextual percentile=0.867; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.407); ProteomeLM contextual percentile is high (0.867); Target-priority score is high (75.6) rescued_from_possible_false_negative_by_supporting_evidence 0.902855 essential Essential ML1842 78 O33000 rpsE ML1842 MLCB2492.21 Small ribosomal subunit protein uS5 (30S ribosomal protein S5) 217 0.20275 non-essential 0.32157 non-essential medium NA medium_confidence NP_215235.1 87.4 0.752035065748278 71.151 Strong candidate ESM-2 calibrated P(essential)=0.203; HANSEN integrated essentiality score=0.322; ProteomeLM contextual percentile=0.752; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.752); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.940151 essential Essential ML1843 75 O32999 rplR ML1843 MLCB2492.20 Large ribosomal subunit protein uL18 (50S ribosomal protein L18) 122 0.28398 non-essential 0.32406 non-essential medium NA medium_confidence NP_215234.1 82.8 0.4226675015654352 61.401 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.324; ProteomeLM contextual percentile=0.423; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.278448 non-essential Uncertain ML1844 60 O32998 rplF ML1844 MLCB2492.19 Large ribosomal subunit protein uL6 (50S ribosomal protein L6) 179 0.42684 non-essential 0.3698 non-essential medium NA medium_confidence NP_215233.1 90.5 0.07138384470882905 49.468 Exploratory ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.370; ProteomeLM contextual percentile=0.071; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.942235 essential Essential ML1845 284 O32997 rpsH ML1845 MLCB2492.18 Small ribosomal subunit protein uS8 (30S ribosomal protein S8) 132 0.16674 non-essential 0.22741 non-essential high NA medium_confidence NP_215232.1 93.9 0.39323731997495304 60.992 Moderate candidate ESM-2 calibrated P(essential)=0.167; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.393; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.258751 non-essential Uncertain ML1846 44 O32996 rpsZ rpsN ML1846 MLCB2492.17 Small ribosomal subunit protein uS14 (30S ribosomal protein S14 type Z) 61 0.28398 non-essential 0.40682 non-essential medium NA medium_confidence YP_177747.1 91.8 0.8616155291170946 77.676 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.407; ProteomeLM contextual percentile=0.862; target-priority score=77.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.407); ProteomeLM contextual percentile is high (0.862); Target-priority score is high (77.7) rescued_from_possible_false_negative_by_supporting_evidence 0.074005 non-essential Non-essential ML1847 858 O32995 rplE ML1847 MLCB2492.16 Large ribosomal subunit protein uL5 (50S ribosomal protein L5) 187 0.13486 non-essential 0.16239 non-essential high NA high_confidence_nonessential NP_215230.1 92.0 0.18033813400125234 53.096 Moderate candidate ESM-2 calibrated P(essential)=0.135; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.180; target-priority score=53.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.731997 essential Essential ML1848 260 O32994 rplX ML1848 MLCB2492.15 Large ribosomal subunit protein uL24 (50S ribosomal protein L24) 105 0.19764 non-essential 0.23072 non-essential high NA medium_confidence NP_215229.1 93.3 0.2867877269881027 55.604 Moderate candidate ESM-2 calibrated P(essential)=0.198; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.287; target-priority score=55.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.241393 non-essential Uncertain ML1849 124 O32993 rplN ML1849 MLCB2492.14 Large ribosomal subunit protein uL14 (50S ribosomal protein L14) 122 0.1873 non-essential 0.27181 non-essential high NA medium_confidence NP_215228.1 96.7 0.5441452723857232 66.421 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.272; ProteomeLM contextual percentile=0.544; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.516592 essential Likely essential ML1854 54 O32990 rpsQ ML1854 MLCB2492.11 Small ribosomal subunit protein uS17 (30S ribosomal protein S17) 126 0.25141 non-essential 0.38554 non-essential medium NA medium_confidence NP_215224.1 77.2 0.89167188478397 75.711 Strong candidate ESM-2 calibrated P(essential)=0.251; HANSEN integrated essentiality score=0.386; ProteomeLM contextual percentile=0.892; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.892); Target-priority score is high (75.7) rescued_from_possible_false_negative_by_supporting_evidence 0.004843 non-essential Non-essential ML1855 119 O32989 rpmC ML1855 MLCB2492.10 Large ribosomal subunit protein uL29 (50S ribosomal protein L29) 80 0.1367 non-essential 0.27309 non-essential high NA medium_confidence NP_215223.1 91.9 0.7676894176581089 71.9 Strong candidate ESM-2 calibrated P(essential)=0.137; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.768; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.768); Target-priority score is high (71.9) rescued_from_possible_false_negative_by_supporting_evidence 0.1623 non-essential Non-essential ML1856 112 O32988 rplP ML1856 MLCB2492.09 Large ribosomal subunit protein uL16 (50S ribosomal protein L16) 138 0.23313 non-essential 0.27532 non-essential medium NA medium_confidence NP_215222.1 96.4 0.37633061991233563 59.005 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.275; ProteomeLM contextual percentile=0.376; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.999118 essential Essential ML1857 136 O32987 rpsC ML1857 MLCB2492.08 Small ribosomal subunit protein uS3 (30S ribosomal protein S3) 281 0.23815 non-essential 0.26554 non-essential medium NA medium_confidence NP_215221.1 96.1 0.30745147150907953 55.031 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.266; ProteomeLM contextual percentile=0.307; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.76975 essential Essential ML1858 69 O32986 rplV ML1858 MLCB2492.07 Large ribosomal subunit protein uL22 (50S ribosomal protein L22) 175 0.23313 non-essential 0.34142 non-essential medium NA medium_confidence NP_215220.1 89.8 0.7319974953036944 70.286 Strong candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.341; ProteomeLM contextual percentile=0.732; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 0.056287 non-essential Non-essential ML1859 527 O32985 rpsS ML1859 MLCB2492.06 Small ribosomal subunit protein uS19 (30S ribosomal protein S19) 93 0.1873 non-essential 0.1988 non-essential high NA high_confidence_nonessential NP_215219.1 96.8 0.16155291170945524 50.498 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.162; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.437475 essential Likely essential ML1860 63 O32984 rplB ML1860 MLCB2492.05 Large ribosomal subunit protein uL2 (50S ribosomal protein L2) 280 0.42077 non-essential 0.35578 non-essential medium NA medium_confidence NP_215218.1 92.1 0.024420788979336257 46.866 Exploratory ESM-2 calibrated P(essential)=0.421; HANSEN integrated essentiality score=0.356; ProteomeLM contextual percentile=0.024; target-priority score=46.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.421) rescued_from_possible_false_negative_by_supporting_evidence 0.99858 essential Essential ML1861 108 O32983 rplW ML1861 MLCB2492.04 Large ribosomal subunit protein uL23 (50S ribosomal protein L23) 100 0.28398 non-essential 0.27654 non-essential medium NA medium_confidence NP_215217.1 85.0 0.1728240450845335 51.308 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.277; ProteomeLM contextual percentile=0.173; target-priority score=51.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010796 non-essential Non-essential ML1862 780 O32982 rplD ML1862 MLCB2492.03 Large ribosomal subunit protein uL4 (50S ribosomal protein L4) 230 0.15001 non-essential 0.1721 non-essential high NA high_confidence_nonessential NP_215216.1 86.7 0.17345021916092673 51.221 Moderate candidate ESM-2 calibrated P(essential)=0.150; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.173; target-priority score=51.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.859897 essential Essential ML1863 189 P30762 rplC ML1863 MLCB2492.02 Large ribosomal subunit protein uL3 (50S ribosomal protein L3) 217 0.24684 non-essential 0.24688 non-essential medium NA medium_confidence NP_215215.1 93.1 0.1696931747025673 50.99 Moderate candidate ESM-2 calibrated P(essential)=0.247; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.170; target-priority score=51.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.151933 non-essential Non-essential ML1864 190 P30765 rpsJ ML1864 Small ribosomal subunit protein uS10 (30S ribosomal protein S10) 101 0.20179 non-essential 0.24682 non-essential medium NA medium_confidence NP_215214.1 98.0 0.35566687539135877 57.92 Moderate candidate ESM-2 calibrated P(essential)=0.202; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.356; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.040703 non-essential Non-essential ML1877 55 P30768 tuf ML1877 Elongation factor Tu (EF-Tu) (EC 3.6.5.3) 396 0.42684 non-essential 0.38167 non-essential medium NA medium_confidence NP_215199.1 95.2 0.1158422041327489 58.087 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.382; ProteomeLM contextual percentile=0.116; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.562437 essential Likely essential ML1878 91 P30767 fusA efg ML1878 Elongation factor G (EF-G) 701 0.20941 non-essential 0.29565 non-essential medium NA medium_confidence YP_177746.1 90.4 0.577958672510958 68.112 Strong candidate ESM-2 calibrated P(essential)=0.209; HANSEN integrated essentiality score=0.296; ProteomeLM contextual percentile=0.578; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.365362 essential Uncertain ML1879 107 P30764 rpsG ML1879 Small ribosomal subunit protein uS7 (30S ribosomal protein S7) 156 0.1873 non-essential 0.27732 non-essential high NA medium_confidence NP_215197.1 96.8 0.5748278021289919 67.015 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.277; ProteomeLM contextual percentile=0.575; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 0.141553 non-essential Non-essential ML1880 61 P30766 rpsL ML1880 Small ribosomal subunit protein uS12 (30S ribosomal protein S12) 124 0.42684 non-essential 0.36133 non-essential medium NA medium_confidence NP_215196.1 97.6 0.029430181590482152 46.785 Exploratory ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.361; ProteomeLM contextual percentile=0.029; target-priority score=46.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.773296 essential Essential ML1889 1476 P30770 nfo end ML1889 Probable endonuclease 4 (EC 3.1.21.2) (Endodeoxyribonuclease IV) (Endonuclease IV) 252 0.04386 non-essential 0.08562 non-essential high NA high_confidence_nonessential NP_215184.1 86.0 0.12961803381340012 58.751 Moderate candidate ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.086; ProteomeLM contextual percentile=0.130; target-priority score=58.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007473 non-essential Non-essential ML1890 160 P30761 rpoC ML1890 DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (EC 2.7.7.6) (RNA polymerase subunit beta') (Transcriptase subunit beta') 1316 0.26646 non-essential 0.25545 non-essential medium NA medium_confidence NP_215182.1 94.6 0.11333750782717596 56.695 Moderate candidate ESM-2 calibrated P(essential)=0.266; HANSEN integrated essentiality score=0.255; ProteomeLM contextual percentile=0.113; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.109334 non-essential Non-essential ML1891 302 P30760 rpoB ML1891 DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (EC 2.7.7.6) (RNA polymerase subunit beta) (Transcriptase subunit beta) 1178 0.23815 non-essential 0.22433 non-essential medium NA medium_confidence NP_215181.1 94.9 0.0670006261740764 54.371 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.224; ProteomeLM contextual percentile=0.067; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.99413 essential Essential ML1892 110 P30769 mkl ML1892 Probable ribonucleotide transport ATP-binding protein mkl 347 0.1873 non-essential 0.27585 non-essential high NA medium_confidence NP_215169.1 93.2 0.5679398872886663 66.417 Strong candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.276; ProteomeLM contextual percentile=0.568; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.060018 non-essential Non-essential ML1895 1331 P30763 rplL ML1895 Large ribosomal subunit protein bL12 (50S ribosomal protein L7/L12) 130 0.09314 non-essential 0.11087 non-essential high NA high_confidence_nonessential NP_215166.1 80.0 0.08328115216030056 48.123 Exploratory ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.083; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.022448 non-essential Non-essential ML1896 728 Q9CBK7 rplJ ML1896 Large ribosomal subunit protein uL10 (50S ribosomal protein L10) 177 0.12891 non-essential 0.17883 non-essential high NA high_confidence_nonessential NP_215165.1 91.2 0.29618033813400124 55.866 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.296; target-priority score=55.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.048906 non-essential Non-essential ML1898 31 Q9CBK6 ML1898 Protein kinase domain-containing protein 448 0.23313 non-essential 0.44814 non-essential low disagree review_anchor_disagreement Rv0647c 85.3 ES 1 0.3055729492798998 55.406 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.448; Mtb RBH anchor Rv0647c=essential (disagree); ProteomeLM contextual percentile=0.306; target-priority score=55.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.327703 essential Uncertain ML1899 1236 Q9CBK5 lipG ML1899 Probable hydrolase 304 0.0515 non-essential 0.12157 non-essential high NA high_confidence_nonessential NP_215160.1 71.6 0.3112085159674389 56.988 Moderate candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.311; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6.9e-05 non-essential Non-essential ML1900 1271 Q9CBK4 mmaA1 ML1900 Methyl mycolic acid synthase 1 286 0.06981 non-essential 0.11691 non-essential high NA high_confidence_nonessential NP_215159.1 87.4 0.20225422667501566 56.159 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.117; ProteomeLM contextual percentile=0.202; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7.5e-05 non-essential Non-essential ML1903 1202 Q9CBK3 mmaA4 ML1903 Methyl mycolic acid synthase 4 298 0.09148 non-essential 0.12536 non-essential high NA high_confidence_nonessential NP_215156.1 87.8 0.15779586725109582 54.351 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.125; ProteomeLM contextual percentile=0.158; target-priority score=54.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001252 non-essential Non-essential ML1904 184 Q9CBK2 rplA ML1904 Large ribosomal subunit protein uL1 (50S ribosomal protein L1) 235 0.1873 non-essential 0.24758 non-essential high NA medium_confidence NP_215155.1 93.6 0.4170319348778961 61.193 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.417; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.72036 essential Essential ML1905 665 Q9CBK1 rplK ML1905 Large ribosomal subunit protein uL11 (50S ribosomal protein L11) 142 0.09152 non-essential 0.18557 non-essential high NA high_confidence_nonessential NP_215154.1 92.3 0.4859110832811522 63.154 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.486; target-priority score=63.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001013 non-essential Non-essential ML1906 372 Q9CBK0 nusG ML1906 Transcription termination/antitermination protein NusG 228 0.14132 non-essential 0.21599 non-essential high NA medium_confidence NP_215153.1 93.4 0.4489668127739512 58.874 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.449; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.945186 essential Essential ML1907 294 Q9CBJ9 secE ML1907 Protein translocase subunit SecE 146 0.1873 non-essential 0.22543 non-essential high NA medium_confidence YP_177743.1 56.2 0.31809643080776456 50.53 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.318; target-priority score=50.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.193028 non-essential Non-essential ML1908 1564 Q9CBJ8 ML1908 UPF0336 protein ML1908 166 0.03949 non-essential 0.06407 non-essential high NA high_confidence_nonessential NP_215151.1 89.2 0.061365059486537255 45.678 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.064; ProteomeLM contextual percentile=0.061; target-priority score=45.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000215 non-essential Non-essential ML1909 561 Q9CBJ7 ML1909 MaoC-like domain-containing protein 142 0.08138 non-essential 0.19591 non-essential high NA high_confidence_nonessential NP_215150.1 93.0 0.5873512836568566 65.158 Strong candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.587; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.04341 non-essential Non-essential ML1910 412 Q9CBJ6 ML1910 UPF0336 protein ML1910 159 0.08446 non-essential 0.21109 non-essential high NA medium_confidence NP_215149.1 85.5 0.6612398246712586 65.602 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.661; target-priority score=65.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.6) rescued_from_possible_false_negative_by_supporting_evidence 0.008205 non-essential Non-essential ML1911 165 Q7AQ19 ML1911A Uncharacterized protein 71 0.14132 non-essential 0.25413 non-essential high NA medium_confidence YP_177630.1 92.7 0.646211646837821 68.092 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.254; ProteomeLM contextual percentile=0.646; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.04831 non-essential Non-essential ML1912 1456 Q9CBJ4 ML1912 Glyoxylase II 238 0.06146 non-essential 0.09115 non-essential high NA high_confidence_nonessential NP_215148.1 85.3 0.10770194113963683 49.8 Exploratory ESM-2 calibrated P(essential)=0.061; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.108; target-priority score=49.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML1915 601 Q9CBJ3 ML1915 Uncharacterized protein 114 0.01412 non-essential 0.1917 non-essential high NA high_confidence_nonessential 0.8597370068879149 69.054 Strong candidate ESM-2 calibrated P(essential)=0.014; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.860; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.860); Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 5e-06 non-essential Non-essential ML1918 331 Q9CBJ2 ML1918 Conserved hypothetical membrane protein 263 0.05422 non-essential 0.22064 non-essential high NA medium_confidence NP_218104.1 79.7 0.8440826549780839 69.697 Strong candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.844; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.844); Target-priority score is high (69.7) rescued_from_possible_false_negative_by_supporting_evidence 0.015531 non-essential Non-essential ML1919 796 Q9CBJ1 ML1919 Carbonic anhydrase (EC 4.2.1.1) (Carbonate dehydratase) 213 0.05258 non-essential 0.17001 non-essential high NA high_confidence_nonessential NP_218105.1 84.5 0.5447714464621165 72.766 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.170; ProteomeLM contextual percentile=0.545; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000508 non-essential Non-essential ML1920 1510 Q9CBJ0 mutY ML1920 Adenine DNA glycosylase (EC 3.2.2.31) 297 0.03604 non-essential 0.0788 non-essential high NA high_confidence_nonessential NP_218106.1 74.9 0.1340012523481528 55.829 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.134; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.034018 non-essential Non-essential ML1921 857 Q9CBI9 ML1921 AB hydrolase-1 domain-containing protein 256 0.02734 non-essential 0.16243 non-essential high NA high_confidence_nonessential NP_218108.1 78.5 0.6299311208515967 68.02 Strong candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.630; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.002932 non-essential Non-essential ML1922 188 Q9CBI8 ML1922 ABM domain-containing protein 105 0.12209 non-essential 0.24712 non-essential high NA medium_confidence NP_218109.1 84.6 0.701941139636819 65.121 Strong candidate ESM-2 calibrated P(essential)=0.122; HANSEN integrated essentiality score=0.247; ProteomeLM contextual percentile=0.702; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000108 non-essential Non-essential ML1923 462 Q9CBI7 lpqF ML1923 Probale secreted protein 454 0.09148 non-essential 0.20651 non-essential high NA medium_confidence NP_218110.1 79.2 0.6036318096430808 65.063 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.604; target-priority score=65.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.1) rescued_from_possible_false_negative_by_supporting_evidence 0.00679 non-essential Non-essential ML1925 521 Q9CBI6 sodC ML1925 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) 240 0.03079 non-essential 0.19998 non-essential high NA high_confidence_nonessential NP_214946.1 72.3 0.799624295554164 80.054 High-priority ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.200; ProteomeLM contextual percentile=0.800; target-priority score=80.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.800); Target-priority score is high (80.1) rescued_from_possible_false_negative_by_supporting_evidence 0.04221 non-essential Non-essential ML1926 352 Q9CBI5 ML1926 Tuberculin related peptide (AT103) 167 0.11947 non-essential 0.21788 non-essential high NA medium_confidence NP_214945.1 62.7 0.5579211020663745 59.682 Moderate candidate ESM-2 calibrated P(essential)=0.119; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.558; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000518 non-essential Non-essential ML1927 28 Q9CBI4 ML1927 DUF3263 domain-containing protein 102 0.23737 non-essential 0.45702 non-essential low disagree review_anchor_disagreement Rv0430 93.1 ES 1 0.37820914214151535 53.551 Moderate candidate ESM-2 calibrated P(essential)=0.237; HANSEN integrated essentiality score=0.457; Mtb RBH anchor Rv0430=essential (disagree); ProteomeLM contextual percentile=0.378; target-priority score=53.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.002098 non-essential Non-essential ML1928 162 Q9CBI3 ML1928 Uncharacterized protein 45 0.06279 non-essential 0.25457 non-essential high NA medium_confidence 0.989355040701315 74.8 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.255; ProteomeLM contextual percentile=0.989; target-priority score=74.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.989); Target-priority score is high (74.8) rescued_from_possible_false_negative_by_supporting_evidence 7e-06 non-essential Non-essential ML1929 1109 Q9CBI2 def ML1929 Peptide deformylase (PDF) (EC 3.5.1.88) (Polypeptide deformylase) 197 0.03949 non-essential 0.13346 non-essential high NA high_confidence_nonessential NP_214943.1 83.7 0.4007514088916719 69.059 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.401; target-priority score=69.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.1) rescued_from_possible_false_negative_by_supporting_evidence 0.126951 non-essential Non-essential ML1932 673 Q9CBI1 ML1932 Transmembrane protein 137 0.01019 non-essential 0.1849 non-essential high NA high_confidence_nonessential NP_214940.1 69.0 0.8422041327489042 67.554 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.842; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.842); Target-priority score is high (67.6) rescued_from_possible_false_negative_by_supporting_evidence 2.6e-05 non-essential Non-essential ML1936 1513 Q7AQ18 ychF ML1936 Ribosome-binding ATPase YchF 356 0.03861 non-essential 0.07836 non-essential high NA high_confidence_nonessential NP_215628.1 86.2 0.1289918597370069 52.633 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.129; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006383 non-essential Non-essential ML1937 53 Q9CBI0 ML1937 Probable integral membrane protein 410 0.0186 non-essential 0.38566 non-essential low disagree review_anchor_disagreement Rv1111c 45.3 ESD 1 0.8998121477770821 69.037 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.386; Mtb RBH anchor Rv1111c=essential (disagree); ProteomeLM contextual percentile=0.900; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.050493 non-essential Non-essential ML1938 256 Q9X781 ispH lytB lytB2 ML1938 MLCB1222.06c 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (HMBPP reductase) (EC 1.17.7.4) 332 0.19217 non-essential 0.23177 non-essential high NA medium_confidence YP_177788.1 82.9 0.2830306825297433 67.52 Strong candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.232; ProteomeLM contextual percentile=0.283; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 0.399846 essential Uncertain ML1939 1302 Q7AQ17 ML1939 Lipid droplet-associated protein 205 0.03949 non-essential 0.11312 non-essential high agree high_confidence_nonessential Rv1109c 68.1 NE 0 0.5979962429555417 59.249 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv1109c=non-essential (agree); ProteomeLM contextual percentile=0.598; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009556 non-essential Non-essential ML1940 1446 Q9X783 xseA ML1940 MLCB1222.08 Exodeoxyribonuclease 7 large subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII large subunit) (Exonuclease VII large subunit) 428 0.07767 non-essential 0.09206 non-essential high NA high_confidence_nonessential NP_215624.1 81.2 0.034439574201628055 51.232 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.092; ProteomeLM contextual percentile=0.034; target-priority score=51.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.253209 non-essential Uncertain ML1941 220 Q9X784 xseB ML1941 MLCB1222.09 Exodeoxyribonuclease 7 small subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII small subunit) (Exonuclease VII small subunit) 78 0.06636 non-essential 0.23807 non-essential high NA medium_confidence NP_215623.1 84.1 0.8634940513462742 79.03 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.238; ProteomeLM contextual percentile=0.863; target-priority score=79.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.863); Target-priority score is high (79.0) rescued_from_possible_false_negative_by_supporting_evidence 0.004094 non-essential Non-essential ML1942 295 Q7AQ16 ML1942 Probable cholesterol dehydrogenase 376 0.10115 non-essential 0.22502 non-essential high NA medium_confidence NP_215622.1 75.5 0.6549780839073263 69.561 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.655; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 2.8e-05 non-essential Non-essential ML1945 1094 Q7AQ15 ML1945 Secreted protein 257 0.03135 non-essential 0.13479 non-essential high agree high_confidence_nonessential Rv1100 63.4 NE 0 0.8159048215403882 68.785 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.135; Mtb RBH anchor Rv1100=non-essential (agree); ProteomeLM contextual percentile=0.816; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.816); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.005582 non-essential Non-essential ML1946 634 Q9CBH9 glpX ML1946 Fructose-1,6-bisphosphatase class 2 (FBPase class 2) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase class 2) 355 0.1873 non-essential 0.18881 non-essential high NA high_confidence_nonessential NP_215615.3 89.0 0.07639323731997495 59.465 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.076; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.011819 non-essential Non-essential ML1947 936 Q7AQ14 fum fumC ML1947 Fumarate hydratase class II (Fumarase C) (EC 4.2.1.2) (Aerobic fumarase) (Iron-independent fumarase) 474 0.01889 non-essential 0.15211 non-essential high NA high_confidence_nonessential NP_215614.1 89.5 0.580463368816531 77.406 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.580; target-priority score=77.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.4) rescued_from_possible_false_negative_by_supporting_evidence 0.457761 essential Likely essential ML1949 379 Q9CBH8 ML1949 Uncharacterized protein 119 0.0357 non-essential 0.21505 non-essential high NA medium_confidence 0.9004383218534753 68.266 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.900; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.900); Target-priority score is high (68.3) rescued_from_possible_false_negative_by_supporting_evidence 4.8e-05 non-essential Non-essential ML1950 1358 Q7AQ13 ML1950 Carbohydrate degrading enzyme 291 0.08382 non-essential 0.10579 non-essential high NA high_confidence_nonessential NP_215612.1 81.1 0.09455228553537884 48.669 Exploratory ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.095; target-priority score=48.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005141 non-essential Non-essential ML1951 1521 Q7AQ12 phoH2 ML1951 Protein PhoH2 (EC 5.6.2.5) (RNA 5'-3' helicase PhoH2) (Toxin PhoP2) 433 0.03424 non-essential 0.07724 non-essential high NA high_confidence_nonessential NP_215611.1 93.1 0.13525360050093926 55.085 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.135; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.029793 non-essential Non-essential ML1952 1248 Q7AQ11 desA2 ML1952 Acyl-[ACP] desaturase 275 0.03424 non-essential 0.1199 non-essential high NA high_confidence_nonessential NP_215610.1 78.1 0.3675641828428303 61.415 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.120; ProteomeLM contextual percentile=0.368; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001465 non-essential Non-essential ML1953 1020 Q9X794 glyA ML1953 MLCB1222.22 Serine hydroxymethyltransferase (SHMT) (Serine methylase) (EC 2.1.2.1) 426 0.10418 non-essential 0.14231 non-essential high NA high_confidence_nonessential YP_177787.3 89.9 0.17031934877896054 64.203 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.170; target-priority score=64.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.187179 non-essential Non-essential ML1954 1387 Q9X795 coaA ML1954 MLCB1222.23 Pantothenate kinase (EC 2.7.1.33) (Pantothenic acid kinase) 312 0.03769 non-essential 0.10266 non-essential high NA high_confidence_nonessential NP_215608.1 93.6 0.2366938008766437 66.055 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.237; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000985 non-essential Non-essential ML1955 320 Q9X796 truA ML1955 MLCB1222.25c tRNA pseudouridine synthase A (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I) 286 0.09201 non-essential 0.22228 non-essential high NA medium_confidence NP_217972.3 77.6 0.6593613024420789 76.845 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.659; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.8) rescued_from_possible_false_negative_by_supporting_evidence 0.125097 non-essential Non-essential ML1956 72 Q9X797 rplQ ML1956 MLCB1222.26c Large ribosomal subunit protein bL17 (50S ribosomal protein L17) 170 0.23313 non-essential 0.3315 non-essential medium NA medium_confidence NP_217973.1 92.0 0.6787726988102692 68.543 Strong candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.332; ProteomeLM contextual percentile=0.679; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.149688 non-essential Non-essential ML1957 59 Q9X798 rpoA ML1957 MLCB1222.27c DNA-directed RNA polymerase subunit alpha (RNAP subunit alpha) (EC 2.7.7.6) (RNA polymerase subunit alpha) (Transcriptase subunit alpha) 347 0.42684 non-essential 0.36985 non-essential medium NA medium_confidence NP_217974.1 95.7 0.056981840951784594 54.459 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.370; ProteomeLM contextual percentile=0.057; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.002545 non-essential Non-essential ML1958 39 Q9X799 rpsD ML1958 MLCB1222.28c Small ribosomal subunit protein uS4 (30S ribosomal protein S4) 201 0.42684 non-essential 0.4209 non-essential medium NA medium_confidence NP_217975.1 93.5 0.34502191609267374 58.617 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.421; ProteomeLM contextual percentile=0.345; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.421); ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.086067 non-essential Non-essential ML1959 912 Q9X7A0 rpsK ML1959 MLCB1222.29c Small ribosomal subunit protein uS11 (30S ribosomal protein S11) 138 0.14132 non-essential 0.15475 non-essential high NA high_confidence_nonessential NP_217976.1 89.9 0.11521603005635567 49.86 Exploratory ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.115; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007851 non-essential Non-essential ML1960 71 Q9X7A1 rpsM ML1960 MLCB1222.30c Small ribosomal subunit protein uS13 (30S ribosomal protein S13) 124 0.28398 non-essential 0.33329 non-essential medium NA medium_confidence NP_217977.1 92.7 0.47526612398246715 61.979 Moderate candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.333; ProteomeLM contextual percentile=0.475; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.004884 non-essential Non-essential ML1961 2 Q9X7A2 rpmJ ML1961 MLCB1222.31c Large ribosomal subunit protein bL36 (50S ribosomal protein L36) 37 0.42684 non-essential 0.54189 essential medium NA medium_confidence NP_217978.1 89.2 0.9912335629304947 80.9 High-priority ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.542; ProteomeLM contextual percentile=0.991; target-priority score=80.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.542); ESM-2 transfer probability is moderate (0.427); ProteomeLM contextual percentile is high (0.991); Target-priority score is high (80.9) none 0.000724 non-essential Non-essential ML1962 52 P0A5H7 infA ML1962 Translation initiation factor IF-1 73 0.42684 non-essential 0.3857 non-essential medium NA medium_confidence NP_217979.1 100.0 0.16217908578584847 50.381 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.386; ProteomeLM contextual percentile=0.162; target-priority score=50.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.15766 non-essential Non-essential ML1964 1088 Q9CBH7 rmlB ML1964 dTDP-glucose 4,6-dehydratase (EC 4.2.1.46) 333 0.10695 non-essential 0.1354 non-essential high NA high_confidence_nonessential NP_217981.1 84.2 0.13713212273011896 57.328 Moderate candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.135; ProteomeLM contextual percentile=0.137; target-priority score=57.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.01019 non-essential Non-essential ML1965 735 Q7AQ10 rmlC ML1965 dTDP-4-dehydrorhamnose 3,5-epimerase (EC 5.1.3.13) (Thymidine diphospho-4-keto-rhamnose 3,5-epimerase) 202 0.00543 non-essential 0.17818 non-essential high NA high_confidence_nonessential NP_217982.1 75.4 0.7745773324984345 84.528 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.775; target-priority score=84.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.775); Target-priority score is high (84.5) rescued_from_possible_false_negative_by_supporting_evidence 0.013103 non-essential Non-essential ML1966 668 Q7AQ09 lpqH ML1966 Possible lipoprotein 161 0.00674 non-essential 0.18515 non-essential high NA high_confidence_nonessential 0.8472135253600501 71.735 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.847; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.847); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML1972 398 Q9CBH6 ML1972 Uncharacterized protein 76 0.0263 non-essential 0.21289 non-essential high NA medium_confidence 0.9223544145272385 71.158 Strong candidate ESM-2 calibrated P(essential)=0.026; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.922; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.922); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000107 non-essential Non-essential ML1974 150 Q9CBH5 ML1974 Transporter 572 0.09604 non-essential 0.25904 non-essential high NA medium_confidence NP_216495.2 77.1 0.8685034439574202 72.967 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.869; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.869); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 0.004749 non-essential Non-essential ML1976 532 Q9CBH4 ML1976 Uncharacterized protein 115 0.00543 non-essential 0.19836 non-essential high NA high_confidence_nonessential 0.9380087664370695 69.329 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.938; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.938); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 3.2e-05 non-essential Non-essential ML1979 552 Q9CBH3 ML1979 Uncharacterized protein 135 0.00198 non-essential 0.1965 non-essential high NA high_confidence_nonessential 0.9405134627426425 70.138 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.941; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.941); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.068601 non-essential Non-essential ML1982 382 Q9CBH2 ML1982 Integral membrane protein 102 0.01709 non-essential 0.21478 non-essential high NA medium_confidence 0.9755792110206637 71.214 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.976; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.976); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 6.4e-05 non-essential Non-essential ML1983 1322 Q9CBH1 ML1983 Polyketide cyclase 155 0.01172 non-essential 0.11161 non-essential high agree high_confidence_nonessential Rv1919c 72.8 NE 0 0.7082028804007514 67.528 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.112; Mtb RBH anchor Rv1919c=non-essential (agree); ProteomeLM contextual percentile=0.708; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000452 non-essential Non-essential ML1985 132 P46831 aceA ML1985 Isocitrate lyase (ICL) (EC 4.1.3.1) (Isocitrase) (Isocitratase) 606 0.09948 non-essential 0.26805 non-essential high NA medium_confidence NP_216431.1 87.1 0.8647463994990607 86.899 High-priority ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.268; ProteomeLM contextual percentile=0.865; target-priority score=86.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.865); Target-priority score is high (86.9) rescued_from_possible_false_negative_by_supporting_evidence 0.000103 non-essential Non-essential ML1987 707 P46839 ctpA ML1987 Copper-exporting P-type ATPase (EC 7.2.2.8) (Copper-exporting P-type ATPase A) 780 0.00543 non-essential 0.18136 non-essential high NA high_confidence_nonessential NP_214606.1 76.5 0.8096430807764559 78.98 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.810; target-priority score=79.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.810); Target-priority score is high (79.0) rescued_from_possible_false_negative_by_supporting_evidence 0.001486 non-essential Non-essential ML1988 1071 Q9CBG8 ML1988 Probable integral membrane protein 237 0.03424 non-essential 0.13699 non-essential high NA high_confidence_nonessential NP_214607.1 70.0 0.4834063869755792 56.207 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.483; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001784 non-essential Non-essential ML1989 491 Q9CBG7 ML1989 Uncharacterized protein 116 0.00543 non-essential 0.20334 non-essential high NA medium_confidence 0.9624295554164057 70.989 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.962; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.962); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 5e-06 non-essential Non-essential ML1990 94 Q9CBG6 ML1990 Integral membrane protein 80 0.11105 non-essential 0.29096 non-essential high NA medium_confidence 0.9881026925485284 72.731 Strong candidate ESM-2 calibrated P(essential)=0.111; HANSEN integrated essentiality score=0.291; ProteomeLM contextual percentile=0.988; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.988); Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.784344 essential Essential ML1991 739 Q9CBG5 PPE ML1991 PPE-family protein 468 0.00198 non-essential 0.17795 non-essential high NA high_confidence_nonessential YP_177690.1 55.3 0.8353162179085786 68.806 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.835; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.835); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.001187 non-essential Non-essential ML1992 820 Q9CBG4 ML1992 Oxidoreductase 289 0.09625 non-essential 0.16696 non-essential high NA high_confidence_nonessential NP_214611.1 76.4 0.3681903569192235 58.586 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.368; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.023765 non-essential Non-essential ML1993 597 Q9CBG3 ML1993 (2E)-enoyl-[ACP] glycyltransferase (EC 4.3.2.11) ((2E)-unsaturated fatty acyl-[ACP] glycyltransferase) 183 0.00543 non-essential 0.1919 non-essential high NA high_confidence_nonessential NP_214612.1 68.0 0.8641202254226675 81.523 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.864; target-priority score=81.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.864); Target-priority score is high (81.5) rescued_from_possible_false_negative_by_supporting_evidence 0.042058 non-essential Non-essential ML1994 786 Q7AQ08 fadD10 ML1994 Acyl-CoA synthase 532 0.10418 non-essential 0.17156 non-essential high NA high_confidence_nonessential NP_214613.1 74.6 0.36130244207889795 57.758 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.361; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.04625 non-essential Non-essential ML1995 982 Q9CBG2 ML1995 Carrier domain-containing protein 78 0.05001 non-essential 0.14645 non-essential high agree high_confidence_nonessential Rv0100 69.0 NE 0 0.8121477770820288 70.453 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.146; Mtb RBH anchor Rv0100=non-essential (agree); ProteomeLM contextual percentile=0.812; target-priority score=70.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.812); Target-priority score is high (70.5) rescued_from_possible_false_negative_by_supporting_evidence 8e-06 non-essential Non-essential ML1996 288 Q7AQ07 nrp ML1996 Probable peptide synthase 1401 0.09148 non-essential 0.22705 non-essential high NA medium_confidence NP_214615.1 68.9 0.7132122730118973 68.889 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.713; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.28853 non-essential Uncertain ML1997 653 Q9CBG1 ML1997 Probable integral membrane protein 210 0.00216 non-essential 0.18682 non-essential high NA high_confidence_nonessential NP_215485.1 51.4 0.8829054477144647 70.074 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.187; ProteomeLM contextual percentile=0.883; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.883); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.021348 non-essential Non-essential ML1998 340 P53525 ML1998 o659 Uncharacterized protein ML1998 659 0.06411 non-essential 0.21949 non-essential high NA medium_confidence NP_214616.1 70.1 0.7864746399499061 71.567 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.786; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.786); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.288612 non-essential Uncertain ML2000 987 P46840 ctpB ML2000 Cation-transporting P-type ATPase B (EC 7.2.2.-) 750 0.03079 non-essential 0.14609 non-essential high NA high_confidence_nonessential NP_214617.1 75.1 0.5122103944896681 69.997 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.512; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.0) rescued_from_possible_false_negative_by_supporting_evidence 0.003045 non-essential Non-essential ML2010 1057 Q7AQ06 ML2010 Lipoprotein 153 0.02975 non-essential 0.13848 non-essential high agree high_confidence_nonessential Rv1906c 64.4 NE 0 0.8553537883531622 70.197 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.138; Mtb RBH anchor Rv1906c=non-essential (agree); ProteomeLM contextual percentile=0.855; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.855); Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 0.002154 non-essential Non-essential ML2011 659 Q7AQ05 aao ML2011 D-amino-acid oxidase (EC 1.4.3.3) 320 0.04552 non-essential 0.18608 non-essential high NA high_confidence_nonessential NP_216421.1 71.4 0.6599874765184721 76.751 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.660; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000353 non-essential Non-essential ML2012 790 Q7AQ04 ML2012 Membrane protein 139 0.00543 non-essential 0.17128 non-essential high NA high_confidence_nonessential NP_216419.1 80.6 0.778334376956794 69.452 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.171; ProteomeLM contextual percentile=0.778; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.778); Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000125 non-essential Non-essential ML2013 351 Q7AQ03 ML2013 Amidohydrolase-related domain-containing protein 126 0.03079 non-essential 0.21796 non-essential high NA medium_confidence 0.9185973700688791 75.563 Strong candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.919; target-priority score=75.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.919); Target-priority score is high (75.6) rescued_from_possible_false_negative_by_supporting_evidence 6.2e-05 non-essential Non-essential ML2015 579 Q9X7D6 cinA ML2015 MLCB561.17 CinA-like protein 428 0.06981 non-essential 0.19378 non-essential high NA high_confidence_nonessential NP_216417.1 77.0 0.63055729492799 64.269 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.631; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.086861 non-essential Non-essential ML2020 814 Q9CBG0 ML2020 Putative S-adenosyl-L-methionine-dependent methyltransferase ML2020 (EC 2.1.1.-) 303 0.00543 non-essential 0.16835 non-essential high NA high_confidence_nonessential NP_216412.1 78.0 0.7395115842204133 76.791 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.168; ProteomeLM contextual percentile=0.740; target-priority score=76.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (76.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000772 non-essential Non-essential ML2022 479 Q9CBF9 ML2022 Uncharacterized protein 174 0.00543 non-essential 0.20423 non-essential high NA medium_confidence Rv1893 62.7 UNCERTAIN 0.9661865998747652 71.485 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.966; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.966); Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000129 non-essential Non-essential ML2023 1218 Q7AQ02 ML2023 Secreted protein 134 0.01019 non-essential 0.1233 non-essential high agree high_confidence_nonessential Rv1891 76.7 NE 0 0.8215403882279274 70.059 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.123; Mtb RBH anchor Rv1891=non-essential (agree); ProteomeLM contextual percentile=0.822; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.822); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000321 non-essential Non-essential ML2028 1131 P31951 fbpB ML2028 MLCB561.03c Diacylglycerol acyltransferase/mycolyltransferase Ag85B (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (30 kDa extracellular protein) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex B) (85B) (Ag85B) (Extracellular alpha-antigen) (Fibronectin-binding protein B) (Fbps B) 327 0.04656 non-essential 0.13116 non-essential high NA high_confidence_nonessential NP_216402.1 83.0 0.36318096430807767 66.209 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.363; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.003331 non-essential Non-essential ML2030 383 Q9CBF8 ML2030 Resuscitation-promoting factor core lysozyme-like domain-containing protein 157 0.04552 non-essential 0.21464 non-essential high NA medium_confidence NP_216400.1 70.2 0.8396994364433312 72.754 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.215; ProteomeLM contextual percentile=0.840; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.840); Target-priority score is high (72.8) rescued_from_possible_false_negative_by_supporting_evidence 1.5e-05 non-essential Non-essential ML2031 1326 Q9CBF7 ML2031 Cyclase 151 0.01861 non-essential 0.11111 non-essential high agree high_confidence_nonessential Rv1883c 76.2 GA 0 0.6693800876643707 66.001 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv1883c=non-essential (agree); ProteomeLM contextual percentile=0.669; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 0.002574 non-essential Non-essential ML2035 252 Q9CBF6 ML2035 Uncharacterized protein 87 0.03604 non-essential 0.23284 non-essential high NA medium_confidence 0.9949906073888541 71.159 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.995; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.995); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 8e-05 non-essential Non-essential ML2038 1438 P43315 bfr bfrA ML2038 Bacterioferritin (BFR) (EC 1.16.3.1) (Major membrane protein II) (MMP-II) 159 0.00674 non-essential 0.09294 non-essential high NA high_confidence_nonessential NP_216392.1 90.6 0.3237319974953037 65.285 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.324; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.3) rescued_from_possible_false_negative_by_supporting_evidence 0.387318 essential Uncertain ML2041 1142 P52678 oxyR ML2041 Probable hydrogen peroxide-inducible genes activator 311 0.03924 non-essential 0.1304 non-essential high NA high_confidence_nonessential 0.41327489041953663 59.074 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.413; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001062 non-essential Non-essential ML2042 1437 Q9CBF5 ahpC ML2042 Alkyl hydroperoxide reductase C (EC 1.11.1.28) (Peroxiredoxin) (Thioredoxin peroxidase) 195 0.02734 non-essential 0.09295 non-essential high NA high_confidence_nonessential NP_216944.1 86.7 0.2385723231058234 62.138 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.239; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.273495 non-essential Uncertain ML2044 202 Q9CBF4 ML2044 Uncharacterized protein 73 0.05242 non-essential 0.2432 non-essential high NA medium_confidence 0.9805886036318097 71.218 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.243; ProteomeLM contextual percentile=0.981; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.981); Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.029445 non-essential Non-essential ML2045 208 Q9CBF3 ML2045 Uncharacterized protein 85 0.06371 non-essential 0.24175 non-essential high NA medium_confidence 0.9160926737633062 72.65 Strong candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.916; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.916); Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000235 non-essential Non-essential ML2046 875 Q9CBF2 lldD2 ML2046 Putative L-lactate dehydrogenase 414 0.04897 non-essential 0.16032 non-essential high NA high_confidence_nonessential NP_216388.1 85.0 0.5178459611772073 68.167 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.518; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.2) rescued_from_possible_false_negative_by_supporting_evidence 0.003433 non-essential Non-essential ML2048 773 Q7AQ01 ML2048 Uncharacterized protein 85 0.06931 non-essential 0.17319 non-essential high agree high_confidence_nonessential Rv1871c 62.0 NE 0 0.9442705072010019 74.343 Strong candidate ESM-2 calibrated P(essential)=0.069; HANSEN integrated essentiality score=0.173; Mtb RBH anchor Rv1871c=non-essential (agree); ProteomeLM contextual percentile=0.944; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.944); Target-priority score is high (74.3) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML2053 1301 Q9CBF1 ML2053 Probable alcohol dehydrogenase AdhA (EC 1.1.1.1) 335 0.03604 non-essential 0.11347 non-essential high NA high_confidence_nonessential NP_216378.1 84.5 0.3149655604257984 63.628 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.315; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00704 non-essential Non-essential ML2054 711 Q9CBF0 ML2054 Integral membrane protein 99 0.01019 non-essential 0.18107 non-essential high NA high_confidence_nonessential NP_216377.1 58.4 0.8115216030056356 70.325 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.812; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.812); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 1.8e-05 non-essential Non-essential ML2055 1126 P46842 apa modD ML2055 MLCB1788.01c Alanine and proline-rich secreted protein Apa (Antigen 43L) (FAP-L) (Fibronectin attachment protein) 287 0.06716 non-essential 0.13176 non-essential high agree high_confidence_nonessential Rv1860 77.2 NE 0 0.6017532874139011 62.576 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.132; Mtb RBH anchor Rv1860=non-essential (agree); ProteomeLM contextual percentile=0.602; target-priority score=62.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003263 non-essential Non-essential ML2059 300 Q7AQ00 ML2059 Short-chain dehydrogenase/reductase family 224 0.09638 non-essential 0.22472 non-essential high NA medium_confidence NP_216372.1 80.4 0.6743894802755166 69.786 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.225; ProteomeLM contextual percentile=0.674; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.004195 non-essential Non-essential ML2061 756 Q7APZ9 ML2061 NADH:ubiquinone reductase (non-electrogenic) (EC 1.6.5.9) 466 0.10418 non-essential 0.17525 non-essential high NA high_confidence_nonessential NP_216370.1 90.8 0.3606762680025047 65.36 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.361; target-priority score=65.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.4) rescued_from_possible_false_negative_by_supporting_evidence 0.046157 non-essential Non-essential ML2063 466 Q7APZ8 ML2063 Transcriptional regulator BlaI 142 0.03604 non-essential 0.20578 non-essential high NA medium_confidence NP_216362.1 95.1 0.8296806512210394 73.249 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.830; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.830); Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 0.001237 non-essential Non-essential ML2064 1520 Q7APZ7 ML2064 Integral membrane protein 316 0.00543 non-essential 0.07746 non-essential high NA high_confidence_nonessential NP_216361.1 87.9 0.27050720100187853 54.483 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.077; ProteomeLM contextual percentile=0.271; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.042462 non-essential Non-essential ML2065 1183 Q9CBE9 gnd ML2065 6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44) 483 0.08554 non-essential 0.12733 non-essential high NA high_confidence_nonessential YP_177848.1 86.8 0.16844082654978085 63.946 Moderate candidate ESM-2 calibrated P(essential)=0.086; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.168; target-priority score=63.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.184764 non-essential Non-essential ML2066 981 O32912 guaB1 ML2066 MLCB1788.20 GMP reductase (EC 1.7.1.7) (Guanosine 5'-monophosphate reductase) (GMPR) 478 0.14132 non-essential 0.14646 non-essential high NA high_confidence_nonessential NP_216359.1 86.4 0.039448966812773954 59.043 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.039; target-priority score=59.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.030525 non-essential Non-essential ML2069 606 O32913 glcB ML2069 MLCB1788.27 Malate synthase G (EC 2.3.3.9) 731 0.19217 non-essential 0.19148 non-essential high NA high_confidence_nonessential NP_216353.1 82.1 0.06887914840325611 59.758 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.069; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.04149 non-essential Non-essential ML2070 1360 Q9CBE8 ML2070 VWFA domain-containing protein 733 0.12066 non-essential 0.10573 non-essential high agree high_confidence_nonessential Rv1836c 65.4 NE 0 0.11208515967438948 44.248 Exploratory ESM-2 calibrated P(essential)=0.121; HANSEN integrated essentiality score=0.106; Mtb RBH anchor Rv1836c=non-essential (agree); ProteomeLM contextual percentile=0.112; target-priority score=44.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.078051 non-essential Non-essential ML2072 886 O32915 gcvP gcvB ML2072 MLCB1788.32c Glycine dehydrogenase (decarboxylating) (EC 1.4.4.2) (Glycine cleavage system P-protein) (Glycine decarboxylase) (Glycine dehydrogenase (aminomethyl-transferring)) 952 0.15871 non-essential 0.15843 non-essential high NA high_confidence_nonessential NP_216348.1 85.0 0.048841577958672514 52.655 Moderate candidate ESM-2 calibrated P(essential)=0.159; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.049; target-priority score=52.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.036764 non-essential Non-essential ML2073 1243 Q7APZ6 ML2073 HTH merR-type domain-containing protein 231 0.06981 non-essential 0.12075 non-essential high NA high_confidence_nonessential NP_216346.1 89.2 0.24107701941139636 50.629 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.241; target-priority score=50.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.142802 non-essential Non-essential ML2074 878 Q7APZ5 ML2074 BFN domain-containing protein 164 0.12863 non-essential 0.16003 non-essential high agree high_confidence_nonessential Rv1829 95.1 NE 0 0.5209768315591734 61.503 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.160; Mtb RBH anchor Rv1829=non-essential (agree); ProteomeLM contextual percentile=0.521; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00198 non-essential Non-essential ML2075 748 Q7APZ4 ML2075 HTH merR-type domain-containing protein 251 0.12863 non-essential 0.17663 non-essential high NA high_confidence_nonessential NP_216344.1 86.5 0.2917971195992486 53.391 Moderate candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.177; ProteomeLM contextual percentile=0.292; target-priority score=53.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.065551 non-essential Non-essential ML2076 141 Q7APZ3 ML2076 FHA domain-containing protein 162 0.1873 non-essential 0.26272 non-essential high NA medium_confidence NP_216343.1 87.6 0.5134627426424546 58.674 Moderate candidate ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.263; ProteomeLM contextual percentile=0.513; target-priority score=58.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009593 non-essential Non-essential ML2077 721 O32920 gcvH ML2077 MLCB1788.37c Glycine cleavage system H protein 132 0.00476 non-essential 0.17951 non-essential high NA high_confidence_nonessential NP_216342.1 79.1 0.8146524733876017 74.603 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.180; ProteomeLM contextual percentile=0.815; target-priority score=74.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.815); Target-priority score is high (74.6) rescued_from_possible_false_negative_by_supporting_evidence 0.016005 non-essential Non-essential ML2081 842 Q7APZ2 pgsA2 ML2081 CDP-diacylglycerol-glycerol-3-phosphate 206 0.03954 non-essential 0.1641 non-essential high NA high_confidence_nonessential NP_216338.1 72.2 0.5810895428929242 68.941 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.581; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.006715 non-essential Non-essential ML2082 910 O32922 secA2 ML2082 MLCB1788.45c Protein translocase subunit SecA 2 (EC 7.4.2.8) 778 0.10418 non-essential 0.15539 non-essential high NA high_confidence_nonessential NP_216337.1 87.1 0.2567313713212273 60.976 Moderate candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.155; ProteomeLM contextual percentile=0.257; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000183 non-essential Non-essential ML2083 312 Q7APZ1 ilvG ML2083 acetolactate synthase (EC 2.2.1.6) 548 0.09638 non-essential 0.22306 non-essential high NA medium_confidence NP_216336.1 86.1 0.6424546023794615 77.328 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.642; target-priority score=77.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.3) rescued_from_possible_false_negative_by_supporting_evidence 0.008477 non-essential Non-essential ML2084 1582 Q7APZ0 ML2084 Probable multidrug resistance pump 638 0.03604 non-essential 0.05719 non-essential high NA high_confidence_nonessential NP_216335.1 73.1 0.038196618659987476 45.167 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.057; ProteomeLM contextual percentile=0.038; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.013801 non-essential Non-essential ML2088 568 Q9CBE7 ML2088 Cytochrome p450 434 0.06543 non-essential 0.19488 non-essential high NA high_confidence_nonessential NP_216396.3 37.5 0.6468378209142142 67.757 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.647; target-priority score=67.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.8) rescued_from_possible_false_negative_by_supporting_evidence 0.002162 non-essential Non-essential ML2091 254 Q9CBE6 ML2091 Uncharacterized protein 61 0.04985 non-essential 0.2324 non-essential high NA medium_confidence 0.9317470256731372 70.251 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.232; ProteomeLM contextual percentile=0.932; target-priority score=70.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.932); Target-priority score is high (70.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00167 non-essential Non-essential ML2093 751 Q50097 pstA phoX1 pstA1 ML2093 Phosphate transport system permease protein PstA 304 0.04985 non-essential 0.17589 non-essential high NA high_confidence_nonessential NP_215445.2 80.6 0.6155291170945523 64.74 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.176; ProteomeLM contextual percentile=0.616; target-priority score=64.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1e-06 non-essential Non-essential ML2094 1361 Q50098 pstC phoW1 pstC2 ML2094 Phosphate transport system permease protein PstC 319 0.00543 non-essential 0.10567 non-essential high NA high_confidence_nonessential NP_215444.1 79.0 0.4245460237946149 58.535 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.425; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 9e-06 non-essential Non-essential ML2095 1052 Q9CBE5 pstS2 phoS2 ML2095 Phosphate-binding protein PstS 3 (PBP 3) (PstS-3) 369 0.01648 non-essential 0.13887 non-essential high NA high_confidence_nonessential YP_177768.1 77.6 0.5491546649968692 65.32 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.549; target-priority score=65.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00541 non-essential Non-essential ML2098 499 Q50103 mntH bcg ML2098 Divalent metal cation transporter MntH 426 0.03453 non-essential 0.2026 non-essential high NA medium_confidence YP_177767.1 74.6 0.8196618659987477 72.648 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.820; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.820); Target-priority score is high (72.6) rescued_from_possible_false_negative_by_supporting_evidence 2.5e-05 non-essential Non-essential ML2111 644 Q50121 ML2111 Transmembrane protein 144 0.06278 non-essential 0.18762 non-essential high NA high_confidence_nonessential NP_215427.1 67.4 0.6261740763932373 64.394 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.626; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 7e-06 non-essential Non-essential ML2113 328 Q50123 ML2113 Toxin 181 0.05001 non-essential 0.22119 non-essential high NA medium_confidence NP_215425.1 83.9 0.8609893550407013 71.642 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.861; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.861); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.006629 non-essential Non-essential ML2114 158 Q9CBE3 ML2114 Antitoxin 56 0.06758 non-essential 0.25598 non-essential high NA medium_confidence NP_215424.1 61.9 0.9793362554790231 73.577 Strong candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.979; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.979); Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.005983 non-essential Non-essential ML2118 1220 Q50130 echA6 ML2118 u650af Probable enoyl-CoA hydratase echA6 (EC 4.2.1.17) 247 0.06981 non-essential 0.12303 non-essential high NA high_confidence_nonessential NP_215420.1 85.8 0.22792736380713838 59.665 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.228; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02926 non-essential Non-essential ML2121 257 Q7APY9 ML2121 Uncharacterized protein 136 0.05162 non-essential 0.23136 non-essential high NA medium_confidence 0.9135879774577332 71.563 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.231; ProteomeLM contextual percentile=0.914; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.914); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.002115 non-essential Non-essential ML2123 838 Q50136 prrA ML2123 MLCB57.61c Transcriptional regulatory protein PrrA 233 0.07767 non-essential 0.16432 non-essential high NA high_confidence_nonessential NP_215418.1 95.7 0.4339386349405135 59.927 Moderate candidate ESM-2 calibrated P(essential)=0.078; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.434; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.043634 non-essential Non-essential ML2124 1259 O33071 prrB ML2124 MLCB57.60c Sensor-type histidine kinase PrrB (EC 2.7.13.3) 446 0.05001 non-essential 0.1181 non-essential high NA high_confidence_nonessential NP_215417.1 92.4 0.28929242329367566 59.829 Moderate candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.289; target-priority score=59.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.25839 non-essential Uncertain ML2130 505 Q7APY8 gltA2 ML2130 Citrate synthase 431 0.14132 non-essential 0.20214 non-essential high NA medium_confidence NP_215411.1 91.2 0.34690043832185347 65.877 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.347; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.229625 non-essential Uncertain ML2131 950 O33065 pdxH ML2131 MLCB57.46 Pyridoxine/pyridoxamine 5'-phosphate oxidase (EC 1.4.3.5) (PNP/PMP oxidase) (PNPOx) (Pyridoxal 5'-phosphate synthase) 219 0.0303 non-essential 0.15035 non-essential high NA high_confidence_nonessential NP_217123.1 67.1 0.5241077019411396 75.231 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.524; target-priority score=75.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.2) rescued_from_possible_false_negative_by_supporting_evidence 0.011721 non-essential Non-essential ML2134 777 O33064 fprB ML2134 MLCB57.39 Probable ferredoxin/ferredoxin--NADP reductase (FNR) (EC 1.18.1.2) 555 0.08883 non-essential 0.17234 non-essential high NA high_confidence_nonessential NP_215401.1 76.1 0.40388227927363807 68.784 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.404; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000137 non-essential Non-essential ML2135 1586 Q7APY7 ML2135 Possible transmembrane protein 341 0.03769 non-essential 0.05286 non-essential high agree high_confidence_nonessential Rv0885 83.9 NE 0 0.06386975579211021 47.728 Exploratory ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.053; Mtb RBH anchor Rv0885=non-essential (agree); ProteomeLM contextual percentile=0.064; target-priority score=47.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.007909 non-essential Non-essential ML2136 848 O33062 serC ML2136 MLCB57.37c Putative phosphoserine aminotransferase (EC 2.6.1.52) (Phosphohydroxythreonine aminotransferase) (PSAT) 376 0.15423 non-essential 0.16319 non-essential high NA high_confidence_nonessential NP_215399.1 87.5 0.07326236693800876 60.869 Moderate candidate ESM-2 calibrated P(essential)=0.154; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.073; target-priority score=60.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012686 non-essential Non-essential ML2137 49 Q7APY6 ML2137 DUF3071 domain-containing protein 251 0.20642 non-essential 0.40143 non-essential low disagree review_anchor_disagreement Rv0883c 79.4 ES 1 0.06324358171571696 42.498 Exploratory ESM-2 calibrated P(essential)=0.206; HANSEN integrated essentiality score=0.401; Mtb RBH anchor Rv0883c=essential (disagree); ProteomeLM contextual percentile=0.063; target-priority score=42.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.845121 essential Essential ML2140 942 O33060 ML2140 MLCB57.31 Uncharacterized HTH-type transcriptional regulator ML2140 143 0.01747 non-essential 0.15104 non-essential high NA high_confidence_nonessential NP_215395.1 90.2 0.6130244207889793 66.401 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.613; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 5e-05 non-essential Non-essential ML2141 928 Q7APY5 ML2141 DUF2530 domain-containing protein 91 0.04552 non-essential 0.15312 non-essential high NA high_confidence_nonessential NP_215394.1 76.9 0.5203506574827802 58.307 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.520; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3.8e-05 non-essential Non-essential ML2142 1554 Q7APY4 ML2142 DUF3027 domain-containing protein 269 0.03604 non-essential 0.06832 non-essential high agree high_confidence_nonessential Rv0877 80.9 GA 0 0.22542266750156542 48.319 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.068; Mtb RBH anchor Rv0877=non-essential (agree); ProteomeLM contextual percentile=0.225; target-priority score=48.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.000787 non-essential Non-essential ML2143 1426 O33057 ML2143 MLCB57.28c Uncharacterized protein ML2143 579 0.03769 non-essential 0.09459 non-essential high NA high_confidence_nonessential NP_215391.1 75.7 0.23606762680025048 50.125 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.095; ProteomeLM contextual percentile=0.236; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.014634 non-essential Non-essential ML2144 1130 Q7APY3 ML2144 Possible exported protein 162 0.0533 non-essential 0.13124 non-essential high agree high_confidence_nonessential Rv0875c 71.6 NE 0 0.667501565435191 65.027 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv0875c=non-essential (agree); ProteomeLM contextual percentile=0.668; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.0) rescued_from_possible_false_negative_by_supporting_evidence 0.035545 non-essential Non-essential ML2147 1480 Q7APY2 cspB ML2147 Probable cold shock protein 136 0.03604 non-essential 0.08473 non-essential high NA high_confidence_nonessential NP_215386.1 86.8 0.18659987476518472 49.789 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.085; ProteomeLM contextual percentile=0.187; target-priority score=49.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001057 non-essential Non-essential ML2151 643 Q7APY1 ML2151 Resuscitation-promoting factor RpfA 174 0.00198 non-essential 0.18765 non-essential high NA high_confidence_nonessential NP_215382.1 72.0 0.8791484032561052 73.309 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.188; ProteomeLM contextual percentile=0.879; target-priority score=73.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.879); Target-priority score is high (73.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000139 non-essential Non-essential ML2155 1112 Q9CBE2 ML2155 Hypothetical 10.1 kDa protein 74 0.01019 non-essential 0.13336 non-essential high agree high_confidence_nonessential Rv0863 78.8 NE 0 0.926111458985598 69.27 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv0863=non-essential (agree); ProteomeLM contextual percentile=0.926; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.926); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 0.001785 non-essential Non-essential ML2156 1474 Q9CBE1 ML2156 Possible DNA-binding protein 753 0.06716 non-essential 0.08624 non-essential high agree high_confidence_nonessential Rv0862c 77.6 NE 0 0.20851596743894804 50.191 Moderate candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.086; Mtb RBH anchor Rv0862c=non-essential (agree); ProteomeLM contextual percentile=0.209; target-priority score=50.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003487 non-essential Non-essential ML2157 744 Q9CBE0 ML2157 DNA 3'-5' helicase (EC 5.6.2.4) 549 0.19217 non-essential 0.17756 non-essential high NA high_confidence_nonessential NP_215376.3 91.1 0.011271133375078271 51.495 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.011; target-priority score=51.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.059499 non-essential Non-essential ML2158 452 Q9CBD9 ML2158 Uncharacterized protein 130 0.00543 non-essential 0.20762 non-essential high NA medium_confidence 0.9830932999373826 72.521 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.983; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.983); Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 0.011057 non-essential Non-essential ML2161 182 Q9CBD8 fadB ML2161 Fatty oxidation complex alpha subunit 714 0.14132 non-essential 0.24834 non-essential high NA medium_confidence NP_215375.1 88.6 0.5942391984971822 74.173 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.594; target-priority score=74.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.2) rescued_from_possible_false_negative_by_supporting_evidence 0.013823 non-essential Non-essential ML2162 533 Q9CBD7 fadA ML2162 Beta-ketoadipyl CoA thiolase 403 0.09148 non-essential 0.19828 non-essential high NA high_confidence_nonessential NP_215374.1 94.5 0.5472761427676894 67.78 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.547; target-priority score=67.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.8) rescued_from_possible_false_negative_by_supporting_evidence 0.000315 non-essential Non-essential ML2167 1078 Q9CBD6 kdc ML2167 Alpha-keto-acid decarboxylase (KDC) (EC 4.1.1.-) 569 0.0533 non-essential 0.13648 non-essential high NA high_confidence_nonessential NP_215368.1 77.8 0.3688165309956168 64.414 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.369; target-priority score=64.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00599 non-essential Non-essential ML2170 117 Q9CBD5 ML2170 Uncharacterized protein 74 0.09928 non-essential 0.27391 non-essential high NA medium_confidence 0.9492798998121478 70.189 Strong candidate ESM-2 calibrated P(essential)=0.099; HANSEN integrated essentiality score=0.274; ProteomeLM contextual percentile=0.949; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.949); Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 1.7e-05 non-essential Non-essential ML2172 600 Q9CBD4 ML2172 Uncharacterized protein 118 0.01233 non-essential 0.19177 non-essential high NA high_confidence_nonessential 0.873512836568566 67.314 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.874; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.874); Target-priority score is high (67.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000825 non-essential Non-essential ML2174 727 Q9CBD3 cdd ML2174 Cytidine deaminase (EC 3.5.4.5) (Cytidine aminohydrolase) 134 0.00262 non-essential 0.17911 non-essential high NA high_confidence_nonessential NP_217832.1 56.8 0.8008766437069506 81.828 High-priority ESM-2 calibrated P(essential)=0.003; HANSEN integrated essentiality score=0.179; ProteomeLM contextual percentile=0.801; target-priority score=81.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.801); Target-priority score is high (81.8) rescued_from_possible_false_negative_by_supporting_evidence 0.030815 non-essential Non-essential ML2176 250 Q9CBD2 ML2176 Uncharacterized protein 85 0.06183 non-essential 0.23326 non-essential high NA medium_confidence 0.886662492172824 68.602 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.887; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.887); Target-priority score is high (68.6) rescued_from_possible_false_negative_by_supporting_evidence 6e-06 non-essential Non-essential ML2177 120 Q9CBD1 ML2177 Uridine phosphorylase (EC 2.4.2.3) 317 0.10418 non-essential 0.27308 non-essential high NA medium_confidence 0.8860363180964308 82.389 High-priority ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.273; ProteomeLM contextual percentile=0.886; target-priority score=82.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.886); Target-priority score is high (82.4) rescued_from_possible_false_negative_by_supporting_evidence 0.458056 essential Likely essential ML2178 424 Q9CBD0 ML2178 VapC45 PIN like domain-containing protein 83 0.01761 non-essential 0.21 non-essential high NA medium_confidence 0.9467752035065748 70.631 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.947; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.947); Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000266 non-essential Non-essential ML2185 1323 Q7APY0 desA1 ML2185 Acyl-[ACP] desaturase 338 0.03424 non-essential 0.1114 non-essential high NA high_confidence_nonessential YP_177758.1 79.9 0.32435817157169694 59.112 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.324; target-priority score=59.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008919 non-essential Non-essential ML2186 1569 Q50049 dus ML2186 Probable tRNA-dihydrouridine synthase (EC 1.3.1.-) 384 0.03424 non-essential 0.06258 non-essential high NA high_confidence_nonessential NP_215338.1 82.3 0.046336881653099564 55.992 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.063; ProteomeLM contextual percentile=0.046; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.488649 essential Likely essential ML2188 1378 Q50047 phoU1 phoY phoY1 ML2188 Phosphate-specific transport system accessory protein PhoU homolog 1 (Pst system accessory protein PhoU homolog 1) 222 0.03925 non-essential 0.10353 non-essential high NA high_confidence_nonessential NP_215336.1 93.0 0.27113337507827173 53.657 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.271; target-priority score=53.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML2189 82 Q50046 pstB phoT ML2189 Phosphate import ATP-binding protein PstB (EC 7.3.2.1) (ABC phosphate transporter) (Phosphate-transporting ATPase) 258 0.23805 non-essential 0.31413 non-essential medium NA medium_confidence NP_215335.1 91.9 0.5416405760801503 72.734 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.314; ProteomeLM contextual percentile=0.542; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.002438 non-essential Non-essential ML2192 566 Q50043 phoS3 ML2192 Phosphate-binding protein 429 0.01709 non-essential 0.19503 non-essential high NA high_confidence_nonessential 0.8478396994364433 75.139 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.848; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.848); Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 7.8e-05 non-essential Non-essential ML2193 1385 Q9CBC9 mshD ML2193 Mycothiol acetyltransferase (MSH acetyltransferase) (EC 2.3.1.189) (Mycothiol synthase) 311 0.07502 non-essential 0.10279 non-essential high NA high_confidence_nonessential NP_215334.1 75.2 0.09329993738259236 56.827 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.093; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02333 non-essential Non-essential ML2195 13 Q7APX9 ML2195 Probable exported protein 283 0.23815 non-essential 0.50126 essential low disagree review_anchor_disagreement Rv0817c 73.0 GD 1 0.7426424546023794 68.21 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.501; Mtb RBH anchor Rv0817c=essential (disagree); ProteomeLM contextual percentile=0.743; target-priority score=68.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.006013 non-essential Non-essential ML2196 396 Q9CBC8 thiX ML2196 Thiredoxin 140 0.0533 non-essential 0.2132 non-essential high NA medium_confidence NP_215331.1 63.8 0.7977457733249843 72.017 Strong candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.798; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.798); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML2197 740 Q7APX8 ML2197 Integral membrane protein 161 0.00543 non-essential 0.17779 non-essential high NA high_confidence_nonessential 0.812773951158422 70.763 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.813; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.813); Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 9.8e-05 non-essential Non-essential ML2198 569 Q50036 cysA cysA3 ML2198 Putative thiosulfate sulfurtransferase (EC 2.8.1.1) (Rhodanese-like protein) 277 0.10695 non-essential 0.19485 non-essential high NA high_confidence_nonessential NP_215330.1 85.2 0.45021916092673764 69.78 Strong candidate ESM-2 calibrated P(essential)=0.107; HANSEN integrated essentiality score=0.195; ProteomeLM contextual percentile=0.450; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 0.069889 non-essential Non-essential ML2199 1285 Q9CBC7 ML2199 DUF1416 domain-containing protein 100 0.06391 non-essential 0.11474 non-essential high agree high_confidence_nonessential Rv0814c 84.0 GA 0 0.4746399499060739 57.856 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv0814c=non-essential (agree); ProteomeLM contextual percentile=0.475; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008766 non-essential Non-essential ML2200 1255 Q9CBC6 ML2200 Ferric nitrobindin-like protein 228 0.03949 non-essential 0.11828 non-essential high agree high_confidence_nonessential Rv0813c 87.4 GA 0 0.6255479023168441 64.073 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.118; Mtb RBH anchor Rv0813c=non-essential (agree); ProteomeLM contextual percentile=0.626; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005807 non-essential Non-essential ML2201 180 Q9CBC5 ML2201 Uncharacterized protein 79 0.06543 non-essential 0.24922 non-essential high NA medium_confidence 0.9592986850344396 70.193 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.249; ProteomeLM contextual percentile=0.959; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.959); Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 9.7e-05 non-essential Non-essential ML2203 23 Q9CBC4 ML2203 Uncharacterized protein 373 0.19756 non-essential 0.46351 non-essential low disagree review_anchor_disagreement Rv0811c 77.4 ES 1 0.6199123356293049 65.966 Strong candidate ESM-2 calibrated P(essential)=0.198; HANSEN integrated essentiality score=0.464; Mtb RBH anchor Rv0811c=essential (disagree); ProteomeLM contextual percentile=0.620; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.287176 non-essential Uncertain ML2204 7 Q9CBC3 ML2204 DUF3073 domain-containing protein 62 0.23311 non-essential 0.52333 essential low disagree review_anchor_disagreement Rv0810c 77.8 ES 1 0.9749530369442705 71.94 Strong candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.523; Mtb RBH anchor Rv0810c=essential (disagree); ProteomeLM contextual percentile=0.975; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.00185 non-essential Non-essential ML2205 1040 Q9CBC2 purM ML2205 Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) 364 0.05912 non-essential 0.14019 non-essential high NA high_confidence_nonessential NP_215324.1 87.1 0.3569192235441453 66.805 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.140; ProteomeLM contextual percentile=0.357; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 0.644411 essential Likely essential ML2206 560 Q50028 purF ML2206 MLCB5.38 Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPATase) 556 0.0515 non-essential 0.19592 non-essential high NA high_confidence_nonessential NP_215323.1 91.3 0.6819035691922355 79.649 Strong candidate ESM-2 calibrated P(essential)=0.051; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.682; target-priority score=79.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (79.6) rescued_from_possible_false_negative_by_supporting_evidence 0.795394 essential Essential ML2207 1065 Q7APX7 ML2207 Bacterial SCP orthologue domain-containing protein 131 0.05767 non-essential 0.13756 non-essential high agree high_confidence_nonessential Rv0807 73.4 NE 0 0.6944270507201001 67.021 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.138; Mtb RBH anchor Rv0807=non-essential (agree); ProteomeLM contextual percentile=0.694; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 5.5e-05 non-essential Non-essential ML2209 1076 Q50025 cpsY ML2209 MLCB5.32c Exopolysaccharide phosphotransferase CpsY (EC 2.7.-.-) (Stealth protein CpsY) 542 0.03769 non-essential 0.13669 non-essential high NA high_confidence_nonessential NP_215321.1 82.3 0.4427050720100188 64.063 Moderate candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.443; target-priority score=64.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.005755 non-essential Non-essential ML2210 1263 Q7APX5 ML2210 Calcineurin-like phosphoesterase domain-containing protein 317 0.02734 non-essential 0.11798 non-essential high NA high_confidence_nonessential NP_215320.1 82.9 0.3969943644333125 58.337 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.118; ProteomeLM contextual percentile=0.397; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.010341 non-essential Non-essential ML2211 1239 Q50023 purL ML2211 MLCB5.30 Phosphoribosylformylglycinamidine synthase subunit PurL (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit II) (FGAR amidotransferase II) (FGAR-AT II) (Glutamine amidotransferase PurL) (Phosphoribosylformylglycinamidine synthase subunit II) 754 0.09638 non-essential 0.12095 non-essential high NA high_confidence_nonessential NP_215318.1 90.5 0.09392611145898559 59.615 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.094; target-priority score=59.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.267712 non-essential Uncertain ML2213 1540 Q50022 apeB pepC pepX ML2213 MLCB5.29 Probable M18 family aminopeptidase 2 (EC 3.4.11.-) 426 0.03424 non-essential 0.07188 non-essential high NA high_confidence_nonessential NP_215315.1 77.6 0.10394489668127739 55.013 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.072; ProteomeLM contextual percentile=0.104; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.029766 non-essential Non-essential ML2219 84 O05755 ML2219.1 ML2219A MLCB5.24 Phosphoribosylformylglycinamidine synthase subunit PurS (FGAM synthase) (EC 6.3.5.3) (Formylglycinamide ribonucleotide amidotransferase subunit III) (FGAR amidotransferase III) (FGAR-AT III) (Phosphoribosylformylglycinamidine synthase subunit III) 79 0.19882 non-essential 0.30855 non-essential high NA medium_confidence NP_215303.1 89.2 0.6668753913587977 80.194 High-priority ESM-2 calibrated P(essential)=0.199; HANSEN integrated essentiality score=0.309; ProteomeLM contextual percentile=0.667; target-priority score=80.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (80.2) rescued_from_possible_false_negative_by_supporting_evidence 0.009224 non-essential Non-essential ML2226 769 Q7APX4 ptrB ML2226 Protease II 724 0.056 non-essential 0.1738 non-essential high NA high_confidence_nonessential 0.5723231058234189 65.652 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.572; target-priority score=65.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.7) rescued_from_possible_false_negative_by_supporting_evidence 0.00289 non-essential Non-essential ML2227 1494 O08361 purC ML2227 MLCB5.16 Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6) (SAICAR synthetase) 297 0.04041 non-essential 0.08286 non-essential high NA high_confidence_nonessential NP_215294.1 81.5 0.12773951158422042 59.242 Moderate candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.128; target-priority score=59.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.651778 essential Likely essential ML2228 1166 Q7APX3 ML2228 Transmembrane protein 206 0.00543 non-essential 0.12879 non-essential high NA high_confidence_nonessential NP_215293.1 67.2 0.5547902316844082 60.478 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.555; target-priority score=60.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00212 non-essential Non-essential ML2230 926 Q9CBC1 purB ML2230 Adenylosuccinate lyase (ASL) (EC 4.3.2.2) (Adenylosuccinase) 472 0.04818 non-essential 0.15331 non-essential high NA high_confidence_nonessential NP_215291.1 86.7 0.4715090795241077 71.154 Strong candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.472; target-priority score=71.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.2) rescued_from_possible_false_negative_by_supporting_evidence 0.110001 non-essential Non-essential ML2235 1565 Q50144 purD ML2235 MLCB5.08 Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase) 422 0.03604 non-essential 0.06394 non-essential high NA high_confidence_nonessential NP_215286.1 82.0 0.038822792736380715 58.468 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.064; ProteomeLM contextual percentile=0.039; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.058422 non-essential Non-essential ML2237 1347 P49774 ML2237 MLCB5.04c u296a Uncharacterized HIT-like protein ML2237 134 0.02105 non-essential 0.10865 non-essential high agree high_confidence_nonessential Rv0759c 81.8 NE 0 0.6268002504696305 66.673 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.109; Mtb RBH anchor Rv0759c=non-essential (agree); ProteomeLM contextual percentile=0.627; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 0.183442 non-essential Non-essential ML2242 269 Q7APX2 ML2242 Uncharacterized protein 243 0.04985 non-essential 0.23 non-essential high NA medium_confidence 0.9117094552285535 72.265 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.912; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.912); Target-priority score is high (72.3) rescued_from_possible_false_negative_by_supporting_evidence 0.00174 non-essential Non-essential ML2244 255 Q9CBC0 ML2244 Uncharacterized protein 113 0.03486 non-essential 0.2319 non-essential high NA medium_confidence 0.9931120851596744 71.751 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.232; ProteomeLM contextual percentile=0.993; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.993); Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.00699 non-essential Non-essential ML2247 1532 Q7APX1 cpsA ML2247 Transcriptional regulator, LytR family protein 516 0.04821 non-essential 0.07491 non-essential high agree high_confidence_nonessential Rv3484 74.5 GA 0 0.2147777082028804 49.011 Exploratory ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.075; Mtb RBH anchor Rv3484=non-essential (agree); ProteomeLM contextual percentile=0.215; target-priority score=49.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.006732 non-essential Non-essential ML2249 283 Q9CBB9 ML2249 Uncharacterized protein 105 0.04897 non-essential 0.22771 non-essential high NA medium_confidence 0.9148403256105198 67.982 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.915; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.915); Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 8.5e-05 non-essential Non-essential ML2252 248 Q7APX0 ML2252 Uncharacterized protein 78 0.04115 non-essential 0.23345 non-essential high NA medium_confidence 0.9737006887914841 71.635 Strong candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.974; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.974); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 8e-06 non-essential Non-essential ML2253 517 Q7APW9 ML2253 Antigen 84 homolog 71 0.00674 non-essential 0.20091 non-essential high NA medium_confidence 0.939261114589856 71.958 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.201; ProteomeLM contextual percentile=0.939; target-priority score=72.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.939); Target-priority score is high (72.0) rescued_from_possible_false_negative_by_supporting_evidence 2.5e-05 non-essential Non-essential ML2254 768 Q50167 otsA ML2254 Trehalose-6-phosphate synthase (TPS) (EC 2.4.1.15) (EC 2.4.1.347) (Alpha,alpha-trehalose-phosphate synthase [UDP-forming]) (Osmoregulatory trehalose synthesis protein A) (OtsA) 498 0.1795 non-essential 0.17383 non-essential high NA high_confidence_nonessential NP_218007.1 80.3 0.028804007514088917 57.833 Moderate candidate ESM-2 calibrated P(essential)=0.180; HANSEN integrated essentiality score=0.174; ProteomeLM contextual percentile=0.029; target-priority score=57.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001224 non-essential Non-essential ML2257 451 Q9CBB8 menE ML2257 O-succinylbenzoic acid-CoA ligase 368 0.09378 non-essential 0.2077 non-essential high NA medium_confidence NP_215056.1 78.3 0.5961177207263619 66.42 Strong candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.596; target-priority score=66.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.4) rescued_from_possible_false_negative_by_supporting_evidence 0.081625 non-essential Non-essential ML2258 24 Q7APW7 ML2258 DUF3349 domain-containing protein 100 0.18451 non-essential 0.46138 non-essential low disagree review_anchor_disagreement Rv0543c 74.5 ES 1 0.6837820914214151 64.594 Moderate candidate ESM-2 calibrated P(essential)=0.185; HANSEN integrated essentiality score=0.461; Mtb RBH anchor Rv0543c=essential (disagree); ProteomeLM contextual percentile=0.684; target-priority score=64.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.006452 non-essential Non-essential ML2259 1108 Q9CBB7 ML2259 Possible membrane protein 96 0.05933 non-essential 0.13346 non-essential high NA high_confidence_nonessential NP_215058.1 65.6 0.3625547902316844 51.091 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.133; ProteomeLM contextual percentile=0.363; target-priority score=51.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002169 non-essential Non-essential ML2260 930 Q50173 pit pitA ML2260 Probable low-affinity inorganic phosphate transporter 414 0.01172 non-essential 0.15275 non-essential high NA high_confidence_nonessential NP_215059.1 76.6 0.6430807764558547 68.568 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.643; target-priority score=68.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.6) rescued_from_possible_false_negative_by_supporting_evidence 0.02092 non-essential Non-essential ML2261 1336 Q9CBB6 ML2261 VOC domain-containing protein 138 0.02105 non-essential 0.11008 non-essential high agree high_confidence_nonessential Rv0546c 84.7 NE 0 0.654351909830933 64.02 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.110; Mtb RBH anchor Rv0546c=non-essential (agree); ProteomeLM contextual percentile=0.654; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.007755 non-essential Non-essential ML2263 983 Q9CBB5 menB ML2263 1,4-dihydroxy-2-naphthoyl-CoA synthase (DHNA-CoA synthase) (EC 4.1.3.36) 300 0.13353 non-essential 0.14635 non-essential high NA high_confidence_nonessential NP_215062.1 93.0 0.07201001878522229 59.922 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.146; ProteomeLM contextual percentile=0.072; target-priority score=59.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.052671 non-essential Non-essential ML2264 326 Q9CBB4 ML2264 Uncharacterized protein 203 0.01889 non-essential 0.22178 non-essential high NA medium_confidence 0.9987476518472135 74.517 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.999; target-priority score=74.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.999); Target-priority score is high (74.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000979 non-essential Non-essential ML2265 228 Q9CBB3 ML2265 Uncharacterized protein 73 0.04027 non-essential 0.23598 non-essential high NA medium_confidence 0.9887288666249218 72.97 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.989; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.989); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 0.000229 non-essential Non-essential ML2268 980 Q9CBB2 menC ML2268 o-succinylbenzoate synthase (OSB synthase) (OSBS) (EC 4.2.1.113) (4-(2'-carboxyphenyl)-4-oxybutyric acid synthase) (o-succinylbenzoic acid synthase) 334 0.056 non-essential 0.14665 non-essential high NA high_confidence_nonessential NP_215067.1 79.5 0.39511584220413276 71.611 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.147; ProteomeLM contextual percentile=0.395; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.038933 non-essential Non-essential ML2269 1135 Q9CBB1 ML2269 Hydrolase 265 0.03604 non-essential 0.13098 non-essential high NA high_confidence_nonessential NP_215068.1 83.9 0.4257983719474014 60.959 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.426; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.03912 non-essential Non-essential ML2270 1231 Q9CBB0 menD ML2270 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (SEPHCHC synthase) (EC 2.2.1.9) (Menaquinone biosynthesis protein MenD) 556 0.03604 non-essential 0.12197 non-essential high NA high_confidence_nonessential NP_215069.1 85.4 0.3525360050093926 67.855 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.353; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.9) rescued_from_possible_false_negative_by_supporting_evidence 0.353272 essential Uncertain ML2271 782 Q9CBA9 ML2271 Membrane protein 175 0.02338 non-essential 0.17202 non-essential high NA high_confidence_nonessential NP_215070.1 79.8 0.7100814026299311 66.137 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.710; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.004851 non-essential Non-essential ML2273 247 Q9CBA8 menG ML2273 Demethylmenaquinone methyltransferase (EC 2.1.1.163) 230 0.09148 non-essential 0.23346 non-essential high NA medium_confidence YP_177738.1 83.8 0.7125860989355041 81.924 High-priority ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.713; target-priority score=81.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.9) rescued_from_possible_false_negative_by_supporting_evidence 0.121189 non-essential Non-essential ML2274 1399 Q9CBA7 ML2274 Secreted protein 112 0.04656 non-essential 0.10177 non-essential high agree high_confidence_nonessential Rv0559c 69.6 NE 0 0.45522855353788355 56.625 Moderate candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.102; Mtb RBH anchor Rv0559c=non-essential (agree); ProteomeLM contextual percentile=0.455; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002803 non-essential Non-essential ML2276 1491 Q9CBA6 ML2276 FAD-linked oxidoreductase 408 0.04823 non-essential 0.08341 non-essential high NA high_confidence_nonessential NP_215075.1 84.3 0.11959924859110833 50.923 Moderate candidate ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.120; target-priority score=50.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.041518 non-essential Non-essential ML2277 1468 Q9CBA5 ML2277 Polyprenyl diphosphate synthase component 330 0.04274 non-essential 0.08698 non-essential high NA high_confidence_nonessential NP_215076.1 77.2 0.1527864746399499 55.335 Moderate candidate ESM-2 calibrated P(essential)=0.043; HANSEN integrated essentiality score=0.087; ProteomeLM contextual percentile=0.153; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.033346 non-essential Non-essential ML2278 692 Q9CBA4 htpX ML2278 Protease HtpX homolog (EC 3.4.24.-) 287 0.05936 non-essential 0.18297 non-essential high NA high_confidence_nonessential NP_215077.1 88.5 0.5954915466499687 70.877 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.595; target-priority score=70.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.9) rescued_from_possible_false_negative_by_supporting_evidence 0.001043 non-essential Non-essential ML2279 1229 Q9CBA3 ML2279 Transmembrane transport protein 496 0.01019 non-essential 0.12222 non-essential high NA high_confidence_nonessential NP_217790.1 53.0 0.4946775203506575 60.351 Moderate candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.495; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002155 non-essential Non-essential ML2283 153 Q9CBA2 ML2283 Uncharacterized protein 104 0.09677 non-essential 0.25869 non-essential high NA medium_confidence 0.8778960551033187 67.93 Strong candidate ESM-2 calibrated P(essential)=0.097; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.878; target-priority score=67.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.878); Target-priority score is high (67.9) rescued_from_possible_false_negative_by_supporting_evidence 2.1e-05 non-essential Non-essential ML2284 581 Q9CBA1 ML2284 Uncharacterized protein 119 0.00674 non-essential 0.19367 non-essential high NA high_confidence_nonessential 0.9029430181590482 69.821 Strong candidate ESM-2 calibrated P(essential)=0.007; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.903; target-priority score=69.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.903); Target-priority score is high (69.8) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML2288 151 Q9CBA0 ML2288 Uncharacterized protein 74 0.07033 non-essential 0.259 non-essential high NA medium_confidence 0.9874765184721352 72.539 Strong candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.259; ProteomeLM contextual percentile=0.987; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.987); Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 0.001909 non-essential Non-essential ML2289 992 Q9CB99 ML2289 Fido domain-containing protein 256 0.07168 non-essential 0.14501 non-essential high agree high_confidence_nonessential Rv3662c 78.4 NE 0 0.6862867877269881 66.752 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.145; Mtb RBH anchor Rv3662c=non-essential (agree); ProteomeLM contextual percentile=0.686; target-priority score=66.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.8) rescued_from_possible_false_negative_by_supporting_evidence 0.0 non-essential Non-essential ML2295 622 Q9CB98 ML2295 Protease 234 0.0587 non-essential 0.19005 non-essential high NA high_confidence_nonessential NP_218185.1 77.1 0.6524733876017533 66.691 Strong candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.652; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 0.016119 non-essential Non-essential ML2296 833 Q9CB97 ML2296 Membrane protein 181 0.02752 non-essential 0.16512 non-essential high NA high_confidence_nonessential NP_218186.1 75.7 0.662492172824045 62.071 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.662; target-priority score=62.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002038 non-essential Non-essential ML2297 1339 Q9CB96 ML2297 Hydrolase 324 0.04656 non-essential 0.10924 non-essential high NA high_confidence_nonessential NP_218187.1 80.2 0.2667501565435191 55.163 Moderate candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.267; target-priority score=55.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000444 non-essential Non-essential ML2298 1589 Q9CB95 ML2298 Membrane-associated serine protease 401 0.02975 non-essential 0.05073 non-essential high NA high_confidence_nonessential NP_218188.1 75.6 0.027551659361302442 45.678 Exploratory ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.051; ProteomeLM contextual percentile=0.028; target-priority score=45.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001574 non-essential Non-essential ML2299 1303 Q9CB94 ML2299 Nudix hydrolase domain-containing protein 266 0.03604 non-essential 0.11308 non-essential high agree high_confidence_nonessential Rv3672c 76.4 NE 0 0.588603631809643 65.196 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.113; Mtb RBH anchor Rv3672c=non-essential (agree); ProteomeLM contextual percentile=0.589; target-priority score=65.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.2) rescued_from_possible_false_negative_by_supporting_evidence 0.011308 non-essential Non-essential ML2300 126 Q9CB93 ML2300 Membrane protein 215 0.14132 non-essential 0.27096 non-essential high NA medium_confidence NP_218190.1 71.9 0.736380713838447 71.098 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.271; ProteomeLM contextual percentile=0.736; target-priority score=71.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.1) rescued_from_possible_false_negative_by_supporting_evidence 0.296869 non-essential Uncertain ML2301 1128 Q9CB92 nth ML2301 Endonuclease III (EC 4.2.99.18) (DNA-(apurinic or apyrimidinic site) lyase) 245 0.06981 non-essential 0.13146 non-essential high NA high_confidence_nonessential NP_218191.2 89.3 0.26737633061991234 63.104 Moderate candidate ESM-2 calibrated P(essential)=0.070; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.267; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.256913 non-essential Uncertain ML2302 1581 Q9CB91 ML2302 CRP-like cAMP-activated global transcriptional regulator (cAMP receptor protein) (cAMP regulatory protein) 224 0.03924 non-essential 0.05744 non-essential high NA high_confidence_nonessential NP_218193.1 96.4 0.023168440826549782 45.793 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.057; ProteomeLM contextual percentile=0.023; target-priority score=45.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000783 non-essential Non-essential ML2303 951 Q9CB90 ML2303 Hydrolase 262 0.09148 non-essential 0.15019 non-essential high NA high_confidence_nonessential NP_218194.1 82.1 0.29805886036318097 56.328 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.150; ProteomeLM contextual percentile=0.298; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001821 non-essential Non-essential ML2304 1140 Q9CB89 ML2304 Uncharacterized protein 174 0.01233 non-essential 0.13049 non-essential high agree high_confidence_nonessential Rv3678c 64.2 NE 0 0.8672510958046337 72.748 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv3678c=non-essential (agree); ProteomeLM contextual percentile=0.867; target-priority score=72.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.867); Target-priority score is high (72.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000296 non-essential Non-essential ML2305 818 Q9CB88 ML2305 Probable anion transporter protein 341 0.13339 non-essential 0.16747 non-essential high NA high_confidence_nonessential NP_218196.1 84.2 0.22103944896681277 51.707 Moderate candidate ESM-2 calibrated P(essential)=0.133; HANSEN integrated essentiality score=0.167; ProteomeLM contextual percentile=0.221; target-priority score=51.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000508 non-essential Non-essential ML2306 1407 Q9CB87 ML2306 Probable anion transporter protein 381 0.09148 non-essential 0.10022 non-essential high NA high_confidence_nonessential NP_218197.1 87.7 0.036944270507201005 45.174 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.037; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3.6e-05 non-essential Non-essential ML2307 85 Q9CB86 whiB ML2307 Transcriptional regulator WhiB 81 0.23801 non-essential 0.30809 non-essential medium NA medium_confidence NP_218198.2 88.5 0.5259862241703194 66.063 Strong candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.308; ProteomeLM contextual percentile=0.526; target-priority score=66.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000151 non-essential Non-essential ML2308 273 Q9CB85 pon1 ML2308 Penicillin binding protein (Class A) 803 0.14132 non-essential 0.2295 non-essential high NA medium_confidence YP_178005.1 87.4 0.504070131496556 67.163 Strong candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.504; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (67.2) rescued_from_possible_false_negative_by_supporting_evidence 0.0458 non-essential Non-essential ML2309 1356 Q9CB84 ML2309 Calcineurin-like phosphoesterase domain-containing protein 330 0.02105 non-essential 0.10596 non-essential high agree high_confidence_nonessential Rv3683 84.9 NE 0 0.6023794614902943 66.188 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.106; Mtb RBH anchor Rv3683=non-essential (agree); ProteomeLM contextual percentile=0.602; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.001307 non-essential Non-essential ML2312 612 Q9CB83 ML2312 Possible membrane protein 196 0.00543 non-essential 0.19099 non-essential high NA high_confidence_nonessential NP_218212.1 70.5 0.8910457107075767 70.565 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.191; ProteomeLM contextual percentile=0.891; target-priority score=70.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.891); Target-priority score is high (70.6) rescued_from_possible_false_negative_by_supporting_evidence 6.1e-05 non-essential Non-essential ML2313 633 Q9CB82 ML2313 Transcription regulator PadR N-terminal domain-containing protein 200 0.01709 non-essential 0.18892 non-essential high NA high_confidence_nonessential 0.8271759549154665 69.936 Strong candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.827; target-priority score=69.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.827); Target-priority score is high (69.9) rescued_from_possible_false_negative_by_supporting_evidence 9e-06 non-essential Non-essential ML2314 931 Q9CB81 glpK ML2314 Glycerol kinase (EC 2.7.1.30) (ATP:glycerol 3-phosphotransferase) (Glycerokinase) (GK) 508 0.03604 non-essential 0.15264 non-essential high NA high_confidence_nonessential NP_218213.1 91.3 0.5115842204132749 75.126 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.153; ProteomeLM contextual percentile=0.512; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.006246 non-essential Non-essential ML2320 995 Q9CB80 ML2320 PknH-like extracellular domain-containing protein 215 0.04656 non-essential 0.14476 non-essential high agree high_confidence_nonessential Rv3705c 79.8 NE 0 0.8134001252348153 70.966 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.145; Mtb RBH anchor Rv3705c=non-essential (agree); ProteomeLM contextual percentile=0.813; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.813); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 5.8e-05 non-essential Non-essential ML2321 927 Q9CB79 ML2321 DUF4185 domain-containing protein 336 0.04552 non-essential 0.15324 non-essential high agree high_confidence_nonessential Rv3707c 81.6 NE 0 0.8879148403256105 74.275 Strong candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.153; Mtb RBH anchor Rv3707c=non-essential (agree); ProteomeLM contextual percentile=0.888; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.888); Target-priority score is high (74.3) rescued_from_possible_false_negative_by_supporting_evidence 0.890709 essential Essential ML2322 1351 Q9CB78 asd ML2322 Aspartate-semialdehyde dehydrogenase (ASA dehydrogenase) (ASADH) (EC 1.2.1.11) (Aspartate-beta-semialdehyde dehydrogenase) 351 0.05422 non-essential 0.10782 non-essential high NA high_confidence_nonessential NP_218225.1 84.4 0.1947401377582968 64.834 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.108; ProteomeLM contextual percentile=0.195; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.547354 essential Likely essential ML2323 187 Q9CB77 ask ML2323 Aspartokinase (EC 2.7.2.4) 421 0.27523 non-essential 0.24751 non-essential medium NA medium_confidence NP_218226.1 92.9 0.023794614902943018 57.572 Moderate candidate ESM-2 calibrated P(essential)=0.275; HANSEN integrated essentiality score=0.248; ProteomeLM contextual percentile=0.024; target-priority score=57.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.921666 essential Essential ML2324 994 Q9CB76 leuA ML2324 MLCB2407.26c 2-isopropylmalate synthase (EC 2.3.3.13) (Alpha-IPM synthase) (Alpha-isopropylmalate synthase) 607 0.14132 non-essential 0.14484 non-essential high NA high_confidence_nonessential NP_218227.3 80.9 0.03318722604884158 57.93 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.145; ProteomeLM contextual percentile=0.033; target-priority score=57.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.015307 non-essential Non-essential ML2326 1244 Q7APW6 murT ML2326 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit MurT (EC 6.3.5.13) 411 0.11406 non-essential 0.12063 non-essential high NA high_confidence_nonessential NP_218229.1 84.1 0.010644959298685034 59.707 Moderate candidate ESM-2 calibrated P(essential)=0.114; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.011; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.436764 essential Likely essential ML2327 1373 Q7APW5 gatD ML2327 Lipid II isoglutaminyl synthase (glutamine-hydrolyzing) subunit GatD (EC 6.3.5.13) (Lipid II isoglutaminyl synthase glutaminase subunit) (EC 3.5.1.2) 230 0.09187 non-essential 0.10423 non-essential high NA high_confidence_nonessential NP_218230.1 86.1 0.013775829680651221 60.465 Moderate candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.104; ProteomeLM contextual percentile=0.014; target-priority score=60.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.047955 non-essential Non-essential ML2329 395 O69520 recR ML2329 MLCB2407.21 Recombination protein RecR 203 0.19217 non-essential 0.21324 non-essential high NA medium_confidence NP_218232.1 91.6 0.22041327489041954 51.753 Moderate candidate ESM-2 calibrated P(essential)=0.192; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.220; target-priority score=51.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001234 non-essential Non-essential ML2330 1139 O69519 ML2330 MLCB2407.20 Nucleoid-associated protein ML2330 116 0.02975 non-essential 0.13053 non-essential high agree high_confidence_nonessential Rv3716c 85.6 NE 0 0.7802128991859737 69.324 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.131; Mtb RBH anchor Rv3716c=non-essential (agree); ProteomeLM contextual percentile=0.780; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.780); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 0.001068 non-essential Non-essential ML2331 1443 Q9CB75 ML2331 Possible secreted protein 256 0.01709 non-essential 0.09238 non-essential high agree high_confidence_nonessential Rv3717 82.0 NE 0 0.5034439574201628 63.564 Moderate candidate ESM-2 calibrated P(essential)=0.017; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv3717=non-essential (agree); ProteomeLM contextual percentile=0.503; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4.8e-05 non-essential Non-essential ML2332 1026 Q7APW4 ML2332 Polyketide cyclase 145 0.05192 non-essential 0.14161 non-essential high agree high_confidence_nonessential Rv3718c 81.9 NE 0 0.7582968065122104 69.267 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.142; Mtb RBH anchor Rv3718c=non-essential (agree); ProteomeLM contextual percentile=0.758; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.758); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 0.008481 non-essential Non-essential ML2333 1547 Q7APW3 ML2333 Delta(24)-sterol reductase (EC 1.3.1.72) 459 0.05275 non-essential 0.07075 non-essential high agree high_confidence_nonessential Rv3719 82.8 NE 0 0.12523481527864747 53.153 Moderate candidate ESM-2 calibrated P(essential)=0.053; HANSEN integrated essentiality score=0.071; Mtb RBH anchor Rv3719=non-essential (agree); ProteomeLM contextual percentile=0.125; target-priority score=53.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.05309 non-essential Non-essential ML2334 1023 Q9CB74 ML2334 Polyketide synthase-like methyltransferase domain-containing protein 420 0.09148 non-essential 0.14203 non-essential high NA high_confidence_nonessential NP_218237.3 86.4 0.25547902316844084 54.478 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.142; ProteomeLM contextual percentile=0.255; target-priority score=54.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.029674 non-essential Non-essential ML2335 578 Q7APW2 dnaZX dnaX ML2335 DNA polymerase III subunit gamma/tau (EC 2.7.7.7) 611 0.18413 non-essential 0.19384 non-essential high NA high_confidence_nonessential NP_218238.1 78.2 0.13337507827175954 55.093 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.133; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.351123 essential Uncertain ML2336 40 Q9CB73 ML2336 Aspartate transaminase 463 0.14132 non-essential 0.41851 non-essential low disagree review_anchor_disagreement Rv3722c 87.3 ES 1 0.5184721352536005 63.748 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.419; Mtb RBH anchor Rv3722c=essential (disagree); ProteomeLM contextual percentile=0.518; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.00419 non-essential Non-essential ML2337 344 Q7APW1 ML2337 Membrane protein 250 0.04985 non-essential 0.21889 non-essential high NA medium_confidence NP_218240.1 77.7 0.8547276142767689 69.403 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.855; target-priority score=69.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.855); Target-priority score is high (69.4) rescued_from_possible_false_negative_by_supporting_evidence 0.001665 non-essential Non-essential ML2341 602 Q9CB72 ML2341 Possible regulatory protein 732 0.056 non-essential 0.19163 non-essential high NA high_confidence_nonessential 0.6725109580463369 67.24 Strong candidate ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.673; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.2) rescued_from_possible_false_negative_by_supporting_evidence 6e-06 non-essential Non-essential ML2346 1009 Q49942 ML2346 Methyltransferase FkbM domain-containing protein 301 0.03424 non-essential 0.14382 non-essential high NA high_confidence_nonessential 0.5072010018785222 61.78 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.507; target-priority score=61.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006058 non-essential Non-essential ML2347 207 Q7APW0 ML2347 Membrane protein 336 0.07497 non-essential 0.24223 non-essential high NA medium_confidence 0.8697557921102066 71.781 Strong candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.870; target-priority score=71.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.870); Target-priority score is high (71.8) rescued_from_possible_false_negative_by_supporting_evidence 0.024587 non-essential Non-essential ML2348 592 Q49929 ML2348 L518_C2_147 MLCB2407.02c Uncharacterized glycosyltransferase ML2348 (EC 2.4.-.-) 421 0.03424 non-essential 0.19249 non-essential high NA high_confidence_nonessential NP_216040.1 62.9 0.754539762053851 75.029 Strong candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.755; target-priority score=75.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.755); Target-priority score is high (75.0) rescued_from_possible_false_negative_by_supporting_evidence 9.4e-05 non-essential Non-essential ML2349 1096 Q49939 papA5 ML2349 MLCB2407.01 Phthiocerol/phthiodiolone dimycocerosyl transferase (EC 2.3.1.282) (Acyltransferase PapA5) (Phthiocerol/phthiodiolone O-acyltransferase) (Polyketide synthase-associated protein A5) 423 0.03949 non-essential 0.13446 non-essential high NA high_confidence_nonessential NP_217455.1 84.0 0.4113963681903569 67.438 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.411; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.4) rescued_from_possible_false_negative_by_supporting_evidence 3.7e-05 non-essential Non-essential ML2350 877 Q9CB71 ML2350 Transport permease protein 276 0.00228 non-essential 0.16007 non-essential high NA high_confidence_nonessential NP_217454.1 79.0 0.7276142767689417 69.203 Strong candidate ESM-2 calibrated P(essential)=0.002; HANSEN integrated essentiality score=0.160; ProteomeLM contextual percentile=0.728; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000118 non-essential Non-essential ML2351 1160 Q49935 ML2351 Probable antibiotic resistance membrane protein 288 0.00543 non-essential 0.12942 non-essential high NA high_confidence_nonessential NP_217453.1 64.4 0.5516593613024421 62.814 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.552; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6.1e-05 non-essential Non-essential ML2352 576 Q49938 ML2352 Probable antibiotic resistance efflux protein 331 0.13176 non-essential 0.19395 non-essential high NA high_confidence_nonessential NP_217452.1 85.2 0.3706950532247965 56.327 Moderate candidate ESM-2 calibrated P(essential)=0.132; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.371; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.023629 non-essential Non-essential ML2353 267 Q49934 ML2353 Phenolphthiocerol/phthiocerol polyketide synthase subunit E (EC 2.3.1.292) ((Phenol)carboxyphthiodiolenone synthase subunit E) (Beta-ketoacyl-acyl-carrier-protein synthase I) (Phthiocerol synthesis polyketide synthase type I PpsE) 1489 0.06543 non-essential 0.23016 non-essential high NA medium_confidence NP_217451.1 82.0 0.8071383844708829 83.821 High-priority ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.807; target-priority score=83.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.807); Target-priority score is high (83.8) rescued_from_possible_false_negative_by_supporting_evidence 0.041451 non-essential Non-essential ML2354 628 Q9CB70 ML2354 Polyketide synthase 1822 0.03949 non-essential 0.18945 non-essential high NA high_confidence_nonessential NP_217450.1 80.3 0.7226048841577959 71.607 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.723; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.008789 non-essential Non-essential ML2355 544 Q49933 ML2355 Polyketide synthase 2201 0.03604 non-essential 0.19741 non-essential high NA high_confidence_nonessential NP_217449.1 81.7 0.7795867251095805 73.542 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.780; target-priority score=73.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.780); Target-priority score is high (73.5) rescued_from_possible_false_negative_by_supporting_evidence 0.018494 non-essential Non-essential ML2356 603 Q7APV9 ML2356 Polyketide synthase 1540 0.02338 non-essential 0.19156 non-essential high NA high_confidence_nonessential NP_217448.1 75.8 0.8090169067000627 71.587 Strong candidate ESM-2 calibrated P(essential)=0.023; HANSEN integrated essentiality score=0.192; ProteomeLM contextual percentile=0.809; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.809); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.024777 non-essential Non-essential ML2357 690 Q7APV8 ML2357 Polyketide synthase 1871 0.01648 non-essential 0.18322 non-essential high NA high_confidence_nonessential NP_217447.1 75.3 0.7921102066374452 71.423 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.183; ProteomeLM contextual percentile=0.792; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.792); Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 0.004074 non-essential Non-essential ML2358 943 Q7APV7 fadD26 ML2358 Probable acyl-CoA synthase 583 0.09148 non-essential 0.15095 non-essential high NA high_confidence_nonessential NP_217446.2 76.8 0.3005635566687539 56.997 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.151; ProteomeLM contextual percentile=0.301; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001095 non-essential Non-essential ML2359 330 Q9Z5K4 tesA ML2359 MLCB12.04c Thioesterase TesA (EC 3.1.2.-) 261 0.04805 non-essential 0.22077 non-essential high NA medium_confidence NP_217444.1 73.2 0.8378209142141515 81.716 High-priority ESM-2 calibrated P(essential)=0.048; HANSEN integrated essentiality score=0.221; ProteomeLM contextual percentile=0.838; target-priority score=81.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.838); Target-priority score is high (81.7) rescued_from_possible_false_negative_by_supporting_evidence 0.000102 non-essential Non-essential ML2366 405 Q7APV5 ML2366 Membrane protein 113 0.04042 non-essential 0.21189 non-essential high NA medium_confidence NP_218277.1 70.2 0.8566061365059486 69.48 Strong candidate ESM-2 calibrated P(essential)=0.040; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.857; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.857); Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 7e-06 non-essential Non-essential ML2377 319 P54880 ML2377 u1740w Probable transport accessory protein MmpS4 154 0.08425 non-essential 0.22231 non-essential high NA medium_confidence NP_214965.1 75.0 0.7219787100814026 67.729 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.222; ProteomeLM contextual percentile=0.722; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.7) rescued_from_possible_false_negative_by_supporting_evidence 0.001416 non-essential Non-essential ML2378 1346 P54881 mmpL4 ML2378 u1740v Probable transport protein MmpL4 959 0.02518 non-essential 0.10865 non-essential high NA high_confidence_nonessential NP_214964.1 76.4 0.35817157169693176 56.24 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.358; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 5.6e-05 non-essential Non-essential ML2379 772 Q9CB69 ML2379 Uncharacterized protein 109 0.00543 non-essential 0.17327 non-essential high NA high_confidence_nonessential 0.7927363807138385 68.55 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.793; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.793); Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.014144 non-essential Non-essential ML2380 1430 Q9CB68 ML2380 Possible secreted protein 153 0.03604 non-essential 0.09392 non-essential high agree high_confidence_nonessential Rv0455c 66.4 NE 0 0.4364433312460864 57.311 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.094; Mtb RBH anchor Rv0455c=non-essential (agree); ProteomeLM contextual percentile=0.436; target-priority score=57.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000135 non-essential Non-essential ML2387 157 Q50068 lpd ML2387 u1740l Dihydrolipoyl dehydrogenase (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (E3 component of alpha-ketoacid dehydrogenase complexes) 467 0.23815 non-essential 0.25613 non-essential medium NA medium_confidence NP_214976.1 83.3 0.2285535378835316 63.042 Moderate candidate ESM-2 calibrated P(essential)=0.238; HANSEN integrated essentiality score=0.256; ProteomeLM contextual percentile=0.229; target-priority score=63.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.536107 essential Likely essential ML2388 418 Q7APV4 ML2388 Possible membrane protein 101 0.06278 non-essential 0.21046 non-essential high NA medium_confidence NP_214977.1 57.9 0.7539135879774578 66.659 Strong candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.754; target-priority score=66.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.754); Target-priority score is high (66.7) rescued_from_possible_false_negative_by_supporting_evidence 3e-06 non-essential Non-essential ML2390 894 Q9CB67 ML2390 Possible secreted protein 101 0.06768 non-essential 0.15708 non-essential high agree high_confidence_nonessential Rv1083 58.4 NE 0 0.8321853475266124 66.502 Strong candidate ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.157; Mtb RBH anchor Rv1083=non-essential (agree); ProteomeLM contextual percentile=0.832; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.832); Target-priority score is high (66.5) rescued_from_possible_false_negative_by_supporting_evidence 0.0026 non-essential Non-essential ML2391 1143 Q7APV3 mca ML2391 Mycothiol S-conjugate amidase (EC 3.5.1.115) 290 0.10015 non-essential 0.13032 non-essential high NA high_confidence_nonessential NP_215598.1 86.8 0.13462742642454603 58.63 Moderate candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.135; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000424 non-essential Non-essential ML2392 348 Q9CB66 ML2392 Conserved membrane protein 144 0.06543 non-essential 0.21847 non-essential high NA medium_confidence NP_215597.1 69.0 0.7845961177207263 68.103 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.785; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.785); Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.02786 non-essential Non-essential ML2393 658 P46808 greA ML2393 Transcription elongation factor GreA (Transcript cleavage factor GreA) 164 0.0797 non-essential 0.18631 non-essential high NA high_confidence_nonessential NP_215596.1 94.5 0.5428929242329368 63.706 Moderate candidate ESM-2 calibrated P(essential)=0.080; HANSEN integrated essentiality score=0.186; ProteomeLM contextual percentile=0.543; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000122 non-essential Non-essential ML2394 854 P46807 metB ML2394 Cystathionine gamma-synthase (CGS) (EC 2.5.1.48) (O-succinylhomoserine (thiol)-lyase) 388 0.14132 non-essential 0.16279 non-essential high NA high_confidence_nonessential NP_215595.1 87.3 0.1427676894176581 56.587 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.163; ProteomeLM contextual percentile=0.143; target-priority score=56.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.067556 non-essential Non-essential ML2395 1105 P41484 ag36 pra ML2395 Proline-rich antigen (Pra) (36 kDa antigen) 249 0.01172 non-essential 0.13362 non-essential high agree high_confidence_nonessential Rv1078 66.7 NE 0 0.9010644959298685 72.974 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.134; Mtb RBH anchor Rv1078=non-essential (agree); ProteomeLM contextual percentile=0.901; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.901); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 0.336148 essential Uncertain ML2396 559 Q9CB65 cysM2 ML2396 Cystathionine beta-synthase (EC 4.2.1.22) 464 0.10418 non-essential 0.196 non-essential high NA high_confidence_nonessential YP_177782.1 90.1 0.47589229805886035 67.692 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.196; ProteomeLM contextual percentile=0.476; target-priority score=67.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.7) rescued_from_possible_false_negative_by_supporting_evidence 0.027067 non-essential Non-essential ML2400 1411 Q9CB64 ML2400 Probable transmembrane protein 285 0.04554 non-essential 0.09994 non-essential high NA high_confidence_nonessential NP_215588.1 77.9 0.2329367564182843 49.654 Exploratory ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.100; ProteomeLM contextual percentile=0.233; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.014668 non-essential Non-essential ML2401 1124 Q7APV2 ML2401 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) 345 0.05813 non-essential 0.13184 non-essential high NA high_confidence_nonessential NP_215587.1 78.0 0.3231058234189105 63.142 Moderate candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.132; ProteomeLM contextual percentile=0.323; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.02828 non-essential Non-essential ML2402 346 O07137 echA8 ML2402 MLCB1306.05c Probable enoyl-CoA hydratase echA8 (EC 4.2.1.17) 257 0.09638 non-essential 0.2186 non-essential high NA medium_confidence NP_215586.1 86.4 0.6286787726988102 73.09 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.219; ProteomeLM contextual percentile=0.629; target-priority score=73.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.1) rescued_from_possible_false_negative_by_supporting_evidence 8.8e-05 non-essential Non-essential ML2406 1215 O07134 menA ML2406 MLB1306.02c 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74) 294 0.02518 non-essential 0.12403 non-essential high NA high_confidence_nonessential NP_215048.1 81.1 0.4082654978083907 69.982 Strong candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.408; target-priority score=70.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.0) rescued_from_possible_false_negative_by_supporting_evidence 0.05853 non-essential Non-essential ML2407 787 Q9CB63 ML2407 Membrane protein 111 0.01233 non-essential 0.17156 non-essential high NA high_confidence_nonessential NP_215045.1 64.9 0.7614276768941766 65.011 Strong candidate ESM-2 calibrated P(essential)=0.012; HANSEN integrated essentiality score=0.172; ProteomeLM contextual percentile=0.761; target-priority score=65.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.761); Target-priority score is high (65.0) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML2409 1455 Q7APV1 ML2409 Possible cytochrome C biogenesis protein 327 0.06768 non-essential 0.09126 non-essential high NA high_confidence_nonessential NP_215041.2 83.1 0.09079524107701942 46.071 Exploratory ESM-2 calibrated P(essential)=0.068; HANSEN integrated essentiality score=0.091; ProteomeLM contextual percentile=0.091; target-priority score=46.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.216684 non-essential Uncertain ML2410 1560 Q9CB62 ML2410 Conserved membrane protein 542 0.04552 non-essential 0.06554 non-essential high NA high_confidence_nonessential NP_215042.1 80.9 0.045710707576706325 44.516 Exploratory ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.066; ProteomeLM contextual percentile=0.046; target-priority score=44.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.896918 essential Essential ML2411 1400 Q7APV0 ML2411 Possible cytochrome C-type biogenesis protein 262 0.03731 non-essential 0.10174 non-essential high NA high_confidence_nonessential YP_177735.1 78.6 0.28115216030056356 49.684 Exploratory ESM-2 calibrated P(essential)=0.037; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.281; target-priority score=49.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008087 non-essential Non-essential ML2412 416 Q9CB61 ML2412 Thioredoxin domain-containing protein 222 0.09148 non-essential 0.21062 non-essential high NA medium_confidence NP_215040.1 78.5 0.6236693800876644 66.475 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.624; target-priority score=66.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.5) rescued_from_possible_false_negative_by_supporting_evidence 0.071209 non-essential Non-essential ML2413 3 Q7APU9 ML2413 Possible phosphoglycerate mutase 202 0.28398 non-essential 0.53281 essential low disagree review_anchor_disagreement Rv0525 82.1 ES 1 0.7701941139636819 70.804 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.533; Mtb RBH anchor Rv0525=essential (disagree); ProteomeLM contextual percentile=0.770; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.018208 non-essential Non-essential ML2414 450 P46716 hemL gsa ML2414 B2168_C1_190 Glutamate-1-semialdehyde 2,1-aminomutase (GSA) (EC 5.4.3.8) (Glutamate-1-semialdehyde aminotransferase) (GSA-AT) 446 0.06543 non-essential 0.20774 non-essential high NA medium_confidence NP_215038.1 82.6 0.6906700062617408 78.582 Strong candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.691; target-priority score=78.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (78.6) rescued_from_possible_false_negative_by_supporting_evidence 0.047752 non-essential Non-essential ML2419 1104 P46723 hemB ML2419 B2168_C3_264 Delta-aminolevulinic acid dehydratase (ALAD) (ALADH) (EC 4.2.1.24) (Porphobilinogen synthase) 329 0.10115 non-essential 0.13363 non-essential high NA high_confidence_nonessential NP_215026.1 87.8 0.13963681903569192 61.993 Moderate candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.140; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.248538 non-essential Uncertain ML2420 35 Q9CB60 hemD ML2420 Possible uroporphyrin-III C-methyltransferase 563 0.42684 non-essential 0.42762 non-essential medium NA medium_confidence YP_177733.1 85.7 0.3857232310582342 58.226 Moderate candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.428; ProteomeLM contextual percentile=0.386; target-priority score=58.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.428); ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 0.006502 non-essential Non-essential ML2421 1069 Q49808 hemC ML2421 B2168_C1_179 B2168_C3_262 Porphobilinogen deaminase (PBG) (EC 2.5.1.61) (Hydroxymethylbilane synthase) (HMBS) (Pre-uroporphyrinogen synthase) 315 0.09148 non-essential 0.1372 non-essential high NA high_confidence_nonessential NP_215024.1 87.3 0.20663744520976832 61.438 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.207; target-priority score=61.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.238305 non-essential Uncertain ML2422 681 P46724 hemA ML2422 B2168_C3_261 Glutamyl-tRNA reductase (GluTR) (EC 1.2.1.70) 467 0.10418 non-essential 0.18407 non-essential high NA high_confidence_nonessential NP_215023.1 82.5 0.39824671258609895 70.217 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.398; target-priority score=70.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.2) rescued_from_possible_false_negative_by_supporting_evidence 0.004524 non-essential Non-essential ML2424 1382 Q49823 ML2424 B2168_F1_26 Putative hydrolase ML2424 (EC 3.1.-.-) 300 0.06412 non-essential 0.10306 non-essential high NA high_confidence_nonessential YP_177732.1 83.0 0.1509079524107702 54.774 Moderate candidate ESM-2 calibrated P(essential)=0.064; HANSEN integrated essentiality score=0.103; ProteomeLM contextual percentile=0.151; target-priority score=54.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001284 non-essential Non-essential ML2425 1585 P54879 ML2425 B2168_F2_80 UPF0336 protein ML2425 166 0.01993 non-essential 0.05423 non-essential high agree high_confidence_nonessential Rv0504c 83.1 NE 0 0.18221665623043207 48.111 Exploratory ESM-2 calibrated P(essential)=0.020; HANSEN integrated essentiality score=0.054; Mtb RBH anchor Rv0504c=non-essential (agree); ProteomeLM contextual percentile=0.182; target-priority score=48.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.019155 non-essential Non-essential ML2426 1006 Q49807 cmaA2 ML2426 B2168_F3_130 Cyclopropane mycolic acid synthase 2 (CMAS) (EC 2.1.1.79) (Cyclopropane-fatty-acyl-phospholipid synthase) (CFA synthase) (Cyclopropane fatty acid synthase) (Mycolic acid methyltransferase) (MA-MT) (S-adenosylmethionine-dependent methyltransferase) (AdoMet-MT) (SAM-MT) 308 0.09148 non-essential 0.1439 non-essential high NA high_confidence_nonessential NP_215017.1 80.6 0.2298058860363181 66.942 Strong candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.230; target-priority score=66.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.9) rescued_from_possible_false_negative_by_supporting_evidence 0.011266 non-essential Non-essential ML2427 1562 P54878 ML2427 B2168_C1_175 Uncharacterized protein ML2427 367 0.0393 non-essential 0.0651 non-essential high agree high_confidence_nonessential Rv0502 85.2 NE 0 0.16781465247338762 49.464 Exploratory ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.065; Mtb RBH anchor Rv0502=non-essential (agree); ProteomeLM contextual percentile=0.168; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.003691 non-essential Non-essential ML2428 58 Q9CB57 ML2428 Possible glucose epimerase/dehydratase 364 0.42684 non-essential 0.37311 non-essential medium NA medium_confidence 0.10269254852849093 45.441 Exploratory ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.373; ProteomeLM contextual percentile=0.103; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ESM-2 transfer probability is moderate (0.427) rescued_from_possible_false_negative_by_supporting_evidence 2.8e-05 non-essential Non-essential ML2429 1595 Q7APU8 ML2429 Possible DNA-binding protein 86 0.01889 non-essential 0.03693 non-essential high NA high_confidence_nonessential YP_177624.1 82.6 0.010018785222291797 40.998 Exploratory ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.037; ProteomeLM contextual percentile=0.010; target-priority score=41.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.002557 non-essential Non-essential ML2430 368 P46725 proC ML2430 B2168_C2_211 Pyrroline-5-carboxylate reductase (P5C reductase) (P5CR) (EC 1.5.1.2) (PCA reductase) 294 0.10196 non-essential 0.21636 non-essential high NA medium_confidence NP_215014.1 82.4 0.5823418910457107 75.661 Strong candidate ESM-2 calibrated P(essential)=0.102; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.582; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.7) rescued_from_possible_false_negative_by_supporting_evidence 0.064331 non-essential Non-essential ML2432 1180 P54581 ML2432 B2168_C2_210 Uncharacterized protein ML2432 280 0.09832 non-essential 0.12752 non-essential high agree high_confidence_nonessential Rv0498 89.6 NE 0 0.4001252348152787 57.034 Moderate candidate ESM-2 calibrated P(essential)=0.098; HANSEN integrated essentiality score=0.128; Mtb RBH anchor Rv0498=non-essential (agree); ProteomeLM contextual percentile=0.400; target-priority score=57.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006913 non-essential Non-essential ML2433 209 P54580 ML2433 B2168_C2_209 Uncharacterized protein ML2433 355 0.08883 non-essential 0.24165 non-essential high NA medium_confidence NP_215011.1 51.7 0.8165309956167814 67.095 Strong candidate ESM-2 calibrated P(essential)=0.089; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.817; target-priority score=67.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.817); Target-priority score is high (67.1) rescued_from_possible_false_negative_by_supporting_evidence 0.015218 non-essential Non-essential ML2434 1429 P54882 ML2434 B2168_C2_208 Exopolyphosphatase 1 (ExopolyPase 1) (EC 3.6.1.11) 339 0.09148 non-essential 0.09423 non-essential high agree high_confidence_nonessential Rv0496 85.6 NE 0 0.11772072636192861 55.128 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.094; Mtb RBH anchor Rv0496=non-essential (agree); ProteomeLM contextual percentile=0.118; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000125 non-essential Non-essential ML2435 1470 P54579 ML2435 B2168_F1_37 Probable redox regulatory protein ML2435 277 0.03079 non-essential 0.0869 non-essential high agree high_confidence_nonessential Rv0495c 82.7 NE 0 0.4026299311208516 56.323 Moderate candidate ESM-2 calibrated P(essential)=0.031; HANSEN integrated essentiality score=0.087; Mtb RBH anchor Rv0495c=non-essential (agree); ProteomeLM contextual percentile=0.403; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.187243 non-essential Non-essential ML2439 192 P54884 rgx3 ML2439 B2168_C3_248 Sensory transduction protein RegX3 198 0.12863 non-essential 0.24623 non-essential high NA medium_confidence NP_215005.1 95.4 0.6643706950532248 65.92 Strong candidate ESM-2 calibrated P(essential)=0.129; HANSEN integrated essentiality score=0.246; ProteomeLM contextual percentile=0.664; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.108067 non-essential Non-essential ML2440 1341 P54883 senX3 ML2440 B2168_C3_247 Sensor-like histidine kinase SenX3 (EC 2.7.13.3) 443 0.04656 non-essential 0.10908 non-essential high NA high_confidence_nonessential NP_215004.1 84.1 0.25610519724483405 58.456 Moderate candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.256; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.033543 non-essential Non-essential ML2441 275 P53531 gpmA gpm pgm ML2441 B2168_C3_246 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (BPG-dependent PGAM) (PGAM) (Phosphoglyceromutase) (dPGM) (EC 5.4.2.11) 247 0.09187 non-essential 0.22929 non-essential high NA medium_confidence YP_177731.1 89.0 0.6881653099561679 81.291 High-priority ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.688; target-priority score=81.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (81.3) rescued_from_possible_false_negative_by_supporting_evidence 0.003949 non-essential Non-essential ML2442 1555 P54139 ML2442 B2168_C3_245 u2168e Uncharacterized protein ML2442 184 0.03604 non-essential 0.06829 non-essential high agree high_confidence_nonessential Rv0487 73.1 NE 0 0.2185347526612398 49.624 Exploratory ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.068; Mtb RBH anchor Rv0487=non-essential (agree); ProteomeLM contextual percentile=0.219; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.003864 non-essential Non-essential ML2443 831 P54138 mshA ML2443 B2168_C2_201 u2168f D-inositol 3-phosphate glycosyltransferase (EC 2.4.1.250) (N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase) (GlcNAc-Ins-P N-acetylglucosaminyltransferase) 428 0.1084 non-essential 0.16531 non-essential high NA high_confidence_nonessential NP_215000.1 86.6 0.28804007514088914 63.586 Moderate candidate ESM-2 calibrated P(essential)=0.108; HANSEN integrated essentiality score=0.165; ProteomeLM contextual percentile=0.288; target-priority score=63.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.079952 non-essential Non-essential ML2446 1500 Q9CB49 ML2446 Possible lipoprotein 441 0.03604 non-essential 0.08165 non-essential high NA high_confidence_nonessential NP_214997.1 80.2 0.14652473387601753 57.254 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.147; target-priority score=57.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.027824 non-essential Non-essential ML2447 1098 Q9CB48 murB ML2447 UDP-N-acetylenolpyruvoylglucosamine reductase (EC 1.3.1.98) (UDP-N-acetylmuramate dehydrogenase) 367 0.04656 non-essential 0.13429 non-essential high NA high_confidence_nonessential NP_214996.1 79.0 0.35879774577332496 73.966 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.359; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.0) rescued_from_possible_false_negative_by_supporting_evidence 0.236919 non-essential Uncertain ML2449 1498 Q9CB47 ML2449 Hydrolase 271 0.01889 non-essential 0.08172 non-essential high NA high_confidence_nonessential NP_214994.2 81.9 0.234815278647464 54.14 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.082; ProteomeLM contextual percentile=0.235; target-priority score=54.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.078613 non-essential Non-essential ML2450 278 Q9CB46 ML2450 Possible secreted protein 245 0.08334 non-essential 0.22851 non-essential high NA medium_confidence NP_214993.1 70.0 0.7608015028177834 68.343 Strong candidate ESM-2 calibrated P(essential)=0.083; HANSEN integrated essentiality score=0.229; ProteomeLM contextual percentile=0.761; target-priority score=68.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.761); Target-priority score is high (68.3) rescued_from_possible_false_negative_by_supporting_evidence 0.035055 non-essential Non-essential ML2451 1016 Q9CB45 deoC ML2451 Deoxyribose-phosphate aldolase (DERA) (EC 4.1.2.4) (2-deoxy-D-ribose 5-phosphate aldolase) (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) 226 0.0733 non-essential 0.14259 non-essential high NA high_confidence_nonessential NP_214992.1 78.3 0.3024420788979336 67.993 Strong candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.302; target-priority score=68.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.0) rescued_from_possible_false_negative_by_supporting_evidence 0.010155 non-essential Non-essential ML2452 1044 Q9CB44 ML2452 Uncharacterized protein ML2452 123 0.01019 non-essential 0.13981 non-essential high agree high_confidence_nonessential Rv0477 60.0 GA 0 0.9636819035691923 74.659 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.140; Mtb RBH anchor Rv0477=non-essential (agree); ProteomeLM contextual percentile=0.964; target-priority score=74.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.964); Target-priority score is high (74.7) rescued_from_possible_false_negative_by_supporting_evidence 0.009275 non-essential Non-essential ML2453 367 Q9CB43 ML2453 Uncharacterized protein ML2453 87 0.07625 non-essential 0.21637 non-essential high NA medium_confidence NP_214990.1 83.9 0.7213525360050094 68.538 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.721; target-priority score=68.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000169 non-essential Non-essential ML2454 251 Q9CB42 hbhA ML2454 Heparin-binding hemagglutinin homolog (Adhesin) 188 0.07625 non-essential 0.233 non-essential high NA medium_confidence NP_214989.1 47.0 0.8221665623043206 67.514 Strong candidate ESM-2 calibrated P(essential)=0.076; HANSEN integrated essentiality score=0.233; ProteomeLM contextual percentile=0.822; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.822); Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000312 non-essential Non-essential ML2457 826 Q9CB41 ML2457 Possible TetR-family transcriptional regulator 233 0.0332 non-essential 0.16595 non-essential high NA high_confidence_nonessential NP_214986.1 90.0 0.628052598622417 66.584 Strong candidate ESM-2 calibrated P(essential)=0.033; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.628; target-priority score=66.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.6) rescued_from_possible_false_negative_by_supporting_evidence 0.001778 non-essential Non-essential ML2459 1134 Q9CB40 umaA2 ML2459 Mycolic acid synthase 295 0.09148 non-essential 0.13103 non-essential high NA high_confidence_nonessential YP_177730.1 81.9 0.18722604884157795 55.695 Moderate candidate ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.131; ProteomeLM contextual percentile=0.187; target-priority score=55.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001165 non-essential Non-essential ML2461 543 Q9CB39 fadB2 ML2461 3-hydroxyacyl-CoA dehydrogenase 287 0.08382 non-essential 0.19752 non-essential high NA high_confidence_nonessential NP_214982.1 89.9 0.5691922354414527 70.763 Strong candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.198; ProteomeLM contextual percentile=0.569; target-priority score=70.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.8) rescued_from_possible_false_negative_by_supporting_evidence 0.003303 non-essential Non-essential ML2463 1198 Q9CB38 ML2463 Acyl-ACP thioesterase 264 0.03604 non-essential 0.12569 non-essential high agree high_confidence_nonessential Rv0466 87.5 NE 0 0.6900438321853475 70.131 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.126; Mtb RBH anchor Rv0466=non-essential (agree); ProteomeLM contextual percentile=0.690; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 0.007321 non-essential Non-essential ML2465 1523 Q9CB37 ML2465 Carboxymuconolactone decarboxylase-like domain-containing protein 188 0.02105 non-essential 0.07705 non-essential high agree high_confidence_nonessential Rv0464c 67.8 NE 0 0.3600500939261115 56.828 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.077; Mtb RBH anchor Rv0464c=non-essential (agree); ProteomeLM contextual percentile=0.360; target-priority score=56.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000275 non-essential Non-essential ML2467 166 Q9CB36 ML2467 Short-chain Z-isoprenyl diphosphate synthase (EC 2.5.1.68) ((2Z,6E)-farnesyl diphosphate synthase) (Z-FPP synthase) (Z-isoprenyl diphosphate synthase) 262 0.18914 non-essential 0.2531 non-essential high NA medium_confidence NP_215602.1 90.8 0.4045084533500313 73.607 Strong candidate ESM-2 calibrated P(essential)=0.189; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.405; target-priority score=73.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.6) rescued_from_possible_false_negative_by_supporting_evidence 0.00025 non-essential Non-essential ML2468 463 Q9CB35 ML2468 Uncharacterized protein 126 0.01258 non-essential 0.20634 non-essential high NA medium_confidence 0.949906073888541 70.077 Strong candidate ESM-2 calibrated P(essential)=0.013; HANSEN integrated essentiality score=0.206; ProteomeLM contextual percentile=0.950; target-priority score=70.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.950); Target-priority score is high (70.1) rescued_from_possible_false_negative_by_supporting_evidence 8e-06 non-essential Non-essential ML2472 1086 Q9CB34 ML2472 Possible prephenate dehydrogenase 327 0.03424 non-essential 0.13554 non-essential high NA high_confidence_nonessential NP_218271.3 80.0 0.45585472761427676 62.684 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.136; ProteomeLM contextual percentile=0.456; target-priority score=62.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.03715 non-essential Non-essential ML2473 1333 Q9CB33 ML2473 tRNA adenosine deaminase 159 0.03424 non-essential 0.11072 non-essential high agree high_confidence_nonessential Rv3753c 88.6 NE 0 0.5848465873512837 63.377 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.111; Mtb RBH anchor Rv3753c=non-essential (agree); ProteomeLM contextual percentile=0.585; target-priority score=63.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 8e-05 non-essential Non-essential ML2474 548 Q9CB32 tadA ML2474 tRNA-specific adenosine deaminase (EC 3.5.4.33) 171 0.01648 non-essential 0.19693 non-essential high NA high_confidence_nonessential NP_218269.1 87.4 0.839073262366938 82.859 High-priority ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.839; target-priority score=82.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.839); Target-priority score is high (82.9) rescued_from_possible_false_negative_by_supporting_evidence 0.046886 non-essential Non-essential ML2476 266 Q9CB31 ML2476 Uncharacterized protein 55 0.03579 non-essential 0.23017 non-essential high NA medium_confidence 0.9768315591734502 72.385 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.977; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.977); Target-priority score is high (72.4) rescued_from_possible_false_negative_by_supporting_evidence 5.8e-05 non-essential Non-essential ML2478 104 Q9CB30 ML2478 Uncharacterized protein 129 0.0998 non-essential 0.28095 non-essential high NA medium_confidence 0.9818409517845961 72.387 Strong candidate ESM-2 calibrated P(essential)=0.100; HANSEN integrated essentiality score=0.281; ProteomeLM contextual percentile=0.982; target-priority score=72.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.982); Target-priority score is high (72.4) rescued_from_possible_false_negative_by_supporting_evidence 0.007438 non-essential Non-essential ML2485 998 Q9CB29 ML2485 Possible RNA methyltransferase 182 0.02734 non-essential 0.14428 non-essential high NA high_confidence_nonessential NP_214894.1 88.5 0.5335003130870382 64.507 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.144; ProteomeLM contextual percentile=0.534; target-priority score=64.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.101817 non-essential Non-essential ML2487 282 Q9CB28 pyrE ML2487 Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10) 179 0.12597 non-essential 0.22797 non-essential high NA medium_confidence YP_177723.1 85.4 0.5397620538509705 75.893 Strong candidate ESM-2 calibrated P(essential)=0.126; HANSEN integrated essentiality score=0.228; ProteomeLM contextual percentile=0.540; target-priority score=75.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.9) rescued_from_possible_false_negative_by_supporting_evidence 0.036932 non-essential Non-essential ML2489 17 Q9CB27 ML2489 Possible secreted protein 286 0.2355 non-essential 0.48055 non-essential low disagree review_anchor_disagreement Rv0383c 82.2 GD 1 0.5860989355040701 61.277 Moderate candidate ESM-2 calibrated P(essential)=0.235; HANSEN integrated essentiality score=0.481; Mtb RBH anchor Rv0383c=essential (disagree); ProteomeLM contextual percentile=0.586; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.560418 essential Likely essential ML2490 502 Q9CB26 clpB ML2490 Chaperone protein ClpB 848 0.13353 non-essential 0.20257 non-essential high NA medium_confidence NP_214898.1 89.2 0.4057608015028178 58.871 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.406; target-priority score=58.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001934 non-essential Non-essential ML2491 1214 Q9CB25 ML2491 DUF4185 domain-containing protein 333 0.01019 non-essential 0.12408 non-essential high agree high_confidence_nonessential Rv1754c 70.8 NE 0 0.8202880400751409 71.876 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.124; Mtb RBH anchor Rv1754c=non-essential (agree); ProteomeLM contextual percentile=0.820; target-priority score=71.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.820); Target-priority score is high (71.9) rescued_from_possible_false_negative_by_supporting_evidence 0.024509 non-essential Non-essential ML2493 1461 Q9CB24 hspR ML2493 Heat shock regulator 132 0.04386 non-essential 0.08901 non-essential high NA high_confidence_nonessential NP_214867.1 80.0 0.17658108954289292 49.556 Exploratory ESM-2 calibrated P(essential)=0.044; HANSEN integrated essentiality score=0.089; ProteomeLM contextual percentile=0.177; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 9e-05 non-essential Non-essential ML2494 1533 Q02605 dnaJ1 ML2494 Chaperone protein DnaJ 1 388 0.05587 non-essential 0.07436 non-essential high NA high_confidence_nonessential YP_177719.1 90.0 0.036318096430807766 49.22 Exploratory ESM-2 calibrated P(essential)=0.056; HANSEN integrated essentiality score=0.074; ProteomeLM contextual percentile=0.036; target-priority score=49.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000808 non-essential Non-essential ML2495 1186 Q9CB23 grpE ML2495 Protein GrpE (HSP-70 cofactor) 229 0.05422 non-essential 0.127 non-essential high NA high_confidence_nonessential NP_214865.1 76.0 0.3368816530995617 54.865 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.337; target-priority score=54.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.036205 non-essential Non-essential ML2496 624 P19993 dnaK ML2496 Chaperone protein DnaK (70 kDa antigen) (HSP70) (Heat shock 70 kDa protein) (Heat shock protein 70) 620 0.20204 non-essential 0.1897 non-essential medium NA high_confidence_nonessential NP_214864.1 90.1 0.05572949279899812 45.279 Exploratory ESM-2 calibrated P(essential)=0.202; HANSEN integrated essentiality score=0.190; ProteomeLM contextual percentile=0.056; target-priority score=45.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.341584 essential Uncertain ML2497 547 Q9CB22 ML2497 TetR-family transcriptional regulator 157 0.02105 non-essential 0.19694 non-essential high NA high_confidence_nonessential 0.8465873512836568 73.206 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.197; ProteomeLM contextual percentile=0.847; target-priority score=73.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.847); Target-priority score is high (73.2) rescued_from_possible_false_negative_by_supporting_evidence 9e-06 non-essential Non-essential ML2498 1167 Q9CB21 ML2498 Possible enoyl-CoA hydratase 219 0.06488 non-essential 0.12877 non-essential high NA high_confidence_nonessential 0.2936756418284283 56.465 Moderate candidate ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.294; target-priority score=56.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000197 non-essential Non-essential ML2501 1153 Q9CB20 ML2501 Probable iron-sulphur-binding reductase 880 0.1041 non-essential 0.12979 non-essential high NA high_confidence_nonessential NP_214852.1 78.2 0.14214151534126487 48.863 Exploratory ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.142; target-priority score=48.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.510887 essential Likely essential ML2502 419 Q9CB19 ML2502 Alanine aminotransferase (EC 2.6.1.2) (Alanine transaminase) (Transaminase A) 437 0.23313 non-essential 0.21029 non-essential medium NA medium_confidence NP_214851.1 91.4 0.014402003757044458 52.002 Moderate candidate ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.014; target-priority score=52.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.0096 non-essential Non-essential ML2503 373 Q9CB18 rfbA ML2503 Glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) 288 0.17556 non-essential 0.2158 non-essential high NA medium_confidence NP_214848.1 87.1 0.2748904195366312 64.269 Moderate candidate ESM-2 calibrated P(essential)=0.176; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.275; target-priority score=64.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.234932 non-essential Uncertain ML2507 1556 Q9CB17 dcd ML2507 dCTP deaminase, dUMP-forming (EC 3.5.4.30) (Bifunctional dCTP deaminase:dUTPase) (DCD-DUT) 190 0.02105 non-essential 0.06808 non-essential high NA high_confidence_nonessential NP_214835.1 90.0 0.12398246712586099 61.159 Moderate candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.068; ProteomeLM contextual percentile=0.124; target-priority score=61.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003939 non-essential Non-essential ML2518 1503 Q9CD39 ML2518 Transmembrane protein 130 0.04115 non-essential 0.08091 non-essential high agree high_confidence_nonessential Rv0313 78.1 GA 0 0.3118346900438322 50.076 Moderate candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.081; Mtb RBH anchor Rv0313=non-essential (agree); ProteomeLM contextual percentile=0.312; target-priority score=50.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.006471 non-essential Non-essential ML2522 1163 Q9CD38 ML2522 Secreted protein 218 0.05162 non-essential 0.12916 non-essential high agree high_confidence_nonessential Rv0309 78.0 NE 0 0.6105197244834064 74.274 Strong candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.129; Mtb RBH anchor Rv0309=non-essential (agree); ProteomeLM contextual percentile=0.611; target-priority score=74.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.3) rescued_from_possible_false_negative_by_supporting_evidence 2.6e-05 non-essential Non-essential ML2527 111 Q9CD37 ML2527 Conserved membrane protein 339 0.14724 non-essential 0.27575 non-essential high NA medium_confidence NP_214806.1 59.9 0.743894802755166 68.879 Strong candidate ESM-2 calibrated P(essential)=0.147; HANSEN integrated essentiality score=0.276; ProteomeLM contextual percentile=0.744; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.003749 non-essential Non-essential ML2528 1294 Q9CD36 ML2528 Protease 475 0.09552 non-essential 0.1142 non-essential high NA high_confidence_nonessential NP_214805.1 71.9 0.08578584846587352 50.209 Moderate candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.086; target-priority score=50.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.470797 essential Likely essential ML2529 698 Q9CD35 ML2529 Conserved membrane protein 485 0.03769 non-essential 0.18245 non-essential high NA high_confidence_nonessential NP_214804.1 76.0 0.7025673137132122 67.233 Strong candidate ESM-2 calibrated P(essential)=0.038; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.703; target-priority score=67.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.2) rescued_from_possible_false_negative_by_supporting_evidence 0.079256 non-essential Non-essential ML2530 105 Q9CD34 ML2530 Possible DNA-binding protein 289 0.21735 non-essential 0.27819 non-essential medium NA medium_confidence NP_214803.1 75.9 0.4627426424546024 59.988 Moderate candidate ESM-2 calibrated P(essential)=0.217; HANSEN integrated essentiality score=0.278; ProteomeLM contextual percentile=0.463; target-priority score=60.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.035616 non-essential Non-essential ML2531 704 Q9CD33 esxR ML2531 ESAT-6-like protein EsxR 96 0.0 non-essential 0.18167 non-essential high NA high_confidence_nonessential NP_214802.1 70.8 0.8559799624295554 72.308 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.856; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.856); Target-priority score is high (72.3) rescued_from_possible_false_negative_by_supporting_evidence 0.051039 non-essential Non-essential ML2532 666 Q9CD32 ML2532 PE-family protein 98 0.0 non-essential 0.18537 non-essential high NA high_confidence_nonessential NP_214801.1 77.9 0.8797745773324984 71.614 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.185; ProteomeLM contextual percentile=0.880; target-priority score=71.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.880); Target-priority score is high (71.6) rescued_from_possible_false_negative_by_supporting_evidence 0.21581 non-essential Uncertain ML2534 888 Q9CD31 ML2534 PE-family protein 102 0.0 non-essential 0.15834 non-essential high NA high_confidence_nonessential YP_177710.1 73.0 0.7345021916092673 66.957 Strong candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.158; ProteomeLM contextual percentile=0.735; target-priority score=67.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.0) rescued_from_possible_false_negative_by_supporting_evidence 3.2e-05 non-essential Non-essential ML2535 386 Q9CD30 ML2535 FtsK domain-containing protein 1329 0.0446 non-essential 0.21414 non-essential high NA medium_confidence NP_214798.1 84.2 0.8371947401377583 74.065 Strong candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.837; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.837); Target-priority score is high (74.1) rescued_from_possible_false_negative_by_supporting_evidence 0.108517 non-essential Non-essential ML2536 932 Q9CD29 ML2536 Conserved membrane protein 552 0.11185 non-essential 0.1525 non-essential high NA high_confidence_nonessential NP_214797.1 70.8 0.22917971195992487 52.587 Moderate candidate ESM-2 calibrated P(essential)=0.112; HANSEN integrated essentiality score=0.152; ProteomeLM contextual percentile=0.229; target-priority score=52.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.429139 essential Likely essential ML2537 364 Q9CD28 eccA3 ML2537 ESX-3 secretion system protein EccA3 (ESX conserved component A3) (Type VII secretion system protein EccA3) (T7SS protein EccA3) 640 0.07063 non-essential 0.21676 non-essential high NA medium_confidence NP_214796.1 83.6 0.7407639323731997 71.478 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.217; ProteomeLM contextual percentile=0.741; target-priority score=71.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (71.5) rescued_from_possible_false_negative_by_supporting_evidence 0.690644 essential Likely essential ML2546 701 Q9CD27 fadD2 ML2546 Long-chain-fatty-acid--CoA ligase FadD13 (EC 6.2.1.3) (Fatty acyl-CoA ligase) (Fatty acyl-CoA synthetase) (Very-long-chain fatty-acyl-CoA synthetase) 548 0.14132 non-essential 0.18225 non-essential high NA high_confidence_nonessential NP_214784.1 83.4 0.24796493425172197 59.735 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.248; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 8.5e-05 non-essential Non-essential ML2549 1286 Q9CD26 ML2549 Carboxyltransferase domain-containing protein 222 0.03604 non-essential 0.11458 non-essential high agree high_confidence_nonessential Rv0264c 75.2 NE 0 0.5998747651847214 65.934 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.115; Mtb RBH anchor Rv0264c=non-essential (agree); ProteomeLM contextual percentile=0.600; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.006819 non-essential Non-essential ML2550 1419 Q9CD25 ML2550 Carboxyltransferase domain-containing protein 305 0.03604 non-essential 0.09711 non-essential high agree high_confidence_nonessential Rv0263c 78.3 NE 0 0.4483406386975579 61.309 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.097; Mtb RBH anchor Rv0263c=non-essential (agree); ProteomeLM contextual percentile=0.448; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.039679 non-essential Non-essential ML2551 1342 Q9CD24 aac ML2551 Aminoglycoside 2'-N-acetyltransferase 182 0.0 non-essential 0.10896 non-essential high NA high_confidence_nonessential NP_214776.1 79.1 0.45898559799624294 61.867 Moderate candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.459; target-priority score=61.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001674 non-essential Non-essential ML2557 1365 Q7APU6 ML2557 Uncharacterized protein 98 0.01648 non-essential 0.10507 non-essential high agree high_confidence_nonessential Rv0250c 73.7 NE 0 0.6443331246086412 61.493 Moderate candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.105; Mtb RBH anchor Rv0250c=non-essential (agree); ProteomeLM contextual percentile=0.644; target-priority score=61.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2e-06 non-essential Non-essential ML2561 1308 Q7APU5 ML2561 Probable oxidoreductase 162 0.0 non-essential 0.11277 non-essential high NA high_confidence_nonessential NP_214759.1 82.0 0.4777708202880401 63.106 Moderate candidate ESM-2 calibrated P(essential)=0.000; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.478; target-priority score=63.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000482 non-essential Non-essential ML2562 236 Q9CD23 ML2562 Uncharacterized protein 96 0.04985 non-essential 0.23555 non-essential high NA medium_confidence 0.9517845961177207 69.739 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.236; ProteomeLM contextual percentile=0.952; target-priority score=69.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.952); Target-priority score is high (69.7) rescued_from_possible_false_negative_by_supporting_evidence 0.066642 non-essential Non-essential ML2563 1515 Q7APU4 fadE5 ML2563 Broad-specificity linear acyl-CoA dehydrogenase FadE5 (EC 1.3.8.1) (EC 1.3.8.7) (EC 1.3.8.8) (Long-chain-acyl-CoA dehydrogenase) (Medium-chain-acyl-CoA dehydrogenase) (Short-chain-acyl-CoA dehydrogenase) 611 0.03604 non-essential 0.07827 non-essential high NA high_confidence_nonessential NP_214758.1 89.5 0.11834690043832186 60.09 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.078; ProteomeLM contextual percentile=0.118; target-priority score=60.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001123 non-essential Non-essential ML2564 1391 Q7APU3 fadA2 ML2564 Acetyl-CoA C-acetyltransferase 457 0.03604 non-essential 0.10249 non-essential high NA high_confidence_nonessential NP_214757.1 88.0 0.27551659361302444 55.081 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.102; ProteomeLM contextual percentile=0.276; target-priority score=55.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003243 non-essential Non-essential ML2565 168 Q7APU2 fabG4 ML2565 Possible oxidoreductase 454 0.23512 non-essential 0.25256 non-essential medium NA medium_confidence NP_214756.1 85.0 0.24420788979336255 55.306 Moderate candidate ESM-2 calibrated P(essential)=0.235; HANSEN integrated essentiality score=0.253; ProteomeLM contextual percentile=0.244; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000284 non-essential Non-essential ML2566 840 Q9CD22 ML2566 MaoC-like domain-containing protein 300 0.08446 non-essential 0.16416 non-essential high NA high_confidence_nonessential NP_214755.1 81.8 0.4032561051972448 59.467 Moderate candidate ESM-2 calibrated P(essential)=0.084; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.403; target-priority score=59.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008307 non-essential Non-essential ML2567 366 Q9CD21 ML2567 Uncharacterized protein 159 0.03486 non-essential 0.21638 non-essential high NA medium_confidence 0.9092047589229806 69.248 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.216; ProteomeLM contextual percentile=0.909; target-priority score=69.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.909); Target-priority score is high (69.2) rescued_from_possible_false_negative_by_supporting_evidence 0.00013 non-essential Non-essential ML2568 1191 Q7APU1 ML2568 Possible TetR-family transcriptional regulator 208 0.04947 non-essential 0.12657 non-essential high NA high_confidence_nonessential NP_214752.1 80.9 0.3512836568566061 56.538 Moderate candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.127; ProteomeLM contextual percentile=0.351; target-priority score=56.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 3e-06 non-essential Non-essential ML2569 210 Q9CD20 ML2569.1 ML2569A Putative secreted protein ML2569.1 57 0.06482 non-essential 0.24164 non-essential high NA medium_confidence YP_177702.1 72.8 0.8810269254852849 82.608 High-priority ESM-2 calibrated P(essential)=0.065; HANSEN integrated essentiality score=0.242; ProteomeLM contextual percentile=0.881; target-priority score=82.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.881); Target-priority score is high (82.6) rescued_from_possible_false_negative_by_supporting_evidence 0.004406 non-essential Non-essential ML2570 213 Q9CD19 ML2570 Alpha-(1->3)-arabinofuranosyltransferase (EC 2.4.2.47) (Arabinofuranan 3-O-arabinosyltransferase) 1405 0.10115 non-essential 0.24031 non-essential high NA medium_confidence NP_214750.1 78.7 0.7169693174702567 79.064 Strong candidate ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.240; ProteomeLM contextual percentile=0.717; target-priority score=79.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (79.1) rescued_from_possible_false_negative_by_supporting_evidence 0.948908 essential Essential ML2573 1345 O69497 gabD1 ML2573 MLCB1883.11c Succinate-semialdehyde dehydrogenase [NADP(+)] (SSADH) (SSDH) (EC 1.2.1.79) 457 0.02975 non-essential 0.1087 non-essential high NA high_confidence_nonessential NP_216247.2 85.7 0.308703819661866 66.028 Strong candidate ESM-2 calibrated P(essential)=0.030; HANSEN integrated essentiality score=0.109; ProteomeLM contextual percentile=0.309; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 4.4e-05 non-essential Non-essential ML2580 1529 Q7APT8 ML2580 Possible acyltransferase 384 0.01889 non-essential 0.07592 non-essential high NA high_confidence_nonessential NP_214742.1 79.1 0.2047589229805886 52.752 Moderate candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.076; ProteomeLM contextual percentile=0.205; target-priority score=52.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.498546 essential Likely essential ML2581 354 Q9CD18 ML2581 Integral membrane protein 427 0.06628 non-essential 0.21774 non-essential high NA medium_confidence NP_214741.1 75.6 0.7764558547276142 68.092 Strong candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.776; target-priority score=68.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.776); Target-priority score is high (68.1) rescued_from_possible_false_negative_by_supporting_evidence 0.946158 essential Essential ML2582 1359 Q9CD17 ML2582 Conserved membrane protein 600 0.05764 non-essential 0.10579 non-essential high NA high_confidence_nonessential NP_214740.1 70.1 0.21102066374452097 49.908 Exploratory ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.106; ProteomeLM contextual percentile=0.211; target-priority score=49.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.084875 non-essential Non-essential ML2583 15 Q7APT7 ML2583 Glycosyl transferase 394 0.27123 non-essential 0.48729 non-essential low disagree review_anchor_disagreement Rv0225 84.9 ES 1 0.4402003757044458 61.077 Moderate candidate ESM-2 calibrated P(essential)=0.271; HANSEN integrated essentiality score=0.487; Mtb RBH anchor Rv0225=essential (disagree); ProteomeLM contextual percentile=0.440; target-priority score=61.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.176234 non-essential Non-essential ML2584 484 O69492 ML2584 MLCB1883.02c Uncharacterized methyltransferase ML2584 (EC 2.1.1.-) 269 0.06199 non-essential 0.20387 non-essential high NA medium_confidence NP_214738.1 82.9 0.7000626174076393 73.027 Strong candidate ESM-2 calibrated P(essential)=0.062; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.700; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 0.848062 essential Essential ML2587 708 Q9CD16 yrbE1A ML2587 Conserved membrane protein 267 0.00543 non-essential 0.18131 non-essential high NA high_confidence_nonessential NP_214681.1 88.0 0.828428303068253 72.481 Strong candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.181; ProteomeLM contextual percentile=0.828; target-priority score=72.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.828); Target-priority score is high (72.5) rescued_from_possible_false_negative_by_supporting_evidence 0.000744 non-essential Non-essential ML2588 1439 Q9CD15 yrbE1B ML2588 Conserved membrane protein 289 0.00543 non-essential 0.09273 non-essential high NA high_confidence_nonessential NP_214682.1 84.8 0.35629304946775203 55.844 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.356; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 2.7e-05 non-essential Non-essential ML2589 741 Q9CD14 mce1A ML2589 Cell invasion protein 441 0.0733 non-essential 0.17775 non-essential high NA high_confidence_nonessential YP_177701.1 66.1 0.5385097056981841 58.055 Moderate candidate ESM-2 calibrated P(essential)=0.073; HANSEN integrated essentiality score=0.178; ProteomeLM contextual percentile=0.539; target-priority score=58.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.00113 non-essential Non-essential ML2590 1492 Q9CD13 mce1B ML2590 Secreted protein 346 0.01759 non-essential 0.08318 non-essential high NA high_confidence_nonessential NP_214684.1 75.1 0.2629931120851597 49.502 Exploratory ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.083; ProteomeLM contextual percentile=0.263; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000176 non-essential Non-essential ML2591 1068 Q9CD12 mce1C ML2591 Secreted protein 519 0.02795 non-essential 0.13723 non-essential high NA high_confidence_nonessential NP_214685.1 69.9 0.5084533500313086 57.979 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.137; ProteomeLM contextual percentile=0.508; target-priority score=58.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.039897 non-essential Non-essential ML2592 1436 Q9CD11 mce1D ML2592 Secreted protein 531 0.04324 non-essential 0.09307 non-essential high NA high_confidence_nonessential NP_214686.1 75.1 0.20914214151534127 47.565 Exploratory ESM-2 calibrated P(essential)=0.043; HANSEN integrated essentiality score=0.093; ProteomeLM contextual percentile=0.209; target-priority score=47.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000274 non-essential Non-essential ML2593 1156 Q9CD10 lprK ML2593 Lipoprotein 392 0.02795 non-essential 0.1297 non-essential high NA high_confidence_nonessential NP_214687.1 76.3 0.46900438321853477 56.332 Moderate candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.469; target-priority score=56.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000181 non-essential Non-essential ML2594 1054 Q9CD09 mce1F ML2594 Secreted protein 516 0.03949 non-essential 0.13864 non-essential high NA high_confidence_nonessential NP_214688.1 76.5 0.469630557294928 56.001 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.139; ProteomeLM contextual percentile=0.470; target-priority score=56.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.012867 non-essential Non-essential ML2595 404 Q9CD08 ML2595 Possible membrane protein 182 0.03604 non-essential 0.21192 non-essential high NA medium_confidence NP_214689.3 69.1 0.8691296180338134 72.113 Strong candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.212; ProteomeLM contextual percentile=0.869; target-priority score=72.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.869); Target-priority score is high (72.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000721 non-essential Non-essential ML2596 825 Q9CD07 ML2596 Conserved membrane protein 325 0.01889 non-essential 0.16601 non-essential high NA high_confidence_nonessential NP_214690.1 55.2 0.691296180338134 67.524 Strong candidate ESM-2 calibrated P(essential)=0.019; HANSEN integrated essentiality score=0.166; ProteomeLM contextual percentile=0.691; target-priority score=67.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.5) rescued_from_possible_false_negative_by_supporting_evidence 0.001637 non-essential Non-essential ML2597 1463 Q9CD06 ML2597 Conserved membrane protein 184 0.03424 non-essential 0.08801 non-essential high NA high_confidence_nonessential NP_214691.1 60.9 0.21227301189730746 50.432 Moderate candidate ESM-2 calibrated P(essential)=0.034; HANSEN integrated essentiality score=0.088; ProteomeLM contextual percentile=0.212; target-priority score=50.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003541 non-essential Non-essential ML2598 511 Q9CD05 ML2598 Secreted protein 184 0.07168 non-essential 0.20155 non-essential high NA medium_confidence NP_214692.1 77.9 0.6618659987476518 66.249 Strong candidate ESM-2 calibrated P(essential)=0.072; HANSEN integrated essentiality score=0.202; ProteomeLM contextual percentile=0.662; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.000933 non-essential Non-essential ML2600 1224 Q9CD04 ML2600 Probable conserved membrane protein 465 0.00543 non-essential 0.12262 non-essential high NA high_confidence_nonessential NP_214694.1 77.4 0.5159674389480275 61.334 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.123; ProteomeLM contextual percentile=0.516; target-priority score=61.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.024498 non-essential Non-essential ML2603 493 Q9CD03 ML2603 Monoacylglycerol lipase (EC 3.1.1.23) 279 0.18438 non-essential 0.20326 non-essential high NA medium_confidence NP_214697.2 74.9 0.17720726361928615 58.644 Moderate candidate ESM-2 calibrated P(essential)=0.184; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.177; target-priority score=58.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 6.4e-05 non-essential Non-essential ML2604 1596 Q9CD02 ML2604 Uncharacterized protein 249 0.01019 non-essential 0.03664 non-essential high agree high_confidence_nonessential Rv0184 81.9 NE 0 0.08390732623669381 44.271 Exploratory ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.037; Mtb RBH anchor Rv0184=non-essential (agree); ProteomeLM contextual percentile=0.084; target-priority score=44.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.00276 non-essential Non-essential ML2605 1152 Q7APT5 ML2605 TIGR04338 family metallohydrolase 168 0.05457 non-essential 0.1298 non-essential high agree high_confidence_nonessential Rv0185 76.4 NE 0 0.6393237319974953 66.242 Strong candidate ESM-2 calibrated P(essential)=0.055; HANSEN integrated essentiality score=0.130; Mtb RBH anchor Rv0185=non-essential (agree); ProteomeLM contextual percentile=0.639; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.003661 non-essential Non-essential ML2608 846 O06069 ilvD ML2608 MLCL622.06c Dihydroxy-acid dehydratase (DAD) (EC 4.2.1.9) 564 0.09373 non-essential 0.16354 non-essential high NA high_confidence_nonessential NP_214703.1 90.0 0.32936756418284285 68.878 Strong candidate ESM-2 calibrated P(essential)=0.094; HANSEN integrated essentiality score=0.164; ProteomeLM contextual percentile=0.329; target-priority score=68.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (68.9) rescued_from_possible_false_negative_by_supporting_evidence 0.034782 non-essential Non-essential ML2609 805 Q7APT4 ML2609 CopY family transcriptional regulator 135 0.07065 non-essential 0.16943 non-essential high agree high_confidence_nonessential Rv0190 82.6 GA 0 0.8985597996242956 74.373 Strong candidate ESM-2 calibrated P(essential)=0.071; HANSEN integrated essentiality score=0.169; Mtb RBH anchor Rv0190=non-essential (agree); ProteomeLM contextual percentile=0.899; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.899); Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 1.6e-05 non-essential Non-essential ML2613 1335 Q7APT3 ML2613 Probable zinc metalloprotease 667 0.04552 non-essential 0.11052 non-essential high NA high_confidence_nonessential NP_214712.1 81.0 0.27802128991859737 55.49 Moderate candidate ESM-2 calibrated P(essential)=0.046; HANSEN integrated essentiality score=0.111; ProteomeLM contextual percentile=0.278; target-priority score=55.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.003629 non-essential Non-essential ML2614 415 Q7APT2 ML2614 Conserved membrane protein 224 0.04656 non-essential 0.21066 non-essential high NA medium_confidence NP_214713.1 67.6 0.8209142141515341 69.578 Strong candidate ESM-2 calibrated P(essential)=0.047; HANSEN integrated essentiality score=0.211; ProteomeLM contextual percentile=0.821; target-priority score=69.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.821); Target-priority score is high (69.6) rescued_from_possible_false_negative_by_supporting_evidence 0.000797 non-essential Non-essential ML2615 291 Q7APT1 ML2615 Probable membrane protein 229 0.06716 non-essential 0.22607 non-essential high NA medium_confidence NP_214714.1 74.7 0.8108954289292424 71.669 Strong candidate ESM-2 calibrated P(essential)=0.067; HANSEN integrated essentiality score=0.226; ProteomeLM contextual percentile=0.811; target-priority score=71.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.811); Target-priority score is high (71.7) rescued_from_possible_false_negative_by_supporting_evidence 0.280812 non-essential Uncertain ML2616 906 Q7APT0 ML2616 Uncharacterized protein 170 0.09638 non-essential 0.15574 non-essential high agree high_confidence_nonessential Rv0201c 62.1 NE 0 0.6493425172197871 65.959 Strong candidate ESM-2 calibrated P(essential)=0.096; HANSEN integrated essentiality score=0.156; Mtb RBH anchor Rv0201c=non-essential (agree); ProteomeLM contextual percentile=0.649; target-priority score=66.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.0) rescued_from_possible_false_negative_by_supporting_evidence 8.8e-05 non-essential Non-essential ML2617 755 O06079 mmpL11 ML2617 MLCL622.16c Probable transport protein MmpL11 1014 0.06278 non-essential 0.17531 non-essential high NA high_confidence_nonessential NP_214716.1 72.6 0.5585472761427677 62.768 Moderate candidate ESM-2 calibrated P(essential)=0.063; HANSEN integrated essentiality score=0.175; ProteomeLM contextual percentile=0.559; target-priority score=62.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.226217 non-essential Uncertain ML2618 492 Q9CD01 ML2618 Probable integral membrane protein 352 0.02837 non-essential 0.20328 non-essential high NA medium_confidence NP_214718.2 84.5 0.8528490920475892 72.337 Strong candidate ESM-2 calibrated P(essential)=0.028; HANSEN integrated essentiality score=0.203; ProteomeLM contextual percentile=0.853; target-priority score=72.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.853); Target-priority score is high (72.3) rescued_from_possible_false_negative_by_supporting_evidence 0.070579 non-essential Non-essential ML2620 1364 O06081 mmpL3 ML2620 MLCL622.18c Probable trehalose monomycolate exporter MmpL3 (TMM exporter MmpL3) (MmpL3 transporter) (Mycobacterial membrane protein large 3) 955 0.07497 non-essential 0.1052 non-essential high NA high_confidence_nonessential NP_214720.1 75.4 0.12460864120225423 51.084 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.105; ProteomeLM contextual percentile=0.125; target-priority score=51.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.350638 essential Uncertain ML2621 1111 Q9CD00 ML2621 NYN domain-containing protein 195 0.02105 non-essential 0.13338 non-essential high agree high_confidence_nonessential Rv0207c 60.4 NE 0 0.852222917971196 71.045 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.133; Mtb RBH anchor Rv0207c=non-essential (agree); ProteomeLM contextual percentile=0.852; target-priority score=71.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.852); Target-priority score is high (71.0) rescued_from_possible_false_negative_by_supporting_evidence 0.229792 non-essential Uncertain ML2622 680 Q9CCZ9 trmB ML2622 MLCL622.20c tRNA (guanine-N(7)-)-methyltransferase (EC 2.1.1.33) (tRNA (guanine(46)-N(7))-methyltransferase) (tRNA(m7G46)-methyltransferase) 230 0.05758 non-essential 0.18415 non-essential high NA high_confidence_nonessential NP_214722.1 67.1 0.5917345021916093 77.29 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.184; ProteomeLM contextual percentile=0.592; target-priority score=77.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.3) rescued_from_possible_false_negative_by_supporting_evidence 5.8e-05 non-essential Non-essential ML2624 1511 O06084 pckG pckA ML2624 MLCL622.21 Phosphoenolpyruvate carboxykinase [GTP] (PEP carboxykinase) (PEPCK) (EC 4.1.1.32) 609 0.03861 non-essential 0.07871 non-essential high NA high_confidence_nonessential NP_214725.1 86.1 0.10644959298685035 60.997 Moderate candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.079; ProteomeLM contextual percentile=0.106; target-priority score=61.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000242 non-essential Non-essential ML2627 921 Q7APS9 ML2627 Acyl dehydratase 339 0.07497 non-essential 0.15355 non-essential high NA high_confidence_nonessential NP_214730.1 73.7 0.3926111458985598 56.656 Moderate candidate ESM-2 calibrated P(essential)=0.075; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.393; target-priority score=56.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.115925 non-essential Non-essential ML2629 11 Q7APS8 ML2629 Coenzyme Q-binding protein COQ10 START domain-containing protein 156 0.24246 non-essential 0.51496 essential low disagree review_anchor_disagreement Rv0164 76.8 ES 1 0.8315591734502191 72.642 Strong candidate ESM-2 calibrated P(essential)=0.242; HANSEN integrated essentiality score=0.515; Mtb RBH anchor Rv0164=essential (disagree); ProteomeLM contextual percentile=0.832; target-priority score=72.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.005355 non-essential Non-essential ML2630 355 O06091 ML2630 MLCL622.28c Uncharacterized protein ML2630 123 0.03898 non-essential 0.21767 non-essential high NA medium_confidence 0.8991859737006888 68.793 Strong candidate ESM-2 calibrated P(essential)=0.039; HANSEN integrated essentiality score=0.218; ProteomeLM contextual percentile=0.899; target-priority score=68.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.899); Target-priority score is high (68.8) rescued_from_possible_false_negative_by_supporting_evidence 0.080428 non-essential Non-essential ML2631 1058 Q7APS7 ML2631 Possible oxidoreductase 449 0.05933 non-essential 0.1383 non-essential high NA high_confidence_nonessential NP_214675.1 78.8 0.3656856606136506 59.714 Moderate candidate ESM-2 calibrated P(essential)=0.059; HANSEN integrated essentiality score=0.138; ProteomeLM contextual percentile=0.366; target-priority score=59.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.096656 non-essential Non-essential ML2634 702 Q9CCZ8 pntB ML2634 NAD(P) transhydrogenase subunit beta (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit beta) 472 0.08714 non-essential 0.18172 non-essential high NA high_confidence_nonessential NP_214671.1 83.1 0.47025673137132123 67.608 Strong candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.182; ProteomeLM contextual percentile=0.470; target-priority score=67.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.6) rescued_from_possible_false_negative_by_supporting_evidence 0.022902 non-essential Non-essential ML2635 195 Q9CCZ7 pntAB ML2635 proton-translocating NAD(P)(+) transhydrogenase (EC 7.1.1.1) 112 0.10418 non-essential 0.24516 non-essential high NA medium_confidence NP_214670.1 82.9 0.7451471509079524 74.448 Strong candidate ESM-2 calibrated P(essential)=0.104; HANSEN integrated essentiality score=0.245; ProteomeLM contextual percentile=0.745; target-priority score=74.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (74.4) rescued_from_possible_false_negative_by_supporting_evidence 0.261728 non-essential Uncertain ML2636 447 Q9CCZ6 pntAA ML2636 NAD(P) transhydrogenase subunit alpha part 1 (EC 7.1.1.1) (Nicotinamide nucleotide transhydrogenase subunit alpha 1) (Pyridine nucleotide transhydrogenase subunit alpha 1) 367 0.13959 non-essential 0.20806 non-essential high NA medium_confidence NP_214669.1 88.7 0.3894802755165936 65.924 Strong candidate ESM-2 calibrated P(essential)=0.140; HANSEN integrated essentiality score=0.208; ProteomeLM contextual percentile=0.389; target-priority score=65.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (65.9) rescued_from_possible_false_negative_by_supporting_evidence 0.001244 non-essential Non-essential ML2639 1192 Q9CCZ5 ML2639 Aldehyde dehydrogenase 501 0.06636 non-essential 0.12646 non-essential high NA high_confidence_nonessential NP_214661.1 77.1 0.2680025046963056 58.28 Moderate candidate ESM-2 calibrated P(essential)=0.066; HANSEN integrated essentiality score=0.126; ProteomeLM contextual percentile=0.268; target-priority score=58.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.002004 non-essential Non-essential ML2640 861 Q9CCZ4 ML2640 Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640 (EC 2.1.1.-) 310 0.01019 non-essential 0.16206 non-essential high NA high_confidence_nonessential NP_214660.1 78.1 0.6850344395742016 75.304 Strong candidate ESM-2 calibrated P(essential)=0.010; HANSEN integrated essentiality score=0.162; ProteomeLM contextual percentile=0.685; target-priority score=75.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000264 non-essential Non-essential ML2647 775 Q9CCZ3 msrA ML2647 Peptide methionine sulfoxide reductase MsrA (Protein-methionine-S-oxide reductase) (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) 177 0.00543 non-essential 0.17278 non-essential high NA high_confidence_nonessential NP_214651.1 80.0 0.7557921102066374 80.129 High-priority ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.173; ProteomeLM contextual percentile=0.756; target-priority score=80.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.756); Target-priority score is high (80.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000109 non-essential Non-essential ML2649 1211 Q9CCZ2 ML2649 NodB homology domain-containing protein 271 0.09316 non-essential 0.12446 non-essential high NA high_confidence_nonessential 0.1559173450219161 50.569 Moderate candidate ESM-2 calibrated P(essential)=0.093; HANSEN integrated essentiality score=0.124; ProteomeLM contextual percentile=0.156; target-priority score=50.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.016993 non-essential Non-essential ML2651 454 Q9CCZ1 ML2651 Doubtful CDS 105 0.01806 non-essential 0.20722 non-essential high NA medium_confidence 0.9329993738259236 69.047 Strong candidate ESM-2 calibrated P(essential)=0.018; HANSEN integrated essentiality score=0.207; ProteomeLM contextual percentile=0.933; target-priority score=69.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.933); Target-priority score is high (69.0) rescued_from_possible_false_negative_by_supporting_evidence 4.8e-05 non-essential Non-essential ML2654 872 Q9CCZ0 ML2654 Phosphoesterase (EC 3.1.4.-) 165 0.13353 non-essential 0.16055 non-essential high NA high_confidence_nonessential 0.16906700062617408 55.325 Moderate candidate ESM-2 calibrated P(essential)=0.134; HANSEN integrated essentiality score=0.161; ProteomeLM contextual percentile=0.169; target-priority score=55.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.03213 non-essential Non-essential ML2655 287 Q05862 fbpC fbpC2 ML2655 Diacylglycerol acyltransferase/mycolyltransferase Ag85C (DGAT) (EC 2.3.1.122) (EC 2.3.1.20) (Acyl-CoA:diacylglycerol acyltransferase) (Antigen 85 complex C) (85C) (Ag85C) (Fibronectin-binding protein C) (Fbps C) 333 0.09165 non-essential 0.2273 non-essential high NA medium_confidence YP_177694.1 82.1 0.6887914840325611 77.436 Strong candidate ESM-2 calibrated P(essential)=0.092; HANSEN integrated essentiality score=0.227; ProteomeLM contextual percentile=0.689; target-priority score=77.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (77.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000548 non-essential Non-essential ML2659 483 Q9CCY9 ML2659 Probable secreted serine protease 354 0.04897 non-essential 0.20389 non-essential high NA medium_confidence NP_214639.1 65.9 0.7645585472761428 71.438 Strong candidate ESM-2 calibrated P(essential)=0.049; HANSEN integrated essentiality score=0.204; ProteomeLM contextual percentile=0.765; target-priority score=71.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.765); Target-priority score is high (71.4) rescued_from_possible_false_negative_by_supporting_evidence 0.000632 non-essential Non-essential ML2661 635 Q9CCY8 ML2661 Acyl-CoA synthase 548 0.06907 non-essential 0.18872 non-essential high NA high_confidence_nonessential NP_214633.1 71.3 0.5986224170319349 66.152 Strong candidate ESM-2 calibrated P(essential)=0.069; HANSEN integrated essentiality score=0.189; ProteomeLM contextual percentile=0.599; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.020169 non-essential Non-essential ML2663 919 Q7APS6 oxyS ML2663 Probable hydrogen peroxide-inducible genes activator 310 0.05241 non-essential 0.15368 non-essential high NA high_confidence_nonessential NP_214631.1 81.8 0.48215403882279273 61.673 Moderate candidate ESM-2 calibrated P(essential)=0.052; HANSEN integrated essentiality score=0.154; ProteomeLM contextual percentile=0.482; target-priority score=61.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 4e-06 non-essential Non-essential ML2664 1170 Q7APS5 ML2664 Possible secreted protein 251 0.01648 non-essential 0.12859 non-essential high NA high_confidence_nonessential NP_214630.1 76.0 0.4765184721352536 69.459 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.129; ProteomeLM contextual percentile=0.477; target-priority score=69.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (69.5) rescued_from_possible_false_negative_by_supporting_evidence 0.001986 non-essential Non-essential ML2666 339 Q9CCY7 ML2666 Uncharacterized protein 84 0.03486 non-essential 0.21972 non-essential high NA medium_confidence 0.9286161552911709 69.326 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.929; target-priority score=69.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.929); Target-priority score is high (69.3) rescued_from_possible_false_negative_by_supporting_evidence 1e-06 non-essential Non-essential ML2667 1297 Q9CCY6 ML2667 Possible membrane transport protein 618 0.03466 non-essential 0.11392 non-essential high NA high_confidence_nonessential 0.34940513462742645 54.972 Moderate candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.114; ProteomeLM contextual percentile=0.349; target-priority score=55.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.030211 non-essential Non-essential ML2669 264 Q7APS4 ML2669 Uncharacterized protein 106 0.03486 non-essential 0.23042 non-essential high NA medium_confidence 0.9812147777082029 72.836 Strong candidate ESM-2 calibrated P(essential)=0.035; HANSEN integrated essentiality score=0.230; ProteomeLM contextual percentile=0.981; target-priority score=72.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.981); Target-priority score is high (72.8) rescued_from_possible_false_negative_by_supporting_evidence 0.009562 non-essential Non-essential ML2670 1226 Q9CCY5 ML2670 Conserved integral membrane protein 666 0.03604 non-essential 0.12242 non-essential high NA high_confidence_nonessential NP_214625.1 78.7 0.382592360676268 58.536 Moderate candidate ESM-2 calibrated P(essential)=0.036; HANSEN integrated essentiality score=0.122; ProteomeLM contextual percentile=0.383; target-priority score=58.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.000997 non-essential Non-essential ML2671 580 O53114 ctpI ML2671 MLCB1913.02 Probable cation-transporting ATPase I (EC 7.2.2.-) 1609 0.05767 non-essential 0.19377 non-essential high NA high_confidence_nonessential NP_214621.1 81.4 0.6574827802128992 74.026 Strong candidate ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.194; ProteomeLM contextual percentile=0.657; target-priority score=74.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review Target-priority score is high (74.0) rescued_from_possible_false_negative_by_supporting_evidence 0.206507 non-essential Uncertain ML2672 1145 Q7APS3 icd2 ML2672 Isocitrate dehydrogenase [NADP] (EC 1.1.1.42) (Oxalosuccinate decarboxylase) 746 0.08082 non-essential 0.13002 non-essential high NA high_confidence_nonessential NP_214580.1 85.4 0.2116468378209142 62.013 Moderate candidate ESM-2 calibrated P(essential)=0.081; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.212; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001124 non-essential Non-essential ML2677 316 Q7APS2 ML2677 TetR-family transcriptional regulator 236 0.02929 non-essential 0.22261 non-essential high NA medium_confidence NP_214592.1 71.4 0.9524107701941139 75.711 Strong candidate ESM-2 calibrated P(essential)=0.029; HANSEN integrated essentiality score=0.223; ProteomeLM contextual percentile=0.952; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.952); Target-priority score is high (75.7) rescued_from_possible_false_negative_by_supporting_evidence 2.2e-05 non-essential Non-essential ML2678 1013 Q7APS1 ML2678 Transglutaminase-like domain-containing protein 1000 0.02105 non-essential 0.14291 non-essential high agree high_confidence_nonessential Rv2566 54.4 NE 0 0.9417658108954289 72.194 Strong candidate ESM-2 calibrated P(essential)=0.021; HANSEN integrated essentiality score=0.143; Mtb RBH anchor Rv2566=non-essential (agree); ProteomeLM contextual percentile=0.942; target-priority score=72.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Possible essential / review ProteomeLM contextual percentile is high (0.942); Target-priority score is high (72.2) rescued_from_possible_false_negative_by_supporting_evidence 0.047369 non-essential Non-essential ML2679 1538 Q7APS0 ML2679 Uncharacterized protein 893 0.02518 non-essential 0.07225 non-essential high agree high_confidence_nonessential Rv2567 75.2 NE 0 0.3105823418910457 52.166 Moderate candidate ESM-2 calibrated P(essential)=0.025; HANSEN integrated essentiality score=0.072; Mtb RBH anchor Rv2567=non-essential (agree); ProteomeLM contextual percentile=0.311; target-priority score=52.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.098387 non-essential Non-essential ML2680 523 P46394 dnaB ML2680 MLCB1913.16c Replicative DNA helicase DnaB (EC 5.6.2.3) (DNA 5'-3' helicase DnaB) [Cleaved into: Mle DnaB intein (EC 3.1.-.-)] 604 0.08956 non-essential 0.19944 non-essential high NA high_confidence_nonessential NP_214572.1 67.5 0.5479023168440826 72.865 Strong candidate ESM-2 calibrated P(essential)=0.090; HANSEN integrated essentiality score=0.199; ProteomeLM contextual percentile=0.548; target-priority score=72.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (72.9) rescued_from_possible_false_negative_by_supporting_evidence 0.536111 essential Likely essential ML2682 333 P46385 rplI ML2682 MLCB1913.18c Large ribosomal subunit protein bL9 (50S ribosomal protein L9) 152 0.10977 non-essential 0.22021 non-essential high NA medium_confidence NP_214570.1 88.7 0.593613024420789 67.351 Strong candidate ESM-2 calibrated P(essential)=0.110; HANSEN integrated essentiality score=0.220; ProteomeLM contextual percentile=0.594; target-priority score=67.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (67.4) rescued_from_possible_false_negative_by_supporting_evidence 0.001484 non-essential Non-essential ML2683 212 O53125 rpsR ML2683 MLCB1913.19c Small ribosomal subunit protein bS18 (30S ribosomal protein S18) 84 0.15264 non-essential 0.24095 non-essential high NA medium_confidence YP_177688.1 90.5 0.5297432686286788 63.672 Moderate candidate ESM-2 calibrated P(essential)=0.153; HANSEN integrated essentiality score=0.241; ProteomeLM contextual percentile=0.530; target-priority score=63.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001183 non-essential Non-essential ML2684 900 P46390 ssb ML2684 MLCB1913.20c Single-stranded DNA-binding protein (SSB) 168 0.01648 non-essential 0.15613 non-essential high NA high_confidence_nonessential NP_214568.1 87.5 0.6480901690670007 66.194 Strong candidate ESM-2 calibrated P(essential)=0.016; HANSEN integrated essentiality score=0.156; ProteomeLM contextual percentile=0.648; target-priority score=66.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (66.2) rescued_from_possible_false_negative_by_supporting_evidence 0.010913 non-essential Non-essential ML2685 48 P46389 rpsF ML2685 MLCB1913.21c Small ribosomal subunit protein bS6 (30S ribosomal protein S6) 96 0.28398 non-essential 0.40262 non-essential medium NA medium_confidence NP_214567.1 91.7 0.8428303068252975 75.663 Strong candidate ESM-2 calibrated P(essential)=0.284; HANSEN integrated essentiality score=0.403; ProteomeLM contextual percentile=0.843; target-priority score=75.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.403); ProteomeLM contextual percentile is high (0.843); Target-priority score is high (75.7) rescued_from_possible_false_negative_by_supporting_evidence 0.004771 non-essential Non-essential ML2687 1018 Q7APR9 ML2687 Conserved membrane protein 564 0.02691 non-essential 0.14251 non-essential high NA high_confidence_nonessential NP_214565.1 78.5 0.5266123982467126 63.989 Moderate candidate ESM-2 calibrated P(essential)=0.027; HANSEN integrated essentiality score=0.143; ProteomeLM contextual percentile=0.527; target-priority score=64.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.162264 non-essential Non-essential ML2688 384 Q9CCY4 ponA ML2688 Penicillin-bonding protein 708 0.14132 non-essential 0.21438 non-essential high NA medium_confidence YP_177687.1 83.9 0.42204132748904194 64.799 Moderate candidate ESM-2 calibrated P(essential)=0.141; HANSEN integrated essentiality score=0.214; ProteomeLM contextual percentile=0.422; target-priority score=64.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.025968 non-essential Non-essential ML2689 1478 Q7APR8 ML2689 DUF5318 domain-containing protein 138 0.00543 non-essential 0.08542 non-essential high agree high_confidence_nonessential Rv0049 83.2 NE 0 0.519724483406387 60.381 Moderate candidate ESM-2 calibrated P(essential)=0.005; HANSEN integrated essentiality score=0.085; Mtb RBH anchor Rv0049=non-essential (agree); ProteomeLM contextual percentile=0.520; target-priority score=60.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 1e-06 non-essential Non-essential ML2691 1445 Q9CCY3 ML2691 Transcription regulator PadR N-terminal domain-containing protein 180 0.04472 non-essential 0.09232 non-essential high agree high_confidence_nonessential Rv0047c 89.4 NE 0 0.3738259236067627 56.206 Moderate candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.092; Mtb RBH anchor Rv0047c=non-essential (agree); ProteomeLM contextual percentile=0.374; target-priority score=56.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 9e-06 non-essential Non-essential ML2692 17 proteomelm_only NA proteomelm_only 0.8941765810895429 ProteomeLM-only row imported from proteomelm_ess_predictions; integrated HANSEN essentiality score not available. proteomelm_ess_sync_20260626 2026-06-23T05:39:18Z Uncertain ProteomeLM-only row; integrated HANSEN evidence not available. none 0.4799 essential Likely essential ML2696 428 Q9CCY2 ML2696 MarR-family regulatory protein 243 0.02233 non-essential 0.20987 non-essential high NA medium_confidence NP_214556.1 81.7 0.9142141515341264 74.061 Strong candidate ESM-2 calibrated P(essential)=0.022; HANSEN integrated essentiality score=0.210; ProteomeLM contextual percentile=0.914; target-priority score=74.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.914); Target-priority score is high (74.1) rescued_from_possible_false_negative_by_supporting_evidence 1.4e-05 non-essential Non-essential ML2697 1148 Q9CCY1 pcnA ML2697 PcnA 486 0.13631 non-essential 0.12989 non-essential high NA high_confidence_nonessential YP_178026.1 83.9 0.005009392611145898 45.44 Exploratory ESM-2 calibrated P(essential)=0.136; HANSEN integrated essentiality score=0.130; ProteomeLM contextual percentile=0.005; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.017251 non-essential Non-essential ML2698 1310 Q7APR7 ML2698 Nudix hydrolase domain-containing protein 251 0.05422 non-essential 0.11263 non-essential high NA high_confidence_nonessential NP_218425.1 76.6 0.25923606762680024 52.539 Moderate candidate ESM-2 calibrated P(essential)=0.054; HANSEN integrated essentiality score=0.113; ProteomeLM contextual percentile=0.259; target-priority score=52.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.062048 non-essential Non-essential ML2699 37 Q9CCY0 ML2699 Secreted protein 797 0.23313 non-essential 0.42465 non-essential low disagree review_anchor_disagreement Rv3909 72.3 ES 1 0.1208515967438948 45.372 Exploratory ESM-2 calibrated P(essential)=0.233; HANSEN integrated essentiality score=0.425; Mtb RBH anchor Rv3909=essential (disagree); ProteomeLM contextual percentile=0.121; target-priority score=45.4 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Likely essential Mtb reciprocal-best-hit anchor is experimentally essential or essential-like rescued_from_false_negative_by_mtb_anchor 0.225768 non-essential Uncertain ML2700 1030 Q9CCX9 ML2700 Possible conserved membrane protein 1206 0.08711 non-essential 0.14119 non-essential high NA high_confidence_nonessential NP_218427.1 73.5 0.2817783343769568 50.691 Moderate candidate ESM-2 calibrated P(essential)=0.087; HANSEN integrated essentiality score=0.141; ProteomeLM contextual percentile=0.282; target-priority score=50.7 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:45Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.209722 non-essential Uncertain ML2703 1102 P46843 trxB/A trx ML2703 Bifunctional thioredoxin reductase/thioredoxin [Includes: Thioredoxin reductase (TRXR) (EC 1.8.1.9); Thioredoxin] 458 0.07935 non-essential 0.13378 non-essential high NA high_confidence_nonessential NP_218430.1 83.2 0.24045084533500313 62.034 Moderate candidate ESM-2 calibrated P(essential)=0.079; HANSEN integrated essentiality score=0.134; ProteomeLM contextual percentile=0.240; target-priority score=62.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.009017 non-essential Non-essential ML2704 1241 Q9CCX8 ML2704 Hydrolase 406 0.10115 non-essential 0.12081 non-essential high NA high_confidence_nonessential YP_178027.1 86.9 0.1008140262993112 49.549 Exploratory ESM-2 calibrated P(essential)=0.101; HANSEN integrated essentiality score=0.121; ProteomeLM contextual percentile=0.101; target-priority score=49.5 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.801033 essential Essential ML2705 1460 Q7APR6 ML2705 Acetyltransferase 259 0.04123 non-essential 0.08928 non-essential high agree high_confidence_nonessential Rv3916c 77.9 NE 0 0.36631183469004386 55.825 Moderate candidate ESM-2 calibrated P(essential)=0.041; HANSEN integrated essentiality score=0.089; Mtb RBH anchor Rv3916c=non-essential (agree); ProteomeLM contextual percentile=0.366; target-priority score=55.8 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.001294 non-essential Non-essential ML2706 804 Q50201 parB ML2706 Probable chromosome-partitioning protein ParB 333 0.18715 non-essential 0.16947 non-essential high NA high_confidence_nonessential NP_218435.2 78.6 0.015028177833437696 41.876 Exploratory ESM-2 calibrated P(essential)=0.187; HANSEN integrated essentiality score=0.169; ProteomeLM contextual percentile=0.015; target-priority score=41.9 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score and weak supporting evidence; no essential Mtb anchor none 0.484684 essential Likely essential ML2707 394 Q9CCX7 parA ML2707 Cell division protein 351 0.04459 non-essential 0.21338 non-essential high NA medium_confidence NP_218434.2 86.3 0.8359423919849718 72.986 Strong candidate ESM-2 calibrated P(essential)=0.045; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.836; target-priority score=73.0 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.836); Target-priority score is high (73.0) rescued_from_possible_false_negative_by_supporting_evidence 0.655115 essential Likely essential ML2708 399 Q50203 rsmG gidB ML2708 Ribosomal RNA small subunit methyltransferase G (EC 2.1.1.-) (16S rRNA 7-methylguanosine methyltransferase) (16S rRNA m7G methyltransferase) (Glucose-inhibited division protein B) 245 0.0499 non-essential 0.21279 non-essential high NA medium_confidence NP_218436.2 68.9 0.7896055103318722 79.268 Strong candidate ESM-2 calibrated P(essential)=0.050; HANSEN integrated essentiality score=0.213; ProteomeLM contextual percentile=0.790; target-priority score=79.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review ProteomeLM contextual percentile is high (0.790); Target-priority score is high (79.3) rescued_from_possible_false_negative_by_supporting_evidence 0.000661 non-essential Non-essential ML2709 1488 Q7APR5 ML2709 R3H domain-containing protein 193 0.09148 non-essential 0.08371 non-essential high agree high_confidence_nonessential Rv3920c 73.1 NE 0 0.061991233562930494 45.249 Exploratory ESM-2 calibrated P(essential)=0.091; HANSEN integrated essentiality score=0.084; Mtb RBH anchor Rv3920c=non-essential (agree); ProteomeLM contextual percentile=0.062; target-priority score=45.2 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Lower essentiality evidence low model score, low ProteomeLM context, low target priority and Mtb non-essential anchor none 0.396769 essential Uncertain ML2710 1348 Q50205 yidC ML2710 Membrane protein insertase YidC (Foldase YidC) (Membrane integrase YidC) (Membrane protein YidC) 380 0.05767 non-essential 0.10831 non-essential high NA high_confidence_nonessential NP_218438.1 88.1 0.2266750156543519 49.589 Exploratory ESM-2 calibrated P(essential)=0.058; HANSEN integrated essentiality score=0.108; ProteomeLM contextual percentile=0.227; target-priority score=49.6 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Uncertain insufficient convergent evidence for either essential or lower-essentiality classification none 0.008156 non-essential Non-essential ML2712 95 P46610 rnpA ML2712 Ribonuclease P protein component (RNase P protein) (RNaseP protein) (EC 3.1.26.5) (Protein C5) 120 0.17588 non-essential 0.29075 non-essential high NA medium_confidence NP_218440.3 63.0 0.6825297432686287 75.065 Strong candidate ESM-2 calibrated P(essential)=0.176; HANSEN integrated essentiality score=0.291; ProteomeLM contextual percentile=0.683; target-priority score=75.1 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review Target-priority score is high (75.1) rescued_from_possible_false_negative_by_supporting_evidence 0.000414 non-essential Non-essential ML2713 20 P46386 rpmH ML2713 Large ribosomal subunit protein bL34 (50S ribosomal protein L34) 47 0.42684 non-essential 0.47636 non-essential medium NA medium_confidence NP_218441.1 93.6 0.6455854727614276 67.343 Strong candidate ESM-2 calibrated P(essential)=0.427; HANSEN integrated essentiality score=0.476; ProteomeLM contextual percentile=0.646; target-priority score=67.3 hansen_essentiality_v1_esm2_mtb_transfer_rbh_proteomelm 2026-05-30T13:57:44Z Possible essential / review HANSEN integrated score is moderate (0.476); ESM-2 transfer probability is moderate (0.427); Target-priority score is high (67.3) rescued_from_possible_false_negative_by_supporting_evidence 0.208113 non-essential Uncertain